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The map label for this gene is yisK [H]

Identifier: 57236933

GI number: 57236933

Start: 24542

End: 25420

Strand: Reverse

Name: yisK [H]

Synonym: CJE0021

Alternate gene names: 57236933

Gene position: 25420-24542 (Counterclockwise)

Preceding gene: 57236934

Following gene: 57236932

Centisome position: 1.43

GC content: 31.63

Gene sequence:

>879_bases
ATGAAATTTGTTAATTTTATACAGGGTCAAAAACCCAATCTAGGAGTACTAAATTCTAGTGGAAAAATTGTAAGTTTTGA
TGATCTTGGCATTGAAACTAACGATATGAATGAATTTATTATCCATTTTGATAAATTTAAACACAAACTTACAGACTTGG
ATTCTAAAATAGCCTATGAAATTCCTCAAGAAAATTATCTAGCCCCTATTATAGAACCTCGTCAAGATATTATATGTCTT
GGGATTAATTTTTTAGATCATGCCAAAGAATCTGCCAAATTTAAGGGTGAAAAATTTGAAGAAAGAGAATATCCTGTATA
TTTTGGAAAACGCTGCAATCAAGCTACGCCACCTTTTGGCGATATACCTTTACATGCAGATGTAACTTCTCAGCTTGATT
ATGAATGTGAGCTTGCATTTATTTTAAGTAAAGATGCTTATAAAATCAAAGCTAAAGATGCAAAAGATTATATCTTTGGC
TATACTATTATCAATGAAATTTCAGCTCGCGAACTTCAAAAACGCCACAAACAATTCTACCGAGCAAAAAGTCTTGAAGG
TAGCACTATAATGGGACCTTATATCACAAGCGTAGATGAAATTTCTTATCCTCCTAAACTCCAACTTCAAAGCTATGTCA
ATGATGAACTACGCCAAAACTCTAACACTCAATTGTTTATTTTTGATATTGCTTATGTCTTAGAAGAACTTAGTGCAGGC
ATGCTTTTAAAAGCTGGAAGTATTATATCTATGGGAACTCCTAGTGGAGTAGGTATGGGGTTAAATCCACCTACTTTTTT
AAAATCAGGAGATAAAGTACGCTGTGTAATAGAAAATTTAGGAGAACTTTGTAATAAAATAAAAAATATCAATTATTAA

Upstream 100 bases:

>100_bases
CTACGCTACAATCAATCACTTTTTTACCAAATTTTAAAACAAAAAAATAATTCTTGCTAAAACTTTAAGTATAATTAAAT
AAAAAAGCGAGATTTTCCAA

Downstream 100 bases:

>100_bases
ATAATTTACTAAAATTATACTATAATGGCATTTTAAAAACTTAAATTAAGGCAGAAATTTATCATGAAAAAAATAATAAT
GATTTTATGTTTATCTTATG

Product: fumarylacetoacetate hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKFVNFIQGQKPNLGVLNSSGKIVSFDDLGIETNDMNEFIIHFDKFKHKLTDLDSKIAYEIPQENYLAPIIEPRQDIICL
GINFLDHAKESAKFKGEKFEEREYPVYFGKRCNQATPPFGDIPLHADVTSQLDYECELAFILSKDAYKIKAKDAKDYIFG
YTIINEISARELQKRHKQFYRAKSLEGSTIMGPYITSVDEISYPPKLQLQSYVNDELRQNSNTQLFIFDIAYVLEELSAG
MLLKAGSIISMGTPSGVGMGLNPPTFLKSGDKVRCVIENLGELCNKIKNINY

Sequences:

>Translated_292_residues
MKFVNFIQGQKPNLGVLNSSGKIVSFDDLGIETNDMNEFIIHFDKFKHKLTDLDSKIAYEIPQENYLAPIIEPRQDIICL
GINFLDHAKESAKFKGEKFEEREYPVYFGKRCNQATPPFGDIPLHADVTSQLDYECELAFILSKDAYKIKAKDAKDYIFG
YTIINEISARELQKRHKQFYRAKSLEGSTIMGPYITSVDEISYPPKLQLQSYVNDELRQNSNTQLFIFDIAYVLEELSAG
MLLKAGSIISMGTPSGVGMGLNPPTFLKSGDKVRCVIENLGELCNKIKNINY
>Mature_292_residues
MKFVNFIQGQKPNLGVLNSSGKIVSFDDLGIETNDMNEFIIHFDKFKHKLTDLDSKIAYEIPQENYLAPIIEPRQDIICL
GINFLDHAKESAKFKGEKFEEREYPVYFGKRCNQATPPFGDIPLHADVTSQLDYECELAFILSKDAYKIKAKDAKDYIFG
YTIINEISARELQKRHKQFYRAKSLEGSTIMGPYITSVDEISYPPKLQLQSYVNDELRQNSNTQLFIFDIAYVLEELSAG
MLLKAGSIISMGTPSGVGMGLNPPTFLKSGDKVRCVIENLGELCNKIKNINY

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=287, Percent_Identity=29.9651567944251, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI40786394, Length=287, Percent_Identity=29.9651567944251, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI13654274, Length=222, Percent_Identity=30.6306306306306, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI215422413, Length=188, Percent_Identity=32.9787234042553, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI66348062, Length=188, Percent_Identity=32.9787234042553, Blast_Score=91, Evalue=9e-19,
Organism=Escherichia coli, GI1787428, Length=226, Percent_Identity=24.7787610619469, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17557057, Length=201, Percent_Identity=31.8407960199005, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28572127, Length=292, Percent_Identity=32.5342465753425, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24663695, Length=223, Percent_Identity=29.1479820627803, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571789, Length=160, Percent_Identity=26.25, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 33125; Mature: 33125

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVNFIQGQKPNLGVLNSSGKIVSFDDLGIETNDMNEFIIHFDKFKHKLTDLDSKIAYE
CCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEE
IPQENYLAPIIEPRQDIICLGINFLDHAKESAKFKGEKFEEREYPVYFGKRCNQATPPFG
CCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCC
DIPLHADVTSQLDYECELAFILSKDAYKIKAKDAKDYIFGYTIINEISARELQKRHKQFY
CCCCCCCHHHCCCCEEEEEEEECCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RAKSLEGSTIMGPYITSVDEISYPPKLQLQSYVNDELRQNSNTQLFIFDIAYVLEELSAG
HHHCCCCCEEECCHHCCHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCC
MLLKAGSIISMGTPSGVGMGLNPPTFLKSGDKVRCVIENLGELCNKIKNINY
EEEECCCEEECCCCCCCCCCCCCCHHHCCCCEEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKFVNFIQGQKPNLGVLNSSGKIVSFDDLGIETNDMNEFIIHFDKFKHKLTDLDSKIAYE
CCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHEEE
IPQENYLAPIIEPRQDIICLGINFLDHAKESAKFKGEKFEEREYPVYFGKRCNQATPPFG
CCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCC
DIPLHADVTSQLDYECELAFILSKDAYKIKAKDAKDYIFGYTIINEISARELQKRHKQFY
CCCCCCCHHHCCCCEEEEEEEECCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RAKSLEGSTIMGPYITSVDEISYPPKLQLQSYVNDELRQNSNTQLFIFDIAYVLEELSAG
HHHCCCCCEEECCHHCCHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCC
MLLKAGSIISMGTPSGVGMGLNPPTFLKSGDKVRCVIENLGELCNKIKNINY
EEEECCCEEECCCCCCCCCCCCCCHHHCCCCEEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]