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The map label for this gene is hmgA [H]

Identifier: 21226437

GI number: 21226437

Start: 441695

End: 442951

Strand: Direct

Name: hmgA [H]

Synonym: MM_0335

Alternate gene names: 21226437

Gene position: 441695-442951 (Clockwise)

Preceding gene: 21226436

Following gene: 21226438

Centisome position: 10.78

GC content: 46.86

Gene sequence:

>1257_bases
ATGTTTACGGAAGCTTATGAACTTACTGAGGAAGAGAAACTTCTTTTACAAAAGGTTCTCGATGGAGATATAGCATTTCG
CAAGATTGAAGAATTTGCAGACCCGCTGACAGCCGTAAAGATCCGAAGGCTTGCTATTCAGGAGTATGGAAAACTGGAAT
TTGAGCATATACAGAATTTCTCACTGGACGTGGAAAGCGTAACAAAGAGAAATATCGAAAACATGATAGGCGCAGTCCAG
ATCCCTCTGGGAGTTGCCGGGCTTCTGAAAGTAAACGGAGAATATGCAGCAGGAGAATACTATATTCCTCTGGCTACAAC
GGAAGGAGCACTTGTTGCCAGTGTAAATCGCGGCTGCTCGGTAATCACCAGATCAGGAGGAGCAAATGTAAGAGTTTTTG
AAGACGAAATGACAAGAGCTCCGGTCTTCAAGTTTGAAAGTCTTGAAAGAGCCAGAAAATTTTATGATTGGGTGAAGAGC
CCGGAAACTTTCGAACAGATGAAACAGGCTGCTGAAAAAACGACCCGGTTTGGAAAACTGCTTTCAGTAAAGCCCTTTGT
GACAGGAACATACATCTATCTCAGGTTTTCCTATGATACAAAAGACGCAATGGGCATGAACATGGTGACCATAGCAACGG
ATGCTGTAATGCACCTAATAGAAGATGAGTTCGGCGCACACCCTGTTACCCTTTCAGGAAATATGTGTACGGACAAAAAA
CCTGCGTCCATAAGCGCCATCCTCGGGAGGGGGAAAACCGTAGTTGCTGAAGTGACCATTCCTCAGGAGATAGTCAAAGA
GACTCTCAAATGCACGCCTGAATCAATGTTTGAGGTAAATTACAGTAAAAACCTTCTCGGTTCTGCAAGGGCAGGAGCCA
TGGGGTTCAACGCTCATGCTGCAAACATTATTGCTGCTGTATACCTTGCATGCGGGCAGGATGCTGCTCATGTTGTTGAA
GGCAGTACAGCGATTACAAGTATGGAACTTACAAAGTATGAAGAAATCCATTGCTCTGTCACTCTTCCAGCCCTTCCCGT
GGGTACTGTGGGAGGAGGGACCGGGCTTGGGACACAGAGAGACTGTCTCAATATCCTTGGTGTAGCAGGAGCAGGAGACA
CCCCCGGAATAAATTCGCGGAAATTTGCAGAAATCGTTGCCTCTGCAGTGCTTGCAGGAGAAATTTCCCTGATAGGAGCA
CAGGCAGCCGGACACCTGGCACGCGCTCATGCACAGCTCGGCCGCGGAAAGTTCTGA

Upstream 100 bases:

>100_bases
GCTTCATGTTTAAAAGGATAATATATTCGAATTTGCATTCCTTATTGCGGCACCACAAGACTTTAATTTTTAGTTGAAAG
TAAAAGGATCAGGTGATATC

Downstream 100 bases:

>100_bases
AGCTGGCAAAGGTGCGGGATAAAACAGGTTCAATCTACCGGTAAAATAAGAAACATCAATAAAGAAACACAGTACTGTAC
TGAATGACGGCTTTCATCCC

Product: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MFTEAYELTEEEKLLLQKVLDGDIAFRKIEEFADPLTAVKIRRLAIQEYGKLEFEHIQNFSLDVESVTKRNIENMIGAVQ
IPLGVAGLLKVNGEYAAGEYYIPLATTEGALVASVNRGCSVITRSGGANVRVFEDEMTRAPVFKFESLERARKFYDWVKS
PETFEQMKQAAEKTTRFGKLLSVKPFVTGTYIYLRFSYDTKDAMGMNMVTIATDAVMHLIEDEFGAHPVTLSGNMCTDKK
PASISAILGRGKTVVAEVTIPQEIVKETLKCTPESMFEVNYSKNLLGSARAGAMGFNAHAANIIAAVYLACGQDAAHVVE
GSTAITSMELTKYEEIHCSVTLPALPVGTVGGGTGLGTQRDCLNILGVAGAGDTPGINSRKFAEIVASAVLAGEISLIGA
QAAGHLARAHAQLGRGKF

Sequences:

>Translated_418_residues
MFTEAYELTEEEKLLLQKVLDGDIAFRKIEEFADPLTAVKIRRLAIQEYGKLEFEHIQNFSLDVESVTKRNIENMIGAVQ
IPLGVAGLLKVNGEYAAGEYYIPLATTEGALVASVNRGCSVITRSGGANVRVFEDEMTRAPVFKFESLERARKFYDWVKS
PETFEQMKQAAEKTTRFGKLLSVKPFVTGTYIYLRFSYDTKDAMGMNMVTIATDAVMHLIEDEFGAHPVTLSGNMCTDKK
PASISAILGRGKTVVAEVTIPQEIVKETLKCTPESMFEVNYSKNLLGSARAGAMGFNAHAANIIAAVYLACGQDAAHVVE
GSTAITSMELTKYEEIHCSVTLPALPVGTVGGGTGLGTQRDCLNILGVAGAGDTPGINSRKFAEIVASAVLAGEISLIGA
QAAGHLARAHAQLGRGKF
>Mature_418_residues
MFTEAYELTEEEKLLLQKVLDGDIAFRKIEEFADPLTAVKIRRLAIQEYGKLEFEHIQNFSLDVESVTKRNIENMIGAVQ
IPLGVAGLLKVNGEYAAGEYYIPLATTEGALVASVNRGCSVITRSGGANVRVFEDEMTRAPVFKFESLERARKFYDWVKS
PETFEQMKQAAEKTTRFGKLLSVKPFVTGTYIYLRFSYDTKDAMGMNMVTIATDAVMHLIEDEFGAHPVTLSGNMCTDKK
PASISAILGRGKTVVAEVTIPQEIVKETLKCTPESMFEVNYSKNLLGSARAGAMGFNAHAANIIAAVYLACGQDAAHVVE
GSTAITSMELTKYEEIHCSVTLPALPVGTVGGGTGLGTQRDCLNILGVAGAGDTPGINSRKFAEIVASAVLAGEISLIGA
QAAGHLARAHAQLGRGKF

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=351, Percent_Identity=47.008547008547, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI196049380, Length=298, Percent_Identity=46.3087248322148, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI25144592, Length=419, Percent_Identity=42.4821002386635, Blast_Score=316, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6323483, Length=425, Percent_Identity=42.5882352941177, Blast_Score=300, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6323565, Length=406, Percent_Identity=42.8571428571429, Blast_Score=298, Evalue=8e-82,
Organism=Drosophila melanogaster, GI281362379, Length=427, Percent_Identity=41.6861826697892, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI45553469, Length=427, Percent_Identity=41.6861826697892, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24649399, Length=427, Percent_Identity=41.6861826697892, Blast_Score=265, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 45076; Mature: 45076

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTEAYELTEEEKLLLQKVLDGDIAFRKIEEFADPLTAVKIRRLAIQEYGKLEFEHIQNF
CCCCHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEEHHHHCCC
SLDVESVTKRNIENMIGAVQIPLGVAGLLKVNGEYAAGEYYIPLATTEGALVASVNRGCS
CCCHHHHHHHHHHHHHCEEECCCCEEEEEEECCCEECCEEEEEEECCCCCEEEECCCCCE
VITRSGGANVRVFEDEMTRAPVFKFESLERARKFYDWVKSPETFEQMKQAAEKTTRFGKL
EEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LSVKPFVTGTYIYLRFSYDTKDAMGMNMVTIATDAVMHLIEDEFGAHPVTLSGNMCTDKK
EEECCCEEEEEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
PASISAILGRGKTVVAEVTIPQEIVKETLKCTPESMFEVNYSKNLLGSARAGAMGFNAHA
CCHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCHHHEEECCCHHHCCCCCCCCCCCCHHH
ANIIAAVYLACGQDAAHVVEGSTAITSMELTKYEEIHCSVTLPALPVGTVGGGTGLGTQR
HHHHHHHHHHCCCCHHHHCCCCHHEEEEEHHEEEEEEEEEEECCCCCCCCCCCCCCCCHH
DCLNILGVAGAGDTPGINSRKFAEIVASAVLAGEISLIGAQAAGHLARAHAQLGRGKF
HHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFTEAYELTEEEKLLLQKVLDGDIAFRKIEEFADPLTAVKIRRLAIQEYGKLEFEHIQNF
CCCCHHHCCHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEEHHHHCCC
SLDVESVTKRNIENMIGAVQIPLGVAGLLKVNGEYAAGEYYIPLATTEGALVASVNRGCS
CCCHHHHHHHHHHHHHCEEECCCCEEEEEEECCCEECCEEEEEEECCCCCEEEECCCCCE
VITRSGGANVRVFEDEMTRAPVFKFESLERARKFYDWVKSPETFEQMKQAAEKTTRFGKL
EEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LSVKPFVTGTYIYLRFSYDTKDAMGMNMVTIATDAVMHLIEDEFGAHPVTLSGNMCTDKK
EEECCCEEEEEEEEEEEECCCCCCCCEEEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
PASISAILGRGKTVVAEVTIPQEIVKETLKCTPESMFEVNYSKNLLGSARAGAMGFNAHA
CCHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCHHHEEECCCHHHCCCCCCCCCCCCHHH
ANIIAAVYLACGQDAAHVVEGSTAITSMELTKYEEIHCSVTLPALPVGTVGGGTGLGTQR
HHHHHHHHHHCCCCHHHHCCCCHHEEEEEHHEEEEEEEEEEECCCCCCCCCCCCCCCCHH
DCLNILGVAGAGDTPGINSRKFAEIVASAVLAGEISLIGAQAAGHLARAHAQLGRGKF
HHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]