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The map label for this gene is dapA [H]

Identifier: 21227303

GI number: 21227303

Start: 1426372

End: 1427247

Strand: Direct

Name: dapA [H]

Synonym: MM_1201

Alternate gene names: 21227303

Gene position: 1426372-1427247 (Clockwise)

Preceding gene: 21227302

Following gene: 21227304

Centisome position: 34.82

GC content: 48.06

Gene sequence:

>876_bases
ATGTTTGAAGGAGCAATGCCTGCCCTGATCACTCCTTTTACGAAAGATGACAGGATTGACAGGGAAGGCTTACAGAGGAA
CATAGCGTTTGTTGAAGAGGGAGGGGTTTCAGGAATAGTGCCCTGTGGCACAACCGGAGAATCGGCAACCCTTTCTGCAG
CAGAGCATGAAGAAGTAATAGACATTGCAGTTGAGTGCTCAAAAGTTCCTGTAATTGCAGGAACAGGTTCAAACAATACG
GGTGAAGCACTCCAGTTCACAAAACACGCCGCAGATGCGGGTGTTGACGGTGTACTTCTTATTTCTCCTTATTATAATAA
GCCAAATCCTGCAGGTCTTCTTGCCCATTTTAAGAAGATTGCAGAGGCAGTAGATATCCCCATGATCCTCTACAATGTCC
CTTCCAGGACAGGGCAGGATATGCCTGTAGACGTGATTGTCGAGCTTGCAAAGGTAGAAAACATCGTGGGTATCAAGGAA
GCCAGCGGGAACGCAGCAAAAGTTTCTCAGATCCTTGAGAACACTATGGATGACGACTTTGTAGTTCTCTCAGGCGAGGA
CGGGCTAACTCTTCCGATCATTTCAATGGGAGGCAGAGGAGTCATTTCAGTTGCTGCAAACATTGTGCCTGATAAAATGT
CAGGAATGGTAAATGCAGCCCTCAAAGGAGATTACGAAACTGCAAGAAAGCTGCATTTCGAGATAGCCCCGCTGATCCGT
GCCCTTTTCCTTGAGACAAACCCGATTCCTGTGAAGAAAGCTGCAGAACTTGTCGGGCTTGCAAGCGGACACCTGAGGCT
TCCACTGGCTCCCATCAGCGATGCCAACCAGGCAAAGCTTGCCAACGAACTCAGAAAACTGGGGGTAATGGAATGA

Upstream 100 bases:

>100_bases
TTGCAGGCTACGTCACAAGAAAAGTTGCACGTATGAAAGTCTACTGATCGTACTGGATAGATAAAGAACTAATTTCCGGG
AAACAGGCAGGGATATCTAT

Downstream 100 bases:

>100_bases
TCAATGCAGCAGTACTCGGAGCTTGTGGCAGGATGGGCTCCTTAATTATAGAAAACATCACCTGTTCCACGGATATGCAG
CTTGTAGCTGCATTTGACAT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MFEGAMPALITPFTKDDRIDREGLQRNIAFVEEGGVSGIVPCGTTGESATLSAAEHEEVIDIAVECSKVPVIAGTGSNNT
GEALQFTKHAADAGVDGVLLISPYYNKPNPAGLLAHFKKIAEAVDIPMILYNVPSRTGQDMPVDVIVELAKVENIVGIKE
ASGNAAKVSQILENTMDDDFVVLSGEDGLTLPIISMGGRGVISVAANIVPDKMSGMVNAALKGDYETARKLHFEIAPLIR
ALFLETNPIPVKKAAELVGLASGHLRLPLAPISDANQAKLANELRKLGVME

Sequences:

>Translated_291_residues
MFEGAMPALITPFTKDDRIDREGLQRNIAFVEEGGVSGIVPCGTTGESATLSAAEHEEVIDIAVECSKVPVIAGTGSNNT
GEALQFTKHAADAGVDGVLLISPYYNKPNPAGLLAHFKKIAEAVDIPMILYNVPSRTGQDMPVDVIVELAKVENIVGIKE
ASGNAAKVSQILENTMDDDFVVLSGEDGLTLPIISMGGRGVISVAANIVPDKMSGMVNAALKGDYETARKLHFEIAPLIR
ALFLETNPIPVKKAAELVGLASGHLRLPLAPISDANQAKLANELRKLGVME
>Mature_291_residues
MFEGAMPALITPFTKDDRIDREGLQRNIAFVEEGGVSGIVPCGTTGESATLSAAEHEEVIDIAVECSKVPVIAGTGSNNT
GEALQFTKHAADAGVDGVLLISPYYNKPNPAGLLAHFKKIAEAVDIPMILYNVPSRTGQDMPVDVIVELAKVENIVGIKE
ASGNAAKVSQILENTMDDDFVVLSGEDGLTLPIISMGGRGVISVAANIVPDKMSGMVNAALKGDYETARKLHFEIAPLIR
ALFLETNPIPVKKAAELVGLASGHLRLPLAPISDANQAKLANELRKLGVME

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=293, Percent_Identity=29.6928327645051, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI13540533, Length=296, Percent_Identity=27.7027027027027, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=45.0511945392491, Blast_Score=253, Evalue=7e-69,
Organism=Escherichia coli, GI87082415, Length=282, Percent_Identity=32.6241134751773, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786463, Length=285, Percent_Identity=31.5789473684211, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789620, Length=244, Percent_Identity=30.327868852459, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 30705; Mature: 30705

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEGAMPALITPFTKDDRIDREGLQRNIAFVEEGGVSGIVPCGTTGESATLSAAEHEEVI
CCCCCCCHHCCCCCCCCCCCHHHHHHCCEEEECCCCCEEECCCCCCCCCEECHHHHHHHH
DIAVECSKVPVIAGTGSNNTGEALQFTKHAADAGVDGVLLISPYYNKPNPAGLLAHFKKI
HHEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHH
AEAVDIPMILYNVPSRTGQDMPVDVIVELAKVENIVGIKEASGNAAKVSQILENTMDDDF
HHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCE
VVLSGEDGLTLPIISMGGRGVISVAANIVPDKMSGMVNAALKGDYETARKLHFEIAPLIR
EEEECCCCCEEEEEECCCCEEEEHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ALFLETNPIPVKKAAELVGLASGHLRLPLAPISDANQAKLANELRKLGVME
HHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFEGAMPALITPFTKDDRIDREGLQRNIAFVEEGGVSGIVPCGTTGESATLSAAEHEEVI
CCCCCCCHHCCCCCCCCCCCHHHHHHCCEEEECCCCCEEECCCCCCCCCEECHHHHHHHH
DIAVECSKVPVIAGTGSNNTGEALQFTKHAADAGVDGVLLISPYYNKPNPAGLLAHFKKI
HHEEECCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHH
AEAVDIPMILYNVPSRTGQDMPVDVIVELAKVENIVGIKEASGNAAKVSQILENTMDDDF
HHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCCCCCE
VVLSGEDGLTLPIISMGGRGVISVAANIVPDKMSGMVNAALKGDYETARKLHFEIAPLIR
EEEECCCCCEEEEEECCCCEEEEHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ALFLETNPIPVKKAAELVGLASGHLRLPLAPISDANQAKLANELRKLGVME
HHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]