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The map label for this gene is Pol4 [H]

Identifier: 20808870

GI number: 20808870

Start: 2404797

End: 2406509

Strand: Reverse

Name: Pol4 [H]

Synonym: TTE2516

Alternate gene names: 20808870

Gene position: 2406509-2404797 (Counterclockwise)

Preceding gene: 20808871

Following gene: 20808869

Centisome position: 89.48

GC content: 38.82

Gene sequence:

>1713_bases
ATGGATAAAAAGACTGTTGTGGATATATTAAATGAGATTGGACTTTTGTTAGAGCTTAAAGGGGAAAATCCTTTTAAATC
AAGAGCCTATTACAATGCTGCAAGGGTAATTGAGCTTCTCGATGAAGATTTGGAGACGCTTGTTAAAGAAGACAGGTTAA
AAGATGTGAAAGGGATAGGAGAGGCGCTTAACAAGAAGCTTACAGAGCTTATCACCACCGGGCGAATGGAATATTACGAA
AAATTAAAAGAGTCAGTACCGCCTGGCCTCATAGAAATGTTAAAAATTCCTGGTTTGGGGCCTAAAAAAATAAAGACGCT
TTATGAGAAACTTGGTATAACCACGATTGGGGAATTAGAATACGCCTGCCTTGAAAATAGACTCTTGAAGCTTCCAGGTT
TTGGAGAAAAAACACAGAAAAAGATATTGGAGGGAATACAGTTTGTGAAGCAATATAGCGGACACCATCTCTACTTTGAA
GCCTATGAAGAGGCTACTAAGATTAAAGAATATATCGATGGCACGGGCCTTGCTATCAAATCTGAAATTGCCGGAAGTTT
GAGAAGGAAAAAGGAGATAGTCAAAGACATAGACATACTCGCAACTTCAAAGGAAGCTTTAAAGCTCATGGATGCATTTG
TTAATTATGATGGAGTGAGGGAAGTAATTGCAAAGGGAGAGACTAAAACTAGCGTAGTTTTAAAGTCAGGGATAAACGTG
GACTTGAGGGTTGTGAAGGAAGAGGAGTTTCCTTATGCTCTTCACCATTTCACTGGAAGCAAAGAGCATAATACTGCAAT
GAGACACAGGGCAAAATCCATGGGTATAAAGATGAATGAATACGGACTTTTTAAGGGAGACCATCTCATAGAGTGTAAAG
AGGAAGAAGAGATATTTTCTAAGCTTGGCCTTTTGTATATTCCCCCTGAATTGAGGGAGGACATGGGAGAGATTGAAGCA
GCAGAAAAAGGGGAGATACCCGTCTTGGTAGAGGAAAAGGACATTAAAGGAGTTTTTCACGTGCATACGACTTACAGCGA
TGGGAGAAATTCTCTAGAAGACATGGTGAGAAAGGCAAGAGATCTGGGGTATAAGTATATAGCGATTACTGACCACAGCA
AATCCGCCTTTTATGCAAATGGGCTTACTGAAGAGATGCTTTTAAGACAGTGGGAAGAGATAGATGAATTAAATAAAAAA
TATCCTGATATAGTTATTTTAAAAGGGATAGAATCTGATATTTTGCCTGACGGTTCACTGGATTATGAAGAAGAAATTTT
AAAAAGGTTTGATATGGTAGTTGCTTCAATCCATTCTCACTTCAGAATGAGCAAAGAAGAAATGACTAAAAGGGTCATAA
AAGCGTTGGAGAATAAATACACTAAAATTTTGGGGCATCCAACAGGTAGACTCTTGCTTGCCAGGGATAGTTACGAAATA
GATGTATACGCAGTGATTGATGCAGCAGCTCACTATGGAAAGATAATAGAAATTAATTCGAATCCCTTTAGACTGGACCT
TGACTGGAGGTATATAAAATACGCAAAAGAAAAAGGCGTAAAGTTTGCCATAAATCCTGATGCTCACAGTGTTGATGGAC
TTGAGGATGTCAAATATGGCGTGGGAATTGCGAGAAAAGGCTGGCTTGAAGCCAGGGATGTGATAAATACTTATGAAGTG
GAGGAAGTTTTAACTATTTTGCGCAATATGTGA

Upstream 100 bases:

>100_bases
ACAGACAGGAAAGAAGGGAGAAAAATGCTTAAAGACTCTGACAAGGTTAGTGTAATAATTAAAGTGGATAAAAATAAATC
AAAAAAAGAAGTGGTGGGTT

Downstream 100 bases:

>100_bases
AACTCTTTAGACTGTGTTAGTTTTAAGGCAGTCTCGTTTGTTGATAAAGTCCCATTCAATTAAGTGGCATTTTGTGTTAA
TGCTCCGGAGTTGCAAAGCG

Product: family X DNA polymerase IV

Products: NA

Alternate protein names: DNA polymerase type-X; 3'-5' exodeoxyribonuclease; 3'-5' exonuclease [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MDKKTVVDILNEIGLLLELKGENPFKSRAYYNAARVIELLDEDLETLVKEDRLKDVKGIGEALNKKLTELITTGRMEYYE
KLKESVPPGLIEMLKIPGLGPKKIKTLYEKLGITTIGELEYACLENRLLKLPGFGEKTQKKILEGIQFVKQYSGHHLYFE
AYEEATKIKEYIDGTGLAIKSEIAGSLRRKKEIVKDIDILATSKEALKLMDAFVNYDGVREVIAKGETKTSVVLKSGINV
DLRVVKEEEFPYALHHFTGSKEHNTAMRHRAKSMGIKMNEYGLFKGDHLIECKEEEEIFSKLGLLYIPPELREDMGEIEA
AEKGEIPVLVEEKDIKGVFHVHTTYSDGRNSLEDMVRKARDLGYKYIAITDHSKSAFYANGLTEEMLLRQWEEIDELNKK
YPDIVILKGIESDILPDGSLDYEEEILKRFDMVVASIHSHFRMSKEEMTKRVIKALENKYTKILGHPTGRLLLARDSYEI
DVYAVIDAAAHYGKIIEINSNPFRLDLDWRYIKYAKEKGVKFAINPDAHSVDGLEDVKYGVGIARKGWLEARDVINTYEV
EEVLTILRNM

Sequences:

>Translated_570_residues
MDKKTVVDILNEIGLLLELKGENPFKSRAYYNAARVIELLDEDLETLVKEDRLKDVKGIGEALNKKLTELITTGRMEYYE
KLKESVPPGLIEMLKIPGLGPKKIKTLYEKLGITTIGELEYACLENRLLKLPGFGEKTQKKILEGIQFVKQYSGHHLYFE
AYEEATKIKEYIDGTGLAIKSEIAGSLRRKKEIVKDIDILATSKEALKLMDAFVNYDGVREVIAKGETKTSVVLKSGINV
DLRVVKEEEFPYALHHFTGSKEHNTAMRHRAKSMGIKMNEYGLFKGDHLIECKEEEEIFSKLGLLYIPPELREDMGEIEA
AEKGEIPVLVEEKDIKGVFHVHTTYSDGRNSLEDMVRKARDLGYKYIAITDHSKSAFYANGLTEEMLLRQWEEIDELNKK
YPDIVILKGIESDILPDGSLDYEEEILKRFDMVVASIHSHFRMSKEEMTKRVIKALENKYTKILGHPTGRLLLARDSYEI
DVYAVIDAAAHYGKIIEINSNPFRLDLDWRYIKYAKEKGVKFAINPDAHSVDGLEDVKYGVGIARKGWLEARDVINTYEV
EEVLTILRNM
>Mature_570_residues
MDKKTVVDILNEIGLLLELKGENPFKSRAYYNAARVIELLDEDLETLVKEDRLKDVKGIGEALNKKLTELITTGRMEYYE
KLKESVPPGLIEMLKIPGLGPKKIKTLYEKLGITTIGELEYACLENRLLKLPGFGEKTQKKILEGIQFVKQYSGHHLYFE
AYEEATKIKEYIDGTGLAIKSEIAGSLRRKKEIVKDIDILATSKEALKLMDAFVNYDGVREVIAKGETKTSVVLKSGINV
DLRVVKEEEFPYALHHFTGSKEHNTAMRHRAKSMGIKMNEYGLFKGDHLIECKEEEEIFSKLGLLYIPPELREDMGEIEA
AEKGEIPVLVEEKDIKGVFHVHTTYSDGRNSLEDMVRKARDLGYKYIAITDHSKSAFYANGLTEEMLLRQWEEIDELNKK
YPDIVILKGIESDILPDGSLDYEEEILKRFDMVVASIHSHFRMSKEEMTKRVIKALENKYTKILGHPTGRLLLARDSYEI
DVYAVIDAAAHYGKIIEINSNPFRLDLDWRYIKYAKEKGVKFAINPDAHSVDGLEDVKYGVGIARKGWLEARDVINTYEV
EEVLTILRNM

Specific function: Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a sing

COG id: COG1796

COG function: function code L; DNA polymerase IV (family X)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PHP family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002054
- InterPro:   IPR010996
- InterPro:   IPR003583
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR022311 [H]

Pfam domain/function: PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65138; Mature: 65138

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKTVVDILNEIGLLLELKGENPFKSRAYYNAARVIELLDEDLETLVKEDRLKDVKGIG
CCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALNKKLTELITTGRMEYYEKLKESVPPGLIEMLKIPGLGPKKIKTLYEKLGITTIGELE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEHHHH
YACLENRLLKLPGFGEKTQKKILEGIQFVKQYSGHHLYFEAYEEATKIKEYIDGTGLAIK
HHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCEEH
SEIAGSLRRKKEIVKDIDILATSKEALKLMDAFVNYDGVREVIAKGETKTSVVLKSGINV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHCCCCHHEEEEECCCCE
DLRVVKEEEFPYALHHFTGSKEHNTAMRHRAKSMGIKMNEYGLFKGDHLIECKEEEEIFS
EEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCEEECCHHHHHHH
KLGLLYIPPELREDMGEIEAAEKGEIPVLVEEKDIKGVFHVHTTYSDGRNSLEDMVRKAR
HCCEEEECHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHH
DLGYKYIAITDHSKSAFYANGLTEEMLLRQWEEIDELNKKYPDIVILKGIESDILPDGSL
HCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
DYEEEILKRFDMVVASIHSHFRMSKEEMTKRVIKALENKYTKILGHPTGRLLLARDSYEI
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCE
DVYAVIDAAAHYGKIIEINSNPFRLDLDWRYIKYAKEKGVKFAINPDAHSVDGLEDVKYG
EEEEEEHHHHHCCEEEEECCCCEEEECCHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHC
VGIARKGWLEARDVINTYEVEEVLTILRNM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKKTVVDILNEIGLLLELKGENPFKSRAYYNAARVIELLDEDLETLVKEDRLKDVKGIG
CCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALNKKLTELITTGRMEYYEKLKESVPPGLIEMLKIPGLGPKKIKTLYEKLGITTIGELE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHCCCEEHHHH
YACLENRLLKLPGFGEKTQKKILEGIQFVKQYSGHHLYFEAYEEATKIKEYIDGTGLAIK
HHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCEEH
SEIAGSLRRKKEIVKDIDILATSKEALKLMDAFVNYDGVREVIAKGETKTSVVLKSGINV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHCCCCHHEEEEECCCCE
DLRVVKEEEFPYALHHFTGSKEHNTAMRHRAKSMGIKMNEYGLFKGDHLIECKEEEEIFS
EEEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCEEECCHHHHHHH
KLGLLYIPPELREDMGEIEAAEKGEIPVLVEEKDIKGVFHVHTTYSDGRNSLEDMVRKAR
HCCEEEECHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEEECCCCCHHHHHHHHHHHH
DLGYKYIAITDHSKSAFYANGLTEEMLLRQWEEIDELNKKYPDIVILKGIESDILPDGSL
HCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
DYEEEILKRFDMVVASIHSHFRMSKEEMTKRVIKALENKYTKILGHPTGRLLLARDSYEI
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCE
DVYAVIDAAAHYGKIIEINSNPFRLDLDWRYIKYAKEKGVKFAINPDAHSVDGLEDVKYG
EEEEEEHHHHHCCEEEEECCCCEEEECCHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHC
VGIARKGWLEARDVINTYEVEEVLTILRNM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]