Click here to switch to the map view.

The map label for this gene is argB [H]

Identifier: 21227322

GI number: 21227322

Start: 1446195

End: 1447073

Strand: Reverse

Name: argB [H]

Synonym: MM_1220

Alternate gene names: 21227322

Gene position: 1447073-1446195 (Counterclockwise)

Preceding gene: 21227323

Following gene: 21227319

Centisome position: 35.33

GC content: 45.73

Gene sequence:

>879_bases
ATGGAACTCAAAAGAGAGAATGTGCTTATTGAAGCCCTGCCCTATATGCAGGAGTTTTACGATTCAATTATGGTTATCAA
AGTGGGTGGAAACGCAATGGTCAGCGCCCAGATCATGGAGGATATCATAAAAGATATCGTCCTTCTGCGTTATGTGGGGA
TCAAGCCGGTTATTGTACACGGCGGTGGGCCTGAAATCACGGAAAAAATGGAGCGCATGGGCAAAAAAGCTGAGTTCTTC
CAGGGACTTCGCATTACGGATGATGAAACCATGGAAATTGCCAGAATGGTTCTGGTAGGAAACATAAATACGAAAATCGT
GTCTCTTATTGGTTTATTCGGCGGCAAAGGCGTTGGGTTTACGGGCTATGACGGAAGAATGATCCTTGGCCATAAACAGG
CTGCAAAACATGTGCTCATCGACGGTGTGGAGACTGAAGTGGATATCGGCTGGGTTGGAGAAAGTGAGGTCATAAATCCC
GAGATCCTCCATATTATGCTTGAAAAAGGGTATATCCCTGTTATTTCCCCTATTGCTGTGGATGCAAAAGGAAATGCCCT
TAACATAAATGCGGATACTGTCGCAGGAGATATTGCAGCAGCCCTCCACGCTAAAAAACTTATCCTCATGACCGACGTCT
CCGGTCTTCTCAGAAACATAAAAGATCCTGGTAGCCGCATATCACGTGTAAAACTCGACGATATTGACCTCCTTATTGAG
GAAGGAGTCATCAGCGGCGGAATGATCCCGAAAATCAAAGGTGCGGCTGTTGCAGTTAAAAGCGGAGTAGAAAGAGCACA
TATCATAAATGGAAGCGTTTCCCACTCCATGCTTCTTGAACTCTTTACTGACGGCGGAGTCGGGACCATGATTTACTGA

Upstream 100 bases:

>100_bases
TTTATTTGAGTTTTTTATATTGATCTTTTCAGGGAATTTTTCTAATTATACCTTTATACTCAACGATAAGTTTAAAAAGA
GATTTTCTGATTCCTAAATC

Downstream 100 bases:

>100_bases
ACCCTTCTTCAGTAATTCGCAGCAATATTCAACGTTTCCTGAAAAGAAACCCGTATTCCAGAAGTGAAGTCGGTAAGTTT
ACTTATCAGGCCTGTCAGAC

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MELKRENVLIEALPYMQEFYDSIMVIKVGGNAMVSAQIMEDIIKDIVLLRYVGIKPVIVHGGGPEITEKMERMGKKAEFF
QGLRITDDETMEIARMVLVGNINTKIVSLIGLFGGKGVGFTGYDGRMILGHKQAAKHVLIDGVETEVDIGWVGESEVINP
EILHIMLEKGYIPVISPIAVDAKGNALNINADTVAGDIAAALHAKKLILMTDVSGLLRNIKDPGSRISRVKLDDIDLLIE
EGVISGGMIPKIKGAAVAVKSGVERAHIINGSVSHSMLLELFTDGGVGTMIY

Sequences:

>Translated_292_residues
MELKRENVLIEALPYMQEFYDSIMVIKVGGNAMVSAQIMEDIIKDIVLLRYVGIKPVIVHGGGPEITEKMERMGKKAEFF
QGLRITDDETMEIARMVLVGNINTKIVSLIGLFGGKGVGFTGYDGRMILGHKQAAKHVLIDGVETEVDIGWVGESEVINP
EILHIMLEKGYIPVISPIAVDAKGNALNINADTVAGDIAAALHAKKLILMTDVSGLLRNIKDPGSRISRVKLDDIDLLIE
EGVISGGMIPKIKGAAVAVKSGVERAHIINGSVSHSMLLELFTDGGVGTMIY
>Mature_292_residues
MELKRENVLIEALPYMQEFYDSIMVIKVGGNAMVSAQIMEDIIKDIVLLRYVGIKPVIVHGGGPEITEKMERMGKKAEFF
QGLRITDDETMEIARMVLVGNINTKIVSLIGLFGGKGVGFTGYDGRMILGHKQAAKHVLIDGVETEVDIGWVGESEVINP
EILHIMLEKGYIPVISPIAVDAKGNALNINADTVAGDIAAALHAKKLILMTDVSGLLRNIKDPGSRISRVKLDDIDLLIE
EGVISGGMIPKIKGAAVAVKSGVERAHIINGSVSHSMLLELFTDGGVGTMIY

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1789181, Length=298, Percent_Identity=26.1744966442953, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693208, Length=239, Percent_Identity=31.3807531380753, Blast_Score=92, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320913, Length=277, Percent_Identity=27.4368231046931, Blast_Score=98, Evalue=2e-21,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004662
- InterPro:   IPR001048 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.2.8 [H]

Molecular weight: Translated: 31515; Mature: 31515

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKRENVLIEALPYMQEFYDSIMVIKVGGNAMVSAQIMEDIIKDIVLLRYVGIKPVIVH
CCCCHHCCHHHHHHHHHHHHCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEE
GGGPEITEKMERMGKKAEFFQGLRITDDETMEIARMVLVGNINTKIVSLIGLFGGKGVGF
CCCCHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
TGYDGRMILGHKQAAKHVLIDGVETEVDIGWVGESEVINPEILHIMLEKGYIPVISPIAV
CCCCCEEEEECHHHHCEEEEECCCCEEEEEECCCCCCCCHHHHHEEHHCCCCCEECCEEE
DAKGNALNINADTVAGDIAAALHAKKLILMTDVSGLLRNIKDPGSRISRVKLDDIDLLIE
ECCCCEEEECHHHHHHHHHHHHHHHEEEEEECHHHHHHHCCCCCHHHCEEEECHHHHHHC
EGVISGGMIPKIKGAAVAVKSGVERAHIINGSVSHSMLLELFTDGGVGTMIY
CCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure
MELKRENVLIEALPYMQEFYDSIMVIKVGGNAMVSAQIMEDIIKDIVLLRYVGIKPVIVH
CCCCHHCCHHHHHHHHHHHHCCEEEEEECCCEEEHHHHHHHHHHHHHHHHHCCCCEEEEE
GGGPEITEKMERMGKKAEFFQGLRITDDETMEIARMVLVGNINTKIVSLIGLFGGKGVGF
CCCCHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
TGYDGRMILGHKQAAKHVLIDGVETEVDIGWVGESEVINPEILHIMLEKGYIPVISPIAV
CCCCCEEEEECHHHHCEEEEECCCCEEEEEECCCCCCCCHHHHHEEHHCCCCCEECCEEE
DAKGNALNINADTVAGDIAAALHAKKLILMTDVSGLLRNIKDPGSRISRVKLDDIDLLIE
ECCCCEEEECHHHHHHHHHHHHHHHEEEEEECHHHHHHHCCCCCHHHCEEEECHHHHHHC
EGVISGGMIPKIKGAAVAVKSGVERAHIINGSVSHSMLLELFTDGGVGTMIY
CCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]