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The map label for this gene is eIF1A2

Identifier: 21228438

GI number: 21228438

Start: 2794031

End: 2794351

Strand: Direct

Name: eIF1A2

Synonym: MM_2336

Alternate gene names: 21228438

Gene position: 2794031-2794351 (Clockwise)

Preceding gene: 21228437

Following gene: 21228439

Centisome position: 68.21

GC content: 46.42

Gene sequence:

>321_bases
ATGAGAAAGAGAAGAGAAGGAACAGCAAATAATTCACCCACTCCGGAAGTGACAAGGGTGCGTACTCCAAGAAAGGAGAA
CCACGAAGTGCTGGCAACGGTAGGAAGTCTTCTTGGCTCAAAAAGGGTCAATTTACAGTGTATGGACGGAGTTGTCAGGA
TGGGGAGGATACCGGGGTCCAAAAACAAGAAAATGTGGATCCGTGAAGGTGATATTGTAATTGCGACTCCGTGGGAAATT
CAGGACTCGAAAGCTGATGTTATCTGGAAGTACACAAGGCCCCAGATAGAATGGCTTGAACGCAAAGGCTACCTGAAATA
A

Upstream 100 bases:

>100_bases
TCCTGAACCTGAATTCGAATTTAAAATCAAAAATTTAAAACCAAAATTCAAATATCAAATAAACAAACGAGGAATCAACC
TGGCTAATTATCGAAGCAAC

Downstream 100 bases:

>100_bases
TGCCCTGATGGCAATTTTATTACTCAAAAATGCTGTAAAACTGGTTTTAACCCGTGCTGGTTAAACCTCTTATTCTTCTT
TTGATAACTCTTTTAGCGTA

Product: translation initiation factor IF-1A

Products: NA

Alternate protein names: aIF-1A 2

Number of amino acids: Translated: 106; Mature: 106

Protein sequence:

>106_residues
MRKRREGTANNSPTPEVTRVRTPRKENHEVLATVGSLLGSKRVNLQCMDGVVRMGRIPGSKNKKMWIREGDIVIATPWEI
QDSKADVIWKYTRPQIEWLERKGYLK

Sequences:

>Translated_106_residues
MRKRREGTANNSPTPEVTRVRTPRKENHEVLATVGSLLGSKRVNLQCMDGVVRMGRIPGSKNKKMWIREGDIVIATPWEI
QDSKADVIWKYTRPQIEWLERKGYLK
>Mature_106_residues
MRKRREGTANNSPTPEVTRVRTPRKENHEVLATVGSLLGSKRVNLQCMDGVVRMGRIPGSKNKKMWIREGDIVIATPWEI
QDSKADVIWKYTRPQIEWLERKGYLK

Specific function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits

COG id: COG0361

COG function: function code J; Translation initiation factor 1 (IF-1)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1-like domain

Homologues:

Organism=Saccharomyces cerevisiae, GI6323916, Length=81, Percent_Identity=35.8024691358025, Blast_Score=61, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45553405, Length=91, Percent_Identity=40.6593406593407, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24647907, Length=91, Percent_Identity=40.6593406593407, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF1A2_METMA (Q8PUJ8)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_634360.1
- ProteinModelPortal:   Q8PUJ8
- SMR:   Q8PUJ8
- GeneID:   1480678
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2336
- NMPDR:   fig|192952.1.peg.2336
- HOGENOM:   HBG521228
- OMA:   PRKENHE
- ProtClustDB:   PRK04012
- BioCyc:   MMAZ192952:MM2336-MONOMER
- HAMAP:   MF_00216
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR006196
- InterPro:   IPR001253
- InterPro:   IPR018104
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR21668
- ProDom:   PD005579
- SMART:   SM00652
- TIGRFAMs:   TIGR00523

Pfam domain/function: PF01176 eIF-1a; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 12288; Mature: 12288

Theoretical pI: Translated: 10.96; Mature: 10.96

Prosite motif: PS01262 IF1A; PS50832 S1_IF1_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKRREGTANNSPTPEVTRVRTPRKENHEVLATVGSLLGSKRVNLQCMDGVVRMGRIPGS
CCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCC
KNKKMWIREGDIVIATPWEIQDSKADVIWKYTRPQIEWLERKGYLK
CCCEEEEEECCEEEECCCCCCCCCCEEEEEECCCHHHHHHCCCCCC
>Mature Secondary Structure
MRKRREGTANNSPTPEVTRVRTPRKENHEVLATVGSLLGSKRVNLQCMDGVVRMGRIPGS
CCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCC
KNKKMWIREGDIVIATPWEIQDSKADVIWKYTRPQIEWLERKGYLK
CCCEEEEEECCEEEECCCCCCCCCCEEEEEECCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824