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The map label for this gene is MscS [H]

Identifier: 20809112

GI number: 20809112

Start: 2671939

End: 2672787

Strand: Reverse

Name: MscS [H]

Synonym: TTE2783

Alternate gene names: 20809112

Gene position: 2672787-2671939 (Counterclockwise)

Preceding gene: 20809114

Following gene: 20809111

Centisome position: 99.38

GC content: 38.4

Gene sequence:

>849_bases
ATGTGGGCAGATATATACCACAAGCTAGTAGAAATTTATGACATAAAAGCAGTAAAATTTTTATTAGATGTGCTAAAAAT
ACTCATCATTGCCTTCATTGGCATTAAGTTTGCTGATTTTCTAATATATAGGTTTTATAAGTTGTACAGTAAATCCAAAA
TTCAATTGCCTCAGAGGAAAATAGACACTCTGACATCTCTTACAAAAAATGCTGTCAGGTATATAATCTATTTTCTCGCC
GGAGCTTCTATTCTCAAACTTTTCAACATAGATATGACCTCTTTACTGGCTGTTGCAGGTATCGGAAGCCTTGCCATAGG
ATTTGGAGCGCAGAATCTGGTGAAAGACATGATTTCAGGCTTTTTTATAATCTTTGAAGACCAGTTTTCTGTTGGGGATT
ATGTTACCATCAATGGGATTTCCGGTACAGTGGAGGAGATTGGTTTAAGAGTTACAAAAATTCGTGGCTTTTCTGATGGC
CTTCACATAATACCGAACGGAGAAATAAAGATGGTAACTAATCTCACAAAAGACAGCATGATGGCAGTGGTCAATATAGC
ATTTCCGATAGATGAGGACGTAGACAAGATAATAGAAGGGCTTCAAGAGATATGCGAGGAAGTAAAGAAGTCGAGGGACG
ACTTAATAGAGGGCCCGACAGTATTAGGGATAACAGATATGCAGGATTCAAAGCTTGTCATAATGGTTTACGCAAAGACC
CAGCCTATGCAAAAATGGGCGGTGGAAAGAGACATCCGCTACAGAGTTAAAAAGATGTTTGACCAGAAGAACATATCTTT
CCCCTACCCGCGCACAACCGTCATTCTTTCAGAAAAGAAAACTAATTGA

Upstream 100 bases:

>100_bases
AAATTTACATACACTCAATTTAATCTAAAAGCAGCGGTTGAAAAAAAGAGTAGATTCGTGTAATATAAAGATAAAACAGA
AAAACAAGGTGATGGAGAAA

Downstream 100 bases:

>100_bases
GGTGATGGCTTTGCCTAAAGACTTGCACGTTGGTGATATAGTGAAGCTTAAAAAGAAACACCCTTGTGGGTCTGACGAGT
GGGAAATTTTGAGGGTTGGC

Product: small-conductance mechanosensitive channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MWADIYHKLVEIYDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLPQRKIDTLTSLTKNAVRYIIYFLA
GASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTINGISGTVEEIGLRVTKIRGFSDG
LHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRDDLIEGPTVLGITDMQDSKLVIMVYAKT
QPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKTN

Sequences:

>Translated_282_residues
MWADIYHKLVEIYDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLPQRKIDTLTSLTKNAVRYIIYFLA
GASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTINGISGTVEEIGLRVTKIRGFSDG
LHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRDDLIEGPTVLGITDMQDSKLVIMVYAKT
QPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKTN
>Mature_282_residues
MWADIYHKLVEIYDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLPQRKIDTLTSLTKNAVRYIIYFLA
GASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTINGISGTVEEIGLRVTKIRGFSDG
LHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRDDLIEGPTVLGITDMQDSKLVIMVYAKT
QPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKTN

Specific function: May play a role in resistance to osmotic downshock [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI87081787, Length=216, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789291, Length=226, Percent_Identity=26.5486725663717, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787591, Length=198, Percent_Identity=26.7676767676768, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367355, Length=213, Percent_Identity=24.4131455399061, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1786670, Length=130, Percent_Identity=30, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR011014 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 32034; Mature: 32034

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWADIYHKLVEIYDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLPQRK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
IDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
FFIIFEDQFSVGDYVTINGISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSM
EEEEEECCCCCCCEEEEECCCCCHHHHCCEEEEEECCCCCEEEECCCCEEEEECCCHHHH
MAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRDDLIEGPTVLGITDMQDSKLVIMVYAKT
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECC
QPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKTN
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MWADIYHKLVEIYDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLPQRK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
IDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
FFIIFEDQFSVGDYVTINGISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSM
EEEEEECCCCCCCEEEEECCCCCHHHHCCEEEEEECCCCCEEEECCCCEEEEECCCHHHH
MAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRDDLIEGPTVLGITDMQDSKLVIMVYAKT
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECC
QPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKTN
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]