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The map label for this gene is moeB [H]

Identifier: 21227635

GI number: 21227635

Start: 1831830

End: 1832564

Strand: Direct

Name: moeB [H]

Synonym: MM_1533

Alternate gene names: 21227635

Gene position: 1831830-1832564 (Clockwise)

Preceding gene: 21227631

Following gene: 21227636

Centisome position: 44.72

GC content: 41.77

Gene sequence:

>735_bases
ATGGATAAGATGGAAAGAGAAAAGTACAGCCGGCAGATTCTTCTTTTTGGAGAGGAAGGGCAGGAGAAATTAAAAGCTGC
AAAGGTATTTGTTGCCGGTGCCGGGGGACTTGGGTCTCCTGTATCTACTTACCTTGCAATTGCAGGGATAGGAAAAATAA
TCCTTGCGGATTTTGACACTGTAGACTCTACCAACCTGAACAGGCAGTTCCTGCATTATGAAAAAGACGTTGGGAGAGCA
AAGGTTGAATCTGCAAAGGAGAAGCTTCTTTTAATGAACCCTTTAATTGAAGTTGAGATAATTAAAGAGATGCTTACCGA
GTCAAATATTGATTATCTTGTCCCTGAATGCGATATTATAATTGATGCCCTGGATAATATGGAAACAAGGCATATTCTTA
ACAGGTTTTCGATTAAACGGAGCATTCCTTTAATTCACGGGGCAGTTACGGGTTATGACGGGCAGGTCACAACAATTATT
CCAGGAAAAACCCCCTGTTTTTACTGTATTTTTCCACGAATCCCGAAAAAAGAAGTTTTCCCGATTCTCGGAGCCACTCC
GGGTATTATAGGTTCAATTCAGGTAAGTGAAGCAGTCAAGTTTCTGACAGGAAAAGGAAAACTTCTGGAGGGCAGACTTT
TATTCTGGAACGGGCTTTCAGGGAGTTTCAGTGAAATTTCACTCGCAAAACTGAACAACTGCCCGGTTTGCGGAAGTAAT
GGTGAAAAGGTTTGA

Upstream 100 bases:

>100_bases
GATTCCCCATATTTTGCCGTTATTAAAACCAGTTTTCAAGCAGTCAATATAAATTAATCTCATCATAATTCCTGAAATTA
ATATTCTGGAAGGAATTCAC

Downstream 100 bases:

>100_bases
TCAGGCTGCTTCCTTTCGGCATGATACGATTGCTTTGTTCCACTCCTATTTTTTCATTTTATATTTCCTGTTGATCAATT
TTTATATATCCTCAGTGATA

Product: molybdopterin biosynthesis MoeB protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MDKMEREKYSRQILLFGEEGQEKLKAAKVFVAGAGGLGSPVSTYLAIAGIGKIILADFDTVDSTNLNRQFLHYEKDVGRA
KVESAKEKLLLMNPLIEVEIIKEMLTESNIDYLVPECDIIIDALDNMETRHILNRFSIKRSIPLIHGAVTGYDGQVTTII
PGKTPCFYCIFPRIPKKEVFPILGATPGIIGSIQVSEAVKFLTGKGKLLEGRLLFWNGLSGSFSEISLAKLNNCPVCGSN
GEKV

Sequences:

>Translated_244_residues
MDKMEREKYSRQILLFGEEGQEKLKAAKVFVAGAGGLGSPVSTYLAIAGIGKIILADFDTVDSTNLNRQFLHYEKDVGRA
KVESAKEKLLLMNPLIEVEIIKEMLTESNIDYLVPECDIIIDALDNMETRHILNRFSIKRSIPLIHGAVTGYDGQVTTII
PGKTPCFYCIFPRIPKKEVFPILGATPGIIGSIQVSEAVKFLTGKGKLLEGRLLFWNGLSGSFSEISLAKLNNCPVCGSN
GEKV
>Mature_244_residues
MDKMEREKYSRQILLFGEEGQEKLKAAKVFVAGAGGLGSPVSTYLAIAGIGKIILADFDTVDSTNLNRQFLHYEKDVGRA
KVESAKEKLLLMNPLIEVEIIKEMLTESNIDYLVPECDIIIDALDNMETRHILNRFSIKRSIPLIHGAVTGYDGQVTTII
PGKTPCFYCIFPRIPKKEVFPILGATPGIIGSIQVSEAVKFLTGKGKLLEGRLLFWNGLSGSFSEISLAKLNNCPVCGSN
GEKV

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=240, Percent_Identity=34.5833333333333, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI4885649, Length=163, Percent_Identity=39.2638036809816, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI23510338, Length=171, Percent_Identity=31.5789473684211, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI23510340, Length=171, Percent_Identity=31.5789473684211, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI38045944, Length=177, Percent_Identity=35.0282485875706, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI38045942, Length=177, Percent_Identity=35.0282485875706, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI225543285, Length=150, Percent_Identity=28.6666666666667, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI225543288, Length=150, Percent_Identity=28.6666666666667, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4885585, Length=150, Percent_Identity=28.6666666666667, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI38045948, Length=166, Percent_Identity=30.1204819277108, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI150417996, Length=196, Percent_Identity=27.0408163265306, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI38327032, Length=238, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI13376212, Length=238, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787048, Length=246, Percent_Identity=36.1788617886179, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI87082356, Length=252, Percent_Identity=34.1269841269841, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1789177, Length=152, Percent_Identity=32.2368421052632, Blast_Score=82, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17540406, Length=250, Percent_Identity=36, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI193203301, Length=154, Percent_Identity=36.3636363636364, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI86565433, Length=237, Percent_Identity=26.5822784810127, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI86565431, Length=237, Percent_Identity=26.5822784810127, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71984476, Length=192, Percent_Identity=30.7291666666667, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17508819, Length=208, Percent_Identity=27.4038461538462, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321903, Length=254, Percent_Identity=31.1023622047244, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320598, Length=188, Percent_Identity=34.5744680851064, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6322639, Length=192, Percent_Identity=31.25, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325323, Length=161, Percent_Identity=33.5403726708075, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325438, Length=143, Percent_Identity=28.6713286713287, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321790, Length=164, Percent_Identity=29.8780487804878, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24582879, Length=242, Percent_Identity=40.0826446280992, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24660640, Length=164, Percent_Identity=38.4146341463415, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28573937, Length=184, Percent_Identity=30.9782608695652, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20129973, Length=194, Percent_Identity=27.8350515463918, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24641311, Length=238, Percent_Identity=27.7310924369748, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357111, Length=113, Percent_Identity=27.4336283185841, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26793; Mature: 26793

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKMEREKYSRQILLFGEEGQEKLKAAKVFVAGAGGLGSPVSTYLAIAGIGKIILADFDT
CCCHHHHHHCCEEEEECCCCHHHHHHEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCC
VDSTNLNRQFLHYEKDVGRAKVESAKEKLLLMNPLIEVEIIKEMLTESNIDYLVPECDII
CCCCCCCHHHHHHHHHCCHHHHHHHHHHEEHHCCCHHHHHHHHHHHCCCCCEECCCHHHH
IDALDNMETRHILNRFSIKRSIPLIHGAVTGYDGQVTTIIPGKTPCFYCIFPRIPKKEVF
HHHHCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCEEEEECCCCCHHHHC
PILGATPGIIGSIQVSEAVKFLTGKGKLLEGRLLFWNGLSGSFSEISLAKLNNCPVCGSN
CCCCCCCCCEEEEEHHHHHHHHCCCCCEEECEEEEEECCCCCCHHEEEECCCCCCCCCCC
GEKV
CCCC
>Mature Secondary Structure
MDKMEREKYSRQILLFGEEGQEKLKAAKVFVAGAGGLGSPVSTYLAIAGIGKIILADFDT
CCCHHHHHHCCEEEEECCCCHHHHHHEEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCC
VDSTNLNRQFLHYEKDVGRAKVESAKEKLLLMNPLIEVEIIKEMLTESNIDYLVPECDII
CCCCCCCHHHHHHHHHCCHHHHHHHHHHEEHHCCCHHHHHHHHHHHCCCCCEECCCHHHH
IDALDNMETRHILNRFSIKRSIPLIHGAVTGYDGQVTTIIPGKTPCFYCIFPRIPKKEVF
HHHHCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCEEEEECCCCCHHHHC
PILGATPGIIGSIQVSEAVKFLTGKGKLLEGRLLFWNGLSGSFSEISLAKLNNCPVCGSN
CCCCCCCCCEEEEEHHHHHHHHCCCCCEEECEEEEEECCCCCCHHEEEECCCCCCCCCCC
GEKV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA