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The map label for this gene is moeA [C]

Identifier: 21226932

GI number: 21226932

Start: 980136

End: 981326

Strand: Reverse

Name: moeA [C]

Synonym: MM_0830

Alternate gene names: 21226932

Gene position: 981326-980136 (Counterclockwise)

Preceding gene: 21226933

Following gene: 21226931

Centisome position: 23.96

GC content: 49.96

Gene sequence:

>1191_bases
GTGGGCAGGATATTCAAAGAACGTACTTCCGTTGACGAGGCTTTGGAGCTTTTCTTTGAGAGCTTTTCTTCTCTGAGTCA
CACTGAAGAAGTACCGCTTGAAGCCTGTACGGGCAGGGTACTTGCAGAGCCTGTAATTTCCGGAAGGGATGTCCCTCACT
ACAGGCGCGCTGCAATGGATGGATATGCTGTCAGGTCATCTGATACTTCGGGAGCTTCTCCTTCAAATCCTGTGTTTTTG
CAGCTTTCGGATTGCGTAGAGGAAGGAACTGCTATGTGGGTTCATACGGGAGCTGTTCTGCCTGAAGGGGCTGATGCTGT
TGTGGTGGTTGAGGACACCGTTACAGCCGGAAACATGGTTGAAATCAGGGCTCAGGTCCATCCGGGAAAGAATGTGGGAC
AGGCTGGAGAGGATATCAAAAAAGAAAATCTGGTTTTTAAGGAAGGTCACCTCCTTCGCCCCTGTGATGCTGCAGTTCTT
GCCTCTCTCGGACTGGATATGGCGAAGGTTTTCAGAAAACCTGTGGTTGTGGTCATCCCTACAGGAGATGAACTGGTAAG
CCGTGAAAAGGCCGGGCAAGTTCCTCCCCCCGGAATGGTGCTCGAAACGAACGGGCTTATGACTGCTCTTTATGTGGAAA
AGTGGGGTGGAGTTCCCAGACATACAGGTATCGTGCCTGACCGTCCTGAGAGTATAAAAGAAGCCATAGAGGCAAACCTT
GACGCTGACATGATTCTCCTGTCCGGCGGGACTTCGGTCGGCAAAAGAGACCATGCTCCCGAAGTTGTGGAATCTCTGGG
AAAACTGCTTGTCCATGGGGTGGCGGTCAGTCCTGGAAAGCCAGCAGCGCTTGGGGTTATAGGTAAAACTCCTGTGGTTT
GCCTTCCAGGCTACCCGGTTGCTGGGCTTGTTGCCCTGTATTTCTTTGTCCGTCCCGGGATAAGGAAGCTTGGATCAATA
CCCAAAGTGCCGGAATTTGTCTTTAGAAGGCGGCTGGCTGCAAAAATAAGTTCTAAAATAGGTTATGTCAATTTTGTCCG
GGTTGTTTTTGAAGGGGATAAAATACGCCCTCTTACTGGAAAGGCAGGAGTTCTGAGCTCGGTTGCAAAGGCTGACGGTT
ACGTGCTGGTGCCTGAAAATATAGAAGGTTATGAAGAGGGGCAGGAAGTTGATGTTTTTTTAATTGAGTGA

Upstream 100 bases:

>100_bases
CAGGCACCTTGAAGGGCTTGACACTGACCTTAAAGATTCGGATGAAATTGGGGTTCTTCCTCCTGTCTCCGGAGGATAAG
TTTTCAGGGGGGCCAGGATT

Downstream 100 bases:

>100_bases
AAAAAACATCAATAAGCAGCTATGGCTTACTTCCTCCACTTTTCTCTTCTTTTAAAATAAATAGTATTTTATACTTGTAG
GAGGTAATAGGAAAGAATTA

Product: molybdopterin biosynthesis MoeA protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MGRIFKERTSVDEALELFFESFSSLSHTEEVPLEACTGRVLAEPVISGRDVPHYRRAAMDGYAVRSSDTSGASPSNPVFL
QLSDCVEEGTAMWVHTGAVLPEGADAVVVVEDTVTAGNMVEIRAQVHPGKNVGQAGEDIKKENLVFKEGHLLRPCDAAVL
ASLGLDMAKVFRKPVVVVIPTGDELVSREKAGQVPPPGMVLETNGLMTALYVEKWGGVPRHTGIVPDRPESIKEAIEANL
DADMILLSGGTSVGKRDHAPEVVESLGKLLVHGVAVSPGKPAALGVIGKTPVVCLPGYPVAGLVALYFFVRPGIRKLGSI
PKVPEFVFRRRLAAKISSKIGYVNFVRVVFEGDKIRPLTGKAGVLSSVAKADGYVLVPENIEGYEEGQEVDVFLIE

Sequences:

>Translated_396_residues
MGRIFKERTSVDEALELFFESFSSLSHTEEVPLEACTGRVLAEPVISGRDVPHYRRAAMDGYAVRSSDTSGASPSNPVFL
QLSDCVEEGTAMWVHTGAVLPEGADAVVVVEDTVTAGNMVEIRAQVHPGKNVGQAGEDIKKENLVFKEGHLLRPCDAAVL
ASLGLDMAKVFRKPVVVVIPTGDELVSREKAGQVPPPGMVLETNGLMTALYVEKWGGVPRHTGIVPDRPESIKEAIEANL
DADMILLSGGTSVGKRDHAPEVVESLGKLLVHGVAVSPGKPAALGVIGKTPVVCLPGYPVAGLVALYFFVRPGIRKLGSI
PKVPEFVFRRRLAAKISSKIGYVNFVRVVFEGDKIRPLTGKAGVLSSVAKADGYVLVPENIEGYEEGQEVDVFLIE
>Mature_395_residues
GRIFKERTSVDEALELFFESFSSLSHTEEVPLEACTGRVLAEPVISGRDVPHYRRAAMDGYAVRSSDTSGASPSNPVFLQ
LSDCVEEGTAMWVHTGAVLPEGADAVVVVEDTVTAGNMVEIRAQVHPGKNVGQAGEDIKKENLVFKEGHLLRPCDAAVLA
SLGLDMAKVFRKPVVVVIPTGDELVSREKAGQVPPPGMVLETNGLMTALYVEKWGGVPRHTGIVPDRPESIKEAIEANLD
ADMILLSGGTSVGKRDHAPEVVESLGKLLVHGVAVSPGKPAALGVIGKTPVVCLPGYPVAGLVALYFFVRPGIRKLGSIP
KVPEFVFRRRLAAKISSKIGYVNFVRVVFEGDKIRPLTGKAGVLSSVAKADGYVLVPENIEGYEEGQEVDVFLIE

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=415, Percent_Identity=30.1204819277108, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI66932975, Length=415, Percent_Identity=30.1204819277108, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1787049, Length=381, Percent_Identity=34.3832020997375, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI25147659, Length=336, Percent_Identity=29.4642857142857, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17562606, Length=336, Percent_Identity=25.8928571428571, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17136978, Length=326, Percent_Identity=28.5276073619632, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24638841, Length=326, Percent_Identity=28.5276073619632, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42324; Mature: 42193

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRIFKERTSVDEALELFFESFSSLSHTEEVPLEACTGRVLAEPVISGRDVPHYRRAAMD
CCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHCCCCCCHHHHHHCC
GYAVRSSDTSGASPSNPVFLQLSDCVEEGTAMWVHTGAVLPEGADAVVVVEDTVTAGNMV
CEEEECCCCCCCCCCCCEEEEEHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEE
EIRAQVHPGKNVGQAGEDIKKENLVFKEGHLLRPCDAAVLASLGLDMAKVFRKPVVVVIP
EEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCCHHHHHHHHHCHHHHHHHHCCEEEEEC
TGDELVSREKAGQVPPPGMVLETNGLMTALYVEKWGGVPRHTGIVPDRPESIKEAIEANL
CCHHHHHHHHCCCCCCCCEEEECCCCEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHCCC
DADMILLSGGTSVGKRDHAPEVVESLGKLLVHGVAVSPGKPAALGVIGKTPVVCLPGYPV
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCEEECCCCCCEEEEECCCCEEEECCCCH
AGLVALYFFVRPGIRKLGSIPKVPEFVFRRRLAAKISSKIGYVNFVRVVFEGDKIRPLTG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEECCC
KAGVLSSVAKADGYVLVPENIEGYEEGQEVDVFLIE
CHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure 
GRIFKERTSVDEALELFFESFSSLSHTEEVPLEACTGRVLAEPVISGRDVPHYRRAAMD
CCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHCCCCCCHHHHHHCC
GYAVRSSDTSGASPSNPVFLQLSDCVEEGTAMWVHTGAVLPEGADAVVVVEDTVTAGNMV
CEEEECCCCCCCCCCCCEEEEEHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCCCCCEE
EIRAQVHPGKNVGQAGEDIKKENLVFKEGHLLRPCDAAVLASLGLDMAKVFRKPVVVVIP
EEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCCHHHHHHHHHCHHHHHHHHCCEEEEEC
TGDELVSREKAGQVPPPGMVLETNGLMTALYVEKWGGVPRHTGIVPDRPESIKEAIEANL
CCHHHHHHHHCCCCCCCCEEEECCCCEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHCCC
DADMILLSGGTSVGKRDHAPEVVESLGKLLVHGVAVSPGKPAALGVIGKTPVVCLPGYPV
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCEEECCCCCCEEEEECCCCEEEECCCCH
AGLVALYFFVRPGIRKLGSIPKVPEFVFRRRLAAKISSKIGYVNFVRVVFEGDKIRPLTG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEECCC
KAGVLSSVAKADGYVLVPENIEGYEEGQEVDVFLIE
CHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]