Click here to switch to the map view.

The map label for this gene is hypA

Identifier: 21228419

GI number: 21228419

Start: 2774571

End: 2774984

Strand: Direct

Name: hypA

Synonym: MM_2317

Alternate gene names: 21228419

Gene position: 2774571-2774984 (Clockwise)

Preceding gene: 21228418

Following gene: 21228420

Centisome position: 67.73

GC content: 45.41

Gene sequence:

>414_bases
ATGCATGAACTTTCCATTGCCTGTGAAATCTTTGAGCAGGTTAAGGTTACTGCCGAAGCTCACGGAGCCACAGAAGTCAA
ACATGTGACTCTTCAAATGGGAAGGCTGTCCCATACGAATCCTGAACAGCTGAGTTTCTGTTTTAAGACTCTTGCAGAAG
GGAGTATTGCTGAAAATGCGGATCTCATCGTAGAAATGGTGCCTCCAACCCTTGAATGCGAATGCGGATACACAGGAACT
ATAGACCAGGAAAGGATACGGGAAAGCAACGAACTGACAAGTGAACTCCTTGCTTATATAGCAGCTATGGACTGCCCTGT
GTGTGGAAAACAGGCCCATATTGCAGGCGGCAGGGAATTGATCATAAAGAGCATAGAGATTGAAACTGAAAACGAAAATG
AATCGCAGCGGTAA

Upstream 100 bases:

>100_bases
AAAGAATGCACTCCAAAAAAACCAGCGGGTCCCTGCATGGTAAGTCAGGAAGGTATGTGCTATAACTGGTATAAATATTC
TCGAGAAGGAGGTAGTAAAA

Downstream 100 bases:

>100_bases
AAAATAATAAGCAACCCTGGTGATGTTTATGTTAATGCATGTAATCCATATGGGACATGATGTTTACAAGGCAAATGACA
AAATTGCCGAAAAGAACAGA

Product: hydrogenase nickel incorporation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MHELSIACEIFEQVKVTAEAHGATEVKHVTLQMGRLSHTNPEQLSFCFKTLAEGSIAENADLIVEMVPPTLECECGYTGT
IDQERIRESNELTSELLAYIAAMDCPVCGKQAHIAGGRELIIKSIEIETENENESQR

Sequences:

>Translated_137_residues
MHELSIACEIFEQVKVTAEAHGATEVKHVTLQMGRLSHTNPEQLSFCFKTLAEGSIAENADLIVEMVPPTLECECGYTGT
IDQERIRESNELTSELLAYIAAMDCPVCGKQAHIAGGRELIIKSIEIETENENESQR
>Mature_137_residues
MHELSIACEIFEQVKVTAEAHGATEVKHVTLQMGRLSHTNPEQLSFCFKTLAEGSIAENADLIVEMVPPTLECECGYTGT
IDQERIRESNELTSELLAYIAAMDCPVCGKQAHIAGGRELIIKSIEIETENENESQR

Specific function: Probably plays a role in an hydrogenase nickel cofactor insertion step

COG id: COG0375

COG function: function code R; Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hypA/hybF family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HYPA_METMA (Q8PUL7)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_634341.1
- GeneID:   1480659
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2317
- NMPDR:   fig|192952.1.peg.2317
- HOGENOM:   HBG688671
- OMA:   AMVNPEQ
- ProtClustDB:   PRK00762
- BioCyc:   MMAZ192952:MM2317-MONOMER
- HAMAP:   MF_00213
- InterPro:   IPR000688
- InterPro:   IPR020538
- TIGRFAMs:   TIGR00100

Pfam domain/function: PF01155 HypA

EC number: NA

Molecular weight: Translated: 15135; Mature: 15135

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS01249 HYPA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHELSIACEIFEQVKVTAEAHGATEVKHVTLQMGRLSHTNPEQLSFCFKTLAEGSIAENA
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCC
DLIVEMVPPTLECECGYTGTIDQERIRESNELTSELLAYIAAMDCPVCGKQAHIAGGREL
CEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
IIKSIEIETENENESQR
EEEEEEEEECCCCCCCC
>Mature Secondary Structure
MHELSIACEIFEQVKVTAEAHGATEVKHVTLQMGRLSHTNPEQLSFCFKTLAEGSIAENA
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCC
DLIVEMVPPTLECECGYTGTIDQERIRESNELTSELLAYIAAMDCPVCGKQAHIAGGREL
CEEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
IIKSIEIETENENESQR
EEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824