| Definition | Methanosarcina mazei Go1 chromosome, complete genome. |
|---|---|
| Accession | NC_003901 |
| Length | 4,096,345 |
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The map label for this gene is hyuA [H]
Identifier: 21226170
GI number: 21226170
Start: 91254
End: 92966
Strand: Reverse
Name: hyuA [H]
Synonym: MM_0068
Alternate gene names: 21226170
Gene position: 92966-91254 (Counterclockwise)
Preceding gene: 21226171
Following gene: 21226169
Centisome position: 2.27
GC content: 49.27
Gene sequence:
>1713_bases ATGCTAATAGGAATTGATGTAGGGGGCACCACCACGGATGCGGTGCTTATAAGGAACGGAGAGGTATACAGCACAGCCAA GGTTCCCACGGAGCCAGGAGACCTTTTGAAGTCTCTTCTCGGTGCCCTTGATGAGGTTAGCAGAGGAGTTCCCCCGGAAC AGTTTGAGAGGGTGGTGTTCAGTACAACTGTAATAACAAACCTTATTGCAGAGGGTAAAACCGAGAGGGTAGCTTTACTG CTCATCCCGGGCCCTGGAGTTAACCCCGCAAGTTACGTTTTTCCCGACAGTTTCTGTATTAAGGGAGCTATGGATTACAG GGGAAGGGAAATACAGCCCATAGACGAGGAAGAGGTTCGGGGGACTGTAAGCCGGATAAGGGATCAGGGCTTTTTAAGGG TTGCTGTGGTAAGCAAATTCGGGCAGAGAAACCCTTCTCATGAACTCAGGATAGAAGAAATCATCAGGGAAATGCACCCG GACTGTAAAGTGGAACTCGGTCATAAAGTTTCAGGCAAACTGAATTTCCCAAGAAGGGTCGCTACTTCTATGCTGGCATC CGCTACAGGAGAGCATTACCAGAACTTCGTTTCTGAGATCAAAAAAGCCCTGGAGGAAAGAAAAATCCGGGCTTCTGTCT TTATTCTTAAAGCTGATGGAGGGACTCTGCCAATTGAAAAATCAGTGGAACTCCCTGTGGAGACTATTTTTTCAGGCCCT GCTGCAAGCACTATAGGAGCCCTTGCCATTACCCCTGAAGGGCAAACATCCGTTGTGGTGGATATAGGCGGGACGACTAC AGACCTTGCCCTTATCCTCTCTGGAAAACCGCTTATCGCTTCCAAAGGTGCCAGGCTGGGAGATTTCCTGACCCATGTCC GGGCTTTTGCTGTCCGCTCGATAGCTGTAGGAGGAGACAGCATTGTAAGGGTTAAAGAAACAGACAGTGGGCTCAGGACG ATAAGCATAGGGCCTGAAAGGGTGGGTCCGGCTTACTGCATGGGAGGAAAAGAGCCAACCCCTACGGATGCTTTGAGAGT TCTCAGGCTTGTGGAAGTAGGAGATTCTCAAAGGGCAAATGAGGCAATATCTTCTGTAGCTTCCAGTCTTGGTAAATCTG TACTGGAAACCGCGTCCCTTATAGTGGACATAACCGCAGAAATGATTGCACAGGCAGTGAGAGAGATGTTTCTTGAATGG GAACAGGAGCCTGCTTACAGGATATGGGAAGTTCTGCAGAAGAAAAAAGAAAGGCCTGAAAATGTGGTCGGAATAGGCGG CGGGGCAAAGGGACTGATTGCAGGGGTTGCTGAAAAATTGAACGCTAAACCGGTTATTCCCTCCCATTCGGAGGTTGGAA ATGCTATCGGGGCAGCCGTTGCAAGGCCTACTCTTACTCTCAACCTGCGCATTGATACCGAGCAGAAGGTCTATTCGGTA GCCGAAGATGGAGAGATTGCAAGCCTTAAATTTACGGATATCGGGAATTTCAACAGGATGCGTTCGGAAGAAGCCGAAAC CCTTGCAGCAAAACTTCTCAGGGACCGTGCAAAAAGGTTTGGGATTTTCGAGTACGTGGAAGAAGCCGAAGTTGTTAGCA GCGAAGTTTTTAACATAGTGGAAGGCTGGCTTACTGTGGGGAGGCTTTTTGACGTAAGTATGCAGATCCCGGCAGGCCTC ATTCCAGAATGGAGCAGGAGGGAAAAGGCATGA
Upstream 100 bases:
>100_bases TAAATCAATTGAAACTGGCTACAAGCCACATTTATTATAAATTTACTAAAGTGAAATAATTGAAGATATATTCATTCAGG TGAGGATAGGCGAATTGTGA
Downstream 100 bases:
>100_bases AACTCGGGATCGGGAAGATTAAGGATGTACTCAAAAGCGGAGCCGGAAAAAGTACCGAATCCGGGAGAGAAGAACAAAAA ATAGAGGAAATTGAGCCTGA
Product: N-methylhydantoinase
Products: ADP; phosphate; N-carbamoylsarcosine
Alternate protein names: ORF2 [H]
Number of amino acids: Translated: 570; Mature: 570
Protein sequence:
>570_residues MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVFSTTVITNLIAEGKTERVALL LIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVRGTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHP DCKVELGHKVSGKLNFPRRVATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRSIAVGGDSIVRVKETDSGLRT ISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRANEAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEW EQEPAYRIWEVLQKKKERPENVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIVEGWLTVGRLFDVSMQIPAGL IPEWSRREKA
Sequences:
>Translated_570_residues MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVFSTTVITNLIAEGKTERVALL LIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVRGTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHP DCKVELGHKVSGKLNFPRRVATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRSIAVGGDSIVRVKETDSGLRT ISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRANEAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEW EQEPAYRIWEVLQKKKERPENVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIVEGWLTVGRLFDVSMQIPAGL IPEWSRREKA >Mature_570_residues MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVFSTTVITNLIAEGKTERVALL LIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVRGTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHP DCKVELGHKVSGKLNFPRRVATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRSIAVGGDSIVRVKETDSGLRT ISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRANEAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEW EQEPAYRIWEVLQKKKERPENVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIVEGWLTVGRLFDVSMQIPAGL IPEWSRREKA
Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]
COG id: COG0145
COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit
Gene ontology:
Cell location: Cytoplasmic
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the oxoprolinase family [H]
Homologues:
Organism=Drosophila melanogaster, GI45550492, Length=247, Percent_Identity=28.3400809716599, Blast_Score=68, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR008040 - InterPro: IPR002821 [H]
Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]
EC number: 3.5.2.14
Molecular weight: Translated: 61664; Mature: 61664
Theoretical pI: Translated: 5.38; Mature: 5.38
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.1 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVF CEEEEECCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH STTVITNLIAEGKTERVALLLIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVR HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEECCCHHHCCCCCCCCCCCCCCCCHHHHH GTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHPDCKVELGHKVSGKLNFPRRV HHHHHHHCCCCEEEHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCHHHH ATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP HHHHHHHHCHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHCCC AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRS CHHHCCEEEECCCCCEEEEEECCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHH IAVGGDSIVRVKETDSGLRTISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRAN HEECCCCEEEEEECCCCCEEEECCHHHCCCHHCCCCCCCCHHHHHHHHHHHHCCCCHHHH EAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEWEQEPAYRIWEVLQKKKERPE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC NVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV CEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHH AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIV CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH EGWLTVGRLFDVSMQIPAGLIPEWSRREKA HHHHHHHHHHEEHCCCCCCCCCCCHHCCCC >Mature Secondary Structure MLIGIDVGGTTTDAVLIRNGEVYSTAKVPTEPGDLLKSLLGALDEVSRGVPPEQFERVVF CEEEEECCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH STTVITNLIAEGKTERVALLLIPGPGVNPASYVFPDSFCIKGAMDYRGREIQPIDEEEVR HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEECCCHHHCCCCCCCCCCCCCCCCHHHHH GTVSRIRDQGFLRVAVVSKFGQRNPSHELRIEEIIREMHPDCKVELGHKVSGKLNFPRRV HHHHHHHCCCCEEEHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCCCCCHHHH ATSMLASATGEHYQNFVSEIKKALEERKIRASVFILKADGGTLPIEKSVELPVETIFSGP HHHHHHHHCHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHCCC AASTIGALAITPEGQTSVVVDIGGTTTDLALILSGKPLIASKGARLGDFLTHVRAFAVRS CHHHCCEEEECCCCCEEEEEECCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHH IAVGGDSIVRVKETDSGLRTISIGPERVGPAYCMGGKEPTPTDALRVLRLVEVGDSQRAN HEECCCCEEEEEECCCCCEEEECCHHHCCCHHCCCCCCCCHHHHHHHHHHHHCCCCHHHH EAISSVASSLGKSVLETASLIVDITAEMIAQAVREMFLEWEQEPAYRIWEVLQKKKERPE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC NVVGIGGGAKGLIAGVAEKLNAKPVIPSHSEVGNAIGAAVARPTLTLNLRIDTEQKVYSV CEEEECCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCHHHHHHH AEDGEIASLKFTDIGNFNRMRSEEAETLAAKLLRDRAKRFGIFEYVEEAEVVSSEVFNIV CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH EGWLTVGRLFDVSMQIPAGLIPEWSRREKA HHHHHHHHHHEEHCCCCCCCCCCCHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O
Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1732229 [H]