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The map label for this gene is hypB [H]

Identifier: 21228420

GI number: 21228420

Start: 2775004

End: 2775678

Strand: Direct

Name: hypB [H]

Synonym: MM_2318

Alternate gene names: 21228420

Gene position: 2775004-2775678 (Clockwise)

Preceding gene: 21228419

Following gene: 21228421

Centisome position: 67.74

GC content: 43.85

Gene sequence:

>675_bases
GTGATGTTTATGTTAATGCATGTAATCCATATGGGACATGATGTTTACAAGGCAAATGACAAAATTGCCGAAAAGAACAG
AAAAACTCTTGACAAACACGGTGTCTTCTCAGTAAATGTTATGGGAGCAATAGGGTCAGGAAAGACCACTTTGATTGAAG
AGGCTATCAGGCACCTTAAGGATAAATACAGAATAGCCGTTGTTGCAGGCGATGTTATTGCAGAGATGGACGCTTCCCGT
TTTAGAAAGCTGGATGTTCCGACAATCCCTGTAAATACCGGAAAAGAGTGCCACCTGGATGCGAAGCTTGTAGAAAAGGC
TCTGGGTGAGATAGACCTTGATAACACTGATCTCCTGATTATTGAGAATGTAGGCAACCTTATCTGCCCTGTGGACTTCA
AGCTGGGAGAACACCTGCGGGTTGTGGTTGTGAGCGTCACGGAAGGAGACGACATTATCCTCAAGCACCCCATGATTTTC
AAGACTTCAGAGCTTGCTGTCATAAACAAGGTTGATATTGCACATGCAGTTGATGTTGATTCCGAAAAGATGAGGGACGA
CATCCTTTCCTTAAACCCTGAAGTGCCGGTGATCCTTACATCAAAACACGACTGGGAAAGCCTTGAAACATGGATAGGTT
TCATCGAGAGCGGACTTGAAAAACGCACTAAATAA

Upstream 100 bases:

>100_bases
GCCCATATTGCAGGCGGCAGGGAATTGATCATAAAGAGCATAGAGATTGAAACTGAAAACGAAAATGAATCGCAGCGGTA
AAAAATAATAAGCAACCCTG

Downstream 100 bases:

>100_bases
ACTTAATAGAGTCTTACGAGGATAAAGGAGCTTTAGATGAAATCCAATACAATTTCTCTCGAACACGGCGCCGGTGGAGA
GGTAATGCAGGCGCTTATAG

Product: hydrogenase expression/formation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MMFMLMHVIHMGHDVYKANDKIAEKNRKTLDKHGVFSVNVMGAIGSGKTTLIEEAIRHLKDKYRIAVVAGDVIAEMDASR
FRKLDVPTIPVNTGKECHLDAKLVEKALGEIDLDNTDLLIIENVGNLICPVDFKLGEHLRVVVVSVTEGDDIILKHPMIF
KTSELAVINKVDIAHAVDVDSEKMRDDILSLNPEVPVILTSKHDWESLETWIGFIESGLEKRTK

Sequences:

>Translated_224_residues
MMFMLMHVIHMGHDVYKANDKIAEKNRKTLDKHGVFSVNVMGAIGSGKTTLIEEAIRHLKDKYRIAVVAGDVIAEMDASR
FRKLDVPTIPVNTGKECHLDAKLVEKALGEIDLDNTDLLIIENVGNLICPVDFKLGEHLRVVVVSVTEGDDIILKHPMIF
KTSELAVINKVDIAHAVDVDSEKMRDDILSLNPEVPVILTSKHDWESLETWIGFIESGLEKRTK
>Mature_224_residues
MMFMLMHVIHMGHDVYKANDKIAEKNRKTLDKHGVFSVNVMGAIGSGKTTLIEEAIRHLKDKYRIAVVAGDVIAEMDASR
FRKLDVPTIPVNTGKECHLDAKLVEKALGEIDLDNTDLLIIENVGNLICPVDFKLGEHLRVVVVSVTEGDDIILKHPMIF
KTSELAVINKVDIAHAVDVDSEKMRDDILSLNPEVPVILTSKHDWESLETWIGFIESGLEKRTK

Specific function: Could be involved in nickel binding and accumulation [H]

COG id: COG0378

COG function: function code OK; Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hypB/hupM family [H]

Homologues:

Organism=Escherichia coli, GI1789082, Length=204, Percent_Identity=41.6666666666667, Blast_Score=171, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR004392
- InterPro:   IPR012202 [H]

Pfam domain/function: PF02492 cobW [H]

EC number: NA

Molecular weight: Translated: 25059; Mature: 25059

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFMLMHVIHMGHDVYKANDKIAEKNRKTLDKHGVFSVNVMGAIGSGKTTLIEEAIRHLK
CHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHH
DKYRIAVVAGDVIAEMDASRFRKLDVPTIPVNTGKECHLDAKLVEKALGEIDLDNTDLLI
HHEEEEEEECHHHHHHCHHHHHCCCCCEECCCCCCCCEECHHHHHHHHCCCCCCCCCEEE
IENVGNLICPVDFKLGEHLRVVVVSVTEGDDIILKHPMIFKTSELAVINKVDIAHAVDVD
EECCCCEEEEECCCCCCCEEEEEEEEECCCCEEEECCEEEECCCEEEEEEECHHEEECCC
SEKMRDDILSLNPEVPVILTSKHDWESLETWIGFIESGLEKRTK
HHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMFMLMHVIHMGHDVYKANDKIAEKNRKTLDKHGVFSVNVMGAIGSGKTTLIEEAIRHLK
CHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHH
DKYRIAVVAGDVIAEMDASRFRKLDVPTIPVNTGKECHLDAKLVEKALGEIDLDNTDLLI
HHEEEEEEECHHHHHHCHHHHHCCCCCEECCCCCCCCEECHHHHHHHHCCCCCCCCCEEE
IENVGNLICPVDFKLGEHLRVVVVSVTEGDDIILKHPMIFKTSELAVINKVDIAHAVDVD
EECCCCEEEEECCCCCCCEEEEEEEEECCCCEEEECCEEEECCCEEEEEEECHHEEECCC
SEKMRDDILSLNPEVPVILTSKHDWESLETWIGFIESGLEKRTK
HHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]