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The map label for this gene is aroK [H]

Identifier: 21226186

GI number: 21226186

Start: 109844

End: 110374

Strand: Reverse

Name: aroK [H]

Synonym: MM_0084

Alternate gene names: 21226186

Gene position: 110374-109844 (Counterclockwise)

Preceding gene: 21226187

Following gene: 21226185

Centisome position: 2.69

GC content: 42.75

Gene sequence:

>531_bases
ATGGGCAGGAAGCGTGTGGTAATGAACATAACATTAATCGGTATGGCAGGAGCGGGGAAAAGTACCATAGGAAAAGCGCT
TGCAAAACGTCTGGATTATACTTTTATTGATGTTGACCGTTTGATCACAGATAGAACTGGAATGCCCCTCCAGGTACTCA
TTGATAAACAGGGCGATTCTGCTCTTCTCAGATTTGAGGAAGAAGCTATTCTGGGTCTTGGGCAGGTGGATAACTGTATT
ATTTCCCCGGGAGGGAGCGTAATTTATTCCGAAAAATCCATGGTCTACTTAAAAAACATCTCAAAAGTTGTCTTTCTGGA
CGCTTCTTTCAGGAGCATCGCAAGGCGAATACCGAATGCAAGAAGAAGAGGTATAGTGGGCCTGAGGGATAGAAGCCTTA
AAGAACTATTTGAAGAAAGGCTGGTTCTGTATAATAAATACGCTGATTTCTCCGTAAAAATCAGGGGAAAGGAAAATATT
CAGGGGATTGTAGATCGAGTGATCAGGCTCTGTTTTATGGTGGAATCCTGA

Upstream 100 bases:

>100_bases
CACGTTGTATCTTTTATATAGCAGAAGATTATATTCTGTCCTGAAATTATGGACTGCCGATCTTCATATCTGGAATTTTC
GGCGTCTTGTTCTTGATTTT

Downstream 100 bases:

>100_bases
TTTGAGCATTAATTTTTCCTGAATAAGAGACTGATCCTGTTTTGTTTGTTTTCCATTCATTTCTATCTGTTTTCATACAT
TATTATATATTATTATACAT

Product: shikimate kinase

Products: NA

Alternate protein names: SK [H]

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MGRKRVVMNITLIGMAGAGKSTIGKALAKRLDYTFIDVDRLITDRTGMPLQVLIDKQGDSALLRFEEEAILGLGQVDNCI
ISPGGSVIYSEKSMVYLKNISKVVFLDASFRSIARRIPNARRRGIVGLRDRSLKELFEERLVLYNKYADFSVKIRGKENI
QGIVDRVIRLCFMVES

Sequences:

>Translated_176_residues
MGRKRVVMNITLIGMAGAGKSTIGKALAKRLDYTFIDVDRLITDRTGMPLQVLIDKQGDSALLRFEEEAILGLGQVDNCI
ISPGGSVIYSEKSMVYLKNISKVVFLDASFRSIARRIPNARRRGIVGLRDRSLKELFEERLVLYNKYADFSVKIRGKENI
QGIVDRVIRLCFMVES
>Mature_175_residues
GRKRVVMNITLIGMAGAGKSTIGKALAKRLDYTFIDVDRLITDRTGMPLQVLIDKQGDSALLRFEEEAILGLGQVDNCII
SPGGSVIYSEKSMVYLKNISKVVFLDASFRSIARRIPNARRRGIVGLRDRSLKELFEERLVLYNKYADFSVKIRGKENIQ
GIVDRVIRLCFMVES

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate [H]

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=162, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI87082255, Length=156, Percent_Identity=30.7692307692308, Blast_Score=70, Evalue=8e-14,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000623
- InterPro:   IPR023000 [H]

Pfam domain/function: PF01202 SKI [H]

EC number: =2.7.1.71 [H]

Molecular weight: Translated: 19802; Mature: 19670

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRKRVVMNITLIGMAGAGKSTIGKALAKRLDYTFIDVDRLITDRTGMPLQVLIDKQGDS
CCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCEEEEHHHHHHCCCCCCEEEEEECCCCC
ALLRFEEEAILGLGQVDNCIISPGGSVIYSEKSMVYLKNISKVVFLDASFRSIARRIPNA
EEEEECHHHHCCCCCCCCEEECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHCCCH
RRRGIVGLRDRSLKELFEERLVLYNKYADFSVKIRGKENIQGIVDRVIRLCFMVES
HHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GRKRVVMNITLIGMAGAGKSTIGKALAKRLDYTFIDVDRLITDRTGMPLQVLIDKQGDS
CCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCEEEEHHHHHHCCCCCCEEEEEECCCCC
ALLRFEEEAILGLGQVDNCIISPGGSVIYSEKSMVYLKNISKVVFLDASFRSIARRIPNA
EEEEECHHHHCCCCCCCCEEECCCCCEEECCCCEEEEECCCEEEEEECHHHHHHHHCCCH
RRRGIVGLRDRSLKELFEERLVLYNKYADFSVKIRGKENIQGIVDRVIRLCFMVES
HHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]