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The map label for this gene is pyrC [H]

Identifier: 21228113

GI number: 21228113

Start: 2396738

End: 2398108

Strand: Direct

Name: pyrC [H]

Synonym: MM_2011

Alternate gene names: 21228113

Gene position: 2396738-2398108 (Clockwise)

Preceding gene: 21228112

Following gene: 21228120

Centisome position: 58.51

GC content: 48.07

Gene sequence:

>1371_bases
ATGCCTGATATTCATATCAAAAATACAAGAATTTACTATAATAATTCTCTCCAGCCTGCAGAAATCATTATTGAGCACGG
CAAGATTACAAAAATAGGGAAAGATTTCAGGGTATCAAGTTCGGATATGGTGATAGATGCAAAGGGATCGCTCACTCTGC
CAGCAGGAATTGATGTTCACGTCCATTTCAGGGAACCGGGCATGACCCTGAAAGAGAACTGGTACACCGGGTCATGTGCT
GCAGCTGCCGGGGGGATTGCCACAGTTATCGACCAGCCGAATACTATACCTCCTACAACTGACAGGCGCTCTTTTGAACA
GAAGCTTGAGCTTGCCAGGAAGAAGTCCATAGTAGACTTCGGGATCAATGGCGGAGTAACAGGGAATATAGAGAAGCTCA
AAGAACTCTGGAGGCTGGGGGTTACAGCTTTTGGAGAGATTTTCATGGCTGAGTCTACGGGCGGGCTTAATATCAAAGAA
GAAGATTTTGAAGAAGCCCTGGCTGAGATCAAAAGACTCGGAGCCCTTGCCACGATCCATGCTGAGGATGAAAAGATGCG
GCTTGAACTGGAGCAGCTGCTGAAAGGGGATGTTTCCTGTGACTATCATTCGAAGGTACGCCCGAATGCGTGCGAGGCAT
CTGCTGTCCAGTGTGCGCTTGAGATTATTTCCAGGCTTGGAGTAAAGGCACATTTCTGCCACCTGAGCACACTTGAAGCT
GTGGGGATGATCCGAAAGGAAAAGTATCTTGCAAAAAGAGAAAATAAGGAACCTCTTTTTACGTGCGAGGTCACTCCTCA
TCACCTCTTTCTTTCCACAAGGGACTGGGAGAGGCTCGGGGTTTTTGGCAAAATGAATCCTCCTCTCAGGGGGAGCCACA
GCATCAAGGCGCTTGTAAACGGGCTGAATGACGGGACTATTGATATGGTAGCCTCGGATCACGCTCCTCACCTTGAATCT
GAAAAGGGCCCTGATATCCGGGCTGCTCCGTCAGGAGTGCCGGGGGTTGAAACTCTTATGCCTCTTATGCTTGCAGCAGT
CCGGAAAAACATCCTGCCACTTGCAAAGATGATAATGCTCACAAGCTGGAATCCTGCAAGAGCTTTCGGGCTGGACCTTC
TGGGAAAAGGAAAACTTGAGGTGAGTTATGATGCAGATCTTATGATTGTGGACCCTCGAAACCTCCAGCCTGTAAGAGCT
GATATGCTTCACAGCAAGGCGGGATGGACCCCCTTCGAAGGCATTGATGCGGTTTTTCCGGAATATACTCTGTCGAGAGG
CGAGGTTATCTGGATGGAAGAATCCATTAATGCAAAACCCGGAAGAGGTAAATTCCTTGAAGGCAAAGGAAAAATGTCAG
AAGAAGATTAA

Upstream 100 bases:

>100_bases
TTTCTTTTTTCTTCCCTTTTTCCTTTTTTACTTTTCGTTTCTGGCTCTCACTTTTCGCCCATGTGTATGTTTTAAGTACG
TTTTAAGCATATAGACGCCC

Downstream 100 bases:

>100_bases
GAAGAGGCCGGATAAGAATAAGATTCCGGAACTCTCCTTTTTTAATTAATTATTGTAATGGTCTTTCTTTTTTTAGTAAA
AGTCTACCGAGTCCAGCTGC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MPDIHIKNTRIYYNNSLQPAEIIIEHGKITKIGKDFRVSSSDMVIDAKGSLTLPAGIDVHVHFREPGMTLKENWYTGSCA
AAAGGIATVIDQPNTIPPTTDRRSFEQKLELARKKSIVDFGINGGVTGNIEKLKELWRLGVTAFGEIFMAESTGGLNIKE
EDFEEALAEIKRLGALATIHAEDEKMRLELEQLLKGDVSCDYHSKVRPNACEASAVQCALEIISRLGVKAHFCHLSTLEA
VGMIRKEKYLAKRENKEPLFTCEVTPHHLFLSTRDWERLGVFGKMNPPLRGSHSIKALVNGLNDGTIDMVASDHAPHLES
EKGPDIRAAPSGVPGVETLMPLMLAAVRKNILPLAKMIMLTSWNPARAFGLDLLGKGKLEVSYDADLMIVDPRNLQPVRA
DMLHSKAGWTPFEGIDAVFPEYTLSRGEVIWMEESINAKPGRGKFLEGKGKMSEED

Sequences:

>Translated_456_residues
MPDIHIKNTRIYYNNSLQPAEIIIEHGKITKIGKDFRVSSSDMVIDAKGSLTLPAGIDVHVHFREPGMTLKENWYTGSCA
AAAGGIATVIDQPNTIPPTTDRRSFEQKLELARKKSIVDFGINGGVTGNIEKLKELWRLGVTAFGEIFMAESTGGLNIKE
EDFEEALAEIKRLGALATIHAEDEKMRLELEQLLKGDVSCDYHSKVRPNACEASAVQCALEIISRLGVKAHFCHLSTLEA
VGMIRKEKYLAKRENKEPLFTCEVTPHHLFLSTRDWERLGVFGKMNPPLRGSHSIKALVNGLNDGTIDMVASDHAPHLES
EKGPDIRAAPSGVPGVETLMPLMLAAVRKNILPLAKMIMLTSWNPARAFGLDLLGKGKLEVSYDADLMIVDPRNLQPVRA
DMLHSKAGWTPFEGIDAVFPEYTLSRGEVIWMEESINAKPGRGKFLEGKGKMSEED
>Mature_455_residues
PDIHIKNTRIYYNNSLQPAEIIIEHGKITKIGKDFRVSSSDMVIDAKGSLTLPAGIDVHVHFREPGMTLKENWYTGSCAA
AAGGIATVIDQPNTIPPTTDRRSFEQKLELARKKSIVDFGINGGVTGNIEKLKELWRLGVTAFGEIFMAESTGGLNIKEE
DFEEALAEIKRLGALATIHAEDEKMRLELEQLLKGDVSCDYHSKVRPNACEASAVQCALEIISRLGVKAHFCHLSTLEAV
GMIRKEKYLAKRENKEPLFTCEVTPHHLFLSTRDWERLGVFGKMNPPLRGSHSIKALVNGLNDGTIDMVASDHAPHLESE
KGPDIRAAPSGVPGVETLMPLMLAAVRKNILPLAKMIMLTSWNPARAFGLDLLGKGKLEVSYDADLMIVDPRNLQPVRAD
MLHSKAGWTPFEGIDAVFPEYTLSRGEVIWMEESINAKPGRGKFLEGKGKMSEED

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=395, Percent_Identity=32.6582278481013, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI4503051, Length=459, Percent_Identity=27.0152505446623, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI62422571, Length=459, Percent_Identity=27.0152505446623, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI4503379, Length=456, Percent_Identity=26.9736842105263, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI4503375, Length=463, Percent_Identity=26.7818574514039, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI4503377, Length=459, Percent_Identity=26.3616557734205, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI19923821, Length=457, Percent_Identity=26.9146608315098, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI190194363, Length=458, Percent_Identity=26.2008733624454, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786722, Length=457, Percent_Identity=31.2910284463895, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI87082175, Length=462, Percent_Identity=29.8701298701299, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI193204318, Length=427, Percent_Identity=32.0843091334895, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71989490, Length=472, Percent_Identity=24.7881355932203, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17539558, Length=460, Percent_Identity=26.0869565217391, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI86575075, Length=459, Percent_Identity=23.0936819172113, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=466, Percent_Identity=27.4678111587983, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24642586, Length=404, Percent_Identity=31.6831683168317, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI17137462, Length=465, Percent_Identity=26.0215053763441, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI221377917, Length=468, Percent_Identity=26.0683760683761, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI18859883, Length=407, Percent_Identity=28.2555282555283, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24644287, Length=250, Percent_Identity=27.2, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644289, Length=232, Percent_Identity=28.8793103448276, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 50332; Mature: 50200

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIHIKNTRIYYNNSLQPAEIIIEHGKITKIGKDFRVSSSDMVIDAKGSLTLPAGIDVH
CCCCEEECEEEEECCCCCHHHHEEECCCEEECCCCCEECCCCEEEECCCCEEECCCCEEE
VHFREPGMTLKENWYTGSCAAAAGGIATVIDQPNTIPPTTDRRSFEQKLELARKKSIVDF
EEEECCCCCEECCCCCCCHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCEEEE
GINGGVTGNIEKLKELWRLGVTAFGEIFMAESTGGLNIKEEDFEEALAEIKRLGALATIH
CCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEE
AEDEKMRLELEQLLKGDVSCDYHSKVRPNACEASAVQCALEIISRLGVKAHFCHLSTLEA
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
VGMIRKEKYLAKRENKEPLFTCEVTPHHLFLSTRDWERLGVFGKMNPPLRGSHSIKALVN
HHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHCCCCCCCCCCCCCHHHHHHHC
GLNDGTIDMVASDHAPHLESEKGPDIRAAPSGVPGVETLMPLMLAAVRKNILPLAKMIML
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TSWNPARAFGLDLLGKGKLEVSYDADLMIVDPRNLQPVRADMLHSKAGWTPFEGIDAVFP
CCCCCHHHHCCCEECCCCEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHCC
EYTLSRGEVIWMEESINAKPGRGKFLEGKGKMSEED
CCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCC
>Mature Secondary Structure 
PDIHIKNTRIYYNNSLQPAEIIIEHGKITKIGKDFRVSSSDMVIDAKGSLTLPAGIDVH
CCCEEECEEEEECCCCCHHHHEEECCCEEECCCCCEECCCCEEEECCCCEEECCCCEEE
VHFREPGMTLKENWYTGSCAAAAGGIATVIDQPNTIPPTTDRRSFEQKLELARKKSIVDF
EEEECCCCCEECCCCCCCHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCEEEE
GINGGVTGNIEKLKELWRLGVTAFGEIFMAESTGGLNIKEEDFEEALAEIKRLGALATIH
CCCCCCCCCHHHHHHHHHHHHHHHCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEE
AEDEKMRLELEQLLKGDVSCDYHSKVRPNACEASAVQCALEIISRLGVKAHFCHLSTLEA
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
VGMIRKEKYLAKRENKEPLFTCEVTPHHLFLSTRDWERLGVFGKMNPPLRGSHSIKALVN
HHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCHHHHCCCCCCCCCCCCCHHHHHHHC
GLNDGTIDMVASDHAPHLESEKGPDIRAAPSGVPGVETLMPLMLAAVRKNILPLAKMIML
CCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TSWNPARAFGLDLLGKGKLEVSYDADLMIVDPRNLQPVRADMLHSKAGWTPFEGIDAVFP
CCCCCHHHHCCCEECCCCEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHCC
EYTLSRGEVIWMEESINAKPGRGKFLEGKGKMSEED
CCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]