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The map label for this gene is comEC [H]

Identifier: 21227778

GI number: 21227778

Start: 2009304

End: 2011112

Strand: Direct

Name: comEC [H]

Synonym: MM_1676

Alternate gene names: 21227778

Gene position: 2009304-2011112 (Clockwise)

Preceding gene: 21227777

Following gene: 21227779

Centisome position: 49.05

GC content: 41.79

Gene sequence:

>1809_bases
GTGTGCATTGGTACGACACCATCGCCTACACCTACACCAATTCCAACCCCAGAGCCAGAGCCAGAGCCACAACCTGAACC
TACACCAGCACCTACACCAGCACCTGCACCAACGCCTACACCAGCACCTACACCAGCACCTACAACAACGACAACACCTG
TCAATGGAAATTTAACTATTCACTTTATCAATGTTGGTCAAGGGGACTCGATTCTTTTAGAGTATGGCGATAATGACATG
CTCATTGATGCTGGAGATAATGGAAAAGGTGATGACGTTGCTAATTACGTGAAAAAAGAAGGAATAACGTCATTGGATTA
TGTGGTTGCAACACATCCTCACGAAGATCATATTGGTGGAATGGATGAAATCCTTAACGATTTTCCGATTGGGGAGTTCA
TAGACAGTGGATATCCTCATACAACCCAGACATATGAAGACATGTTGAATACCATTAGCAATAAAAATATTCACTTTTCA
ACGGTGAAAAGAGGGGATCAGATAAATTTCGCTCCAGGAATTGTTGTTGAGGTTCTCAATCCAGGAAATACATATTTCGA
TGATGACCTCAATCAGAATTCAATTGTTTTAAAGGTCACGGATGGACAAATATCGTTTCTGCTAATGGGTGATGCAGGAG
TAGAAGCAGAAAACGCAATAATGGGAGACGGATATGATGTCGATGCCGATGTTCTGAAAGCAGGACATCACGGGAGCAGC
ACGTCCAGTGGGAAAACTTTCATTTCTGCTGTAAGTCCAAGTGTAAGCGTTATCGAAGTTGGTGCGGAAAACGATTACGG
TCACCCACATGATGGAGCACTTGAAACGCTACAAAAAGTATCAAAGGTTTACAGAACAGATATTGATGGTACAATCACAA
TAACAACTGATGGCTCTACTTATTCTGTAGTCACAGAGAAGACAGCAGATACAGATTCAACAGAAACTCCGACTGAAACT
TCCACTGAAACACCAACAGAAACACCTGCTGAAACCCCGACTGAGACTCCTACCGAAACCGTCACTGAAACTCCAACACC
AACTGAAATTCCTACGGGAACTCCGACAGAAGAATCAGATTCTGATTCCAGTGGAAGCTCAGGAGGCAGTTCTCACAGCT
CTGGATCATCAGGCGGTGGAGCTGGTGGATCTCCGGAACCACAGAGCAATGTAGAATATAAAGACACAACTAAAGCGTTC
ATATCGAATGGAAGAACTGTAACTTTCAATTTTACAAACGATGTTACCGTAGTCAACAGCATAAACTTCGAGTCAGATAA
AACCATGGGTAAGACTACTGCCATCGTTGAGAACCTAAAGGAGAAATCCTCTCTTGTTTCAGATCTACCAGAAGGAGAGA
TCTACAAATCTTTCAACATATGGGTCGGTAATGCTGGTTATGGAAATTCTGACAGTATCATGAATGCTATTGTAAACTTC
AAGGTTGAAAAATCCTGGTCGCAGATGAATGGAATAGACCAATCTTCTATCATCCTATACAATTATGATGAAGAGAATAA
GGAATGGGAAAAGCTTCCAGTGATTTTGTCAGGTGAAGACAATGAGTACCTGTACCTTACAGCTGAAGTCCCGGGGTATT
CTTCTTTCGTTATAACAGGAGATGTAGGAACTCCAAATGTACAGACCACAGAACCTACTGCAACATATAAAAGCAGTAAC
TCAGAAGAAAGTGAAGGTGTCACTGTAACTGAAGAATCTGCAGAAGACCAAGAATCTCCTGGATTTGGTTTAATCAGTGG
AATTGTTTGTCTATTCTGCATGTTCTTGTACAAAATTAAAAATCAGTAA

Upstream 100 bases:

>100_bases
TGTTGAAGGATGCCGTTACGTCTCACGAATTAAGCCAGAGAATCTCATCACATTTGACAGTATACAAGAAGCAGAAGAAG
CTGGTTATAGACCATGCAGT

Downstream 100 bases:

>100_bases
ACCATAGAGAATAGTAATCAAGTAGAAGGTTATTTACCAAATCTTGCCAGGTCAAATTCGAAAGTCACCTTCTGCTTTCT
GTTTTTCCATAATAGGTACG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MCIGTTPSPTPTPIPTPEPEPEPQPEPTPAPTPAPAPTPTPAPTPAPTTTTTPVNGNLTIHFINVGQGDSILLEYGDNDM
LIDAGDNGKGDDVANYVKKEGITSLDYVVATHPHEDHIGGMDEILNDFPIGEFIDSGYPHTTQTYEDMLNTISNKNIHFS
TVKRGDQINFAPGIVVEVLNPGNTYFDDDLNQNSIVLKVTDGQISFLLMGDAGVEAENAIMGDGYDVDADVLKAGHHGSS
TSSGKTFISAVSPSVSVIEVGAENDYGHPHDGALETLQKVSKVYRTDIDGTITITTDGSTYSVVTEKTADTDSTETPTET
STETPTETPAETPTETPTETVTETPTPTEIPTGTPTEESDSDSSGSSGGSSHSSGSSGGGAGGSPEPQSNVEYKDTTKAF
ISNGRTVTFNFTNDVTVVNSINFESDKTMGKTTAIVENLKEKSSLVSDLPEGEIYKSFNIWVGNAGYGNSDSIMNAIVNF
KVEKSWSQMNGIDQSSIILYNYDEENKEWEKLPVILSGEDNEYLYLTAEVPGYSSFVITGDVGTPNVQTTEPTATYKSSN
SEESEGVTVTEESAEDQESPGFGLISGIVCLFCMFLYKIKNQ

Sequences:

>Translated_602_residues
MCIGTTPSPTPTPIPTPEPEPEPQPEPTPAPTPAPAPTPTPAPTPAPTTTTTPVNGNLTIHFINVGQGDSILLEYGDNDM
LIDAGDNGKGDDVANYVKKEGITSLDYVVATHPHEDHIGGMDEILNDFPIGEFIDSGYPHTTQTYEDMLNTISNKNIHFS
TVKRGDQINFAPGIVVEVLNPGNTYFDDDLNQNSIVLKVTDGQISFLLMGDAGVEAENAIMGDGYDVDADVLKAGHHGSS
TSSGKTFISAVSPSVSVIEVGAENDYGHPHDGALETLQKVSKVYRTDIDGTITITTDGSTYSVVTEKTADTDSTETPTET
STETPTETPAETPTETPTETVTETPTPTEIPTGTPTEESDSDSSGSSGGSSHSSGSSGGGAGGSPEPQSNVEYKDTTKAF
ISNGRTVTFNFTNDVTVVNSINFESDKTMGKTTAIVENLKEKSSLVSDLPEGEIYKSFNIWVGNAGYGNSDSIMNAIVNF
KVEKSWSQMNGIDQSSIILYNYDEENKEWEKLPVILSGEDNEYLYLTAEVPGYSSFVITGDVGTPNVQTTEPTATYKSSN
SEESEGVTVTEESAEDQESPGFGLISGIVCLFCMFLYKIKNQ
>Mature_602_residues
MCIGTTPSPTPTPIPTPEPEPEPQPEPTPAPTPAPAPTPTPAPTPAPTTTTTPVNGNLTIHFINVGQGDSILLEYGDNDM
LIDAGDNGKGDDVANYVKKEGITSLDYVVATHPHEDHIGGMDEILNDFPIGEFIDSGYPHTTQTYEDMLNTISNKNIHFS
TVKRGDQINFAPGIVVEVLNPGNTYFDDDLNQNSIVLKVTDGQISFLLMGDAGVEAENAIMGDGYDVDADVLKAGHHGSS
TSSGKTFISAVSPSVSVIEVGAENDYGHPHDGALETLQKVSKVYRTDIDGTITITTDGSTYSVVTEKTADTDSTETPTET
STETPTETPAETPTETPTETVTETPTPTEIPTGTPTEESDSDSSGSSGGSSHSSGSSGGGAGGSPEPQSNVEYKDTTKAF
ISNGRTVTFNFTNDVTVVNSINFESDKTMGKTTAIVENLKEKSSLVSDLPEGEIYKSFNIWVGNAGYGNSDSIMNAIVNF
KVEKSWSQMNGIDQSSIILYNYDEENKEWEKLPVILSGEDNEYLYLTAEVPGYSSFVITGDVGTPNVQTTEPTATYKSSN
SEESEGVTVTEESAEDQESPGFGLISGIVCLFCMFLYKIKNQ

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG3291

COG function: function code R; FOG: PKD repeat

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 64104; Mature: 64104

Theoretical pI: Translated: 3.87; Mature: 3.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCIGTTPSPTPTPIPTPEPEPEPQPEPTPAPTPAPAPTPTPAPTPAPTTTTTPVNGNLTI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
HFINVGQGDSILLEYGDNDMLIDAGDNGKGDDVANYVKKEGITSLDYVVATHPHEDHIGG
EEEEECCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHCCC
MDEILNDFPIGEFIDSGYPHTTQTYEDMLNTISNKNIHFSTVKRGDQINFAPGIVVEVLN
HHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCEEEEEEC
PGNTYFDDDLNQNSIVLKVTDGQISFLLMGDAGVEAENAIMGDGYDVDADVLKAGHHGSS
CCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCCEEECCCCCCCHHHHHCCCCCCC
TSSGKTFISAVSPSVSVIEVGAENDYGHPHDGALETLQKVSKVYRTDIDGTITITTDGST
CCCCCEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCE
YSVVTEKTADTDSTETPTETSTETPTETPAETPTETPTETVTETPTPTEIPTGTPTEESD
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDSSGSSGGSSHSSGSSGGGAGGSPEPQSNVEYKDTTKAFISNGRTVTFNFTNDVTVVNS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCEEEEEE
INFESDKTMGKTTAIVENLKEKSSLVSDLPEGEIYKSFNIWVGNAGYGNSDSIMNAIVNF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHE
KVEKSWSQMNGIDQSSIILYNYDEENKEWEKLPVILSGEDNEYLYLTAEVPGYSSFVITG
EEECCHHHHCCCCCCEEEEEECCCCCCCHHHCCEEEECCCCCEEEEEEECCCCCEEEEEC
DVGTPNVQTTEPTATYKSSNSEESEGVTVTEESAEDQESPGFGLISGIVCLFCMFLYKIK
CCCCCCCCCCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
NQ
CC
>Mature Secondary Structure
MCIGTTPSPTPTPIPTPEPEPEPQPEPTPAPTPAPAPTPTPAPTPAPTTTTTPVNGNLTI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
HFINVGQGDSILLEYGDNDMLIDAGDNGKGDDVANYVKKEGITSLDYVVATHPHEDHIGG
EEEEECCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHCCC
MDEILNDFPIGEFIDSGYPHTTQTYEDMLNTISNKNIHFSTVKRGDQINFAPGIVVEVLN
HHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCEEECCCCEEEEEEC
PGNTYFDDDLNQNSIVLKVTDGQISFLLMGDAGVEAENAIMGDGYDVDADVLKAGHHGSS
CCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCCEEECCCCCCCHHHHHCCCCCCC
TSSGKTFISAVSPSVSVIEVGAENDYGHPHDGALETLQKVSKVYRTDIDGTITITTDGST
CCCCCEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCE
YSVVTEKTADTDSTETPTETSTETPTETPAETPTETPTETVTETPTPTEIPTGTPTEESD
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDSSGSSGGSSHSSGSSGGGAGGSPEPQSNVEYKDTTKAFISNGRTVTFNFTNDVTVVNS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCEEEEEE
INFESDKTMGKTTAIVENLKEKSSLVSDLPEGEIYKSFNIWVGNAGYGNSDSIMNAIVNF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHE
KVEKSWSQMNGIDQSSIILYNYDEENKEWEKLPVILSGEDNEYLYLTAEVPGYSSFVITG
EEECCHHHHCCCCCCEEEEEECCCCCCCHHHCCEEEECCCCCEEEEEEECCCCCEEEEEC
DVGTPNVQTTEPTATYKSSNSEESEGVTVTEESAEDQESPGFGLISGIVCLFCMFLYKIK
CCCCCCCCCCCCCCEECCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
NQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]