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The map label for this gene is proA [H]

Identifier: 21226921

GI number: 21226921

Start: 969941

End: 971284

Strand: Reverse

Name: proA [H]

Synonym: MM_0819

Alternate gene names: 21226921

Gene position: 971284-969941 (Counterclockwise)

Preceding gene: 21226923

Following gene: 21226920

Centisome position: 23.71

GC content: 45.76

Gene sequence:

>1344_bases
ATGGCTAATGATATTGAATCTAAAGTAATTAAAGCAAAAAAAGCTTCAATTGAGCTTGCCAGTGTAAGCTCCGAGGTAAA
AAACAGGGCTCTTGAAGCTATGGCGGAAGCCCTTGATAAAGAGAGAAAAATCATCCTTGAAGCGAATTTAAAGGATCTTG
AATATGCAGCCCAACTGAAAAAAGCCGGAAAGCTTACTCAGGCTCTTGTAGACCGGCTTAAGGTTACGGACTCAAAAGTT
GACGGGATGATTGCAGGAATCAGAGACGTAATAAAACTTAAAGACCCTGTGGGAGAAACCCTTTCCACTCTTGAACTCGA
TGACGACCTGATCCTCTACCAGGTCAGCTGCCCTATAGGTCTTATAGGGGTAATTTTTGAGTCCAGGCCTGACGTGGTGC
CCCAGGTAATGTCTCTCTGCCTGAAAAGTGGCAATGCAACCATTTTCAAAGGGGGAAGCGAAGCCAGGGAGTCTAACCGT
ACTATTTTCGATATTCTTGTAAGAGCCATAGAGTCCACCGGGGGCATGCCTGAAGGGGCGTTCCAGCTTATGGAAACCAG
GGAAGAAATCATGAGCCTTCTGAGCCTTGATGCGTATGTCGACCTCCTTATCCCCAGAGGGTCCAATGAATTTGTCAAAT
TTATCCAGGACAATACAAAAATCCCTGTACTCGGGCATACAAGCGGCATCTGCCACATCTATGTGGACGAATTTGCAGAC
CCTGATACAGCCTGGCAGGTCTGTTTTGATGCCAAAGTCCAGTACCCCGCAGTTTGCAATGCCATAGAAACCCTTCTTGT
GAACCGCAATATTGCAGAAGTTTTCCTGCCCAAAATGGCTGAAATGTATCTAAAGGCAGGGGTTGAACTGCGCTGCGATG
AAGGTAGTTATTCTCTGCTCTCAGAAAAAGGGCTATCTCCCCTTTCAAGAGCAACTGATGAGGACTGGAGCCTTGAATAC
AATGACCTTATCCTCTCAATAAAACTCGTAGATACCATTAAGGAAGCAGTTGACCACATAAACACCTTTGGTTCCCATCA
CACAGACGGGATAATCACGGAAAACGCTTCCCGCAGGAAGGAGTTCATAGGGCTTGTTGACTCTTCAAGCGTTATGGTGA
ACGCTTCAACACGTTTTGCTGACGGTTACAGATATGGAAAAGGTGCCGAAGTCGGGATCAGCACAAATAAGATCCATTCG
CGCGGGCCTGTCGGTATGGAAGGGCTGTTAATTTACAAGTATATCCTCATGGGTAAAGGGCAGGTTGTTGCAGACTATGC
AGGAAAAAATGCAAAACCCTATACTCACAGGAAGCTTGACCTTAAGTTCGAGGATGTGAATTAA

Upstream 100 bases:

>100_bases
TTTGATTTTCAGGTCTGAATAGATAATTGAATCTGGTCCAGAACCTGTTTCAGGCTTATGTGGGCAAAGCCCTCGCAATT
ATTGCAAAGACGGTGAGTAT

Downstream 100 bases:

>100_bases
CACATCCCTGATAATTTCTGATATGTTTATATATTTGAATCGAAATACCAGCGCAGGTTAAGTGCAAAAACCGGAAACCC
GGCTATTATAGAAATCAAGC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MANDIESKVIKAKKASIELASVSSEVKNRALEAMAEALDKERKIILEANLKDLEYAAQLKKAGKLTQALVDRLKVTDSKV
DGMIAGIRDVIKLKDPVGETLSTLELDDDLILYQVSCPIGLIGVIFESRPDVVPQVMSLCLKSGNATIFKGGSEARESNR
TIFDILVRAIESTGGMPEGAFQLMETREEIMSLLSLDAYVDLLIPRGSNEFVKFIQDNTKIPVLGHTSGICHIYVDEFAD
PDTAWQVCFDAKVQYPAVCNAIETLLVNRNIAEVFLPKMAEMYLKAGVELRCDEGSYSLLSEKGLSPLSRATDEDWSLEY
NDLILSIKLVDTIKEAVDHINTFGSHHTDGIITENASRRKEFIGLVDSSSVMVNASTRFADGYRYGKGAEVGISTNKIHS
RGPVGMEGLLIYKYILMGKGQVVADYAGKNAKPYTHRKLDLKFEDVN

Sequences:

>Translated_447_residues
MANDIESKVIKAKKASIELASVSSEVKNRALEAMAEALDKERKIILEANLKDLEYAAQLKKAGKLTQALVDRLKVTDSKV
DGMIAGIRDVIKLKDPVGETLSTLELDDDLILYQVSCPIGLIGVIFESRPDVVPQVMSLCLKSGNATIFKGGSEARESNR
TIFDILVRAIESTGGMPEGAFQLMETREEIMSLLSLDAYVDLLIPRGSNEFVKFIQDNTKIPVLGHTSGICHIYVDEFAD
PDTAWQVCFDAKVQYPAVCNAIETLLVNRNIAEVFLPKMAEMYLKAGVELRCDEGSYSLLSEKGLSPLSRATDEDWSLEY
NDLILSIKLVDTIKEAVDHINTFGSHHTDGIITENASRRKEFIGLVDSSSVMVNASTRFADGYRYGKGAEVGISTNKIHS
RGPVGMEGLLIYKYILMGKGQVVADYAGKNAKPYTHRKLDLKFEDVN
>Mature_446_residues
ANDIESKVIKAKKASIELASVSSEVKNRALEAMAEALDKERKIILEANLKDLEYAAQLKKAGKLTQALVDRLKVTDSKVD
GMIAGIRDVIKLKDPVGETLSTLELDDDLILYQVSCPIGLIGVIFESRPDVVPQVMSLCLKSGNATIFKGGSEARESNRT
IFDILVRAIESTGGMPEGAFQLMETREEIMSLLSLDAYVDLLIPRGSNEFVKFIQDNTKIPVLGHTSGICHIYVDEFADP
DTAWQVCFDAKVQYPAVCNAIETLLVNRNIAEVFLPKMAEMYLKAGVELRCDEGSYSLLSEKGLSPLSRATDEDWSLEYN
DLILSIKLVDTIKEAVDHINTFGSHHTDGIITENASRRKEFIGLVDSSSVMVNASTRFADGYRYGKGAEVGISTNKIHSR
GPVGMEGLLIYKYILMGKGQVVADYAGKNAKPYTHRKLDLKFEDVN

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=446, Percent_Identity=41.2556053811659, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI62912457, Length=446, Percent_Identity=41.2556053811659, Blast_Score=325, Evalue=4e-89,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=40.3846153846154, Blast_Score=318, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI17569967, Length=440, Percent_Identity=41.3636363636364, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI17569969, Length=440, Percent_Identity=41.3636363636364, Blast_Score=322, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6324899, Length=449, Percent_Identity=43.8752783964365, Blast_Score=349, Evalue=5e-97,
Organism=Drosophila melanogaster, GI21357643, Length=445, Percent_Identity=39.7752808988764, Blast_Score=318, Evalue=5e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 49255; Mature: 49124

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANDIESKVIKAKKASIELASVSSEVKNRALEAMAEALDKERKIILEANLKDLEYAAQLK
CCCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
KAGKLTQALVDRLKVTDSKVDGMIAGIRDVIKLKDPVGETLSTLELDDDLILYQVSCPIG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCEEEEEECCCCE
LIGVIFESRPDVVPQVMSLCLKSGNATIFKGGSEARESNRTIFDILVRAIESTGGMPEGA
EHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHCCCHHHHHHHHHHHHCCCCCHHH
FQLMETREEIMSLLSLDAYVDLLIPRGSNEFVKFIQDNTKIPVLGHTSGICHIYVDEFAD
HHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCCCEEEEECCCCEEEEEECCCCC
PDTAWQVCFDAKVQYPAVCNAIETLLVNRNIAEVFLPKMAEMYLKAGVELRCDEGSYSLL
CCHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHH
SEKGLSPLSRATDEDWSLEYNDLILSIKLVDTIKEAVDHINTFGSHHTDGIITENASRRK
HHCCCCHHHHCCCCCCCEEECCEEEEEHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHH
EFIGLVDSSSVMVNASTRFADGYRYGKGAEVGISTNKIHSRGPVGMEGLLIYKYILMGKG
HHHEEECCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHCCC
QVVADYAGKNAKPYTHRKLDLKFEDVN
CEEEECCCCCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
ANDIESKVIKAKKASIELASVSSEVKNRALEAMAEALDKERKIILEANLKDLEYAAQLK
CCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHH
KAGKLTQALVDRLKVTDSKVDGMIAGIRDVIKLKDPVGETLSTLELDDDLILYQVSCPIG
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCEEEEEECCCCE
LIGVIFESRPDVVPQVMSLCLKSGNATIFKGGSEARESNRTIFDILVRAIESTGGMPEGA
EHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHCCCHHHHHHHHHHHHCCCCCHHH
FQLMETREEIMSLLSLDAYVDLLIPRGSNEFVKFIQDNTKIPVLGHTSGICHIYVDEFAD
HHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHCCCCEEEEECCCCEEEEEECCCCC
PDTAWQVCFDAKVQYPAVCNAIETLLVNRNIAEVFLPKMAEMYLKAGVELRCDEGSYSLL
CCHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHH
SEKGLSPLSRATDEDWSLEYNDLILSIKLVDTIKEAVDHINTFGSHHTDGIITENASRRK
HHCCCCHHHHCCCCCCCEEECCEEEEEHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHH
EFIGLVDSSSVMVNASTRFADGYRYGKGAEVGISTNKIHSRGPVGMEGLLIYKYILMGKG
HHHEEECCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHCCC
QVVADYAGKNAKPYTHRKLDLKFEDVN
CEEEECCCCCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]