Click here to switch to the map view.

The map label for this gene is appC [H]

Identifier: 21228559

GI number: 21228559

Start: 2931602

End: 2932531

Strand: Reverse

Name: appC [H]

Synonym: MM_2457

Alternate gene names: 21228559

Gene position: 2932531-2931602 (Counterclockwise)

Preceding gene: 21228560

Following gene: 21228558

Centisome position: 71.59

GC content: 45.59

Gene sequence:

>930_bases
ATGATAAAGGATGTTGCTGCCTCTGGAAATGCCAGAATTATTTCATTTGCTCAGGCGTTAAATATTGACAAATTTGTAAG
CGGTACAGCTGAAACATTTTCGAAGTTCAGCACTGAAGGTAAAATTGCTGTCTTTGGCATCATCTGTATCATTTTAATGG
CAGTTTTTGCTCCTGTGATAACAATTTATCCCCCCCAGAAGATTACAGGGAATTCACTTGAACCCCCAGGTCCGGAACAC
ATACTTGGAACGGATGAACTGGGCATGGACATCTGGTCACAGATATGTTACGGGGCAAGGATGAGCCTTACAATAGGGCT
TGCAGTAGCGTTTGCGGCAGGTTTTGGAGGAGGGGCTGTCGGGATACTGGCAGGATACATAGGAGGGAATGTTGACGAGG
CACTGATGAGAGTAATCGATATAACAATGGCTCTCCCGAGTTTTCCTCTCCTTATCGTAATATCCGCTTTTCTCGGACCG
AGCATTCTTAACGTAATTCTTATTCTTGTCCTTTTCAGCTGGGCAAAACCCGCACGAATTGCACGTTCCCAGACCCTGGC
ATTAAAGAAGAACGACTACATCACTGCAGCCCGAAATTACGGTGCAAAACCATTTTACCTGCTCTGGAGGCATATATTTC
CCGAAGTTATGCCTGTCCTGCTTGTGCTTGTAATCGGTATATCCTCACACGCAATCATAGCCGAAACTGGGCTTGCTTTT
CTGGGGCTTGGGGACCCTACTTCCAAGAGCTGGGGGATGATGCTTAACCATGCAACCGGCTTCAGGTCGATATATTTTAC
ACCCTACTGGCAATGGTGGCTGTTGCCTCCGCTGTTTATGCTTATTTTCCTCCTGCTCTGTCTTGCGTTCATAAGCAGGG
ATATGGAAAGGATACTTGATCCCAAACTAAAAATAAAGAAAGGTTTCTGA

Upstream 100 bases:

>100_bases
CTCTTATCCAGGGAATTCTGCTGGTAATTGCAGTCTCCATACTCGTCTGCAACCTGATGGTTGACAAAATATACGGGAAA
CTTGATCCGAGAGTTGTGGT

Downstream 100 bases:

>100_bases
TTATGAGTCTGCTTAAAGTAAATGACCTTAAATGCCACTACATAACTGACATTAACACGGTCAGGGCTGTAGACGGAATT
TCTTTTGAAATTGAAGAGGG

Product: peptide ABC transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MIKDVAASGNARIISFAQALNIDKFVSGTAETFSKFSTEGKIAVFGIICIILMAVFAPVITIYPPQKITGNSLEPPGPEH
ILGTDELGMDIWSQICYGARMSLTIGLAVAFAAGFGGGAVGILAGYIGGNVDEALMRVIDITMALPSFPLLIVISAFLGP
SILNVILILVLFSWAKPARIARSQTLALKKNDYITAARNYGAKPFYLLWRHIFPEVMPVLLVLVIGISSHAIIAETGLAF
LGLGDPTSKSWGMMLNHATGFRSIYFTPYWQWWLLPPLFMLIFLLLCLAFISRDMERILDPKLKIKKGF

Sequences:

>Translated_309_residues
MIKDVAASGNARIISFAQALNIDKFVSGTAETFSKFSTEGKIAVFGIICIILMAVFAPVITIYPPQKITGNSLEPPGPEH
ILGTDELGMDIWSQICYGARMSLTIGLAVAFAAGFGGGAVGILAGYIGGNVDEALMRVIDITMALPSFPLLIVISAFLGP
SILNVILILVLFSWAKPARIARSQTLALKKNDYITAARNYGAKPFYLLWRHIFPEVMPVLLVLVIGISSHAIIAETGLAF
LGLGDPTSKSWGMMLNHATGFRSIYFTPYWQWWLLPPLFMLIFLLLCLAFISRDMERILDPKLKIKKGF
>Mature_309_residues
MIKDVAASGNARIISFAQALNIDKFVSGTAETFSKFSTEGKIAVFGIICIILMAVFAPVITIYPPQKITGNSLEPPGPEH
ILGTDELGMDIWSQICYGARMSLTIGLAVAFAAGFGGGAVGILAGYIGGNVDEALMRVIDITMALPSFPLLIVISAFLGP
SILNVILILVLFSWAKPARIARSQTLALKKNDYITAARNYGAKPFYLLWRHIFPEVMPVLLVLVIGISSHAIIAETGLAF
LGLGDPTSKSWGMMLNHATGFRSIYFTPYWQWWLLPPLFMLIFLLLCLAFISRDMERILDPKLKIKKGF

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787760, Length=263, Percent_Identity=31.1787072243346, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1787054, Length=287, Percent_Identity=32.0557491289199, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1789889, Length=248, Percent_Identity=33.8709677419355, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787498, Length=305, Percent_Identity=33.7704918032787, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789964, Length=263, Percent_Identity=34.9809885931559, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788505, Length=173, Percent_Identity=33.5260115606936, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787549, Length=258, Percent_Identity=28.6821705426357, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33730; Mature: 33730

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKDVAASGNARIISFAQALNIDKFVSGTAETFSKFSTEGKIAVFGIICIILMAVFAPVI
CCCCCCCCCCCCEEHHHHHHCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TIYPPQKITGNSLEPPGPEHILGTDELGMDIWSQICYGARMSLTIGLAVAFAAGFGGGAV
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHH
GILAGYIGGNVDEALMRVIDITMALPSFPLLIVISAFLGPSILNVILILVLFSWAKPARI
HHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHH
ARSQTLALKKNDYITAARNYGAKPFYLLWRHIFPEVMPVLLVLVIGISSHAIIAETGLAF
HHHHHEEEECCCCEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCEEE
LGLGDPTSKSWGMMLNHATGFRSIYFTPYWQWWLLPPLFMLIFLLLCLAFISRDMERILD
EECCCCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKLKIKKGF
CCCEECCCC
>Mature Secondary Structure
MIKDVAASGNARIISFAQALNIDKFVSGTAETFSKFSTEGKIAVFGIICIILMAVFAPVI
CCCCCCCCCCCCEEHHHHHHCHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TIYPPQKITGNSLEPPGPEHILGTDELGMDIWSQICYGARMSLTIGLAVAFAAGFGGGAV
EECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHH
GILAGYIGGNVDEALMRVIDITMALPSFPLLIVISAFLGPSILNVILILVLFSWAKPARI
HHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHH
ARSQTLALKKNDYITAARNYGAKPFYLLWRHIFPEVMPVLLVLVIGISSHAIIAETGLAF
HHHHHEEEECCCCEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHCCEEE
LGLGDPTSKSWGMMLNHATGFRSIYFTPYWQWWLLPPLFMLIFLLLCLAFISRDMERILD
EECCCCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKLKIKKGF
CCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]