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The map label for this gene is tetA [H]

Identifier: 21228433

GI number: 21228433

Start: 2788491

End: 2789837

Strand: Reverse

Name: tetA [H]

Synonym: MM_2331

Alternate gene names: 21228433

Gene position: 2789837-2788491 (Counterclockwise)

Preceding gene: 21228435

Following gene: 21228416

Centisome position: 68.11

GC content: 45.06

Gene sequence:

>1347_bases
ATGGAACAGAACTCGGGAACTTCCTCTGCAAGCGGCAGAGCACTTTTTCCATTATATGCCATAACATTTATAGGAACCCT
CGGGTTTGGCATCATACTTACTTTTCTCGTATTCCTTGTAACAGACTATGGAGGCAATGCCCTTGTCTACGGCATACTCG
CTTCAACTTACCCTGCCTTCCAGCTTATCGGAGCTCCTGTACTGGGCAGGTGGTCTGACCTTTATGGGAGAAAAAAGATT
CTATTATTGAGTCAGATTGGGACCATGCTTGCCTGGATCATTTTTTTTGCCGCCCTGTTTTTTCCAGTAATCCCGCTGAT
AGAGGTCAGGTCTGATCTTCTTGGAACATTTACAATTACTCTCCCTTTGCTTATACTCTTTTTAGCGAGGGCTCTTGACG
GTGCTACAGGGGGAAATGTTTCAGTTGCCAATGCTTATCTTGCCGACCTCACCTCGGAAGAAGAAAGAAATAAAAACTAC
GGACGAATGTCCGTAGCCTCAAATCTGGGATATGTCTTTGGTCCTGCGATTGCCGGAGTTCTCGGGACAACAGCCTATGG
CGAAATTCTGCCAGTATCCGCCGCACTGGTGATTTCAATCATAGGAACTCTTATAGTACTTTTTCTTCTCCCAGATTCCC
GGCCCTGCGCCATTGAAGAATACCCCGAATCCACCGGGATTAGAAAAATACTCGGGCAGGAACAAAAAGAGTGCTATCAG
GTTGAGGCAGGAAGTAAAATAACATTTCGTGAAGTCTTCAAGCTTGAGTACATCCCTTTTATGCTGGTTGTTTACTTCCT
TATTTTTCTGGGCTTCAATATATATTATACCGCATTCCCTATCTTTGCCGTTGTTGCCCTTGAATGGAGCCCTGCGGAGC
TGGGTATTTATTTTTCCGTAATCAGTGCGCTTATGGCATTTGTACAGGGCCCGGTCCTTGCAAAGCTTGCCAGAAGATAT
AGGGAGTCTATAATGGTTGTTGGCGGCGGTTTTATTCTGGGACTTCAGTTTATCCTTATAGTATCCGGAGACTATCTTCT
TCTGTACCTTGCAGCCGTGTTTTTTGCTTTTGGGAACGGGATTATGTGGCCTTCTATTCTCTCCATCCTCTCCAAATTTG
CGGGTAAAAAATACCAGGGATCTGTTCAGGGCTTTGCAATGAGCGCGAGCAGCCTTGCAAGCATAATCGGCCTTCTTGCA
GGAGGCTTCCTGTATACGCAGTTTGGAGTTATAGCCTTCCTTATCGCAGCCGCAATAATATATCTTGTAGTTTTCCTCTC
TTTCAGGCTTCTAAGAATTGAGAAAGAGAAACTGATAGAAACTGAGGCTGCGAAAACTCCAGTTTAA

Upstream 100 bases:

>100_bases
CAGCCGTATCTGTAAAGGTTAAAATGAAACGGCATCACGGGACCTCTTTAAATTCTGGAAGAGAAATAGTATAAGGGGCA
GAAACACATATATTCCTTCG

Downstream 100 bases:

>100_bases
TCCTTAAAAAAGTGACTGGTTTTTGGGATATTGAAAAATGACTGGCTGGTTTTAATGGATCTCAGAATTTTAATAGATTT
CCTTAACCCTGCCTACCTGC

Product: permease

Products: NA

Alternate protein names: TetA(D) [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MEQNSGTSSASGRALFPLYAITFIGTLGFGIILTFLVFLVTDYGGNALVYGILASTYPAFQLIGAPVLGRWSDLYGRKKI
LLLSQIGTMLAWIIFFAALFFPVIPLIEVRSDLLGTFTITLPLLILFLARALDGATGGNVSVANAYLADLTSEEERNKNY
GRMSVASNLGYVFGPAIAGVLGTTAYGEILPVSAALVISIIGTLIVLFLLPDSRPCAIEEYPESTGIRKILGQEQKECYQ
VEAGSKITFREVFKLEYIPFMLVVYFLIFLGFNIYYTAFPIFAVVALEWSPAELGIYFSVISALMAFVQGPVLAKLARRY
RESIMVVGGGFILGLQFILIVSGDYLLLYLAAVFFAFGNGIMWPSILSILSKFAGKKYQGSVQGFAMSASSLASIIGLLA
GGFLYTQFGVIAFLIAAAIIYLVVFLSFRLLRIEKEKLIETEAAKTPV

Sequences:

>Translated_448_residues
MEQNSGTSSASGRALFPLYAITFIGTLGFGIILTFLVFLVTDYGGNALVYGILASTYPAFQLIGAPVLGRWSDLYGRKKI
LLLSQIGTMLAWIIFFAALFFPVIPLIEVRSDLLGTFTITLPLLILFLARALDGATGGNVSVANAYLADLTSEEERNKNY
GRMSVASNLGYVFGPAIAGVLGTTAYGEILPVSAALVISIIGTLIVLFLLPDSRPCAIEEYPESTGIRKILGQEQKECYQ
VEAGSKITFREVFKLEYIPFMLVVYFLIFLGFNIYYTAFPIFAVVALEWSPAELGIYFSVISALMAFVQGPVLAKLARRY
RESIMVVGGGFILGLQFILIVSGDYLLLYLAAVFFAFGNGIMWPSILSILSKFAGKKYQGSVQGFAMSASSLASIIGLLA
GGFLYTQFGVIAFLIAAAIIYLVVFLSFRLLRIEKEKLIETEAAKTPV
>Mature_448_residues
MEQNSGTSSASGRALFPLYAITFIGTLGFGIILTFLVFLVTDYGGNALVYGILASTYPAFQLIGAPVLGRWSDLYGRKKI
LLLSQIGTMLAWIIFFAALFFPVIPLIEVRSDLLGTFTITLPLLILFLARALDGATGGNVSVANAYLADLTSEEERNKNY
GRMSVASNLGYVFGPAIAGVLGTTAYGEILPVSAALVISIIGTLIVLFLLPDSRPCAIEEYPESTGIRKILGQEQKECYQ
VEAGSKITFREVFKLEYIPFMLVVYFLIFLGFNIYYTAFPIFAVVALEWSPAELGIYFSVISALMAFVQGPVLAKLARRY
RESIMVVGGGFILGLQFILIVSGDYLLLYLAAVFFAFGNGIMWPSILSILSKFAGKKYQGSVQGFAMSASSLASIIGLLA
GGFLYTQFGVIAFLIAAAIIYLVVFLSFRLLRIEKEKLIETEAAKTPV

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=365, Percent_Identity=25.7534246575342, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI217416366, Length=434, Percent_Identity=22.8110599078341, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551570, Length=354, Percent_Identity=23.4463276836158, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71996331, Length=365, Percent_Identity=23.2876712328767, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17738085, Length=368, Percent_Identity=20.9239130434783, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357569, Length=369, Percent_Identity=23.5772357723577, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48701; Mature: 48701

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQNSGTSSASGRALFPLYAITFIGTLGFGIILTFLVFLVTDYGGNALVYGILASTYPAF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHH
QLIGAPVLGRWSDLYGRKKILLLSQIGTMLAWIIFFAALFFPVIPLIEVRSDLLGTFTIT
HHHCCCHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLLILFLARALDGATGGNVSVANAYLADLTSEEERNKNYGRMSVASNLGYVFGPAIAGV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHCCCHHHHHHHHHH
LGTTAYGEILPVSAALVISIIGTLIVLFLLPDSRPCAIEEYPESTGIRKILGQEQKECYQ
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHH
VEAGSKITFREVFKLEYIPFMLVVYFLIFLGFNIYYTAFPIFAVVALEWSPAELGIYFSV
HCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ISALMAFVQGPVLAKLARRYRESIMVVGGGFILGLQFILIVSGDYLLLYLAAVFFAFGNG
HHHHHHHHCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
IMWPSILSILSKFAGKKYQGSVQGFAMSASSLASIIGLLAGGFLYTQFGVIAFLIAAAII
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLVVFLSFRLLRIEKEKLIETEAAKTPV
HHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEQNSGTSSASGRALFPLYAITFIGTLGFGIILTFLVFLVTDYGGNALVYGILASTYPAF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHH
QLIGAPVLGRWSDLYGRKKILLLSQIGTMLAWIIFFAALFFPVIPLIEVRSDLLGTFTIT
HHHCCCHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLLILFLARALDGATGGNVSVANAYLADLTSEEERNKNYGRMSVASNLGYVFGPAIAGV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHCCCHHHHHHHHHH
LGTTAYGEILPVSAALVISIIGTLIVLFLLPDSRPCAIEEYPESTGIRKILGQEQKECYQ
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHH
VEAGSKITFREVFKLEYIPFMLVVYFLIFLGFNIYYTAFPIFAVVALEWSPAELGIYFSV
HCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ISALMAFVQGPVLAKLARRYRESIMVVGGGFILGLQFILIVSGDYLLLYLAAVFFAFGNG
HHHHHHHHCCHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
IMWPSILSILSKFAGKKYQGSVQGFAMSASSLASIIGLLAGGFLYTQFGVIAFLIAAAII
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLVVFLSFRLLRIEKEKLIETEAAKTPV
HHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8384294 [H]