Click here to switch to the map view.

The map label for this gene is yfcY [C]

Identifier: 21226972

GI number: 21226972

Start: 1028232

End: 1029404

Strand: Reverse

Name: yfcY [C]

Synonym: MM_0870

Alternate gene names: 21226972

Gene position: 1029404-1028232 (Counterclockwise)

Preceding gene: 21226973

Following gene: 21226971

Centisome position: 25.13

GC content: 50.72

Gene sequence:

>1173_bases
ATGAGAGACGTAGCAATTATCGGAGTAAAGAATACTAAATTTGGCGAACTCTGGGAGCGCTCCTTAAGAGACATAGTCGT
GGAAGCCGGAATCGGAGCAATCCAGGACGCAGGAGTAAGCGGAAAAGATATTGATGCCCTTTATATTGGAAACATGAGTG
GAGGCCGCTTTGTTGAGCAGGAACACATAGGCGCACTCATCGCAGATTATTCCGGGCTTTCAAGGAACCTTCATGTCCCG
GCTACCAGGGTGGAGGCTGCCTGTGCATCTGGAGGGCTTGCCCTGCGCCAGGCTATAATGGCTGTGGCTTCAGGTTACAG
CGAAATCGTGGTCGCAGCAGGGGCAGAGAAAATGACAGATGTAGGCTCTGAAGAAGCATCTTCGGCTCTTGCGGCAGCCG
CTGACCGTGAATGGGAAGGCATGGCAGGAGCAACATTTCCCGGGCTGTATGCAATGATTGCAAAGCTTCACATGCATATG
TACGGAACCACAGGTGAGCAGCTTGCGGAAGTAGCTGTGAAGAACCACAAAAACGGATCTTTTAACCCTATTGCCCAGTA
CAAGAACACAATCACCGTAGATAATGTTCTGAACTCAATAATGGTAGCTGACCCGTTGCATATCTTTGACTGCTCTCCGA
TAACAGATGGAGCATCTGCGCTTGTCCTTGCACCTGCGGAGATTGCCCACAAATATACCGACACCCCAATTTACATTAAA
GCAACAGCACAGGCAAGCGATACAATTGCCCTGCATGACAGGAGAGACATCACAACTCTGGATGCAACCGTGATGGCTGC
AAAGCGGGCATATTCTATGGCAAAACTTACCCCTGAAGATATCGACCTGGTAGAGGTCCATGACTGCTTTACCATTGCCG
AGATCTGTGCAATTGAAGACCTCGGCTTTGCAGAGAAAGGTAAAGGCGGAATTGTCACAGAAAACGGAGAAACCGCAATT
GGAGGCAGGATTCCTGTCAACACATCCGGCGGCCTTAAAGCCTGCGGGCATCCTGTAGGGGCAACCGGAATAAAACAGGC
GGTGGAAATCGTAACCCAGCTGCGTGGAGAAGCAGGAAAGCGCCAGGTAGAAGGAGCTGAGTACGGGATGACCCATAACG
TCGGAGGGTCAGGAGCGACAGCAGTAGTACATATTTTCTCGAGGGGGATGTGA

Upstream 100 bases:

>100_bases
CGGTTTCCGAACTTATCAAGGATCCTGTATACATCGACTACGCAAGGTATGCCAGGCATAAAGGCAAGATCCGCCTGGCC
TGAAAACGGGGTGAATAATA

Downstream 100 bases:

>100_bases
TATTCGATGTCTTCTGTTCCAAGATTCTGGAGAAACCTCGGCAGCAGGTATAACCTTGAAGGCACCCGCTGCAAGGAATG
CGGGGAATATTTCTATCCCC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MRDVAIIGVKNTKFGELWERSLRDIVVEAGIGAIQDAGVSGKDIDALYIGNMSGGRFVEQEHIGALIADYSGLSRNLHVP
ATRVEAACASGGLALRQAIMAVASGYSEIVVAAGAEKMTDVGSEEASSALAAAADREWEGMAGATFPGLYAMIAKLHMHM
YGTTGEQLAEVAVKNHKNGSFNPIAQYKNTITVDNVLNSIMVADPLHIFDCSPITDGASALVLAPAEIAHKYTDTPIYIK
ATAQASDTIALHDRRDITTLDATVMAAKRAYSMAKLTPEDIDLVEVHDCFTIAEICAIEDLGFAEKGKGGIVTENGETAI
GGRIPVNTSGGLKACGHPVGATGIKQAVEIVTQLRGEAGKRQVEGAEYGMTHNVGGSGATAVVHIFSRGM

Sequences:

>Translated_390_residues
MRDVAIIGVKNTKFGELWERSLRDIVVEAGIGAIQDAGVSGKDIDALYIGNMSGGRFVEQEHIGALIADYSGLSRNLHVP
ATRVEAACASGGLALRQAIMAVASGYSEIVVAAGAEKMTDVGSEEASSALAAAADREWEGMAGATFPGLYAMIAKLHMHM
YGTTGEQLAEVAVKNHKNGSFNPIAQYKNTITVDNVLNSIMVADPLHIFDCSPITDGASALVLAPAEIAHKYTDTPIYIK
ATAQASDTIALHDRRDITTLDATVMAAKRAYSMAKLTPEDIDLVEVHDCFTIAEICAIEDLGFAEKGKGGIVTENGETAI
GGRIPVNTSGGLKACGHPVGATGIKQAVEIVTQLRGEAGKRQVEGAEYGMTHNVGGSGATAVVHIFSRGM
>Mature_390_residues
MRDVAIIGVKNTKFGELWERSLRDIVVEAGIGAIQDAGVSGKDIDALYIGNMSGGRFVEQEHIGALIADYSGLSRNLHVP
ATRVEAACASGGLALRQAIMAVASGYSEIVVAAGAEKMTDVGSEEASSALAAAADREWEGMAGATFPGLYAMIAKLHMHM
YGTTGEQLAEVAVKNHKNGSFNPIAQYKNTITVDNVLNSIMVADPLHIFDCSPITDGASALVLAPAEIAHKYTDTPIYIK
ATAQASDTIALHDRRDITTLDATVMAAKRAYSMAKLTPEDIDLVEVHDCFTIAEICAIEDLGFAEKGKGGIVTENGETAI
GGRIPVNTSGGLKACGHPVGATGIKQAVEIVTQLRGEAGKRQVEGAEYGMTHNVGGSGATAVVHIFSRGM

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=405, Percent_Identity=34.0740740740741, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI302344767, Length=324, Percent_Identity=35.4938271604938, Blast_Score=191, Evalue=7e-49,
Organism=Homo sapiens, GI302344760, Length=324, Percent_Identity=35.4938271604938, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI302344762, Length=309, Percent_Identity=35.5987055016181, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI55956775, Length=262, Percent_Identity=33.206106870229, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17537653, Length=393, Percent_Identity=31.8066157760814, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI19921506, Length=395, Percent_Identity=33.4177215189873, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24585051, Length=395, Percent_Identity=32.1518987341772, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 40828; Mature: 40828

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDVAIIGVKNTKFGELWERSLRDIVVEAGIGAIQDAGVSGKDIDALYIGNMSGGRFVEQ
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCEEEEECCCCCCEECH
EHIGALIADYSGLSRNLHVPATRVEAACASGGLALRQAIMAVASGYSEIVVAAGAEKMTD
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHH
VGSEEASSALAAAADREWEGMAGATFPGLYAMIAKLHMHMYGTTGEQLAEVAVKNHKNGS
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
FNPIAQYKNTITVDNVLNSIMVADPLHIFDCSPITDGASALVLAPAEIAHKYTDTPIYIK
CCHHHHHCCCEEHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEECHHHHHHCCCCCEEEE
ATAQASDTIALHDRRDITTLDATVMAAKRAYSMAKLTPEDIDLVEVHDCFTIAEICAIED
EECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHC
LGFAEKGKGGIVTENGETAIGGRIPVNTSGGLKACGHPVGATGIKQAVEIVTQLRGEAGK
CCCCCCCCCCEEECCCCEEECCEECCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCC
RQVEGAEYGMTHNVGGSGATAVVHIFSRGM
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRDVAIIGVKNTKFGELWERSLRDIVVEAGIGAIQDAGVSGKDIDALYIGNMSGGRFVEQ
CCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCEEEEECCCCCCEECH
EHIGALIADYSGLSRNLHVPATRVEAACASGGLALRQAIMAVASGYSEIVVAAGAEKMTD
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHH
VGSEEASSALAAAADREWEGMAGATFPGLYAMIAKLHMHMYGTTGEQLAEVAVKNHKNGS
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
FNPIAQYKNTITVDNVLNSIMVADPLHIFDCSPITDGASALVLAPAEIAHKYTDTPIYIK
CCHHHHHCCCEEHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEECHHHHHHCCCCCEEEE
ATAQASDTIALHDRRDITTLDATVMAAKRAYSMAKLTPEDIDLVEVHDCFTIAEICAIED
EECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHC
LGFAEKGKGGIVTENGETAIGGRIPVNTSGGLKACGHPVGATGIKQAVEIVTQLRGEAGK
CCCCCCCCCCEEECCCCEEECCEECCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCC
RQVEGAEYGMTHNVGGSGATAVVHIFSRGM
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]