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The map label for this gene is 21228355

Identifier: 21228355

GI number: 21228355

Start: 2679995

End: 2681923

Strand: Reverse

Name: 21228355

Synonym: MM_2253

Alternate gene names: NA

Gene position: 2681923-2679995 (Counterclockwise)

Preceding gene: 21228357

Following gene: 21228354

Centisome position: 65.47

GC content: 45.78

Gene sequence:

>1929_bases
ATGCAGTATAGCCTGGGGATTGATGCAGGAGGCACATACACAGATGCTGTGATTATAAGGGACTCGGATGGCATCATTGT
CGATTCAAATAAGGCACTTACAACCTACCCGGATCTTCACCCTGGTATCAAAAACGTACTCGACAGCCTGAACCCTGATT
ACCTGAAAAACACAAAGCTGGTTTCGGTTTCCACAACTCTTTCTACCAATACAATTCTAGAGGGCACTGGTTTTCCAGTA
GCCGTGATCCTTATAGGAGATCATCCACTTGAACGAGAACTACCGACCGAATATGTACTTTATGTTACAGGTGGACACGA
CCACAATGGGGAAGAAAAGGCTTCACTCAACCTGGAAGCTATTGAGAAATTCTCCCTTAATGTTAAGGGCAGGGTTTTAG
CTTTTGCCATATCGTCATATTTTAGCACTAGAAACCCGGAACACGAACTGAAAGCAAAGGACCGAATCCTTGAGCTTACG
GGGCTGCCTGTGGTTTGCGGGCATGAGCTTTCCCAGGAACTGGGAGCTTACGAAAGGGCAGTAACAGCTTTTCTTAATGC
GCAGCTAATCCCCATAACAGGGCAGTTCGTACAGTCCATAATCACAGATATAAAAGAGCGGGGAATTAATGCCAGGCTCC
TTATGCTAAAATGTGACGGTTCAGTTGTCGGAATCAAAGATGCCCTGAGAAAGCCAATAGAAACTATATTCTCAGGTCCG
GCAGCAAGTCTTATTGGAGCTTCTTACCTCTCTGGACTTGAGACCTGTGCCGTAATTGATGTAGGAGGCACAAGTACGGA
CATCTCCTCGATCCATATAGGCGTTCCTGATCTGAACAACGAGGGAGCTGTTGTAGGGGGCTGGAAAACCCGCGTTAGAG
CGATAAGGATGGAAACAACGGCTACAGGCGGGGACAGCCACATCTGGACAGTAAATAGGGAACTCTACCTTGGACCCAGG
AGAGTTATACCGCTTGCAGTCGCTGCAGTAAAATACCCAAATTTTCTGAATAATCTCAAAAGGACTCCAATGCCTGCCAG
AGAAAATCTGTGTGAGAACATTCAGCCCACAAAGTTTTTTGCCAGATCAGGATATATTGCAGGTGAGCTGAGTAAAGCCG
AAGCCGAAGTACTGAAGGTAATAGGAGAAGAACCTGTTTCTGTGTTCGAAATATCAGCCCTTACAAGAAAAGACTTTCAT
CCTCAGACGCTTGACTGTCTCATCAAAAAACGCCTTGTTCAGGTAATTGGCTTTACACCAACAGACGCTCTGCATGTGTT
AGGGGAATACACAGCCTGGCGTGAAGAAGCTTCGCGTACAGGAGCAGAAAGGCTTGGAAGACTCATGCGCATGACACCAA
TAGAATTCTGTACTGCCGTAAAAAAGAAAGTTGCCAGAAATATGGCACTTCATCTTCTCTCGTATATCCTGACAGGTGTC
CCATGCGAATCCATTGAGAAGATTTTGGACGTAGACTATCCCGCAAAATTCAAACTGCAACTTCCTGTTGTCCTGCTTGG
AGGACCTGTTAGAGCGCATAGAAAGGAACTGGAAGAACTGATAGATGCAGATATCCTGGTTCCAGAACATGCCGAGGTAG
GGAATGCAGTTGGAGCACTTGTAGGAAAAGGAATCAAAAGAGCTGAAATTCTCATAAGGCCAGAGAGCCTCATGTCTCCT
GACAGGGATTTTCTTGTCTTTGCCCCGGGAAGCAGACTGAAATTTGAGACTTACTCAAAAGCTTTGGAGAAAGCAACCGA
GATTGGAAAAAAGCTTGTTGAAGATTATATGAAAGAATGTGGGCTCAGTGGCAACCAGGTTGAAATCTCTAGTGAGAAAA
AGACCGTTTCTCCTGACGGCTGGAACCATCCTCCTATGGAAACAAATCTGCTGGTTGTGGGAGTAGGTATGAGAGAATTG
CACGTTTGA

Upstream 100 bases:

>100_bases
CTTTATGTGCTTTATAAATTTAAATAAAATGGATAATTGTGAAAATAAAAGAATATCAATAATTTCCTTAAAAAAGTAGC
AAAAAAGGAGTAGTTTCAAC

Downstream 100 bases:

>100_bases
GCAACTGACTCAGAATCGAATCATGAAAGCTGGCAAGGGTTTTTAAAAAACAATTAATAAGTTTGTCTTATCAGGCTATA
CCCAGGATCCACGTTTAAGA

Product: dihydropyrimidinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MQYSLGIDAGGTYTDAVIIRDSDGIIVDSNKALTTYPDLHPGIKNVLDSLNPDYLKNTKLVSVSTTLSTNTILEGTGFPV
AVILIGDHPLERELPTEYVLYVTGGHDHNGEEKASLNLEAIEKFSLNVKGRVLAFAISSYFSTRNPEHELKAKDRILELT
GLPVVCGHELSQELGAYERAVTAFLNAQLIPITGQFVQSIITDIKERGINARLLMLKCDGSVVGIKDALRKPIETIFSGP
AASLIGASYLSGLETCAVIDVGGTSTDISSIHIGVPDLNNEGAVVGGWKTRVRAIRMETTATGGDSHIWTVNRELYLGPR
RVIPLAVAAVKYPNFLNNLKRTPMPARENLCENIQPTKFFARSGYIAGELSKAEAEVLKVIGEEPVSVFEISALTRKDFH
PQTLDCLIKKRLVQVIGFTPTDALHVLGEYTAWREEASRTGAERLGRLMRMTPIEFCTAVKKKVARNMALHLLSYILTGV
PCESIEKILDVDYPAKFKLQLPVVLLGGPVRAHRKELEELIDADILVPEHAEVGNAVGALVGKGIKRAEILIRPESLMSP
DRDFLVFAPGSRLKFETYSKALEKATEIGKKLVEDYMKECGLSGNQVEISSEKKTVSPDGWNHPPMETNLLVVGVGMREL
HV

Sequences:

>Translated_642_residues
MQYSLGIDAGGTYTDAVIIRDSDGIIVDSNKALTTYPDLHPGIKNVLDSLNPDYLKNTKLVSVSTTLSTNTILEGTGFPV
AVILIGDHPLERELPTEYVLYVTGGHDHNGEEKASLNLEAIEKFSLNVKGRVLAFAISSYFSTRNPEHELKAKDRILELT
GLPVVCGHELSQELGAYERAVTAFLNAQLIPITGQFVQSIITDIKERGINARLLMLKCDGSVVGIKDALRKPIETIFSGP
AASLIGASYLSGLETCAVIDVGGTSTDISSIHIGVPDLNNEGAVVGGWKTRVRAIRMETTATGGDSHIWTVNRELYLGPR
RVIPLAVAAVKYPNFLNNLKRTPMPARENLCENIQPTKFFARSGYIAGELSKAEAEVLKVIGEEPVSVFEISALTRKDFH
PQTLDCLIKKRLVQVIGFTPTDALHVLGEYTAWREEASRTGAERLGRLMRMTPIEFCTAVKKKVARNMALHLLSYILTGV
PCESIEKILDVDYPAKFKLQLPVVLLGGPVRAHRKELEELIDADILVPEHAEVGNAVGALVGKGIKRAEILIRPESLMSP
DRDFLVFAPGSRLKFETYSKALEKATEIGKKLVEDYMKECGLSGNQVEISSEKKTVSPDGWNHPPMETNLLVVGVGMREL
HV
>Mature_642_residues
MQYSLGIDAGGTYTDAVIIRDSDGIIVDSNKALTTYPDLHPGIKNVLDSLNPDYLKNTKLVSVSTTLSTNTILEGTGFPV
AVILIGDHPLERELPTEYVLYVTGGHDHNGEEKASLNLEAIEKFSLNVKGRVLAFAISSYFSTRNPEHELKAKDRILELT
GLPVVCGHELSQELGAYERAVTAFLNAQLIPITGQFVQSIITDIKERGINARLLMLKCDGSVVGIKDALRKPIETIFSGP
AASLIGASYLSGLETCAVIDVGGTSTDISSIHIGVPDLNNEGAVVGGWKTRVRAIRMETTATGGDSHIWTVNRELYLGPR
RVIPLAVAAVKYPNFLNNLKRTPMPARENLCENIQPTKFFARSGYIAGELSKAEAEVLKVIGEEPVSVFEISALTRKDFH
PQTLDCLIKKRLVQVIGFTPTDALHVLGEYTAWREEASRTGAERLGRLMRMTPIEFCTAVKKKVARNMALHLLSYILTGV
PCESIEKILDVDYPAKFKLQLPVVLLGGPVRAHRKELEELIDADILVPEHAEVGNAVGALVGKGIKRAEILIRPESLMSP
DRDFLVFAPGSRLKFETYSKALEKATEIGKKLVEDYMKECGLSGNQVEISSEKKTVSPDGWNHPPMETNLLVVGVGMREL
HV

Specific function: Unknown

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.2

Molecular weight: Translated: 70252; Mature: 70252

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYSLGIDAGGTYTDAVIIRDSDGIIVDSNKALTTYPDLHPGIKNVLDSLNPDYLKNTKL
CCEEECCCCCCCEEEEEEEECCCCEEEECCCCEEECCCCCHHHHHHHHCCCCCHHCCCEE
VSVSTTLSTNTILEGTGFPVAVILIGDHPLERELPTEYVLYVTGGHDHNGEEKASLNLEA
EEEEEEECCCEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCHHCCCHHH
IEKFSLNVKGRVLAFAISSYFSTRNPEHELKAKDRILELTGLPVVCGHELSQELGAYERA
HHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHEEEECCCCEEECHHHHHHHHHHHHH
VTAFLNAQLIPITGQFVQSIITDIKERGINARLLMLKCDGSVVGIKDALRKPIETIFSGP
HHHHHCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEEECCCEECHHHHHHHHHHHHHCCC
AASLIGASYLSGLETCAVIDVGGTSTDISSIHIGVPDLNNEGAVVGGWKTRVRAIRMETT
HHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCEEECHHHEEEEEEEEEE
ATGGDSHIWTVNRELYLGPRRVIPLAVAAVKYPNFLNNLKRTPMPARENLCENIQPTKFF
CCCCCCEEEEECCEEEECCCHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHCCCCCCHHH
ARSGYIAGELSKAEAEVLKVIGEEPVSVFEISALTRKDFHPQTLDCLIKKRLVQVIGFTP
HHCCCEEECCHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
TDALHVLGEYTAWREEASRTGAERLGRLMRMTPIEFCTAVKKKVARNMALHLLSYILTGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PCESIEKILDVDYPAKFKLQLPVVLLGGPVRAHRKELEELIDADILVPEHAEVGNAVGAL
CHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHH
VGKGIKRAEILIRPESLMSPDRDFLVFAPGSRLKFETYSKALEKATEIGKKLVEDYMKEC
HHCCCCEEEEEECCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GLSGNQVEISSEKKTVSPDGWNHPPMETNLLVVGVGMRELHV
CCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHCC
>Mature Secondary Structure
MQYSLGIDAGGTYTDAVIIRDSDGIIVDSNKALTTYPDLHPGIKNVLDSLNPDYLKNTKL
CCEEECCCCCCCEEEEEEEECCCCEEEECCCCEEECCCCCHHHHHHHHCCCCCHHCCCEE
VSVSTTLSTNTILEGTGFPVAVILIGDHPLERELPTEYVLYVTGGHDHNGEEKASLNLEA
EEEEEEECCCEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCHHCCCHHH
IEKFSLNVKGRVLAFAISSYFSTRNPEHELKAKDRILELTGLPVVCGHELSQELGAYERA
HHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHEEEECCCCEEECHHHHHHHHHHHHH
VTAFLNAQLIPITGQFVQSIITDIKERGINARLLMLKCDGSVVGIKDALRKPIETIFSGP
HHHHHCCEEEEECHHHHHHHHHHHHHCCCCEEEEEEEECCCEECHHHHHHHHHHHHHCCC
AASLIGASYLSGLETCAVIDVGGTSTDISSIHIGVPDLNNEGAVVGGWKTRVRAIRMETT
HHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCEEECHHHEEEEEEEEEE
ATGGDSHIWTVNRELYLGPRRVIPLAVAAVKYPNFLNNLKRTPMPARENLCENIQPTKFF
CCCCCCEEEEECCEEEECCCHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHCCCCCCHHH
ARSGYIAGELSKAEAEVLKVIGEEPVSVFEISALTRKDFHPQTLDCLIKKRLVQVIGFTP
HHCCCEEECCHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
TDALHVLGEYTAWREEASRTGAERLGRLMRMTPIEFCTAVKKKVARNMALHLLSYILTGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PCESIEKILDVDYPAKFKLQLPVVLLGGPVRAHRKELEELIDADILVPEHAEVGNAVGAL
CHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCEECCCCHHHHHHHHHH
VGKGIKRAEILIRPESLMSPDRDFLVFAPGSRLKFETYSKALEKATEIGKKLVEDYMKEC
HHCCCCEEEEEECCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GLSGNQVEISSEKKTVSPDGWNHPPMETNLLVVGVGMRELHV
CCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]