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The map label for this gene is hdrE

Identifier: 21227945

GI number: 21227945

Start: 2195032

End: 2195811

Strand: Direct

Name: hdrE

Synonym: MM_1843

Alternate gene names: 21227945

Gene position: 2195032-2195811 (Clockwise)

Preceding gene: 21227944

Following gene: 21227946

Centisome position: 53.59

GC content: 45.77

Gene sequence:

>780_bases
ATGGCATACTTCTCTGGACTCTCGGACGCACTTCGTCTTACGTTTGTCCAGATAATGATACTCAGCGCTATAGCTGTTGT
AATTTTTTTATACGGTATGATCGGTAATTTCCAGAAATGGGGGGCAGGAGTGACAGGTTACGCTCTCGAACCTCCAACAG
GAAAGAAAGGAAGCGCGATCAGGTTCTTAAAAACCTGGTGGGCACAGGTCAGAGCAGAATCTCATCACCATGGAAAGCCC
ATTTTAGAGGTTCTCATCCTTGACATCTTTTTCCAGAGAAGAATCCTTAAAAGAAGCCCTATTCGCTGGTTCATGCACTT
TACTATCTTTGCAGGCTGGATGTCCCTTTTCGCTCTGTCAGGACTGATGTTTGCAGTCGAAATGACCGAAAAGATCGGAA
TTGAACTTCCGTTTACTCCTGCCGAATTTAGAGAGATGCTATCTCTTCCGAACTACATATTCGGCTATATCCTGCTTATA
GGAGTCATGATTGCAGTAGTAAGAAGGCTCTTTGTTTCTGAAGTCAGGGAAGCTTCCATTATGTATGACTGGGTTCTGCT
TGGAGGAGTTTTCATAGTCACCATCTCCGGCTTTATTGCCGACGGTATCAGAACCGGAATCATCTGGGGCTTCGGACTCG
ATCCCGTAACAGCACCTCCGGCAGCTCTCTTCCACTCTGTGATCTCCCTGCTCTTCTGTATCGCATATATCCCATACAGC
AAGTATATACATGTAATCGCCACCCCGCTTGCAATCCTTGCAAATAAGGGAGGAGAATAA

Upstream 100 bases:

>100_bases
CTTTGCTATTGTTGATATTCTGTAATCAATAATAATTCTAAAGCAGTATCAGTTCTCAGTTTTTACCCATATATAGGAGG
AATAAACTATTAGCAGTGAG

Downstream 100 bases:

>100_bases
AATGGCAAAAAAAACTCCATCAATAGACACCAAAAACCTTACAGCAGTCCAGCTCATGGAGCTCGACTCCTGCACCCGCT
GTGGTGAATGTGTAAAATGG

Product: heterodisulfide reductase subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MAYFSGLSDALRLTFVQIMILSAIAVVIFLYGMIGNFQKWGAGVTGYALEPPTGKKGSAIRFLKTWWAQVRAESHHHGKP
ILEVLILDIFFQRRILKRSPIRWFMHFTIFAGWMSLFALSGLMFAVEMTEKIGIELPFTPAEFREMLSLPNYIFGYILLI
GVMIAVVRRLFVSEVREASIMYDWVLLGGVFIVTISGFIADGIRTGIIWGFGLDPVTAPPAALFHSVISLLFCIAYIPYS
KYIHVIATPLAILANKGGE

Sequences:

>Translated_259_residues
MAYFSGLSDALRLTFVQIMILSAIAVVIFLYGMIGNFQKWGAGVTGYALEPPTGKKGSAIRFLKTWWAQVRAESHHHGKP
ILEVLILDIFFQRRILKRSPIRWFMHFTIFAGWMSLFALSGLMFAVEMTEKIGIELPFTPAEFREMLSLPNYIFGYILLI
GVMIAVVRRLFVSEVREASIMYDWVLLGGVFIVTISGFIADGIRTGIIWGFGLDPVTAPPAALFHSVISLLFCIAYIPYS
KYIHVIATPLAILANKGGE
>Mature_258_residues
AYFSGLSDALRLTFVQIMILSAIAVVIFLYGMIGNFQKWGAGVTGYALEPPTGKKGSAIRFLKTWWAQVRAESHHHGKPI
LEVLILDIFFQRRILKRSPIRWFMHFTIFAGWMSLFALSGLMFAVEMTEKIGIELPFTPAEFREMLSLPNYIFGYILLIG
VMIAVVRRLFVSEVREASIMYDWVLLGGVFIVTISGFIADGIRTGIIWGFGLDPVTAPPAALFHSVISLLFCIAYIPYSK
YIHVIATPLAILANKGGE

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrE may be responsible for anchoring the complex to the membrane

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hdrE family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HDRE_METMA (Q8PVW4)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633867.1
- ProteinModelPortal:   Q8PVW4
- GeneID:   1480185
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1843
- NMPDR:   fig|192952.1.peg.1843
- HOGENOM:   HBG538650
- OMA:   REASIMY
- ProtClustDB:   CLSK568762
- BioCyc:   MMAZ192952:MM1843-MONOMER
- BRENDA:   1.8.98.1
- GO:   GO:0015948
- InterPro:   IPR003816

Pfam domain/function: PF02665 Nitrate_red_gam

EC number: =1.8.98.1

Molecular weight: Translated: 28989; Mature: 28858

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe4b4aa4)-; HASH(0xf4a5540)-; HASH(0xf746218)-; HASH(0xf6d4054)-; HASH(0xf40bf14)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
AYFSGLSDALRLTFVQIMILSAIAVVIFLYGMIGNFQKWGAGVTGYALEPPTGKKGSAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCEECCCCCCCCCHH
RFLKTWWAQVRAESHHHGKPILEVLILDIFFQRRILKRSPIRWFMHFTIFAGWMSLFALS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
GLMFAVEMTEKIGIELPFTPAEFREMLSLPNYIFGYILLIGVMIAVVRRLFVSEVREASI
HHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYDWVLLGGVFIVTISGFIADGIRTGIIWGFGLDPVTAPPAALFHSVISLLFCIAYIPYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
KYIHVIATPLAILANKGGE
HHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12125824