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The map label for this gene is wecC [H]

Identifier: 21227274

GI number: 21227274

Start: 1390623

End: 1391879

Strand: Direct

Name: wecC [H]

Synonym: MM_1172

Alternate gene names: 21227274

Gene position: 1390623-1391879 (Clockwise)

Preceding gene: 21227273

Following gene: 21227287

Centisome position: 33.95

GC content: 44.39

Gene sequence:

>1257_bases
GTGTCAAAAATCTGCGTACTCGGCCAGGGATATATTGGCCTCCCAACTGCTCTTCTTTTTGCAAACAACGGCCACGAAGT
CGTGGGCATTGATGTAAACAAACGTGTTGTCGATACCCTCAAAGCAGGCAAAATGCCCTTTGAAGAAAAAGGCTTCCAGG
AACTGCTGGACGGAGCCATTGCCAAAAATGCCTTCAGGGCAGAATCCCTTGTTGAAGAAGCCGATACCTTCCTAGTTGCA
GTTCCGACACCTTTTGATTCAGAAATGCGGATGGCAGACCTTAAATATGTGGTCTCTGCCTGTGAGATGATCGTCCCCCA
CCTGAAAAAAGGCAACCTCGTAATTATAGAGTCCACGATCCCCCCCAAAACCTGTGACAAACAGGTAAAACAAATCTTGG
AAAAGTCCATCCTTAAAATGTGCGAGGACTTTTATGTTTCCCACTGTCCCGAAAGAGCGATCCCAGGCAACACCCTCCAT
GAAATGGTCTACAACGACCGCGTAATTGGAGGAGTAGACGAAAAGTCCACCCAGCTTACAGCTGAACTTTATTCTTCCTT
TGTAAAAGGAAACCTCCACCTGACCACCAGCACAACCGCAGAAATGATCAAGCTAATGGAAAATACTTTCCGTGACGTCA
ACATCGCCCTTGCCAACGAGTTCGCCCAAATCGCTGACGACTACGGCATAGACGTCTGGAAAGCCATCGAAATCGCAAAC
AAGCACCCTCGCGTAAGCATATTAAAACCCGGCCCAGGCGTAGGCGGTCACTGCATAGCTATCGATCCCTGGTTCCTCAC
CGAAAACGCCAACAACAGCAGCCTCATCATGATGTCCAGGCAGATAAACGACTCGATGCCCCAGTATGTTTTGAAGATGG
TAAAGGAAATTCTTGTAGGGATTGAGAATCCGACGATTACTGTTTTTGGGGTTGCGTATAAGGGAGATATTGCAGATACA
AGAGCTACTCCAGCAAAGAAGTTTATAAGGCTTGCAGAAAAGGAAGGGTTCAAGGTTAAGATTTACGATCCTTTTGTTAA
GGAGTGGAGCTATCCGATTCTGGAGTTAGGAGAGGCTGTGGAGGGAAGTGATTGTATAGTAGTTTTGACTGATCATTCAG
AATTTAAGGAAATGGATCCTGAAAAATTCGGTAGCAAAATGAATAAATTGAATATTATAGATACAAGAAATATCATTAAC
AAAAGTTTATGGAAAAAATCAGGATATAATATAAAAATCATTGGAAATGAGAGCTGA

Upstream 100 bases:

>100_bases
AAATTGAATTTATTTTTTGAGTAAAAACATTAAACTCCATAAAAAATATATAGAACAAATATTAAAAGTTAAAAACATAA
GATGAACCAGAGGTATATCT

Downstream 100 bases:

>100_bases
TAAAAAGAGATATTTAGCTTATAAAAAATCTAACTATATTATTGAAAGTTATGCTTAACTGTAGAGATTTAAACTTTTAT
ATCCAATTGAATTACTTGTG

Product: UDP-N-acetyl-D-mannosamine 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSKICVLGQGYIGLPTALLFANNGHEVVGIDVNKRVVDTLKAGKMPFEEKGFQELLDGAIAKNAFRAESLVEEADTFLVA
VPTPFDSEMRMADLKYVVSACEMIVPHLKKGNLVIIESTIPPKTCDKQVKQILEKSILKMCEDFYVSHCPERAIPGNTLH
EMVYNDRVIGGVDEKSTQLTAELYSSFVKGNLHLTTSTTAEMIKLMENTFRDVNIALANEFAQIADDYGIDVWKAIEIAN
KHPRVSILKPGPGVGGHCIAIDPWFLTENANNSSLIMMSRQINDSMPQYVLKMVKEILVGIENPTITVFGVAYKGDIADT
RATPAKKFIRLAEKEGFKVKIYDPFVKEWSYPILELGEAVEGSDCIVVLTDHSEFKEMDPEKFGSKMNKLNIIDTRNIIN
KSLWKKSGYNIKIIGNES

Sequences:

>Translated_418_residues
MSKICVLGQGYIGLPTALLFANNGHEVVGIDVNKRVVDTLKAGKMPFEEKGFQELLDGAIAKNAFRAESLVEEADTFLVA
VPTPFDSEMRMADLKYVVSACEMIVPHLKKGNLVIIESTIPPKTCDKQVKQILEKSILKMCEDFYVSHCPERAIPGNTLH
EMVYNDRVIGGVDEKSTQLTAELYSSFVKGNLHLTTSTTAEMIKLMENTFRDVNIALANEFAQIADDYGIDVWKAIEIAN
KHPRVSILKPGPGVGGHCIAIDPWFLTENANNSSLIMMSRQINDSMPQYVLKMVKEILVGIENPTITVFGVAYKGDIADT
RATPAKKFIRLAEKEGFKVKIYDPFVKEWSYPILELGEAVEGSDCIVVLTDHSEFKEMDPEKFGSKMNKLNIIDTRNIIN
KSLWKKSGYNIKIIGNES
>Mature_417_residues
SKICVLGQGYIGLPTALLFANNGHEVVGIDVNKRVVDTLKAGKMPFEEKGFQELLDGAIAKNAFRAESLVEEADTFLVAV
PTPFDSEMRMADLKYVVSACEMIVPHLKKGNLVIIESTIPPKTCDKQVKQILEKSILKMCEDFYVSHCPERAIPGNTLHE
MVYNDRVIGGVDEKSTQLTAELYSSFVKGNLHLTTSTTAEMIKLMENTFRDVNIALANEFAQIADDYGIDVWKAIEIANK
HPRVSILKPGPGVGGHCIAIDPWFLTENANNSSLIMMSRQINDSMPQYVLKMVKEILVGIENPTITVFGVAYKGDIADTR
ATPAKKFIRLAEKEGFKVKIYDPFVKEWSYPILELGEAVEGSDCIVVLTDHSEFKEMDPEKFGSKMNKLNIIDTRNIINK
SLWKKSGYNIKIIGNES

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=464, Percent_Identity=25.6465517241379, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI296040443, Length=457, Percent_Identity=22.9759299781182, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI296040438, Length=366, Percent_Identity=24.8633879781421, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI48994968, Length=421, Percent_Identity=38.7173396674584, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1788340, Length=368, Percent_Identity=27.7173913043478, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17560350, Length=461, Percent_Identity=26.6811279826464, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136908, Length=461, Percent_Identity=24.295010845987, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46559; Mature: 46428

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKICVLGQGYIGLPTALLFANNGHEVVGIDVNKRVVDTLKAGKMPFEEKGFQELLDGAI
CCCEEEECCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHH
AKNAFRAESLVEEADTFLVAVPTPFDSEMRMADLKYVVSACEMIVPHLKKGNLVIIESTI
HHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
PPKTCDKQVKQILEKSILKMCEDFYVSHCPERAIPGNTLHEMVYNDRVIGGVDEKSTQLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEECCCCCHHHHHH
AELYSSFVKGNLHLTTSTTAEMIKLMENTFRDVNIALANEFAQIADDYGIDVWKAIEIAN
HHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCHHHHHHHCC
KHPRVSILKPGPGVGGHCIAIDPWFLTENANNSSLIMMSRQINDSMPQYVLKMVKEILVG
CCCCEEEECCCCCCCCEEEEECCEEEECCCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHC
IENPTITVFGVAYKGDIADTRATPAKKFIRLAEKEGFKVKIYDPFVKEWSYPILELGEAV
CCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHCCCCHHHHCCCC
EGSDCIVVLTDHSEFKEMDPEKFGSKMNKLNIIDTRNIINKSLWKKSGYNIKIIGNES
CCCCEEEEEECCHHHHHCCHHHHCCHHHCEEEEEHHHHHHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
SKICVLGQGYIGLPTALLFANNGHEVVGIDVNKRVVDTLKAGKMPFEEKGFQELLDGAI
CCEEEECCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHH
AKNAFRAESLVEEADTFLVAVPTPFDSEMRMADLKYVVSACEMIVPHLKKGNLVIIESTI
HHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
PPKTCDKQVKQILEKSILKMCEDFYVSHCPERAIPGNTLHEMVYNDRVIGGVDEKSTQLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEECCCCCHHHHHH
AELYSSFVKGNLHLTTSTTAEMIKLMENTFRDVNIALANEFAQIADDYGIDVWKAIEIAN
HHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCHHHHHHHCC
KHPRVSILKPGPGVGGHCIAIDPWFLTENANNSSLIMMSRQINDSMPQYVLKMVKEILVG
CCCCEEEECCCCCCCCEEEEECCEEEECCCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHC
IENPTITVFGVAYKGDIADTRATPAKKFIRLAEKEGFKVKIYDPFVKEWSYPILELGEAV
CCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHCCCCHHHHCCCC
EGSDCIVVLTDHSEFKEMDPEKFGSKMNKLNIIDTRNIINKSLWKKSGYNIKIIGNES
CCCCEEEEEECCHHHHHCCHHHHCCHHHCEEEEEHHHHHHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA