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The map label for this gene is yugH [H]

Identifier: 21228143

GI number: 21228143

Start: 2437800

End: 2438981

Strand: Direct

Name: yugH [H]

Synonym: MM_2041

Alternate gene names: 21228143

Gene position: 2437800-2438981 (Clockwise)

Preceding gene: 21228142

Following gene: 21228145

Centisome position: 59.51

GC content: 46.53

Gene sequence:

>1182_bases
TTGAGACCTCCATGCGATCCTTCAAAATTCATTGCGGAAGCTGTAAAGAGTATCCCCCCATCAGGAATACGCCGTTTTTT
TGACCTGGTTTCCGGACTTGAGGACATTATCTCCCTTGGTGTGGGAGAGCCTGATTTCATCACTCCCTGGCATATCCGTG
AGATGTGCATTCACTCACTTGAAAAAGGGCAGACTTCATATACCTCAAACTCCGGGCTTCCGGAACTCAGAGACGAACTT
ACAAGGACCTATTACAGGCGCTATGGACTGGACTATAATCCGGAATCCGAAATTCTTATCACTACAGGAGTAAGCGAAGC
CCTTGATATAGCAATCCGGGCAGTGGTAAACCCCGGAGATGAGGTAATTGTGGTTCAGCCCTCTTATGTAGCGTATGTCC
CTTCAGTGATTATGGCAGGAGGCAAGCCTGTTATTGTTTCCACACACAGGGACGATGATTTCAGCCTTACTGCAGAAGTT
CTTGAACCTGCAATCACCAGCAAAACAAAGGCAATAGTCCTCAATTTCCCCAACAACCCTACAGGCGCAATTATGCAAAA
GGAAGGAATGGAGGATATCGCAGACCTCGTTGTTGAGAATGACTTATTTTTAATTTCCGACGAGGTTTATGAGTGCCTCA
CCTATGAAGGCACCCATGTCCCATTCTCTTCCCTTGAAGGCATGAAAGACCGTACCGTTATGCTGAACGGCTTTTCCAAG
GCTTATGCCATGACGGGATTAAGACTCGGTTTTGCTATGGGAGCTCCGGATATCATTCATTCTATGATGATGATCCACCA
GTACTGCATGCTCTGTGCCCCCATAACCGCGCAGGTAGGGGCAATTGAGGCTCTCCGCAATGGTAAAGGAGAGATGGAGA
GGATGGTCAGGGAATATGACCGGCGCAGGCACTTTATTGTAAATGGTTTTAATAGGATAGGGCTTGAATGCTGTAACCCT
AAAGGAGCTTTTTATGCCTTCCCTTACATAGGAGATACAGGGCTTTCCTCTTCTGACTTTGCAGAGCGCCTGCTGAATGA
AAAGAAAATTGTTACTATCCCGGGAGATGTCTTTGGAGAAGCGGGTGAAGGTTTCCTGCGCTGTGCATATGCAGCATCTC
TTGATGACATTAAAAAAGCAATCGAGAGAATGGGAGATTTTGTAGACGGATTAAAACAGTGA

Upstream 100 bases:

>100_bases
GCTCCCGGTTTCGTTTTAATGCGAAACTGCTTAAACACTACCCCTTTTATCCCGTTTTACTTTACATCTGATTTAAATAA
TTTTTTATAGAGGTGTTTGC

Downstream 100 bases:

>100_bases
GTATGACCGAATTTTTCGGTCTACATTTTTCTTATTCTTTTCTGCTGGTTTCTACATTTTTCCTTAATTCTGATCTTTAA
CTACTTTCTTATTTTTAATT

Product: aspartate aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRPPCDPSKFIAEAVKSIPPSGIRRFFDLVSGLEDIISLGVGEPDFITPWHIREMCIHSLEKGQTSYTSNSGLPELRDEL
TRTYYRRYGLDYNPESEILITTGVSEALDIAIRAVVNPGDEVIVVQPSYVAYVPSVIMAGGKPVIVSTHRDDDFSLTAEV
LEPAITSKTKAIVLNFPNNPTGAIMQKEGMEDIADLVVENDLFLISDEVYECLTYEGTHVPFSSLEGMKDRTVMLNGFSK
AYAMTGLRLGFAMGAPDIIHSMMMIHQYCMLCAPITAQVGAIEALRNGKGEMERMVREYDRRRHFIVNGFNRIGLECCNP
KGAFYAFPYIGDTGLSSSDFAERLLNEKKIVTIPGDVFGEAGEGFLRCAYAASLDDIKKAIERMGDFVDGLKQ

Sequences:

>Translated_393_residues
MRPPCDPSKFIAEAVKSIPPSGIRRFFDLVSGLEDIISLGVGEPDFITPWHIREMCIHSLEKGQTSYTSNSGLPELRDEL
TRTYYRRYGLDYNPESEILITTGVSEALDIAIRAVVNPGDEVIVVQPSYVAYVPSVIMAGGKPVIVSTHRDDDFSLTAEV
LEPAITSKTKAIVLNFPNNPTGAIMQKEGMEDIADLVVENDLFLISDEVYECLTYEGTHVPFSSLEGMKDRTVMLNGFSK
AYAMTGLRLGFAMGAPDIIHSMMMIHQYCMLCAPITAQVGAIEALRNGKGEMERMVREYDRRRHFIVNGFNRIGLECCNP
KGAFYAFPYIGDTGLSSSDFAERLLNEKKIVTIPGDVFGEAGEGFLRCAYAASLDDIKKAIERMGDFVDGLKQ
>Mature_393_residues
MRPPCDPSKFIAEAVKSIPPSGIRRFFDLVSGLEDIISLGVGEPDFITPWHIREMCIHSLEKGQTSYTSNSGLPELRDEL
TRTYYRRYGLDYNPESEILITTGVSEALDIAIRAVVNPGDEVIVVQPSYVAYVPSVIMAGGKPVIVSTHRDDDFSLTAEV
LEPAITSKTKAIVLNFPNNPTGAIMQKEGMEDIADLVVENDLFLISDEVYECLTYEGTHVPFSSLEGMKDRTVMLNGFSK
AYAMTGLRLGFAMGAPDIIHSMMMIHQYCMLCAPITAQVGAIEALRNGKGEMERMVREYDRRRHFIVNGFNRIGLECCNP
KGAFYAFPYIGDTGLSSSDFAERLLNEKKIVTIPGDVFGEAGEGFLRCAYAASLDDIKKAIERMGDFVDGLKQ

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=357, Percent_Identity=28.8515406162465, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI169881279, Length=357, Percent_Identity=28.8515406162465, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI56713256, Length=358, Percent_Identity=31.0055865921788, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI56713254, Length=358, Percent_Identity=31.0055865921788, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI169881281, Length=326, Percent_Identity=26.3803680981595, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI7705897, Length=432, Percent_Identity=23.6111111111111, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33469970, Length=432, Percent_Identity=23.6111111111111, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI215599424, Length=373, Percent_Identity=23.0563002680965, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI19263340, Length=370, Percent_Identity=23.5135135135135, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4507369, Length=386, Percent_Identity=20.9844559585492, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4885351, Length=347, Percent_Identity=22.7665706051873, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788722, Length=352, Percent_Identity=31.5340909090909, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786816, Length=355, Percent_Identity=27.887323943662, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1788627, Length=374, Percent_Identity=27.5401069518717, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790797, Length=303, Percent_Identity=25.4125412541254, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788332, Length=244, Percent_Identity=24.5901639344262, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567369, Length=356, Percent_Identity=29.2134831460674, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994472, Length=272, Percent_Identity=32.3529411764706, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71994476, Length=272, Percent_Identity=32.3529411764706, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17567663, Length=412, Percent_Identity=24.7572815533981, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322401, Length=395, Percent_Identity=25.8227848101266, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323118, Length=375, Percent_Identity=24, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320317, Length=358, Percent_Identity=22.9050279329609, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28573069, Length=390, Percent_Identity=31.025641025641, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24646114, Length=390, Percent_Identity=31.025641025641, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI28573067, Length=390, Percent_Identity=31.025641025641, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI28573065, Length=390, Percent_Identity=31.025641025641, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI18859735, Length=401, Percent_Identity=21.9451371571072, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551451, Length=394, Percent_Identity=24.6192893401015, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641770, Length=394, Percent_Identity=24.6192893401015, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641760, Length=394, Percent_Identity=24.6192893401015, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641768, Length=394, Percent_Identity=24.6192893401015, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641766, Length=394, Percent_Identity=24.6192893401015, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641764, Length=394, Percent_Identity=24.6192893401015, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 43475; Mature: 43475

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPPCDPSKFIAEAVKSIPPSGIRRFFDLVSGLEDIISLGVGEPDFITPWHIREMCIHSL
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
EKGQTSYTSNSGLPELRDELTRTYYRRYGLDYNPESEILITTGVSEALDIAIRAVVNPGD
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHEECCCC
EVIVVQPSYVAYVPSVIMAGGKPVIVSTHRDDDFSLTAEVLEPAITSKTKAIVLNFPNNP
CEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
TGAIMQKEGMEDIADLVVENDLFLISDEVYECLTYEGTHVPFSSLEGMKDRTVMLNGFSK
CCCHHHHCCHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCCHHHHCCCCCCEEEEECHHH
AYAMTGLRLGFAMGAPDIIHSMMMIHQYCMLCAPITAQVGAIEALRNGKGEMERMVREYD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RRRHFIVNGFNRIGLECCNPKGAFYAFPYIGDTGLSSSDFAERLLNEKKIVTIPGDVFGE
HCCEEEECCHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHCCCEEEECCCHHCCC
AGEGFLRCAYAASLDDIKKAIERMGDFVDGLKQ
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRPPCDPSKFIAEAVKSIPPSGIRRFFDLVSGLEDIISLGVGEPDFITPWHIREMCIHSL
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
EKGQTSYTSNSGLPELRDELTRTYYRRYGLDYNPESEILITTGVSEALDIAIRAVVNPGD
HCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHEECCCC
EVIVVQPSYVAYVPSVIMAGGKPVIVSTHRDDDFSLTAEVLEPAITSKTKAIVLNFPNNP
CEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCC
TGAIMQKEGMEDIADLVVENDLFLISDEVYECLTYEGTHVPFSSLEGMKDRTVMLNGFSK
CCCHHHHCCHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCCHHHHCCCCCCEEEEECHHH
AYAMTGLRLGFAMGAPDIIHSMMMIHQYCMLCAPITAQVGAIEALRNGKGEMERMVREYD
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RRRHFIVNGFNRIGLECCNPKGAFYAFPYIGDTGLSSSDFAERLLNEKKIVTIPGDVFGE
HCCEEEECCHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHCCCEEEECCCHHCCC
AGEGFLRCAYAASLDDIKKAIERMGDFVDGLKQ
CCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]