Click here to switch to the map view.

The map label for this gene is nrdD [C]

Identifier: 21227469

GI number: 21227469

Start: 1636066

End: 1638450

Strand: Reverse

Name: nrdD [C]

Synonym: MM_1367

Alternate gene names: 21227469

Gene position: 1638450-1636066 (Counterclockwise)

Preceding gene: 21227470

Following gene: 21227468

Centisome position: 40.0

GC content: 47.8

Gene sequence:

>2385_bases
ATGACAGGCGAGATTTTCTTAACCGATGACGAATTGTCTGACAGCCAGCCAGTGCGAAAGGCACTTACCGGGCTTTCTAT
CTCTTCCCTCCCTAAAAATGACAAGTTATCTGACAACCAGCCCGTGCAGAAGACACTTGATGGGCTGTCTGTCTCTCCCC
TCCCCAAAGTCAGGACAACAGAAGGTTTCATTCTCAACTGGGACAGGAATATCATTGTAAGCCAGCTTCTGAAAGAAACA
AAATTGAGCGAGATCTTTTACAGCAAGCCCGCAATCACAAAAGAAGAAGCCATTGACATTGCAAAAGAAGCTGAAAAAAT
CATCCGAAAAATGAATATCAAGTTCCTATCAGGCCCTCTTATACGGGAAATAGTAAACAATATTCTGCTTGACAGGGGGC
ATGTGGAATGGAGAAACATTATGACAAGAGTCGGGGCATCCGTCTACGATGCTTATGAAATCGACTCAGGATACGGCTTC
GGGGCAAACGACAATGCAAACCAGCTGAACAATGCCGAGACGTCCCACAAGAGAAAAGCCGACAAAATGTCCAAAGAGCA
AAACCTCCTCCTGATGCCAAAAGAGCTTTCAGACCTGCACTTAAACGGCGACTTCCATATCCATGACCTTGAATACATGG
GCACAAGGCCTTTCTGCCAGGACTGGGACCTTCGATACTTCTTCTACTATGGGCTCATGCCTGATGGAGTGGGCACACAG
TCAAGTGTTGCAAAACCCGCAAAGAATGCAGAGGTAGCTTTCCTTCATGCTGTTAAGGCAATGGGCTCAGCTCAGACTAA
CTTTGCAGGCGGGCAGGGATTTTACAATTTCCTGACTTTTATTGCACCCTATCTGGAAGGCAAATCCGGGAATGAGATCA
AACAGCTTATGCAGATGTTCGTTTATGAAATGATGCAGATGATGTGTGCAAGAGGCGGACAGACTGTTTTCTCCTCAGTC
CAGCTTTCCCCCGGTGTCCCGAAGCTCTGGAAAAATATCCCGGTTGTTGCCATGGGCATGGTCTGGGACGGAAAGCAGGC
ACCTCTCAGGACATACGGCGAATTCGAAACAGAAGTTCGCCTCGGATTTAAGGCTCTTATGGACGTTATGCTTGAAGGAG
ACGCCTGGGGCAAGCCTTTCAGTTTCCCCAAGCCTGAGATTTCTCTCGAACCCGACTTCATGGAAGAAGACGAAGATTTC
AACAGGGCTCACCCCGAACTTCCGACTTATAAAGAACTTTACAGGCTGACCTTTGAACTGGCTGCCAAATTCGGGACCCC
TTACTTTGATAACCAGCTTCCCGAGTACAGAGGCGCAGGAGAAGGAATTTCATGTTACCAGTGCTGTGCTTACCAGTTCT
CTGCAAACCCCACAGATGATAAAGAATTTGATGACAAACTGCACTTCAGGGATGGAAAGCACTTTTCAATGGGCTCGTGG
ATGGTCCTGTCTTTAAACTGCCCGAGGGCCGCATACAGGGCTGAATATGATGATGAGAAGCTGTTCACAGAACTCAAGAA
TCTGATGAACAGAGGTGTGGAAGTCTTCAAAATCAAGAGAAAATGGATGAACAGCCTGATAAAGAAAAACAGAATTCCCT
TTGCAGCTCAGTGCCCCAAAGACCCGAATACCGGGGAAAAAGGAGCAATGGCTGTGGACTTTGACAGCCTTGTATATACA
ATAGGGGTTGTGGGAATCAATGAGATGGTCCAGTACCATACAGGCTACCAGATACATGAGTCTCCTGTTGCGTACAAGCT
TGCTATCAGGGCTATGTTCGAAATGAAGATGCATGCCCAGAAGCTTTCGAAAGAAAATAGCATGGAAATTGCCCTTGCAA
GGACTCCGGCAGAAACTACAGCCCAGCGCTTTGCAGTGTCTGACCTCCTGCACAGGGAATATGCTGATAAAGCAAAGCTC
ACGATTAAAGGCGACCTGAAAACCGCAATGAAGGAGTTTAACGAGACTCGCGACCTGCCGATTTACTATACCAATGGTAC
CCATATACCGCCAGGGGCTGATGTCTCCCTGCCTGAAAGGATAAAGTATGAGCATACTTTCTTCCCGATAGTTGACGGAG
GAAATATTATGCATATCTGGCTTGGAGAGGGAAAGCCCGATCCCGACGGTCTGCAGGAGCTTGCCATGCATATAGCAAAG
AACACACAAACAGGTTACTTTGCCTTCACAAGGGACATGACCGTGTGCACTGATGAAGGGTATGTAGCAGCCGGTCTGCT
GGACAGATGCCCTAAATGCGGGTCCGAAAATGTTCAGCACCTCTCAAGGATTACTGGATACCTCCAGTCCGTAGAAGGCT
GGAACAGGGGCAAACGCCAGGAACTCAGGGACAGGAAAAGATACGGTACAAGGGAGCTCAGATGA

Upstream 100 bases:

>100_bases
AAACTCCTTGGAATTGTATAACAGGTATCTGAAAATTTAAAAACAAATAAAAACTTTGCAGATTCCATCCTATCATTAAC
CGATTACCGAAGATGAGAAA

Downstream 100 bases:

>100_bases
GTTCCCCTAGCTCTTTTTTACACAAATAAGCTGGAATATAAAAATGGGAACTGCTATGAGAGTAAATTACGCAGGTGTCG
TCCCTCTTTCAACCCTTGAC

Product: anaerobic ribonucleoside-triphosphate reductase

Products: ribonucleoside triphosphate; thioredoxin

Alternate protein names: NA

Number of amino acids: Translated: 794; Mature: 793

Protein sequence:

>794_residues
MTGEIFLTDDELSDSQPVRKALTGLSISSLPKNDKLSDNQPVQKTLDGLSVSPLPKVRTTEGFILNWDRNIIVSQLLKET
KLSEIFYSKPAITKEEAIDIAKEAEKIIRKMNIKFLSGPLIREIVNNILLDRGHVEWRNIMTRVGASVYDAYEIDSGYGF
GANDNANQLNNAETSHKRKADKMSKEQNLLLMPKELSDLHLNGDFHIHDLEYMGTRPFCQDWDLRYFFYYGLMPDGVGTQ
SSVAKPAKNAEVAFLHAVKAMGSAQTNFAGGQGFYNFLTFIAPYLEGKSGNEIKQLMQMFVYEMMQMMCARGGQTVFSSV
QLSPGVPKLWKNIPVVAMGMVWDGKQAPLRTYGEFETEVRLGFKALMDVMLEGDAWGKPFSFPKPEISLEPDFMEEDEDF
NRAHPELPTYKELYRLTFELAAKFGTPYFDNQLPEYRGAGEGISCYQCCAYQFSANPTDDKEFDDKLHFRDGKHFSMGSW
MVLSLNCPRAAYRAEYDDEKLFTELKNLMNRGVEVFKIKRKWMNSLIKKNRIPFAAQCPKDPNTGEKGAMAVDFDSLVYT
IGVVGINEMVQYHTGYQIHESPVAYKLAIRAMFEMKMHAQKLSKENSMEIALARTPAETTAQRFAVSDLLHREYADKAKL
TIKGDLKTAMKEFNETRDLPIYYTNGTHIPPGADVSLPERIKYEHTFFPIVDGGNIMHIWLGEGKPDPDGLQELAMHIAK
NTQTGYFAFTRDMTVCTDEGYVAAGLLDRCPKCGSENVQHLSRITGYLQSVEGWNRGKRQELRDRKRYGTRELR

Sequences:

>Translated_794_residues
MTGEIFLTDDELSDSQPVRKALTGLSISSLPKNDKLSDNQPVQKTLDGLSVSPLPKVRTTEGFILNWDRNIIVSQLLKET
KLSEIFYSKPAITKEEAIDIAKEAEKIIRKMNIKFLSGPLIREIVNNILLDRGHVEWRNIMTRVGASVYDAYEIDSGYGF
GANDNANQLNNAETSHKRKADKMSKEQNLLLMPKELSDLHLNGDFHIHDLEYMGTRPFCQDWDLRYFFYYGLMPDGVGTQ
SSVAKPAKNAEVAFLHAVKAMGSAQTNFAGGQGFYNFLTFIAPYLEGKSGNEIKQLMQMFVYEMMQMMCARGGQTVFSSV
QLSPGVPKLWKNIPVVAMGMVWDGKQAPLRTYGEFETEVRLGFKALMDVMLEGDAWGKPFSFPKPEISLEPDFMEEDEDF
NRAHPELPTYKELYRLTFELAAKFGTPYFDNQLPEYRGAGEGISCYQCCAYQFSANPTDDKEFDDKLHFRDGKHFSMGSW
MVLSLNCPRAAYRAEYDDEKLFTELKNLMNRGVEVFKIKRKWMNSLIKKNRIPFAAQCPKDPNTGEKGAMAVDFDSLVYT
IGVVGINEMVQYHTGYQIHESPVAYKLAIRAMFEMKMHAQKLSKENSMEIALARTPAETTAQRFAVSDLLHREYADKAKL
TIKGDLKTAMKEFNETRDLPIYYTNGTHIPPGADVSLPERIKYEHTFFPIVDGGNIMHIWLGEGKPDPDGLQELAMHIAK
NTQTGYFAFTRDMTVCTDEGYVAAGLLDRCPKCGSENVQHLSRITGYLQSVEGWNRGKRQELRDRKRYGTRELR
>Mature_793_residues
TGEIFLTDDELSDSQPVRKALTGLSISSLPKNDKLSDNQPVQKTLDGLSVSPLPKVRTTEGFILNWDRNIIVSQLLKETK
LSEIFYSKPAITKEEAIDIAKEAEKIIRKMNIKFLSGPLIREIVNNILLDRGHVEWRNIMTRVGASVYDAYEIDSGYGFG
ANDNANQLNNAETSHKRKADKMSKEQNLLLMPKELSDLHLNGDFHIHDLEYMGTRPFCQDWDLRYFFYYGLMPDGVGTQS
SVAKPAKNAEVAFLHAVKAMGSAQTNFAGGQGFYNFLTFIAPYLEGKSGNEIKQLMQMFVYEMMQMMCARGGQTVFSSVQ
LSPGVPKLWKNIPVVAMGMVWDGKQAPLRTYGEFETEVRLGFKALMDVMLEGDAWGKPFSFPKPEISLEPDFMEEDEDFN
RAHPELPTYKELYRLTFELAAKFGTPYFDNQLPEYRGAGEGISCYQCCAYQFSANPTDDKEFDDKLHFRDGKHFSMGSWM
VLSLNCPRAAYRAEYDDEKLFTELKNLMNRGVEVFKIKRKWMNSLIKKNRIPFAAQCPKDPNTGEKGAMAVDFDSLVYTI
GVVGINEMVQYHTGYQIHESPVAYKLAIRAMFEMKMHAQKLSKENSMEIALARTPAETTAQRFAVSDLLHREYADKAKLT
IKGDLKTAMKEFNETRDLPIYYTNGTHIPPGADVSLPERIKYEHTFFPIVDGGNIMHIWLGEGKPDPDGLQELAMHIAKN
TQTGYFAFTRDMTVCTDEGYVAAGLLDRCPKCGSENVQHLSRITGYLQSVEGWNRGKRQELRDRKRYGTRELR

Specific function: Unknown

COG id: COG1328

COG function: function code F; Oxygen-sensitive ribonucleoside-triphosphate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 DOD-type homing endonuclease domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR003586
- InterPro:   IPR003587
- InterPro:   IPR007869
- InterPro:   IPR006142
- InterPro:   IPR004042
- InterPro:   IPR006141
- InterPro:   IPR012833 [H]

Pfam domain/function: PF03477 ATP-cone; PF05204 Hom_end [H]

EC number: 1.17.4.2

Molecular weight: Translated: 90189; Mature: 90058

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGEIFLTDDELSDSQPVRKALTGLSISSLPKNDKLSDNQPVQKTLDGLSVSPLPKVRTT
CCCCEEEECCCCCCCHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
EGFILNWDRNIIVSQLLKETKLSEIFYSKPAITKEEAIDIAKEAEKIIRKMNIKFLSGPL
CCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCHH
IREIVNNILLDRGHVEWRNIMTRVGASVYDAYEIDSGYGFGANDNANQLNNAETSHKRKA
HHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHEECCCCCCCCCCCCHHHCCCCHHHHHHHH
DKMSKEQNLLLMPKELSDLHLNGDFHIHDLEYMGTRPFCQDWDLRYFFYYGLMPDGVGTQ
HHHHCCCCEEEECCCCCCEEECCCEEEEEHHHCCCCCCCCCCCCEEEEEECCCCCCCCCH
SSVAKPAKNAEVAFLHAVKAMGSAQTNFAGGQGFYNFLTFIAPYLEGKSGNEIKQLMQMF
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VYEMMQMMCARGGQTVFSSVQLSPGVPKLWKNIPVVAMGMVWDGKQAPLRTYGEFETEVR
HHHHHHHHHHCCCCHHHHHEECCCCCHHHHCCCCEEEEEEEECCCCCCCHHCCCCHHHHH
LGFKALMDVMLEGDAWGKPFSFPKPEISLEPDFMEEDEDFNRAHPELPTYKELYRLTFEL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHH
AAKFGTPYFDNQLPEYRGAGEGISCYQCCAYQFSANPTDDKEFDDKLHFRDGKHFSMGSW
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCE
MVLSLNCPRAAYRAEYDDEKLFTELKNLMNRGVEVFKIKRKWMNSLIKKNRIPFAAQCPK
EEEEECCCHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEECCC
DPNTGEKGAMAVDFDSLVYTIGVVGINEMVQYHTGYQIHESPVAYKLAIRAMFEMKMHAQ
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
KLSKENSMEIALARTPAETTAQRFAVSDLLHREYADKAKLTIKGDLKTAMKEFNETRDLP
HHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCE
IYYTNGTHIPPGADVSLPERIKYEHTFFPIVDGGNIMHIWLGEGKPDPDGLQELAMHIAK
EEECCCCCCCCCCCCCCCHHHCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHC
NTQTGYFAFTRDMTVCTDEGYVAAGLLDRCPKCGSENVQHLSRITGYLQSVEGWNRGKRQ
CCCCCEEEEECCEEEECCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
ELRDRKRYGTRELR
HHHHHHHCCCCCCC
>Mature Secondary Structure 
TGEIFLTDDELSDSQPVRKALTGLSISSLPKNDKLSDNQPVQKTLDGLSVSPLPKVRTT
CCCEEEECCCCCCCHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCC
EGFILNWDRNIIVSQLLKETKLSEIFYSKPAITKEEAIDIAKEAEKIIRKMNIKFLSGPL
CCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCHH
IREIVNNILLDRGHVEWRNIMTRVGASVYDAYEIDSGYGFGANDNANQLNNAETSHKRKA
HHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHEECCCCCCCCCCCCHHHCCCCHHHHHHHH
DKMSKEQNLLLMPKELSDLHLNGDFHIHDLEYMGTRPFCQDWDLRYFFYYGLMPDGVGTQ
HHHHCCCCEEEECCCCCCEEECCCEEEEEHHHCCCCCCCCCCCCEEEEEECCCCCCCCCH
SSVAKPAKNAEVAFLHAVKAMGSAQTNFAGGQGFYNFLTFIAPYLEGKSGNEIKQLMQMF
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VYEMMQMMCARGGQTVFSSVQLSPGVPKLWKNIPVVAMGMVWDGKQAPLRTYGEFETEVR
HHHHHHHHHHCCCCHHHHHEECCCCCHHHHCCCCEEEEEEEECCCCCCCHHCCCCHHHHH
LGFKALMDVMLEGDAWGKPFSFPKPEISLEPDFMEEDEDFNRAHPELPTYKELYRLTFEL
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHH
AAKFGTPYFDNQLPEYRGAGEGISCYQCCAYQFSANPTDDKEFDDKLHFRDGKHFSMGSW
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCE
MVLSLNCPRAAYRAEYDDEKLFTELKNLMNRGVEVFKIKRKWMNSLIKKNRIPFAAQCPK
EEEEECCCHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEECCC
DPNTGEKGAMAVDFDSLVYTIGVVGINEMVQYHTGYQIHESPVAYKLAIRAMFEMKMHAQ
CCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
KLSKENSMEIALARTPAETTAQRFAVSDLLHREYADKAKLTIKGDLKTAMKEFNETRDLP
HHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCE
IYYTNGTHIPPGADVSLPERIKYEHTFFPIVDGGNIMHIWLGEGKPDPDGLQELAMHIAK
EEECCCCCCCCCCCCCCCHHHCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHC
NTQTGYFAFTRDMTVCTDEGYVAAGLLDRCPKCGSENVQHLSRITGYLQSVEGWNRGKRQ
CCCCCEEEEECCEEEECCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHH
ELRDRKRYGTRELR
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2'-deoxyribonucleoside triphosphate; thioredoxin disulfide; H2O

Specific reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]