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The map label for this gene is mtmP [C]

Identifier: 21227537

GI number: 21227537

Start: 1715594

End: 1717000

Strand: Reverse

Name: mtmP [C]

Synonym: MM_1435

Alternate gene names: 21227537

Gene position: 1717000-1715594 (Counterclockwise)

Preceding gene: 21227538

Following gene: 21227536

Centisome position: 41.92

GC content: 48.19

Gene sequence:

>1407_bases
ATGTCTGAACACAACGAAGCCGCCAACCTGGTAAAAACTCTGCGGCCTTTCCATATATGGGCTCTTGGAGTAGGAATTGT
TCTGGTCGGAGAGTATATGGGCTGGAACTTTACTGTTGCAAAAGGAGGAATTCTTGGTTCTCTGCTTGCCATGCTGGTTG
CAGGAACAATGTATGTAATAATTGCCCTCTGTGCCAGTGAACTCGGATCAGCAACCAAACTTGCAGGAGGACCTTATGAT
TGGGCGAGATTGTTCGTCGGACCCGGAGCAGCTGCCAGTGTAGGGCTTGCAGTATATATGGAATATATAGCCCTTGAAGC
GGCGGATGCTATTGTTGTCGCATTTATTGCACAGAGCATCTTTCCGGAACTGCAGGTTTTTCCTGTAACATTGCTTGTAA
TCGCACTTCTTACCTTCATTAACTACCGTGGCGTTGTTGCGGCACTGACCCTTAACTTTGTCCTGACGATGATCGCTTTC
ATTGCAATAGTGGTCTTCTTCTTCGCAACTGCCTTTGGAGGAGTGAACATCCACCCTGAATATCTTTTCCAGGGAGCACT
TCCAAACGGTATGATAGGACTCTTTGCAGCCCTGCAGTTTGGGCCCTGGTTCTATCTGGGAATAGAAGGAGCAGCAATGT
GCGCTGAGGAATGTAAACACCCATCAAGGGCAGTACCTCTCGGACAGCAGGCCGGGATGATCACACTGCTTGTAGGAGCG
GCAATGACACTCTATTTATGTTCCGTGCTGATCCCGACTGACCTTCTGGGAGTTTCCGTATATCCACTCTTTGAGGCTGC
ACAGAACAGCGGCATATTTATATTCATCGCCCTGCTCGGGCTCGGGACATTCCTGACATGTGTTGCCAGTGCAAACGGAT
GTGTCTGTGACTCTTCACGCTCCTGGTTTGCCCTTTCCAGAGATAAATATGTGTCTTCCTGGTTCTCGGCGGTGCACCCG
AGGTATAATACCCCATACAGGGCAGTGATTTTCACAATGCCCGTTGCGATAGGCTTTGCATTCAGCGGTTTCCTTGACCA
GGTAATTACTTTCTCCATTGTCTCGGGTCTTCTCTGCTATGTACTGATTCCTTTCTCCCTGATACGTTTCAGGAATCTCT
TCCCGCAGACTACAAGCAAGGTCAGGCCTTTTGCAGGTCCTCTTCAGCCGTATATTGCTTACTTTGCAATAGCAATCGCA
ATTACCATTCTTTCAACGCTGTTCTGGGGCTATAAATACAACCTGATCTTTGCCTTTGTGTTCTACGGCATTGCGTACTT
CTACTTCAGCCACAGGCACAAGAATTCGAACATCGAAAACAACTGGGCTGAAATGGGCTGGCCATTACCCAATGGTTCGG
AAAATGGAAGAATAGGAAAGGAGGCGGTAGGCTTTGGAGACGAATAA

Upstream 100 bases:

>100_bases
GACTGTTATAAACGGACTGATATATCTTCTGGCTTTCGGGCTGATGGCCTGGGTTCTACTTGATGCCAGCAGGGTTTCAA
AAAGAAGGGGTTGATACGGC

Downstream 100 bases:

>100_bases
CCGGGAACTTGAAAGCAAATATCACAGCAAACTCAATGGAGATACGCTCCTTGTCATTGGCATGCTTGCTTTGCTAGTGG
GCGTGGAAGGGTTCATAATA

Product: monomethylamine permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSEHNEAANLVKTLRPFHIWALGVGIVLVGEYMGWNFTVAKGGILGSLLAMLVAGTMYVIIALCASELGSATKLAGGPYD
WARLFVGPGAAASVGLAVYMEYIALEAADAIVVAFIAQSIFPELQVFPVTLLVIALLTFINYRGVVAALTLNFVLTMIAF
IAIVVFFFATAFGGVNIHPEYLFQGALPNGMIGLFAALQFGPWFYLGIEGAAMCAEECKHPSRAVPLGQQAGMITLLVGA
AMTLYLCSVLIPTDLLGVSVYPLFEAAQNSGIFIFIALLGLGTFLTCVASANGCVCDSSRSWFALSRDKYVSSWFSAVHP
RYNTPYRAVIFTMPVAIGFAFSGFLDQVITFSIVSGLLCYVLIPFSLIRFRNLFPQTTSKVRPFAGPLQPYIAYFAIAIA
ITILSTLFWGYKYNLIFAFVFYGIAYFYFSHRHKNSNIENNWAEMGWPLPNGSENGRIGKEAVGFGDE

Sequences:

>Translated_468_residues
MSEHNEAANLVKTLRPFHIWALGVGIVLVGEYMGWNFTVAKGGILGSLLAMLVAGTMYVIIALCASELGSATKLAGGPYD
WARLFVGPGAAASVGLAVYMEYIALEAADAIVVAFIAQSIFPELQVFPVTLLVIALLTFINYRGVVAALTLNFVLTMIAF
IAIVVFFFATAFGGVNIHPEYLFQGALPNGMIGLFAALQFGPWFYLGIEGAAMCAEECKHPSRAVPLGQQAGMITLLVGA
AMTLYLCSVLIPTDLLGVSVYPLFEAAQNSGIFIFIALLGLGTFLTCVASANGCVCDSSRSWFALSRDKYVSSWFSAVHP
RYNTPYRAVIFTMPVAIGFAFSGFLDQVITFSIVSGLLCYVLIPFSLIRFRNLFPQTTSKVRPFAGPLQPYIAYFAIAIA
ITILSTLFWGYKYNLIFAFVFYGIAYFYFSHRHKNSNIENNWAEMGWPLPNGSENGRIGKEAVGFGDE
>Mature_467_residues
SEHNEAANLVKTLRPFHIWALGVGIVLVGEYMGWNFTVAKGGILGSLLAMLVAGTMYVIIALCASELGSATKLAGGPYDW
ARLFVGPGAAASVGLAVYMEYIALEAADAIVVAFIAQSIFPELQVFPVTLLVIALLTFINYRGVVAALTLNFVLTMIAFI
AIVVFFFATAFGGVNIHPEYLFQGALPNGMIGLFAALQFGPWFYLGIEGAAMCAEECKHPSRAVPLGQQAGMITLLVGAA
MTLYLCSVLIPTDLLGVSVYPLFEAAQNSGIFIFIALLGLGTFLTCVASANGCVCDSSRSWFALSRDKYVSSWFSAVHPR
YNTPYRAVIFTMPVAIGFAFSGFLDQVITFSIVSGLLCYVLIPFSLIRFRNLFPQTTSKVRPFAGPLQPYIAYFAIAIAI
TILSTLFWGYKYNLIFAFVFYGIAYFYFSHRHKNSNIENNWAEMGWPLPNGSENGRIGKEAVGFGDE

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI7657683, Length=378, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI71979932, Length=439, Percent_Identity=24.373576309795, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI115648063, Length=354, Percent_Identity=25.7062146892655, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI115648022, Length=354, Percent_Identity=25.7062146892655, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1789017, Length=425, Percent_Identity=23.2941176470588, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081708, Length=350, Percent_Identity=22.8571428571429, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=495, Percent_Identity=21.2121212121212, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324990, Length=465, Percent_Identity=24.7311827956989, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24641993, Length=438, Percent_Identity=24.8858447488584, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641995, Length=364, Percent_Identity=25.8241758241758, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50841; Mature: 50710

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHNEAANLVKTLRPFHIWALGVGIVLVGEYMGWNFTVAKGGILGSLLAMLVAGTMYVI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
IALCASELGSATKLAGGPYDWARLFVGPGAAASVGLAVYMEYIALEAADAIVVAFIAQSI
HHHHHHHHCCCHHCCCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPELQVFPVTLLVIALLTFINYRGVVAALTLNFVLTMIAFIAIVVFFFATAFGGVNIHPE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
YLFQGALPNGMIGLFAALQFGPWFYLGIEGAAMCAEECKHPSRAVPLGQQAGMITLLVGA
HHHCCCCCCHHHHHHHHHHHCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
AMTLYLCSVLIPTDLLGVSVYPLFEAAQNSGIFIFIALLGLGTFLTCVASANGCVCDSSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCC
SWFALSRDKYVSSWFSAVHPRYNTPYRAVIFTMPVAIGFAFSGFLDQVITFSIVSGLLCY
CEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLIPFSLIRFRNLFPQTTSKVRPFAGPLQPYIAYFAIAIAITILSTLFWGYKYNLIFAFV
HHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYGIAYFYFSHRHKNSNIENNWAEMGWPLPNGSENGRIGKEAVGFGDE
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
SEHNEAANLVKTLRPFHIWALGVGIVLVGEYMGWNFTVAKGGILGSLLAMLVAGTMYVI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
IALCASELGSATKLAGGPYDWARLFVGPGAAASVGLAVYMEYIALEAADAIVVAFIAQSI
HHHHHHHHCCCHHCCCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPELQVFPVTLLVIALLTFINYRGVVAALTLNFVLTMIAFIAIVVFFFATAFGGVNIHPE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
YLFQGALPNGMIGLFAALQFGPWFYLGIEGAAMCAEECKHPSRAVPLGQQAGMITLLVGA
HHHCCCCCCHHHHHHHHHHHCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
AMTLYLCSVLIPTDLLGVSVYPLFEAAQNSGIFIFIALLGLGTFLTCVASANGCVCDSSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCC
SWFALSRDKYVSSWFSAVHPRYNTPYRAVIFTMPVAIGFAFSGFLDQVITFSIVSGLLCY
CEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLIPFSLIRFRNLFPQTTSKVRPFAGPLQPYIAYFAIAIAITILSTLFWGYKYNLIFAFV
HHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYGIAYFYFSHRHKNSNIENNWAEMGWPLPNGSENGRIGKEAVGFGDE
HHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]