BacMap

Definition	Methanosarcina mazei Go1 chromosome, complete genome.
Accession	NC_003901
Length	4,096,345

Click here to switch to the map view.

The map label for this gene is appD [H]

Identifier: 21227958

GI number: 21227958

Start: 2206506

End: 2207459

Strand: Reverse

Name: appD [H]

Synonym: MM_1856

Alternate gene names: 21227958

Gene position: 2207459-2206506 (Counterclockwise)

Preceding gene: 21227959

Following gene: 21227957

Centisome position: 53.89

GC content: 48.53

Gene sequence:

>954_bases
ATGAAGTCTCCCACCAGAGATAAGCTGCTTGAAGTAAAGAACCTCCAGGTCTCATTTTTGGGGATAAAAACCGTAACTGC
CCTTTCAGGGATCTCTTTTTCGATTGGGGAAAGAGAAACACTGGCTCTGGTTGGAGAAACCGGGTGCGGTAAATCCGTAG
CTGCACATGCAATTATGCGCCTTTTGCCCCCCGAGTCCGGAGTGAAAGGGACTGTGGAATTAAGGGGAAGAAACCTGCTC
GGGTTGAGTGAAAAAGAGATGACAGAGATAAGGGGAAAAGAAATCGGGATAATTTTCCAGAACCCCTCCCTTGCCCTCAA
TCCCGTGTATTCCATAGGGCATCAGCTTGCAGAACCCCTGCGCCTGCACAGGAAGGAAAAGAAAAAGAAAGCCCTCTCCA
GGGCAGCAGAAGCCCTTAAAAATATGGGTTTTGCAAATACCGGCGAGATAATCAATTATTACCCTTCATGGTGCTCAGGG
GGAATGAACCAGCGATTTTTGATTGCAGCTTCAACTATCCTTGACCCTGCGCTCCTTATAGCAGATGAGCCTGGAAAAGG
GCTTGACAGAAGTTGCTTATCCGAACTTGAAGCCGGGCTTAAGAGATTGAAAGAAGAAAAGAAAACTGCCCTGCTCCTTA
TAAGCCATGACCTTGGTTTCGTGCGAAACCTTGCAGACAGGGTTGCAGTGATGTATGCAGGAGAGATTGTTGAAATTGCA
GACTCTTCAGGGATTTTCGAAGAACCTCTGCACCCCTACACAAAAGGTCTCCTGAATAGCCTGCCAGAGAAGGGCTTTAT
CCCCATACCCGGATTTTCCCCTCCCCTCAGCAGGCTCCCTTCAGGCTGCAGGTTCCACCCGCGCTGTCCTCTGAGGAAAA
GATGCTGTATTGAAAACCAACCGGAGATTATAGAAACAAACGGAAGAGCTGTGAGGTGTTTCCTATACCCCTGA

Upstream 100 bases:

>100_bases
CGGGAATCTGCATAACCCTCTGCGTAATATCTATTGCACTCATAGGGTTCGGGATCGAAACTAAAAAAGAGGAATATGCA
GCAGGCGGAGAGGATGCTGT

Downstream 100 bases:

>100_bases
GAGCGGACCGGCTTTCAAAAACATACGGAGCCAGCTTTCTGAGCACGGGAAAATGTATTTTCCATGAGATCTCGCTTGAA
ATAAGGCAGGGTGAAACTTT

Product: peptide ABC transporter ATP-binding protein

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKSPTRDKLLEVKNLQVSFLGIKTVTALSGISFSIGERETLALVGETGCGKSVAAHAIMRLLPPESGVKGTVELRGRNLL
GLSEKEMTEIRGKEIGIIFQNPSLALNPVYSIGHQLAEPLRLHRKEKKKKALSRAAEALKNMGFANTGEIINYYPSWCSG
GMNQRFLIAASTILDPALLIADEPGKGLDRSCLSELEAGLKRLKEEKKTALLLISHDLGFVRNLADRVAVMYAGEIVEIA
DSSGIFEEPLHPYTKGLLNSLPEKGFIPIPGFSPPLSRLPSGCRFHPRCPLRKRCCIENQPEIIETNGRAVRCFLYP

Sequences:

>Translated_317_residues
MKSPTRDKLLEVKNLQVSFLGIKTVTALSGISFSIGERETLALVGETGCGKSVAAHAIMRLLPPESGVKGTVELRGRNLL
GLSEKEMTEIRGKEIGIIFQNPSLALNPVYSIGHQLAEPLRLHRKEKKKKALSRAAEALKNMGFANTGEIINYYPSWCSG
GMNQRFLIAASTILDPALLIADEPGKGLDRSCLSELEAGLKRLKEEKKTALLLISHDLGFVRNLADRVAVMYAGEIVEIA
DSSGIFEEPLHPYTKGLLNSLPEKGFIPIPGFSPPLSRLPSGCRFHPRCPLRKRCCIENQPEIIETNGRAVRCFLYP
>Mature_317_residues
MKSPTRDKLLEVKNLQVSFLGIKTVTALSGISFSIGERETLALVGETGCGKSVAAHAIMRLLPPESGVKGTVELRGRNLL
GLSEKEMTEIRGKEIGIIFQNPSLALNPVYSIGHQLAEPLRLHRKEKKKKALSRAAEALKNMGFANTGEIINYYPSWCSG
GMNQRFLIAASTILDPALLIADEPGKGLDRSCLSELEAGLKRLKEEKKTALLLISHDLGFVRNLADRVAVMYAGEIVEIA
DSSGIFEEPLHPYTKGLLNSLPEKGFIPIPGFSPPLSRLPSGCRFHPRCPLRKRCCIENQPEIIETNGRAVRCFLYP

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0444

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI9961252, Length=245, Percent_Identity=28.9795918367347, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4505771, Length=245, Percent_Identity=28.9795918367347, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI9961250, Length=245, Percent_Identity=28.9795918367347, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI42741659, Length=244, Percent_Identity=27.0491803278689, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI156105685, Length=257, Percent_Identity=29.9610894941634, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI171184400, Length=254, Percent_Identity=29.5275590551181, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI255708477, Length=240, Percent_Identity=25, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI21536378, Length=215, Percent_Identity=29.3023255813954, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI48994883, Length=314, Percent_Identity=39.8089171974522, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1787759, Length=316, Percent_Identity=38.6075949367089, Blast_Score=211, Evalue=4e-56,
Organism=Escherichia coli, GI1789963, Length=318, Percent_Identity=37.4213836477987, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI145693107, Length=305, Percent_Identity=37.3770491803279, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1788506, Length=288, Percent_Identity=39.5833333333333, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1787500, Length=328, Percent_Identity=35.6707317073171, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789962, Length=298, Percent_Identity=35.2348993288591, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1787758, Length=322, Percent_Identity=32.9192546583851, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1787548, Length=306, Percent_Identity=33.3333333333333, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1787547, Length=258, Percent_Identity=31.7829457364341, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789890, Length=233, Percent_Identity=33.4763948497854, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI48994997, Length=254, Percent_Identity=32.6771653543307, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788225, Length=254, Percent_Identity=30.3149606299213, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789891, Length=212, Percent_Identity=34.9056603773585, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789032, Length=254, Percent_Identity=29.9212598425197, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786398, Length=240, Percent_Identity=31.25, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081834, Length=205, Percent_Identity=33.6585365853659, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790162, Length=253, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081791, Length=280, Percent_Identity=28.9285714285714, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788761, Length=240, Percent_Identity=27.0833333333333, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787105, Length=231, Percent_Identity=31.6017316017316, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1786703, Length=235, Percent_Identity=30.2127659574468, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790467, Length=249, Percent_Identity=26.1044176706827, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789672, Length=237, Percent_Identity=30.379746835443, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787712, Length=236, Percent_Identity=27.1186440677966, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787089, Length=227, Percent_Identity=30.8370044052863, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87081709, Length=280, Percent_Identity=25, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786872, Length=217, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787029, Length=243, Percent_Identity=28.3950617283951, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082267, Length=232, Percent_Identity=27.1551724137931, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787370, Length=233, Percent_Identity=25.7510729613734, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI48995001, Length=244, Percent_Identity=29.9180327868852, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789864, Length=235, Percent_Identity=26.8085106382979, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786563, Length=208, Percent_Identity=28.8461538461538, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788450, Length=229, Percent_Identity=24.4541484716157, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789873, Length=232, Percent_Identity=28.0172413793103, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788644, Length=131, Percent_Identity=30.5343511450382, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787972, Length=252, Percent_Identity=28.1746031746032, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787143, Length=235, Percent_Identity=27.6595744680851, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786319, Length=270, Percent_Identity=27.4074074074074, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786803, Length=222, Percent_Identity=26.1261261261261, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788165, Length=220, Percent_Identity=28.1818181818182, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209708, Length=251, Percent_Identity=27.8884462151394, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17558664, Length=274, Percent_Identity=24.8175182481752, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI193202349, Length=255, Percent_Identity=28.2352941176471, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI212646699, Length=249, Percent_Identity=25.7028112449799, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17565938, Length=260, Percent_Identity=28.0769230769231, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146777, Length=236, Percent_Identity=25.8474576271186, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17569145, Length=234, Percent_Identity=29.4871794871795, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567265, Length=221, Percent_Identity=28.9592760180996, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193211015, Length=243, Percent_Identity=25.5144032921811, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI115535101, Length=237, Percent_Identity=25.3164556962025, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71996809, Length=265, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193211017, Length=265, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533592, Length=209, Percent_Identity=29.1866028708134, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=231, Percent_Identity=25.974025974026, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17569143, Length=237, Percent_Identity=28.2700421940928, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321752, Length=243, Percent_Identity=27.9835390946502, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324985, Length=253, Percent_Identity=23.3201581027668, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI85726357, Length=249, Percent_Identity=27.3092369477912, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641565, Length=216, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281363262, Length=225, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24653245, Length=225, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24659289, Length=239, Percent_Identity=28.0334728033473, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR010066
- InterPro:   IPR013563 [H]

Pfam domain/function: PF00005 ABC_tran; PF08352 oligo_HPY [H]

EC number: NA

Molecular weight: Translated: 34771; Mature: 34771

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSPTRDKLLEVKNLQVSFLGIKTVTALSGISFSIGERETLALVGETGCGKSVAAHAIMR
CCCCCHHHHHHHHCCEEEEEEHHHHHHHCCCEEECCCCEEEEEEECCCCCHHHHHHHHHH
LLPPESGVKGTVELRGRNLLGLSEKEMTEIRGKEIGIIFQNPSLALNPVYSIGHQLAEPL
HCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHH
RLHRKEKKKKALSRAAEALKNMGFANTGEIINYYPSWCSGGMNQRFLIAASTILDPALLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHCCCCCCEEEEEEHHHHCCEEEE
ADEPGKGLDRSCLSELEAGLKRLKEEKKTALLLISHDLGFVRNLADRVAVMYAGEIVEIA
ECCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEC
DSSGIFEEPLHPYTKGLLNSLPEKGFIPIPGFSPPLSRLPSGCRFHPRCPLRKRCCIENQ
CCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCCCCCCCCCHHHHCCCCCC
PEIIETNGRAVRCFLYP
CCEEECCCCEEEEEECC
>Mature Secondary Structure
MKSPTRDKLLEVKNLQVSFLGIKTVTALSGISFSIGERETLALVGETGCGKSVAAHAIMR
CCCCCHHHHHHHHCCEEEEEEHHHHHHHCCCEEECCCCEEEEEEECCCCCHHHHHHHHHH
LLPPESGVKGTVELRGRNLLGLSEKEMTEIRGKEIGIIFQNPSLALNPVYSIGHQLAEPL
HCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHH
RLHRKEKKKKALSRAAEALKNMGFANTGEIINYYPSWCSGGMNQRFLIAASTILDPALLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHCCCCCCEEEEEEHHHHCCEEEE
ADEPGKGLDRSCLSELEAGLKRLKEEKKTALLLISHDLGFVRNLADRVAVMYAGEIVEIA
ECCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEC
DSSGIFEEPLHPYTKGLLNSLPEKGFIPIPGFSPPLSRLPSGCRFHPRCPLRKRCCIENQ
CCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCCCCCCCCCHHHHCCCCCC
PEIIETNGRAVRCFLYP
CCEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]