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The map label for this gene is thyX

Identifier: 57236938

GI number: 57236938

Start: 31770

End: 32393

Strand: Reverse

Name: thyX

Synonym: CJE0026

Alternate gene names: 57236938

Gene position: 32393-31770 (Counterclockwise)

Preceding gene: 57237048

Following gene: 57236937

Centisome position: 1.82

GC content: 34.29

Gene sequence:

>624_bases
ATGCAAATCACTTTACTTTTTCACACTCCATTATCTGTTTGTTCTCATGCAACAAGAACTTGTTGGCAAAGCTTTGAAAA
AGGCGATTGCGGTGGCGAAAAAGATAAAGAACTTATCGATCGCGTGGGCAACAAATTCAAACACGCTTCAACCTTAGAAC
ATCTAAACTATACTTTTTATATACAAGGAATTTCAAGAGCTTGCTTACAAGAAGTTGCAAGACACCGTCACACTAGTCCT
AGTGTAAAAAGCACGCGTTATACCTTAAAAGAACTTCGCAATGAAGCTGAATTTAAAATAGGAGATTTTGAAAATGCAAG
CCGTTATCTTGTGCTTTGTGGTAATGAAGAGGTTGATAACGCAAGCATTAAAGCCTTAGAAAATTTACGCACTATTTTAC
AAAAAAGCATTAGTCTAGATATAGCCAAATACTGCTTACCAGAAAGCTATAAAACTGAACTTACACTAACGATTAATGCA
AGAAGTTTGCAGAATTTCATTTCTTTGCGTAGTTCAAAATCAGCTCTTTGGGAGATTAGAAATTTAGCAAATGCTTTATT
TGAAGCCTTGCCACAAGAACACAAATTTATATTTGAACATTGCTTACATAAAGATATAGAATAA

Upstream 100 bases:

>100_bases
TTTATCTAATTATAGCTTGATAAAACTTTTTATTTCATTAGAATTTTAAGTAAAAAATGCAAGAATTACAAAAAATATTT
TTATCAAAAAAGGAATAAGC

Downstream 100 bases:

>100_bases
ATCATACTGATTTTATCTTATTTAAAATATTGTTATGCTACCATTTATAAAATCAAGCTTTACGCAAGTATATTTTCATA
TACCTTGTGCTTGATTATAG

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MQITLLFHTPLSVCSHATRTCWQSFEKGDCGGEKDKELIDRVGNKFKHASTLEHLNYTFYIQGISRACLQEVARHRHTSP
SVKSTRYTLKELRNEAEFKIGDFENASRYLVLCGNEEVDNASIKALENLRTILQKSISLDIAKYCLPESYKTELTLTINA
RSLQNFISLRSSKSALWEIRNLANALFEALPQEHKFIFEHCLHKDIE

Sequences:

>Translated_207_residues
MQITLLFHTPLSVCSHATRTCWQSFEKGDCGGEKDKELIDRVGNKFKHASTLEHLNYTFYIQGISRACLQEVARHRHTSP
SVKSTRYTLKELRNEAEFKIGDFENASRYLVLCGNEEVDNASIKALENLRTILQKSISLDIAKYCLPESYKTELTLTINA
RSLQNFISLRSSKSALWEIRNLANALFEALPQEHKFIFEHCLHKDIE
>Mature_207_residues
MQITLLFHTPLSVCSHATRTCWQSFEKGDCGGEKDKELIDRVGNKFKHASTLEHLNYTFYIQGISRACLQEVARHRHTSP
SVKSTRYTLKELRNEAEFKIGDFENASRYLVLCGNEEVDNASIKALENLRTILQKSISLDIAKYCLPESYKTELTLTINA
RSLQNFISLRSSKSALWEIRNLANALFEALPQEHKFIFEHCLHKDIE

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THYX_CAMJE (Q9PJ85)

Other databases:

- EMBL:   AL111168
- PIR:   E81418
- RefSeq:   YP_002343498.1
- ProteinModelPortal:   Q9PJ85
- SMR:   Q9PJ85
- IntAct:   Q9PJ85
- GeneID:   904365
- GenomeReviews:   AL111168_GR
- KEGG:   cje:Cj0026c
- HOGENOM:   HBG458114
- OMA:   WVDEFFG
- ProtClustDB:   PRK00847
- BioCyc:   CJEJ192222:CJ0026C-MONOMER
- BRENDA:   2.1.1.148
- HAMAP:   MF_01408
- InterPro:   IPR003669
- TIGRFAMs:   TIGR02170

Pfam domain/function: PF02511 Thy1; SSF69796 Thy1

EC number: =2.1.1.148

Molecular weight: Translated: 23809; Mature: 23809

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS51331 THYX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQITLLFHTPLSVCSHATRTCWQSFEKGDCGGEKDKELIDRVGNKFKHASTLEHLNYTFY
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEE
IQGISRACLQEVARHRHTSPSVKSTRYTLKELRNEAEFKIGDFENASRYLVLCGNEEVDN
EECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEECCCCCCH
ASIKALENLRTILQKSISLDIAKYCLPESYKTELTLTINARSLQNFISLRSSKSALWEIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCHHHHHHHH
NLANALFEALPQEHKFIFEHCLHKDIE
HHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQITLLFHTPLSVCSHATRTCWQSFEKGDCGGEKDKELIDRVGNKFKHASTLEHLNYTFY
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEE
IQGISRACLQEVARHRHTSPSVKSTRYTLKELRNEAEFKIGDFENASRYLVLCGNEEVDN
EECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEECCCCCCH
ASIKALENLRTILQKSISLDIAKYCLPESYKTELTLTINARSLQNFISLRSSKSALWEIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHCCHHHHHHHH
NLANALFEALPQEHKFIFEHCLHKDIE
HHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204