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The map label for this gene is tbp3

Identifier: 21228286

GI number: 21228286

Start: 2590004

End: 2590561

Strand: Reverse

Name: tbp3

Synonym: MM_2184

Alternate gene names: 21228286

Gene position: 2590561-2590004 (Counterclockwise)

Preceding gene: 21228291

Following gene: 21228285

Centisome position: 63.24

GC content: 43.91

Gene sequence:

>558_bases
ATGGAATCTACAATAACTATAGAGAACGTGGTAGCATCTACCAGGTTGGCAGAAGATTTCGACCTTGAAAAAATGATGGA
GTCTGGGTTGGAAGGCGCAGAATATAACAAAGTGAAGTTCCCTGGTCTCGTCTACAGAATTAATAACCCCAAAGCTGCCT
TTCTAATTTTCACCTCTGGAAAAGTGGTATGCACAGGATCAAAGAGCATCGGGAACGCTCATGCGGCCATAATCAATCTG
GCTAACACGCTCAAATCCATATGTTGCGAGAAAATAGATCTCGAACCTGATGTTCGTGTTCAGAACATTGTAGCTAGTGC
TGATTTAAAAACAAACCTTAACCTGAACACCATTGCTATAGCTTTTGGTCTGGAGAATGTCGAATACGAGCCAGAGGTAT
TTCCGGGGCTTATTTATAGGGTCGAGGCTCCCAAGGTAGTAGTGCTTGTGTTCAGCTCTGGCAAGCTGGTAATCACAGGT
GGAAAATGTCCGGAGGATTGTGAAGAGGGTCTGCGGATCGTCAAGACAGAGTTCGACAACTTAGGACTTCTTTATTAA

Upstream 100 bases:

>100_bases
TAAAAAAAGTAAAAAATGTACCCAATACACACTATTAAAATATTTATTTTTTTGCTTTAAACCGACAATCAGAACTATAG
AACTTCCAAATACATGCTGT

Downstream 100 bases:

>100_bases
ATATATCCTCAAAGTCTCGTAAACTCGTAACGGATGCCACATGCAAAATTGGGAATTACATAAGAGAATAAGAGGAAAAA
ACATGCATATTACCAGCAAG

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein 3; BAP 3; TATA sequence-binding protein 3; TBP 3; TATA-box factor 3

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MESTITIENVVASTRLAEDFDLEKMMESGLEGAEYNKVKFPGLVYRINNPKAAFLIFTSGKVVCTGSKSIGNAHAAIINL
ANTLKSICCEKIDLEPDVRVQNIVASADLKTNLNLNTIAIAFGLENVEYEPEVFPGLIYRVEAPKVVVLVFSSGKLVITG
GKCPEDCEEGLRIVKTEFDNLGLLY

Sequences:

>Translated_185_residues
MESTITIENVVASTRLAEDFDLEKMMESGLEGAEYNKVKFPGLVYRINNPKAAFLIFTSGKVVCTGSKSIGNAHAAIINL
ANTLKSICCEKIDLEPDVRVQNIVASADLKTNLNLNTIAIAFGLENVEYEPEVFPGLIYRVEAPKVVVLVFSSGKLVITG
GKCPEDCEEGLRIVKTEFDNLGLLY
>Mature_185_residues
MESTITIENVVASTRLAEDFDLEKMMESGLEGAEYNKVKFPGLVYRINNPKAAFLIFTSGKVVCTGSKSIGNAHAAIINL
ANTLKSICCEKIDLEPDVRVQNIVASADLKTNLNLNTIAIAFGLENVEYEPEVFPGLIYRVEAPKVVVLVFSSGKLVITG
GKCPEDCEEGLRIVKTEFDNLGLLY

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family

Homologues:

Organism=Homo sapiens, GI39930602, Length=156, Percent_Identity=37.8205128205128, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI285026520, Length=165, Percent_Identity=36.3636363636364, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI4507379, Length=156, Percent_Identity=37.8205128205128, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17555358, Length=165, Percent_Identity=38.1818181818182, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320996, Length=170, Percent_Identity=39.4117647058824, Blast_Score=113, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17647997, Length=156, Percent_Identity=37.8205128205128, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17136834, Length=170, Percent_Identity=34.7058823529412, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TBP3_METMA (Q8PUZ4)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_634208.1
- ProteinModelPortal:   Q8PUZ4
- SMR:   Q8PUZ4
- GeneID:   1480526
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2184
- NMPDR:   fig|192952.1.peg.2184
- HOGENOM:   HBG499930
- ProtClustDB:   PRK00394
- BioCyc:   MMAZ192952:MM2184-MONOMER
- HAMAP:   MF_00408
- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294
- Gene3D:   G3DSA:3.30.310.10
- PANTHER:   PTHR10126
- PRINTS:   PR00686

Pfam domain/function: PF00352 TBP; SSF55945 TFIID_C/glycos_N

EC number: NA

Molecular weight: Translated: 20177; Mature: 20177

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTITIENVVASTRLAEDFDLEKMMESGLEGAEYNKVKFPGLVYRINNPKAAFLIFTSG
CCCEEEHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEECCEEEEEECCCCEEEEEEECC
KVVCTGSKSIGNAHAAIINLANTLKSICCEKIDLEPDVRVQNIVASADLKTNLNLNTIAI
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCCCCEEEEE
AFGLENVEYEPEVFPGLIYRVEAPKVVVLVFSSGKLVITGGKCPEDCEEGLRIVKTEFDN
EEECCCCCCCCCCCCCEEEEECCCEEEEEEECCCEEEEECCCCHHHHHHCCEEEEECCCC
LGLLY
CCCCC
>Mature Secondary Structure
MESTITIENVVASTRLAEDFDLEKMMESGLEGAEYNKVKFPGLVYRINNPKAAFLIFTSG
CCCEEEHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEECCEEEEEECCCCEEEEEEECC
KVVCTGSKSIGNAHAAIINLANTLKSICCEKIDLEPDVRVQNIVASADLKTNLNLNTIAI
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEECCCCCCCCCEEEEE
AFGLENVEYEPEVFPGLIYRVEAPKVVVLVFSSGKLVITGGKCPEDCEEGLRIVKTEFDN
EEECCCCCCCCCCCCCEEEEECCCEEEEEEECCCEEEEECCCCHHHHHHCCEEEEECCCC
LGLLY
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824