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The map label for this gene is yvaE [H]

Identifier: 21228435

GI number: 21228435

Start: 2791816

End: 2792142

Strand: Reverse

Name: yvaE [H]

Synonym: MM_2333

Alternate gene names: 21228435

Gene position: 2792142-2791816 (Counterclockwise)

Preceding gene: 21228442

Following gene: 21228433

Centisome position: 68.16

GC content: 39.45

Gene sequence:

>327_bases
ATGAATTATTATTATCTTCTGTTACTTGCAATACTGTTTGAAGTTTGCGGAACAACCTGCATGAAATTATCTGATGGCTT
TTCAAAACTGACCCCATCGATTTTGATTTTCGTATTTTATGCTATCAGTTTCTTTTTCTTTACTCTTGCCCTTAAAGGGC
TGGATGTGAGCATTGCATACGCAATATGGGCAGGGTTAGGGACCGCTTTTATAACAGTTATAGGAATATTCTGGTTCAGA
GAACCTTCCTCGGCCTTCAGGCTAATTTCTCTTGCCTTTGTAGTTATGGGAGTGATCGGGCTTCATCTGAGCGATAGAGT
AGCATAA

Upstream 100 bases:

>100_bases
GTCAGCACTAACAGACTGCTTAGCAGATCAGGAATATAAATAAAGAAAGTATAAAGGGCTAACAGCTAATAATTAATAAT
AGAAATAAAATTATCTATTA

Downstream 100 bases:

>100_bases
ACCATTCTGACAGCATTCTGACAGGGCAGGTTGATCAGATTGAAGAGTTCCGTACTGAGTAAAATCTTAAAAGATAAGAT
CGAGCTTCAAAAATATCAGG

Product: multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 108; Mature: 108

Protein sequence:

>108_residues
MNYYYLLLLAILFEVCGTTCMKLSDGFSKLTPSILIFVFYAISFFFFTLALKGLDVSIAYAIWAGLGTAFITVIGIFWFR
EPSSAFRLISLAFVVMGVIGLHLSDRVA

Sequences:

>Translated_108_residues
MNYYYLLLLAILFEVCGTTCMKLSDGFSKLTPSILIFVFYAISFFFFTLALKGLDVSIAYAIWAGLGTAFITVIGIFWFR
EPSSAFRLISLAFVVMGVIGLHLSDRVA
>Mature_108_residues
MNYYYLLLLAILFEVCGTTCMKLSDGFSKLTPSILIFVFYAISFFFFTLALKGLDVSIAYAIWAGLGTAFITVIGIFWFR
EPSSAFRLISLAFVVMGVIGLHLSDRVA

Specific function: Suppresses A Groel Mutation And Mimics The Effect Of Groe Overexpression. Could Act As A Chaperone. [C]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI87082378, Length=103, Percent_Identity=37.8640776699029, Blast_Score=76, Evalue=6e-16,
Organism=Escherichia coli, GI1786755, Length=106, Percent_Identity=36.7924528301887, Blast_Score=64, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 12028; Mature: 12028

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYYYLLLLAILFEVCGTTCMKLSDGFSKLTPSILIFVFYAISFFFFTLALKGLDVSIAY
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AIWAGLGTAFITVIGIFWFREPSSAFRLISLAFVVMGVIGLHLSDRVA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYYYLLLLAILFEVCGTTCMKLSDGFSKLTPSILIFVFYAISFFFFTLALKGLDVSIAY
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AIWAGLGTAFITVIGIFWFREPSSAFRLISLAFVVMGVIGLHLSDRVA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]