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The map label for this gene is moeA [C]

Identifier: 21227148

GI number: 21227148

Start: 1222217

End: 1224211

Strand: Direct

Name: moeA [C]

Synonym: MM_1046

Alternate gene names: 21227148

Gene position: 1222217-1224211 (Clockwise)

Preceding gene: 21227147

Following gene: 21227149

Centisome position: 29.84

GC content: 47.42

Gene sequence:

>1995_bases
ATGCCGGGAAACGCTATTAAGTTAAAAAACAATCTGAAAACCGATAAGACTCAGGGTTTGATGCTGATGAAACGTAAAGA
ATTTCGGGAACTCGTCTCTGTAGAAGAAGCACGGAAAATAATAAACAGCCTTAAGGTCACTCCGGAAAAGGAATATCTGG
CCCTTGAAAACGCTTATGGAAAAACCCTTGCAGAGGATATAATTACCGAAATTAATGTCCCTCCTTTTCCAAGGGCGGTT
ATGGACGGTTATGCTGTCAGGGCAGAAGATACCTACGCAGGCAGTGAAAAAGTACCCGTAAAACTTAAACTCCTTGGAAA
TATCCCGGCAGGATCGGATGAAAAATTCAGGATTTCGGCAGGGGAAGCCGTGGAGATTGCGACAGGTGCCCCGATTCCCG
AAGGGGCTGATGCCGTGGTAATGGTCGAGTATACTTATGAAGAAAACGAGACTGTCTCCGTCCTCGGGGCTGTAACTGCA
GGGGAAAATATAATGAAAGCAGGTTCGGATATCCGGAAGGGGGAAAGAGTCCTGCGCAGGGGCAGAAAACTCGGCACAAG
AGAAATCGGGGTTCTGGCTTCCACAGGCAAAAAAGAAGTCCCCGTACTCAGGCTGCCCATAGGGATAATCTCAACAGGAG
ACGAACTTGTAAGTCCCGGAGAAAACCTGACTCAGGGAAAAGTGTACGATGCAAACTCTTATACGCTGTATGCAGGCGTT
AAGGAATGCGGAGCTTCCCCTCTTCTTTACGGGATTGTGAAAGACGACGAAAACCTGATGGAAAAAGTACTTGAAACTGC
AATTTCCGAATGTGCCCTGATCCTTACTTCCGGGAGCACGTCCTCAGGATCAGGGGACGTGATGTACAGGCTAATAGACA
GAGCAGGAGAGACCCTTGCCCATGGGGTCAATATAAAACCCGGAAAACCTGTTGTCATCGGCGTCATAAAAAGCGTTCCG
ATTATAGGGCTTCCGGGGAATCCCACGTCTGCTTTAATGATTTTCAATGAATTTGTGGCTCCTCTGCTTAGAAAATCCCT
TGGAGCGGGAGCAGGGACAAGGAAAACGGAAAAAGGAATAATGGGTACTGACCTGCGCTCCGAAGGCAGGCAGCAGCTCC
TTCCGGTTGGGATGGTCAGGGGAAGAGTTTATCCTGCAGACCGGGGTTCAGGCGCCATAACCTCCCTTTCCGGAGCAGAT
GGATTTATAGAAATTCCGCCGAAAACAGAGTTTATAGAGTCCGGGACGCCTGTGGAAGTGACCCTTTTTGGAGAAGTCGA
AAAACCGGACCTCCAGATATCAGGAGGTTTCTGTCCAGGGCTTGACGTTCTGGAAGACCTCAGCGGACTAAGGTTCAGGA
CACTTTATACGGGTTCAAGCGGGGGTTTCAGCGCAATTGCAGCAAAGACGGCAGATATTGCGGGTGTGAACTTACCCTCG
AAATCAAAGGGACAGGCAGAAGCTCTGTACAATATTCCGATAATGAAGAATATGGAGCTTTCAGAAGCTGTACTTGTCAG
GGGGTACAGGCGGGAAGTCGGGCTTCTTGTCAGGCTGGACAGCACGATTAAGGGACTTGAAGACCTGCCAGGAAAGCATT
TAATTAACCGGAACAGAGGGTCCGGGATAAGGGCACTCCTGGATTTGAAAATAGAGGAACTGGCAGGAGAGAAGGAGATT
AACAAAAAAGAGTTTACAGACTCGATACACGGATACTCTTCAGGAGCAAAATCCGAAGTTGCAGTCTGCGAAGCGGTTCT
TTCAGGAAAAGCTGATGCAGGAGTAGGTTTAAGAAACTGTGCAGAGAAAAATAATGACATAAAATTCATAAAAATTGCGG
AAGAGGAATATGATTTTCTGATCAGAAAAGAGGTCCTCGACACCCCTGAAGTCCAAAAATTCCTTCAAACCCTTGGCTCG
AAAGAATTTGCCTCAAAACTTCCTGCAGGGCTTCAGGTATGTGAGAGAACAGGAGAGATTATTTATAATGGATAA

Upstream 100 bases:

>100_bases
GTATTTTAGTTGAGAGTATTTTAGTTGAGAGTATTTTAGTTGAGAGTATTTTAGTTGAGAGTATTTTAGTTGAGACTTCT
AATGTTTAAAGTGTTGACAT

Downstream 100 bases:

>100_bases
AGGCATCTGCTATCCATAATTACCAGAAAGATATATCAATAAGGTTTAAATATTATTATACTTATTCAGTGATATAAATA
TAAATCTACTATGGAATCGG

Product: putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MPGNAIKLKNNLKTDKTQGLMLMKRKEFRELVSVEEARKIINSLKVTPEKEYLALENAYGKTLAEDIITEINVPPFPRAV
MDGYAVRAEDTYAGSEKVPVKLKLLGNIPAGSDEKFRISAGEAVEIATGAPIPEGADAVVMVEYTYEENETVSVLGAVTA
GENIMKAGSDIRKGERVLRRGRKLGTREIGVLASTGKKEVPVLRLPIGIISTGDELVSPGENLTQGKVYDANSYTLYAGV
KECGASPLLYGIVKDDENLMEKVLETAISECALILTSGSTSSGSGDVMYRLIDRAGETLAHGVNIKPGKPVVIGVIKSVP
IIGLPGNPTSALMIFNEFVAPLLRKSLGAGAGTRKTEKGIMGTDLRSEGRQQLLPVGMVRGRVYPADRGSGAITSLSGAD
GFIEIPPKTEFIESGTPVEVTLFGEVEKPDLQISGGFCPGLDVLEDLSGLRFRTLYTGSSGGFSAIAAKTADIAGVNLPS
KSKGQAEALYNIPIMKNMELSEAVLVRGYRREVGLLVRLDSTIKGLEDLPGKHLINRNRGSGIRALLDLKIEELAGEKEI
NKKEFTDSIHGYSSGAKSEVAVCEAVLSGKADAGVGLRNCAEKNNDIKFIKIAEEEYDFLIRKEVLDTPEVQKFLQTLGS
KEFASKLPAGLQVCERTGEIIYNG

Sequences:

>Translated_664_residues
MPGNAIKLKNNLKTDKTQGLMLMKRKEFRELVSVEEARKIINSLKVTPEKEYLALENAYGKTLAEDIITEINVPPFPRAV
MDGYAVRAEDTYAGSEKVPVKLKLLGNIPAGSDEKFRISAGEAVEIATGAPIPEGADAVVMVEYTYEENETVSVLGAVTA
GENIMKAGSDIRKGERVLRRGRKLGTREIGVLASTGKKEVPVLRLPIGIISTGDELVSPGENLTQGKVYDANSYTLYAGV
KECGASPLLYGIVKDDENLMEKVLETAISECALILTSGSTSSGSGDVMYRLIDRAGETLAHGVNIKPGKPVVIGVIKSVP
IIGLPGNPTSALMIFNEFVAPLLRKSLGAGAGTRKTEKGIMGTDLRSEGRQQLLPVGMVRGRVYPADRGSGAITSLSGAD
GFIEIPPKTEFIESGTPVEVTLFGEVEKPDLQISGGFCPGLDVLEDLSGLRFRTLYTGSSGGFSAIAAKTADIAGVNLPS
KSKGQAEALYNIPIMKNMELSEAVLVRGYRREVGLLVRLDSTIKGLEDLPGKHLINRNRGSGIRALLDLKIEELAGEKEI
NKKEFTDSIHGYSSGAKSEVAVCEAVLSGKADAGVGLRNCAEKNNDIKFIKIAEEEYDFLIRKEVLDTPEVQKFLQTLGS
KEFASKLPAGLQVCERTGEIIYNG
>Mature_663_residues
PGNAIKLKNNLKTDKTQGLMLMKRKEFRELVSVEEARKIINSLKVTPEKEYLALENAYGKTLAEDIITEINVPPFPRAVM
DGYAVRAEDTYAGSEKVPVKLKLLGNIPAGSDEKFRISAGEAVEIATGAPIPEGADAVVMVEYTYEENETVSVLGAVTAG
ENIMKAGSDIRKGERVLRRGRKLGTREIGVLASTGKKEVPVLRLPIGIISTGDELVSPGENLTQGKVYDANSYTLYAGVK
ECGASPLLYGIVKDDENLMEKVLETAISECALILTSGSTSSGSGDVMYRLIDRAGETLAHGVNIKPGKPVVIGVIKSVPI
IGLPGNPTSALMIFNEFVAPLLRKSLGAGAGTRKTEKGIMGTDLRSEGRQQLLPVGMVRGRVYPADRGSGAITSLSGADG
FIEIPPKTEFIESGTPVEVTLFGEVEKPDLQISGGFCPGLDVLEDLSGLRFRTLYTGSSGGFSAIAAKTADIAGVNLPSK
SKGQAEALYNIPIMKNMELSEAVLVRGYRREVGLLVRLDSTIKGLEDLPGKHLINRNRGSGIRALLDLKIEELAGEKEIN
KKEFTDSIHGYSSGAKSEVAVCEAVLSGKADAGVGLRNCAEKNNDIKFIKIAEEEYDFLIRKEVLDTPEVQKFLQTLGSK
EFASKLPAGLQVCERTGEIIYNG

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=430, Percent_Identity=33.953488372093, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI66932975, Length=429, Percent_Identity=33.5664335664336, Blast_Score=193, Evalue=4e-49,
Organism=Escherichia coli, GI1787049, Length=304, Percent_Identity=37.5, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI25147659, Length=333, Percent_Identity=34.8348348348348, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=305, Percent_Identity=26.5573770491803, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17136978, Length=358, Percent_Identity=29.3296089385475, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24638841, Length=358, Percent_Identity=29.3296089385475, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 71195; Mature: 71064

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGNAIKLKNNLKTDKTQGLMLMKRKEFRELVSVEEARKIINSLKVTPEKEYLALENAYG
CCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEHHHHH
KTLAEDIITEINVPPFPRAVMDGYAVRAEDTYAGSEKVPVKLKLLGNIPAGSDEKFRISA
HHHHHHHHHHCCCCCCCHHHHCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEEEEEC
GEAVEIATGAPIPEGADAVVMVEYTYEENETVSVLGAVTAGENIMKAGSDIRKGERVLRR
CCEEEEECCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCHHHHCCCHHHHHHHHHHH
GRKLGTREIGVLASTGKKEVPVLRLPIGIISTGDELVSPGENLTQGKVYDANSYTLYAGV
HHHCCCCCEEEEECCCCCCCCEEEECEEEEECCHHHHCCCCCCCCCEEEECCCEEEEECH
KECGASPLLYGIVKDDENLMEKVLETAISECALILTSGSTSSGSGDVMYRLIDRAGETLA
HHHCCCCEEEEEEECCHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHCCHHHH
HGVNIKPGKPVVIGVIKSVPIIGLPGNPTSALMIFNEFVAPLLRKSLGAGAGTRKTEKGI
CCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MGTDLRSEGRQQLLPVGMVRGRVYPADRGSGAITSLSGADGFIEIPPKTEFIESGTPVEV
CCCCHHHCCHHHHCCHHHHCCEEECCCCCCCCEEEECCCCCEEECCCCCHHHCCCCCEEE
TLFGEVEKPDLQISGGFCPGLDVLEDLSGLRFRTLYTGSSGGFSAIAAKTADIAGVNLPS
EEEECCCCCCEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHCCCCCEECCCCCC
KSKGQAEALYNIPIMKNMELSEAVLVRGYRREVGLLVRLDSTIKGLEDLPGKHLINRNRG
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHCCCCC
SGIRALLDLKIEELAGEKEINKKEFTDSIHGYSSGAKSEVAVCEAVLSGKADAGVGLRNC
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
AEKNNDIKFIKIAEEEYDFLIRKEVLDTPEVQKFLQTLGSKEFASKLPAGLQVCERTGEI
HCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHCCCE
IYNG
EECC
>Mature Secondary Structure 
PGNAIKLKNNLKTDKTQGLMLMKRKEFRELVSVEEARKIINSLKVTPEKEYLALENAYG
CCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEHHHHH
KTLAEDIITEINVPPFPRAVMDGYAVRAEDTYAGSEKVPVKLKLLGNIPAGSDEKFRISA
HHHHHHHHHHCCCCCCCHHHHCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEEEEEC
GEAVEIATGAPIPEGADAVVMVEYTYEENETVSVLGAVTAGENIMKAGSDIRKGERVLRR
CCEEEEECCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCHHHHCCCHHHHHHHHHHH
GRKLGTREIGVLASTGKKEVPVLRLPIGIISTGDELVSPGENLTQGKVYDANSYTLYAGV
HHHCCCCCEEEEECCCCCCCCEEEECEEEEECCHHHHCCCCCCCCCEEEECCCEEEEECH
KECGASPLLYGIVKDDENLMEKVLETAISECALILTSGSTSSGSGDVMYRLIDRAGETLA
HHHCCCCEEEEEEECCHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHCCHHHH
HGVNIKPGKPVVIGVIKSVPIIGLPGNPTSALMIFNEFVAPLLRKSLGAGAGTRKTEKGI
CCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MGTDLRSEGRQQLLPVGMVRGRVYPADRGSGAITSLSGADGFIEIPPKTEFIESGTPVEV
CCCCHHHCCHHHHCCHHHHCCEEECCCCCCCCEEEECCCCCEEECCCCCHHHCCCCCEEE
TLFGEVEKPDLQISGGFCPGLDVLEDLSGLRFRTLYTGSSGGFSAIAAKTADIAGVNLPS
EEEECCCCCCEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHCCCCCEECCCCCC
KSKGQAEALYNIPIMKNMELSEAVLVRGYRREVGLLVRLDSTIKGLEDLPGKHLINRNRG
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECHHHHHHHHCCCCHHHCCCCC
SGIRALLDLKIEELAGEKEINKKEFTDSIHGYSSGAKSEVAVCEAVLSGKADAGVGLRNC
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
AEKNNDIKFIKIAEEEYDFLIRKEVLDTPEVQKFLQTLGSKEFASKLPAGLQVCERTGEI
HCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHCCCE
IYNG
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]