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The map label for this gene is tabA [H]

Identifier: 21227987

GI number: 21227987

Start: 2238532

End: 2239794

Strand: Reverse

Name: tabA [H]

Synonym: MM_1885

Alternate gene names: 21227987

Gene position: 2239794-2238532 (Counterclockwise)

Preceding gene: 21227990

Following gene: 21227986

Centisome position: 54.68

GC content: 46.87

Gene sequence:

>1263_bases
ATGGTTTCAAAGAACCTCCCTTTCACAAAAGAAGATATCCTTAAAATAATGGAAAAATATCCCACCCCGTTTCATATTTA
CGATGAGAAAGCCATAAGGGAAAACGCCAGAAGAATGAAATCCGCCTTTAAAGATATTCCGGGTTTCAAGGAGTTTTTTG
CAGTAAAAGCCCTTCCCAATCCCTTCATTCTTAAGATCCTCAAAGAGGAAGGTTTCGGGGCAGACTGCAGTTCTCTGCCG
GAACTCATACTTGCGGAAAAAGCGGGGATGACAGGCGATGACATCATGTTCAGTTCCAATGACACGCCGGCTGAAGAGTT
TATAAAGGCAAAGGAGCTTGGCGGCTTTATCAACCTTGATGATATCAGCCACATCCCTTATCTGGAAAAATCCGCGGGGC
TTCCTGAGATCGTTTGCTTCAGGTACAATCCCGGACCCCTGAAAGAAGGAAATGCAATCATTGGAAAGCCCGAGGAGGCA
AAATACGGATTTACAAGGGAACAGATGTTTGAAGGGTACAGGATCCTAAGGGACAAAGGAGTAAAGCGCTTTGGGATGCA
CACAATGGTCGCCTCGAACGAGCTTAACTCTGATTACTTTGTGGAAACCGCAAGGATCCTTTTCGAACTTATAGTTGAGA
TTTCAAAGGAACTGGGAATTCAGTTCGAGTTCGTAAACCTCGGAGGAGGAATAGGCATCCCGTACAGGCCAGAGCAGGAG
CCCGTCTCCCTTGAAGCCGTGGCAAAAGGTGTAAAAGAGGCTTATGATGCCACAATCACAGCTAACGGGCTCGCTCCTCT
AAAAATATACCTCGAATGCGGCAGGGTCATTACGGGCCCCTACGGATATCTTATCTCTCAGGTCAGGCACTTAAAAAGCA
CATACAAAGACTACGTGGGCCTGGACTCCTGTATGGCAAACCTGATGCGTCCAGGGATGTACGGTGCCTACCACCATATT
ACGGTATTTGGAAAAGAAAAGAAAGCACCTGCCCATAAATATGATGTGACCGGCTCTCTCTGCGAAAACAATGACAAGTT
TGCAATCGACAGGATGCTTCCCGAGGTGGAAATAGGAGACATCCTGGCAATCCACGATGCAGGCGCACACGGACATGCGA
TGGGCTTTAATTATAATGGAAAACTCCGCTCTGCCGAACTTCTGCTTAGAGAAGACGGAAGCGTTGTGCAGATCCGCAGG
GCAGAGACCATCGAAGATTACTTTGCAACCCTCAATTTTGAGCAGTTGAAGAATTTCAGGTAA

Upstream 100 bases:

>100_bases
TCTGCGGGATAGAGGAAAAACTAATAAAGGAATAAAAGTTCAAATTGATACAGAATTGACATAGATTGATTAAGCAAAAA
TCAGGCAAAAGGTTACGATA

Downstream 100 bases:

>100_bases
GCAGCTTTCAAAAAAATTATAGTAAAAAAGTAACTGGCGGATAAAATCCAATTTCTTGAAATCCGTCTTTTTCTTTTTTA
GCTTTATTTATTCCTTATTT

Product: diaminopimelate decarboxylase

Products: L-lysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MVSKNLPFTKEDILKIMEKYPTPFHIYDEKAIRENARRMKSAFKDIPGFKEFFAVKALPNPFILKILKEEGFGADCSSLP
ELILAEKAGMTGDDIMFSSNDTPAEEFIKAKELGGFINLDDISHIPYLEKSAGLPEIVCFRYNPGPLKEGNAIIGKPEEA
KYGFTREQMFEGYRILRDKGVKRFGMHTMVASNELNSDYFVETARILFELIVEISKELGIQFEFVNLGGGIGIPYRPEQE
PVSLEAVAKGVKEAYDATITANGLAPLKIYLECGRVITGPYGYLISQVRHLKSTYKDYVGLDSCMANLMRPGMYGAYHHI
TVFGKEKKAPAHKYDVTGSLCENNDKFAIDRMLPEVEIGDILAIHDAGAHGHAMGFNYNGKLRSAELLLREDGSVVQIRR
AETIEDYFATLNFEQLKNFR

Sequences:

>Translated_420_residues
MVSKNLPFTKEDILKIMEKYPTPFHIYDEKAIRENARRMKSAFKDIPGFKEFFAVKALPNPFILKILKEEGFGADCSSLP
ELILAEKAGMTGDDIMFSSNDTPAEEFIKAKELGGFINLDDISHIPYLEKSAGLPEIVCFRYNPGPLKEGNAIIGKPEEA
KYGFTREQMFEGYRILRDKGVKRFGMHTMVASNELNSDYFVETARILFELIVEISKELGIQFEFVNLGGGIGIPYRPEQE
PVSLEAVAKGVKEAYDATITANGLAPLKIYLECGRVITGPYGYLISQVRHLKSTYKDYVGLDSCMANLMRPGMYGAYHHI
TVFGKEKKAPAHKYDVTGSLCENNDKFAIDRMLPEVEIGDILAIHDAGAHGHAMGFNYNGKLRSAELLLREDGSVVQIRR
AETIEDYFATLNFEQLKNFR
>Mature_420_residues
MVSKNLPFTKEDILKIMEKYPTPFHIYDEKAIRENARRMKSAFKDIPGFKEFFAVKALPNPFILKILKEEGFGADCSSLP
ELILAEKAGMTGDDIMFSSNDTPAEEFIKAKELGGFINLDDISHIPYLEKSAGLPEIVCFRYNPGPLKEGNAIIGKPEEA
KYGFTREQMFEGYRILRDKGVKRFGMHTMVASNELNSDYFVETARILFELIVEISKELGIQFEFVNLGGGIGIPYRPEQE
PVSLEAVAKGVKEAYDATITANGLAPLKIYLECGRVITGPYGYLISQVRHLKSTYKDYVGLDSCMANLMRPGMYGAYHHI
TVFGKEKKAPAHKYDVTGSLCENNDKFAIDRMLPEVEIGDILAIHDAGAHGHAMGFNYNGKLRSAELLLREDGSVVQIRR
AETIEDYFATLNFEQLKNFR

Specific function: Involved in tabtoxin production and pathogenicity [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=427, Percent_Identity=28.5714285714286, Blast_Score=158, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: 4.1.1.20

Molecular weight: Translated: 47191; Mature: 47191

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSKNLPFTKEDILKIMEKYPTPFHIYDEKAIRENARRMKSAFKDIPGFKEFFAVKALPN
CCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PFILKILKEEGFGADCSSLPELILAEKAGMTGDDIMFSSNDTPAEEFIKAKELGGFINLD
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHCCEEECC
DISHIPYLEKSAGLPEIVCFRYNPGPLKEGNAIIGKPEEAKYGFTREQMFEGYRILRDKG
CCCCCCCHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCC
VKRFGMHTMVASNELNSDYFVETARILFELIVEISKELGIQFEFVNLGGGIGIPYRPEQE
CHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCC
PVSLEAVAKGVKEAYDATITANGLAPLKIYLECGRVITGPYGYLISQVRHLKSTYKDYVG
CCCHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHCC
LDSCMANLMRPGMYGAYHHITVFGKEKKAPAHKYDVTGSLCENNDKFAIDRMLPEVEIGD
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEECCCCHHHCCCCCEEHHHHCCCCCCCC
ILAIHDAGAHGHAMGFNYNGKLRSAELLLREDGSVVQIRRAETIEDYFATLNFEQLKNFR
EEEEECCCCCCCEECCCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MVSKNLPFTKEDILKIMEKYPTPFHIYDEKAIRENARRMKSAFKDIPGFKEFFAVKALPN
CCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PFILKILKEEGFGADCSSLPELILAEKAGMTGDDIMFSSNDTPAEEFIKAKELGGFINLD
HHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHCCEEECC
DISHIPYLEKSAGLPEIVCFRYNPGPLKEGNAIIGKPEEAKYGFTREQMFEGYRILRDKG
CCCCCCCHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCC
VKRFGMHTMVASNELNSDYFVETARILFELIVEISKELGIQFEFVNLGGGIGIPYRPEQE
CHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCC
PVSLEAVAKGVKEAYDATITANGLAPLKIYLECGRVITGPYGYLISQVRHLKSTYKDYVG
CCCHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHHCC
LDSCMANLMRPGMYGAYHHITVFGKEKKAPAHKYDVTGSLCENNDKFAIDRMLPEVEIGD
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEECCCCHHHCCCCCEEHHHHCCCCCCCC
ILAIHDAGAHGHAMGFNYNGKLRSAELLLREDGSVVQIRRAETIEDYFATLNFEQLKNFR
EEEEECCCCCCCEECCCCCCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: D-Lysine; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1.7 {meso-2,6-diamininoheptanedioate}} [C]

Substrates: meso-2,6-diaminoheptanedioate

Specific reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2

General reaction: Decarboxylation [C]

Inhibitor: 2, 3-Diaminopropionic acid; Glutamic acid; L-Cystine; L-Lysine; Penicillamine [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1515668 [H]