Click here to switch to the map view.

The map label for this gene is appC [H]

Identifier: 21227959

GI number: 21227959

Start: 2207456

End: 2208424

Strand: Reverse

Name: appC [H]

Synonym: MM_1857

Alternate gene names: 21227959

Gene position: 2208424-2207456 (Counterclockwise)

Preceding gene: 21227960

Following gene: 21227958

Centisome position: 53.91

GC content: 47.16

Gene sequence:

>969_bases
ATGAGCCTGGAAGCTGCCCATAGCGAAAGCTCCTGTATAACAGAAGCCTGTACTGAAGAGCATCCTGAAAAACAGCTTGA
AAATTCGGATTTTATTTTAAAACTCCCTTTAAAACCCCCATTTAATTATTACAGAAAGCAGGGAAGTTTTTTGGGACAAC
TGAATTATGGAGGAATTTTTCTCTTTGCCTTATTCCTGTTTATGGCATTGTTTCCTTCCCTGCTTGCCCCTTACGCCCCT
TATGACCGCTTCACGCCTTACGAAGAACCTTCAGGACAGCACCTTCTCGGGACGAACGACATAGGAAACGATATCCTCTC
AGAACTTGTGTACGGGGCAAAGGTCTCACTGACAGTGGGATTTGCAGCCGCCCTTGTCTCAACCCTGATAGGGACCATCC
TCGGGCTCTGTTCAGGCTATTTCAGGGGGGCTGTTGATGAGCTGCTAATGGGTTTTACAGATATTGTCCTTATTATCCCG
AAAATTCCCCTTATCATAGTCCTGGGAGCGTACCTGCAGCCCAGCATCTGGATCCTTGTCCCCGTGCTCGGCCTCCTATC
CTGGGAATCCACTGCCAGAGTTACCAGATCAAAAACCCTCCAGTTAAGGGAAACAGGCTATGTTAAAAGTGCCAGATGCA
TGGGTTTTTCTTCACAGCACATTATGTTCTCGGATATTTTGCCCAACCTCTACCATGTCCTGCTGCCCAAATTCATGCTG
GCAACAGCCTCGGCAATGATTTCGGAAGCCTCTCTTTCTTTTCTCGGGCTCAGCGATGTAAGCATGAAAAGCTGGGGGAC
AATGCTTTCTTTTGCTTTTTCCAGAGGAGGTTTTATCAGGGACATGTGGTGGTGGTATTTGCCTCCGGGAATCTGCATAA
CCCTCTGCGTAATATCTATTGCACTCATAGGGTTCGGGATCGAAACTAAAAAAGAGGAATATGCAGCAGGCGGAGAGGAT
GCTGTATGA

Upstream 100 bases:

>100_bases
TCCAGGGGGCTTTTCTGGTAATCTCCCTCACAGCCCTGCTTGCAAACATGCTTGCTGACCTGCTCTATGCTTTAATCGAC
CCCAGAGTCAGGAGACCTGC

Downstream 100 bases:

>100_bases
AGTCTCCCACCAGAGATAAGCTGCTTGAAGTAAAGAACCTCCAGGTCTCATTTTTGGGGATAAAAACCGTAACTGCCCTT
TCAGGGATCTCTTTTTCGAT

Product: peptide ABC transporter permease

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSLEAAHSESSCITEACTEEHPEKQLENSDFILKLPLKPPFNYYRKQGSFLGQLNYGGIFLFALFLFMALFPSLLAPYAP
YDRFTPYEEPSGQHLLGTNDIGNDILSELVYGAKVSLTVGFAAALVSTLIGTILGLCSGYFRGAVDELLMGFTDIVLIIP
KIPLIIVLGAYLQPSIWILVPVLGLLSWESTARVTRSKTLQLRETGYVKSARCMGFSSQHIMFSDILPNLYHVLLPKFML
ATASAMISEASLSFLGLSDVSMKSWGTMLSFAFSRGGFIRDMWWWYLPPGICITLCVISIALIGFGIETKKEEYAAGGED
AV

Sequences:

>Translated_322_residues
MSLEAAHSESSCITEACTEEHPEKQLENSDFILKLPLKPPFNYYRKQGSFLGQLNYGGIFLFALFLFMALFPSLLAPYAP
YDRFTPYEEPSGQHLLGTNDIGNDILSELVYGAKVSLTVGFAAALVSTLIGTILGLCSGYFRGAVDELLMGFTDIVLIIP
KIPLIIVLGAYLQPSIWILVPVLGLLSWESTARVTRSKTLQLRETGYVKSARCMGFSSQHIMFSDILPNLYHVLLPKFML
ATASAMISEASLSFLGLSDVSMKSWGTMLSFAFSRGGFIRDMWWWYLPPGICITLCVISIALIGFGIETKKEEYAAGGED
AV
>Mature_321_residues
SLEAAHSESSCITEACTEEHPEKQLENSDFILKLPLKPPFNYYRKQGSFLGQLNYGGIFLFALFLFMALFPSLLAPYAPY
DRFTPYEEPSGQHLLGTNDIGNDILSELVYGAKVSLTVGFAAALVSTLIGTILGLCSGYFRGAVDELLMGFTDIVLIIPK
IPLIIVLGAYLQPSIWILVPVLGLLSWESTARVTRSKTLQLRETGYVKSARCMGFSSQHIMFSDILPNLYHVLLPKFMLA
TASAMISEASLSFLGLSDVSMKSWGTMLSFAFSRGGFIRDMWWWYLPPGICITLCVISIALIGFGIETKKEEYAAGGEDA
V

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789964, Length=252, Percent_Identity=36.5079365079365, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787054, Length=290, Percent_Identity=29.3103448275862, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1787760, Length=262, Percent_Identity=29.3893129770992, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1788505, Length=167, Percent_Identity=32.3353293413174, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787549, Length=260, Percent_Identity=28.4615384615385, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787498, Length=215, Percent_Identity=33.4883720930233, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789889, Length=246, Percent_Identity=25.609756097561, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 35466; Mature: 35335

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEAAHSESSCITEACTEEHPEKQLENSDFILKLPLKPPFNYYRKQGSFLGQLNYGGIF
CCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCEEEECCCCCHHHHHHCCCEEECCCCCHHH
LFALFLFMALFPSLLAPYAPYDRFTPYEEPSGQHLLGTNDIGNDILSELVYGAKVSLTVG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHH
FAAALVSTLIGTILGLCSGYFRGAVDELLMGFTDIVLIIPKIPLIIVLGAYLQPSIWILV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
PVLGLLSWESTARVTRSKTLQLRETGYVKSARCMGFSSQHIMFSDILPNLYHVLLPKFML
HHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
ATASAMISEASLSFLGLSDVSMKSWGTMLSFAFSRGGFIRDMWWWYLPPGICITLCVISI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHH
ALIGFGIETKKEEYAAGGEDAV
HHHHCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
SLEAAHSESSCITEACTEEHPEKQLENSDFILKLPLKPPFNYYRKQGSFLGQLNYGGIF
CCCCCCCCHHHHHHHHHHHCCHHHHCCCCCEEEECCCCCHHHHHHCCCEEECCCCCHHH
LFALFLFMALFPSLLAPYAPYDRFTPYEEPSGQHLLGTNDIGNDILSELVYGAKVSLTVG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCHHHHHHH
FAAALVSTLIGTILGLCSGYFRGAVDELLMGFTDIVLIIPKIPLIIVLGAYLQPSIWILV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHH
PVLGLLSWESTARVTRSKTLQLRETGYVKSARCMGFSSQHIMFSDILPNLYHVLLPKFML
HHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
ATASAMISEASLSFLGLSDVSMKSWGTMLSFAFSRGGFIRDMWWWYLPPGICITLCVISI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHH
ALIGFGIETKKEEYAAGGEDAV
HHHHCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]