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The map label for this gene is purE [H]

Identifier: 21228462

GI number: 21228462

Start: 2817676

End: 2818071

Strand: Reverse

Name: purE [H]

Synonym: MM_2360

Alternate gene names: 21228462

Gene position: 2818071-2817676 (Counterclockwise)

Preceding gene: 21228463

Following gene: 21228456

Centisome position: 68.79

GC content: 48.23

Gene sequence:

>396_bases
ATGGTTGATATTTCACTGATTATGGGTTCTGAGTCCGACAGGGCAATCGCCAACCGTGCGGTTTCAGTAATTGAAAAAAC
CAGGTACACTTACGAAGTAATGGTCATTTCTGCCCACAGAAACCCTGACGAGCTTGATATCTATATATCAAATACGGACG
CAAAAGTCTTTATTACCATAGCGGGTTTGTCAGCAGCTCTTCCCGGAGTCGTGGCCTCCAAGACTAAAAAACCTGTCATA
GGCGTGCCTGTAAGTGCAAAACTCGGCGGGCTTGACGCCCTTCTTTCCATAGCCCAGATGCCTCCGGGAGTGCCTGTCGG
AAGTGTAGGAATTGACAACGGGGCAAATGGGGCGTACCTTGCCCTTAGGATCCTGGATTTAATTGAAAATCCCTGA

Upstream 100 bases:

>100_bases
AAAGGAAATTTTTGAAATCCTTATCAGGATGAGCATCGAACGCCAGAATGAACTGAGTGGAAAGGGAAGCCTGCCCTGAC
CTTTCTCAAAGGAGTAAAAA

Downstream 100 bases:

>100_bases
TAACACCGGGAATTACTGCTTTCAATTTTTTCTCGGAAATTGAAATGCCTTTTTTTGCTGGCTTGATAGTCTCCAAGGAA
GGAGACTTCCCGCCATGGAG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MVDISLIMGSESDRAIANRAVSVIEKTRYTYEVMVISAHRNPDELDIYISNTDAKVFITIAGLSAALPGVVASKTKKPVI
GVPVSAKLGGLDALLSIAQMPPGVPVGSVGIDNGANGAYLALRILDLIENP

Sequences:

>Translated_131_residues
MVDISLIMGSESDRAIANRAVSVIEKTRYTYEVMVISAHRNPDELDIYISNTDAKVFITIAGLSAALPGVVASKTKKPVI
GVPVSAKLGGLDALLSIAQMPPGVPVGSVGIDNGANGAYLALRILDLIENP
>Mature_131_residues
MVDISLIMGSESDRAIANRAVSVIEKTRYTYEVMVISAHRNPDELDIYISNTDAKVFITIAGLSAALPGVVASKTKKPVI
GVPVSAKLGGLDALLSIAQMPPGVPVGSVGIDNGANGAYLALRILDLIENP

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=44.5454545454545, Blast_Score=88, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324702, Length=126, Percent_Identity=45.2380952380952, Blast_Score=97, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 13673; Mature: 13673

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDISLIMGSESDRAIANRAVSVIEKTRYTYEVMVISAHRNPDELDIYISNTDAKVFITI
CEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEEEEEEECCCCEEEEEE
AGLSAALPGVVASKTKKPVIGVPVSAKLGGLDALLSIAQMPPGVPVGSVGIDNGANGAYL
ECCCHHCCCHHHCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
ALRILDLIENP
HHHHHHHHCCC
>Mature Secondary Structure
MVDISLIMGSESDRAIANRAVSVIEKTRYTYEVMVISAHRNPDELDIYISNTDAKVFITI
CEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEEEECCCCCCEEEEEEECCCCEEEEEE
AGLSAALPGVVASKTKKPVIGVPVSAKLGGLDALLSIAQMPPGVPVGSVGIDNGANGAYL
ECCCHHCCCHHHCCCCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
ALRILDLIENP
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]