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The map label for this gene is hdrD [H]

Identifier: 21227946

GI number: 21227946

Start: 2195780

End: 2197042

Strand: Direct

Name: hdrD [H]

Synonym: MM_1844

Alternate gene names: 21227946

Gene position: 2195780-2197042 (Clockwise)

Preceding gene: 21227945

Following gene: 21227947

Centisome position: 53.6

GC content: 49.01

Gene sequence:

>1263_bases
TTGCAATCCTTGCAAATAAGGGAGGAGAATAAAATGGCAAAAAAAACTCCATCAATAGACACCAAAAACCTTACAGCAGT
CCAGCTCATGGAGCTCGACTCCTGCACCCGCTGTGGTGAATGTGTAAAATGGTGTCCAACTTATGCAGCTTCCGGCCAGA
AGCCCGGGTTAGCACCCAGGGATAAGATCCTGCGCTGGAGGCAGTTCATGAACAAATCCTACGGGATTAAAGCAAAACTC
TTCGGTCCTACTGAAATCCCCCAGTCTGAACTTGAAGAATTTAAAGATGACGTGCACGGCTGTACCACCTGTGGTATCTG
TGCAACCGTATGTGAATCAGGCATTAACACTGTTGAACTCTGGGAAGCCCTCAGGACAAACCTTGTAAAGAAAGGGATAG
GTCCTTTTGGGAAGCAGAACATGTTCCCGAAACTTATCGGGCAGTACCATAACCCTTACATGAAGGACCAGAAAGACAGG
CTTAACTGGGTCCCACCAGACGTGAAAATCGAAGACAAAGCAGATGTTGTCTATTTCACTGGCTGTACTGCAGGGTACAA
TCAGCTCGCTTTAGCCTTTGCGACTGCACGTGTGCTTAACAAGCTTGGCGTTAAGTTTTCCATGCTTGGTGAAGAGGAAT
GGTGCTGCGGCTCAGCCCTTATCAGGACAGGTCAGGTTCATGTCGATGATGTGCCCCGTGAACTGGCAAGGCATAATGTC
GAAGCACTCAAGAAAAAGGGTGCCAAAAAAGTTCTTTATGCCTGTGCAGGCTGTTTCCGTGCCTCCAAGGTTGACTGGCC
TAGGCTTCTCGGAGAAGAACTGCCGTTTGAGGTTGTCCACGTTGCAGAGTTCCTCGCGGACCTGATCAAGCAGGACAAAA
TCAAATGGGAAAAGTCCATCAACAAGACAGTCACTTACCATGACCCCTGCCACCTTGGCCGCCATGTAGGTGTTTTTGAT
GCACCCAGATATGTGCTTTCACACATTCCTGGCGTCAAGTTTGTCGAAATGGACAGGGTAAAAGAATTCCAGCGCTGCTG
TGGAGCTGGCGGTGGTGTGAAGGCAGGTATCCCTGATCTCGCTCTGGGAGTCGCAGAATCCAGGGTTAAGGATGCCGTTG
CAACCGATGCAGATATCCTTTCCAGCTGCTGCCCATTCTGTAAGAGAAATCTGATGGACGGCCGTGACTCACTCAAAGTT
GACATGGTTGTCGAGGATGTCATAGAGCTTGTTGCAGAAGCTCTCGGACTTGAGACTAAATAA

Upstream 100 bases:

>100_bases
ACAGCACCTCCGGCAGCTCTCTTCCACTCTGTGATCTCCCTGCTCTTCTGTATCGCATATATCCCATACAGCAAGTATAT
ACATGTAATCGCCACCCCGC

Downstream 100 bases:

>100_bases
GAAGTGAAAGAGATAAAGGGCTGATTTCAGTCCTTTATCTTCATTCCTCATATTTTTGCTATTTTTATTTTTCAGAAAAA
CTTAAATACAGATATCACCC

Product: heterodisulfide reductase subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MQSLQIREENKMAKKTPSIDTKNLTAVQLMELDSCTRCGECVKWCPTYAASGQKPGLAPRDKILRWRQFMNKSYGIKAKL
FGPTEIPQSELEEFKDDVHGCTTCGICATVCESGINTVELWEALRTNLVKKGIGPFGKQNMFPKLIGQYHNPYMKDQKDR
LNWVPPDVKIEDKADVVYFTGCTAGYNQLALAFATARVLNKLGVKFSMLGEEEWCCGSALIRTGQVHVDDVPRELARHNV
EALKKKGAKKVLYACAGCFRASKVDWPRLLGEELPFEVVHVAEFLADLIKQDKIKWEKSINKTVTYHDPCHLGRHVGVFD
APRYVLSHIPGVKFVEMDRVKEFQRCCGAGGGVKAGIPDLALGVAESRVKDAVATDADILSSCCPFCKRNLMDGRDSLKV
DMVVEDVIELVAEALGLETK

Sequences:

>Translated_420_residues
MQSLQIREENKMAKKTPSIDTKNLTAVQLMELDSCTRCGECVKWCPTYAASGQKPGLAPRDKILRWRQFMNKSYGIKAKL
FGPTEIPQSELEEFKDDVHGCTTCGICATVCESGINTVELWEALRTNLVKKGIGPFGKQNMFPKLIGQYHNPYMKDQKDR
LNWVPPDVKIEDKADVVYFTGCTAGYNQLALAFATARVLNKLGVKFSMLGEEEWCCGSALIRTGQVHVDDVPRELARHNV
EALKKKGAKKVLYACAGCFRASKVDWPRLLGEELPFEVVHVAEFLADLIKQDKIKWEKSINKTVTYHDPCHLGRHVGVFD
APRYVLSHIPGVKFVEMDRVKEFQRCCGAGGGVKAGIPDLALGVAESRVKDAVATDADILSSCCPFCKRNLMDGRDSLKV
DMVVEDVIELVAEALGLETK
>Mature_420_residues
MQSLQIREENKMAKKTPSIDTKNLTAVQLMELDSCTRCGECVKWCPTYAASGQKPGLAPRDKILRWRQFMNKSYGIKAKL
FGPTEIPQSELEEFKDDVHGCTTCGICATVCESGINTVELWEALRTNLVKKGIGPFGKQNMFPKLIGQYHNPYMKDQKDR
LNWVPPDVKIEDKADVVYFTGCTAGYNQLALAFATARVLNKLGVKFSMLGEEEWCCGSALIRTGQVHVDDVPRELARHNV
EALKKKGAKKVLYACAGCFRASKVDWPRLLGEELPFEVVHVAEFLADLIKQDKIKWEKSINKTVTYHDPCHLGRHVGVFD
APRYVLSHIPGVKFVEMDRVKEFQRCCGAGGGVKAGIPDLALGVAESRVKDAVATDADILSSCCPFCKRNLMDGRDSLKV
DMVVEDVIELVAEALGLETK

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit [H]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Escherichia coli, GI1788576, Length=252, Percent_Identity=25.7936507936508, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR004017
- InterPro:   IPR012285
- InterPro:   IPR009051 [H]

Pfam domain/function: PF02754 CCG [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 46735; Mature: 46735

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLQIREENKMAKKTPSIDTKNLTAVQLMELDSCTRCGECVKWCPTYAASGQKPGLAPR
CCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
DKILRWRQFMNKSYGIKAKLFGPTEIPQSELEEFKDDVHGCTTCGICATVCESGINTVEL
HHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
WEALRTNLVKKGIGPFGKQNMFPKLIGQYHNPYMKDQKDRLNWVPPDVKIEDKADVVYFT
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCHHCCCCCCCCCEECCCCCEEEEE
GCTAGYNQLALAFATARVLNKLGVKFSMLGEEEWCCGSALIRTGQVHVDDVPRELARHNV
CCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHH
EALKKKGAKKVLYACAGCFRASKVDWPRLLGEELPFEVVHVAEFLADLIKQDKIKWEKSI
HHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
NKTVTYHDPCHLGRHVGVFDAPRYVLSHIPGVKFVEMDRVKEFQRCCGAGGGVKAGIPDL
CCCEEECCHHHCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCHH
ALGVAESRVKDAVATDADILSSCCPFCKRNLMDGRDSLKVDMVVEDVIELVAEALGLETK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQSLQIREENKMAKKTPSIDTKNLTAVQLMELDSCTRCGECVKWCPTYAASGQKPGLAPR
CCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
DKILRWRQFMNKSYGIKAKLFGPTEIPQSELEEFKDDVHGCTTCGICATVCESGINTVEL
HHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
WEALRTNLVKKGIGPFGKQNMFPKLIGQYHNPYMKDQKDRLNWVPPDVKIEDKADVVYFT
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCHHCCCCCCCCCEECCCCCEEEEE
GCTAGYNQLALAFATARVLNKLGVKFSMLGEEEWCCGSALIRTGQVHVDDVPRELARHNV
CCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCEEHHHHHHHHHHHHH
EALKKKGAKKVLYACAGCFRASKVDWPRLLGEELPFEVVHVAEFLADLIKQDKIKWEKSI
HHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
NKTVTYHDPCHLGRHVGVFDAPRYVLSHIPGVKFVEMDRVKEFQRCCGAGGGVKAGIPDL
CCCEEECCHHHCCCCCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCHH
ALGVAESRVKDAVATDADILSSCCPFCKRNLMDGRDSLKVDMVVEDVIELVAEALGLETK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]