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The map label for this gene is deoA [C]

Identifier: 21226189

GI number: 21226189

Start: 112009

End: 113532

Strand: Reverse

Name: deoA [C]

Synonym: MM_0087

Alternate gene names: 21226189

Gene position: 113532-112009 (Counterclockwise)

Preceding gene: 21226190

Following gene: 21226188

Centisome position: 2.77

GC content: 47.44

Gene sequence:

>1524_bases
TTGATGCAGTTGAAGCTGGAACATTATAATATAAAAATTGGACAGCACAAAGTGTTGCTGAATATTGTCGATGCGAAAGA
ACTGGGAGTCAACCCCGGAGATAGGGTCCGCATCCGGGGGCATCAAAGCCTTTCTGCCATTGTGGACACAACTGATGACA
TGGTTCCTCCGGGAACTCTTGGTGTCTTTACTGAAGTTTATGAACATTTCGAAGACTGGGATAAGCCGGTAGAAGTTGTC
CCTTCTTTTCGCTCAAAATCCGCAGCCGTTATCAAAAAAATGCTGGACAAAAAGCCTGTTGTACAGGACGAGATCAAAAT
GCTTGTAAGCGATATCGTTGATGAAAACCTGAGCGATGTCGAGCTTTCTGCCTTTATAACAGCTTCATATATCCACGGGA
TGACCGATGACGAAGTCGAATGGCTGACAAGGGCAATGATAGATACAGGAGACACTATCGAATTCGATACGCACCCTATT
ATGGACAAGCACTCGATAGGTGGGGTTCCCGGAAACAAGATTTCTCTCCTTATTGTCCCCATAGTTGCCGCAAACGGGCT
GCTCATCCCAAAGACCAGTTCAAGGGCTATCACGGGTGCAGGCGGGACTGCCGACCTTATGGAAGTGCTCTCTCCTGTTG
AGTTCAGCTCGCAGGAAGTAAAGGAGATAACCGAAAAGGTAGGAGGAGCACTCGTCTGGGGCGGAGCTACAAATATTGCG
CCTGCAGATGATAAGCTCATCAAAATTGAATATCCCCTGTCCATTGACCCTTATTACCAGATGCTTGCCTCAATCATGGC
AAAAAAAGGAGCCATCGGGGCAGACAATGTGGTAATGGATATCCCTGTCGGGCCGGGCACGAAGGTCCCCACAGTTCAGG
AAGGACAGAAACTGGCCAGAGACCTCATCAACCTCGGGCACAGACTTGGAATGAATGTTGAGTGCGCTATTACTTACGGT
TCGTCTCCTATCGGGAGGAGAGTAGGACCTTCTCTGGAAGTAAAGGAAGCCATGAAAGTCCTTGAGAGCATGGAAGGTCC
AAACAGCCTTATTGAAAAGAGCGCGGCTCTCGCAGGCATTCTTCTTGAAATGGGAGGGGCAGCTCCGAGAGATCAGGGAA
AAGAGCTTGCACTTGAAACTCTCAGGAGTGGAAAAGCTCTCGAGAAAATGAAACAGATCATTGAAGCCCAGGGAGGAGAC
CCGAACATCAAGTCCGATGATATTCAGACAGGGCAGTACACTGCTGATATTTTTGCTTCTACGGACGGGTATGTTATGGA
GTTCGACAACAAATGGATAATTGAGATTGCCAGGCTTGCAGGAGCTCCAAATGACAAGGGAGCTGGAGTTGCAATACACA
AAAAGAGAGGAGAACAGGTTAAAAAAGGAGATCCGATTCTCACCATATATGCCGAAAAAGAGATCAAACTTGATAATGCA
CTGGCAACGGCACAGAGGACAAACCCGATAATAGTCGAAGGCATGCTTCTCAGAAGAATTCCTGGAACTTATGGGTTCCA
GTAA

Upstream 100 bases:

>100_bases
GTTTTCGGCGCTGAAAAAGCCAGCAGAATATCTGGTCCGGGCGAAATAAATTACAATGACATAATCATAATTATATTGAG
AATGAAAAGGATGGTGTTAT

Downstream 100 bases:

>100_bases
TATTTCTGTAAGAACAATTTTCTCTTTTTTTCTTTTTTTCAATGAAAGCTCAGTGAAACCCTTTAATACCTTGTCAGGGT
TTTAGCCGGACATGAAGAGA

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MMQLKLEHYNIKIGQHKVLLNIVDAKELGVNPGDRVRIRGHQSLSAIVDTTDDMVPPGTLGVFTEVYEHFEDWDKPVEVV
PSFRSKSAAVIKKMLDKKPVVQDEIKMLVSDIVDENLSDVELSAFITASYIHGMTDDEVEWLTRAMIDTGDTIEFDTHPI
MDKHSIGGVPGNKISLLIVPIVAANGLLIPKTSSRAITGAGGTADLMEVLSPVEFSSQEVKEITEKVGGALVWGGATNIA
PADDKLIKIEYPLSIDPYYQMLASIMAKKGAIGADNVVMDIPVGPGTKVPTVQEGQKLARDLINLGHRLGMNVECAITYG
SSPIGRRVGPSLEVKEAMKVLESMEGPNSLIEKSAALAGILLEMGGAAPRDQGKELALETLRSGKALEKMKQIIEAQGGD
PNIKSDDIQTGQYTADIFASTDGYVMEFDNKWIIEIARLAGAPNDKGAGVAIHKKRGEQVKKGDPILTIYAEKEIKLDNA
LATAQRTNPIIVEGMLLRRIPGTYGFQ

Sequences:

>Translated_507_residues
MMQLKLEHYNIKIGQHKVLLNIVDAKELGVNPGDRVRIRGHQSLSAIVDTTDDMVPPGTLGVFTEVYEHFEDWDKPVEVV
PSFRSKSAAVIKKMLDKKPVVQDEIKMLVSDIVDENLSDVELSAFITASYIHGMTDDEVEWLTRAMIDTGDTIEFDTHPI
MDKHSIGGVPGNKISLLIVPIVAANGLLIPKTSSRAITGAGGTADLMEVLSPVEFSSQEVKEITEKVGGALVWGGATNIA
PADDKLIKIEYPLSIDPYYQMLASIMAKKGAIGADNVVMDIPVGPGTKVPTVQEGQKLARDLINLGHRLGMNVECAITYG
SSPIGRRVGPSLEVKEAMKVLESMEGPNSLIEKSAALAGILLEMGGAAPRDQGKELALETLRSGKALEKMKQIIEAQGGD
PNIKSDDIQTGQYTADIFASTDGYVMEFDNKWIIEIARLAGAPNDKGAGVAIHKKRGEQVKKGDPILTIYAEKEIKLDNA
LATAQRTNPIIVEGMLLRRIPGTYGFQ
>Mature_507_residues
MMQLKLEHYNIKIGQHKVLLNIVDAKELGVNPGDRVRIRGHQSLSAIVDTTDDMVPPGTLGVFTEVYEHFEDWDKPVEVV
PSFRSKSAAVIKKMLDKKPVVQDEIKMLVSDIVDENLSDVELSAFITASYIHGMTDDEVEWLTRAMIDTGDTIEFDTHPI
MDKHSIGGVPGNKISLLIVPIVAANGLLIPKTSSRAITGAGGTADLMEVLSPVEFSSQEVKEITEKVGGALVWGGATNIA
PADDKLIKIEYPLSIDPYYQMLASIMAKKGAIGADNVVMDIPVGPGTKVPTVQEGQKLARDLINLGHRLGMNVECAITYG
SSPIGRRVGPSLEVKEAMKVLESMEGPNSLIEKSAALAGILLEMGGAAPRDQGKELALETLRSGKALEKMKQIIEAQGGD
PNIKSDDIQTGQYTADIFASTDGYVMEFDNKWIIEIARLAGAPNDKGAGVAIHKKRGEQVKKGDPILTIYAEKEIKLDNA
LATAQRTNPIIVEGMLLRRIPGTYGFQ

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=406, Percent_Identity=27.0935960591133, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4503445, Length=406, Percent_Identity=27.0935960591133, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI166158922, Length=406, Percent_Identity=27.0935960591133, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1790842, Length=403, Percent_Identity=29.0322580645161, Blast_Score=148, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_METMA (Q8Q0P9)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_632111.1
- ProteinModelPortal:   Q8Q0P9
- SMR:   Q8Q0P9
- GeneID:   1478429
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_0087
- NMPDR:   fig|192952.1.peg.87
- HOGENOM:   HBG460532
- OMA:   GGTADLM
- ProtClustDB:   PRK04350
- BioCyc:   MMAZ192952:MM0087-MONOMER
- BRENDA:   2.4.2.4
- HAMAP:   MF_00703
- InterPro:   IPR017713
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR03327
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 54900; Mature: 54900

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQLKLEHYNIKIGQHKVLLNIVDAKELGVNPGDRVRIRGHQSLSAIVDTTDDMVPPGTL
CCEEEEEEEEEEECCEEEEEEEECHHHHCCCCCCEEEEECCCHHHHHHCCCCCCCCCCHH
GVFTEVYEHFEDWDKPVEVVPSFRSKSAAVIKKMLDKKPVVQDEIKMLVSDIVDENLSDV
HHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCE
ELSAFITASYIHGMTDDEVEWLTRAMIDTGDTIEFDTHPIMDKHSIGGVPGNKISLLIVP
EHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEE
IVAANGLLIPKTSSRAITGAGGTADLMEVLSPVEFSSQEVKEITEKVGGALVWGGATNIA
EECCCCEEEECCCCCEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEECCCCCCC
PADDKLIKIEYPLSIDPYYQMLASIMAKKGAIGADNVVMDIPVGPGTKVPTVQEGQKLAR
CCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
DLINLGHRLGMNVECAITYGSSPIGRRVGPSLEVKEAMKVLESMEGPNSLIEKSAALAGI
HHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLEMGGAAPRDQGKELALETLRSGKALEKMKQIIEAQGGDPNIKSDDIQTGQYTADIFAS
HHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEC
TDGYVMEFDNKWIIEIARLAGAPNDKGAGVAIHKKRGEQVKKGDPILTIYAEKEIKLDNA
CCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCEEHHHH
LATAQRTNPIIVEGMLLRRIPGTYGFQ
HHHHHCCCCEEEECHHHHHCCCCCCCC
>Mature Secondary Structure
MMQLKLEHYNIKIGQHKVLLNIVDAKELGVNPGDRVRIRGHQSLSAIVDTTDDMVPPGTL
CCEEEEEEEEEEECCEEEEEEEECHHHHCCCCCCEEEEECCCHHHHHHCCCCCCCCCCHH
GVFTEVYEHFEDWDKPVEVVPSFRSKSAAVIKKMLDKKPVVQDEIKMLVSDIVDENLSDV
HHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCE
ELSAFITASYIHGMTDDEVEWLTRAMIDTGDTIEFDTHPIMDKHSIGGVPGNKISLLIVP
EHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEE
IVAANGLLIPKTSSRAITGAGGTADLMEVLSPVEFSSQEVKEITEKVGGALVWGGATNIA
EECCCCEEEECCCCCEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEECCCCCCC
PADDKLIKIEYPLSIDPYYQMLASIMAKKGAIGADNVVMDIPVGPGTKVPTVQEGQKLAR
CCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
DLINLGHRLGMNVECAITYGSSPIGRRVGPSLEVKEAMKVLESMEGPNSLIEKSAALAGI
HHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
LLEMGGAAPRDQGKELALETLRSGKALEKMKQIIEAQGGDPNIKSDDIQTGQYTADIFAS
HHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEC
TDGYVMEFDNKWIIEIARLAGAPNDKGAGVAIHKKRGEQVKKGDPILTIYAEKEIKLDNA
CCCEEEEECCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCEEHHHH
LATAQRTNPIIVEGMLLRRIPGTYGFQ
HHHHHCCCCEEEECHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824