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The map label for this gene is ndk [H]

Identifier: 21228566

GI number: 21228566

Start: 2939831

End: 2940313

Strand: Reverse

Name: ndk [H]

Synonym: MM_2464

Alternate gene names: 21228566

Gene position: 2940313-2939831 (Counterclockwise)

Preceding gene: 21228567

Following gene: 21228565

Centisome position: 71.78

GC content: 49.9

Gene sequence:

>483_bases
ATGCCTGTTAGTTCGAATACAGAAGGTGTGCATATGGAACAGACATACGTGATGGTAAAGCCTGACGGAGTCCAGCGCGG
GCTGGTCGGAGAGGTAATTTCCAGGATCGAAAAGAGAGGCTTGAAGATTGTTGCCCTCAGGATGAACGTTATCGCCGAAG
CTACTGCAAAGGAACACTACGGTGAGCACGCTGCAAGGCCATTTTTCCCCTCCCTTATCGAGTTCATTACCTCAGGTCCT
TCGGTCTCGATGGTAGTTGCAGGAAAGGATGCAATAAAGGTAATGAGAGCAATAAACGGGGCTACAAACCCTGTGGATGC
AGCTCCCGGAACTATCCGTGGAGACTTTGCTCTTGACGTGGGAAGGAACGTGGTTCATGCCTCCGACTCCCCTGAAGCTG
CAGCAAGAGAGATTGCAATTCACTTTAAGGACTCCGAAATCGCGAATTATTCCAGAGTCGATGAGGTCTGTCTGTACGAG
TAA

Upstream 100 bases:

>100_bases
CATGTGCTCTTCCAAGTGCATGAGCAACTTCGCTCTTGGCAGGCTTCCGCGCCGCACCGAGTGGACTGAGAAAGGCAAAA
TCCAGCTGAAAAAAGCATAA

Downstream 100 bases:

>100_bases
TGCAGGTATATCAAATCCTTTTTCGTGTATCCAGAGTTATCCGGATATGAATTCAGGCATTTGTTTATCCTTACCTGCAA
AATGGGTCCTTCCGGGGAAA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MPVSSNTEGVHMEQTYVMVKPDGVQRGLVGEVISRIEKRGLKIVALRMNVIAEATAKEHYGEHAARPFFPSLIEFITSGP
SVSMVVAGKDAIKVMRAINGATNPVDAAPGTIRGDFALDVGRNVVHASDSPEAAAREIAIHFKDSEIANYSRVDEVCLYE

Sequences:

>Translated_160_residues
MPVSSNTEGVHMEQTYVMVKPDGVQRGLVGEVISRIEKRGLKIVALRMNVIAEATAKEHYGEHAARPFFPSLIEFITSGP
SVSMVVAGKDAIKVMRAINGATNPVDAAPGTIRGDFALDVGRNVVHASDSPEAAAREIAIHFKDSEIANYSRVDEVCLYE
>Mature_159_residues
PVSSNTEGVHMEQTYVMVKPDGVQRGLVGEVISRIEKRGLKIVALRMNVIAEATAKEHYGEHAARPFFPSLIEFITSGPS
VSMVVAGKDAIKVMRAINGATNPVDAAPGTIRGDFALDVGRNVVHASDSPEAAAREIAIHFKDSEIANYSRVDEVCLYE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI38045913, Length=161, Percent_Identity=45.3416149068323, Blast_Score=161, Evalue=2e-40,
Organism=Homo sapiens, GI37693993, Length=152, Percent_Identity=49.3421052631579, Blast_Score=161, Evalue=3e-40,
Organism=Homo sapiens, GI66392227, Length=150, Percent_Identity=46, Blast_Score=160, Evalue=3e-40,
Organism=Homo sapiens, GI66392205, Length=150, Percent_Identity=46, Blast_Score=160, Evalue=3e-40,
Organism=Homo sapiens, GI4505409, Length=150, Percent_Identity=46, Blast_Score=160, Evalue=3e-40,
Organism=Homo sapiens, GI66392192, Length=150, Percent_Identity=46, Blast_Score=160, Evalue=3e-40,
Organism=Homo sapiens, GI66392203, Length=150, Percent_Identity=46, Blast_Score=160, Evalue=4e-40,
Organism=Homo sapiens, GI4557797, Length=150, Percent_Identity=46, Blast_Score=158, Evalue=2e-39,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=48.9208633093525, Blast_Score=148, Evalue=2e-36,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=37.2262773722628, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI7019465, Length=140, Percent_Identity=36.4285714285714, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI37574614, Length=140, Percent_Identity=36.4285714285714, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4505413, Length=147, Percent_Identity=29.2517006802721, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=28.1481481481481, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=41.1347517730496, Blast_Score=121, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17506807, Length=139, Percent_Identity=51.7985611510791, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322783, Length=150, Percent_Identity=47.3333333333333, Blast_Score=166, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45549037, Length=158, Percent_Identity=46.8354430379747, Blast_Score=169, Evalue=5e-43,
Organism=Drosophila melanogaster, GI18860097, Length=144, Percent_Identity=28.4722222222222, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 17279; Mature: 17148

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVSSNTEGVHMEQTYVMVKPDGVQRGLVGEVISRIEKRGLKIVALRMNVIAEATAKEHY
CCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHH
GEHAARPFFPSLIEFITSGPSVSMVVAGKDAIKVMRAINGATNPVDAAPGTIRGDFALDV
HHHCCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEC
GRNVVHASDSPEAAAREIAIHFKDSEIANYSRVDEVCLYE
CCEEEECCCCCHHHHHEEEEEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
PVSSNTEGVHMEQTYVMVKPDGVQRGLVGEVISRIEKRGLKIVALRMNVIAEATAKEHY
CCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHH
GEHAARPFFPSLIEFITSGPSVSMVVAGKDAIKVMRAINGATNPVDAAPGTIRGDFALDV
HHHCCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEC
GRNVVHASDSPEAAAREIAIHFKDSEIANYSRVDEVCLYE
CCEEEECCCCCHHHHHEEEEEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]