| Definition | Methanosarcina mazei Go1 chromosome, complete genome. |
|---|---|
| Accession | NC_003901 |
| Length | 4,096,345 |
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The map label for this gene is coaBC [H]
Identifier: 21228385
GI number: 21228385
Start: 2722300
End: 2723700
Strand: Reverse
Name: coaBC [H]
Synonym: MM_2283
Alternate gene names: 21228385
Gene position: 2723700-2722300 (Counterclockwise)
Preceding gene: 21228393
Following gene: 21228384
Centisome position: 66.49
GC content: 49.32
Gene sequence:
>1401_bases TTGAAAGAGCCTCAAAGTAAGAAGGATCAAAGGAATCCTTGCCAGCGAAATCCAGACGCTGATGCAATCGAACCTGAAGA TTCAGGTCAAAGCTCAGGTCAAAACGGATCTGATGCAGTAAAATCAAAGAACTGGACAGACAGACAGATCCCGGAACGGA ATAAAACAGATAAAATTCATCCTACTCTCTGGATACAGGGACAGAGGAGTTCTTCTCTAGCCGGAAAAACCATAGTCCTT GGAGTTACGGGAAGCATAGGAGCGGTCAGGGTAGTTGAACTTTCAAGGGAACTGATTCGGAACGGGGCAGAAGTCCATGC AGTCATGACAGAGGCTGCAAAGCATATCCTGCACCCTGATGCCCTGCATTATGCCACGGGAAACCCTGTAATTGCCGAAC TGGGCGGCAGGGTTGAGCATGTGGAGTTCTGCGGGTTCAAGGGCAGGGCAGACCTTCTTTTAATAGCGCCGGCAACCGCG AATACCATAGGGAAAATCGCATACGGCATAGATGATACCACAGTCACCTCTTTTGCGACAACGGCTCTCGGTTCAGATGT CCCTGTCATGATTGTCCCTGCAATGCACGAGTCCATGTACAGGCACCCTGCCGTAACTGAAAATATAGCGAGGCTGAAGA GCTGGGGGATCTCCATGGTGGGCCCCAGGTTCGAGGAAGGCGTTGCAAAAATCGCTTCAAACGAAGAAATAGTCCTCGAG GTAGAAAGGGCTCTTGGTGACCGTAGCCTGGAAAACCTGAAGGTAATTATTACAGGCGGCTCAACTGCAGAAAGCCTTGA CCCGATAAGGGTCCTTACAAACAGGGCTTCGGGAAAGACCGGCAGGGAGCTCGCCCTTGAAGCTTACCGCAGAGGCGCTG ATGTAACCCTTGTGCATAGGGACAGGCTGGGGTTTGCTGGCATCAGGGAGATTTTTGCAGAAAGTGCTGCTGAAATGACA GAAGCTGTGCTTTCGGAACTGGAAAAAGGGTATGATGTCCTGATAAGTTCTGCAGCGATTGCAGACTACACAGCAGAACC TTCTCCTGAGAAAATCAAATCCGGAGGGGAGTTTATTCTGAAGCTGAAGCCCACCCGGAAATTGATAAAGGAATGCAGGG AAAAATATCCCGAACTCGTGATAATAGGTTTTAAAGCCGAAACAGGCATCGAAAAAGAAGAGCTTCTAAGAAGGGCAGCT GCAACCCTTGAAGGGACAGAACTCGACATGATCGCAGCAAACGATGTAGGAAAAGGCGGAATGGGTACTGAAGAAAATGA ACTTTACCTGCTTGGGAAGGGAAAATCCGGGCCCAGGCACGTAAGTGGAAACAAGCGTAAACTTGCAGCCAGTATCCTTG AGGAGGTTTCCGAAATTTTAAATTCACGGCAGGTTCTCTGA
Upstream 100 bases:
>100_bases CATATTTAATGTCACTGTGATTTCAGGATTTTTTAAATAAATGAGCTCATTAACACAATTAATCCCTATCGATTACTCCG GTGCCTGAATGAAAAAACCA
Downstream 100 bases:
>100_bases GAGCCTTGTCGCCCTCTGGAAATAAAGACAAAATGAAAACGGAGCCGGTAGAGTGGTCAATCTGCTATATCGGCTAGTTA TGCAAACAGACCTGCGCAAT
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 466; Mature: 466
Protein sequence:
>466_residues MKEPQSKKDQRNPCQRNPDADAIEPEDSGQSSGQNGSDAVKSKNWTDRQIPERNKTDKIHPTLWIQGQRSSSLAGKTIVL GVTGSIGAVRVVELSRELIRNGAEVHAVMTEAAKHILHPDALHYATGNPVIAELGGRVEHVEFCGFKGRADLLLIAPATA NTIGKIAYGIDDTTVTSFATTALGSDVPVMIVPAMHESMYRHPAVTENIARLKSWGISMVGPRFEEGVAKIASNEEIVLE VERALGDRSLENLKVIITGGSTAESLDPIRVLTNRASGKTGRELALEAYRRGADVTLVHRDRLGFAGIREIFAESAAEMT EAVLSELEKGYDVLISSAAIADYTAEPSPEKIKSGGEFILKLKPTRKLIKECREKYPELVIIGFKAETGIEKEELLRRAA ATLEGTELDMIAANDVGKGGMGTEENELYLLGKGKSGPRHVSGNKRKLAASILEEVSEILNSRQVL
Sequences:
>Translated_466_residues MKEPQSKKDQRNPCQRNPDADAIEPEDSGQSSGQNGSDAVKSKNWTDRQIPERNKTDKIHPTLWIQGQRSSSLAGKTIVL GVTGSIGAVRVVELSRELIRNGAEVHAVMTEAAKHILHPDALHYATGNPVIAELGGRVEHVEFCGFKGRADLLLIAPATA NTIGKIAYGIDDTTVTSFATTALGSDVPVMIVPAMHESMYRHPAVTENIARLKSWGISMVGPRFEEGVAKIASNEEIVLE VERALGDRSLENLKVIITGGSTAESLDPIRVLTNRASGKTGRELALEAYRRGADVTLVHRDRLGFAGIREIFAESAAEMT EAVLSELEKGYDVLISSAAIADYTAEPSPEKIKSGGEFILKLKPTRKLIKECREKYPELVIIGFKAETGIEKEELLRRAA ATLEGTELDMIAANDVGKGGMGTEENELYLLGKGKSGPRHVSGNKRKLAASILEEVSEILNSRQVL >Mature_466_residues MKEPQSKKDQRNPCQRNPDADAIEPEDSGQSSGQNGSDAVKSKNWTDRQIPERNKTDKIHPTLWIQGQRSSSLAGKTIVL GVTGSIGAVRVVELSRELIRNGAEVHAVMTEAAKHILHPDALHYATGNPVIAELGGRVEHVEFCGFKGRADLLLIAPATA NTIGKIAYGIDDTTVTSFATTALGSDVPVMIVPAMHESMYRHPAVTENIARLKSWGISMVGPRFEEGVAKIASNEEIVLE VERALGDRSLENLKVIITGGSTAESLDPIRVLTNRASGKTGRELALEAYRRGADVTLVHRDRLGFAGIREIFAESAAEMT EAVLSELEKGYDVLISSAAIADYTAEPSPEKIKSGGEFILKLKPTRKLIKECREKYPELVIIGFKAETGIEKEELLRRAA ATLEGTELDMIAANDVGKGGMGTEENELYLLGKGKSGPRHVSGNKRKLAASILEEVSEILNSRQVL
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=184, Percent_Identity=32.0652173913043, Blast_Score=79, Evalue=7e-15, Organism=Escherichia coli, GI87082301, Length=384, Percent_Identity=34.6354166666667, Blast_Score=154, Evalue=1e-38, Organism=Drosophila melanogaster, GI24657262, Length=156, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=1e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 50460; Mature: 50460
Theoretical pI: Translated: 6.22; Mature: 6.22
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKEPQSKKDQRNPCQRNPDADAIEPEDSGQSSGQNGSDAVKSKNWTDRQIPERNKTDKIH CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCC PTLWIQGQRSSSLAGKTIVLGVTGSIGAVRVVELSRELIRNGAEVHAVMTEAAKHILHPD CEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC ALHYATGNPVIAELGGRVEHVEFCGFKGRADLLLIAPATANTIGKIAYGIDDTTVTSFAT CEEECCCCCHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCHHHEEECCCCCHHHHHHH TALGSDVPVMIVPAMHESMYRHPAVTENIARLKSWGISMVGPRFEEGVAKIASNEEIVLE HHCCCCCCEEEECHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEE VERALGDRSLENLKVIITGGSTAESLDPIRVLTNRASGKTGRELALEAYRRGADVTLVHR EHHHHCCCCCCCEEEEEECCCCCHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEC DRLGFAGIREIFAESAAEMTEAVLSELEKGYDVLISSAAIADYTAEPSPEKIKSGGEFIL CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEE KLKPTRKLIKECREKYPELVIIGFKAETGIEKEELLRRAAATLEGTELDMIAANDVGKGG EECHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCC MGTEENELYLLGKGKSGPRHVSGNKRKLAASILEEVSEILNSRQVL CCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC >Mature Secondary Structure MKEPQSKKDQRNPCQRNPDADAIEPEDSGQSSGQNGSDAVKSKNWTDRQIPERNKTDKIH CCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCC PTLWIQGQRSSSLAGKTIVLGVTGSIGAVRVVELSRELIRNGAEVHAVMTEAAKHILHPD CEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC ALHYATGNPVIAELGGRVEHVEFCGFKGRADLLLIAPATANTIGKIAYGIDDTTVTSFAT CEEECCCCCHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCHHHEEECCCCCHHHHHHH TALGSDVPVMIVPAMHESMYRHPAVTENIARLKSWGISMVGPRFEEGVAKIASNEEIVLE HHCCCCCCEEEECHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEE VERALGDRSLENLKVIITGGSTAESLDPIRVLTNRASGKTGRELALEAYRRGADVTLVHR EHHHHCCCCCCCEEEEEECCCCCHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEC DRLGFAGIREIFAESAAEMTEAVLSELEKGYDVLISSAAIADYTAEPSPEKIKSGGEFIL CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHCCCCCEEE KLKPTRKLIKECREKYPELVIIGFKAETGIEKEELLRRAAATLEGTELDMIAANDVGKGG EECHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCC MGTEENELYLLGKGKSGPRHVSGNKRKLAASILEEVSEILNSRQVL CCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8688087 [H]