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The map label for this gene is gpmA

Identifier: 20808842

GI number: 20808842

Start: 2374021

End: 2374770

Strand: Reverse

Name: gpmA

Synonym: TTE2487

Alternate gene names: 20808842

Gene position: 2374770-2374021 (Counterclockwise)

Preceding gene: 20808846

Following gene: 20808841

Centisome position: 88.3

GC content: 42.67

Gene sequence:

>750_bases
ATGTACAAAGTAGTTTTACTTCGCCATGGAGAAAGCATATGGAACATGGAAAACAGGTTCACAGGTTGGACAGATGTAGA
CCTTTCGCCGAAAGGAATTGAAGAGGCAAAGCAGGCAGGAAAGATTTTGAAAGAGAAGGGATTTACTTTTGATGCGGCGT
TTACTTCAGTTTTGAAGAGGGCAATAAGGACTTTGTGGATAGTTTTAGATGAGCTGGACCTCATGTGGATACCAGTTTAC
AAGTCCTGGCGGTTGAATGAGAGGCATTATGGAGCTCTTCAGGGGCTTAATAAGGCAGAAACCGCAAAAAAATATGGAGA
AGAGCAGGTAAAGCTTTGGAGAAGGTCTGCAGAGGTTAGACCTCCTGCTTTGACTAAGGATGACCCGAGATATCCTGGCA
ATGACCCAAGGTACGCCGACCTTTCTGAGGATGAAATTCCTCTCACAGAGAATTTGATAGACACTATAAATAGAGTTATT
CCCTACTGGGAGTCCACAATTGCACCGACTATAAAGTCTGGCAAGAGAGTGATAATAGCAGCTCATGGAAACAGTTTAAG
AGGCCTTGTGAAGTATCTGGACAATCTTTCTAATGAGGAAATAATGGAGCTAAATATTCCTACAGGTATTCCTCTGGTTT
ATGAGTTAGATGAGAACTTAAAGCCTATAAGGCACTATTATTTAGCTGATGAAGAGGAGCTCAAGAAAAAACAGCAGGAA
GTTGCGGAGCAGGGCAAAGCGAGGGCTTAA

Upstream 100 bases:

>100_bases
GGAAATGGTGTAAGAGCTTTTTGTTGTGTTTATTTATTCAATGAGGTATAATAAAAATAGCCTTTTGGAATAAAATTTAA
AGACGAGAAGGTGGTGTAGC

Downstream 100 bases:

>100_bases
GGGGCCTTTTGGAAAAGGATGATTTTGCGTGGAAAGAAGAGTGTTGAAGAGGCAATGAAAGAATTTGAATAAAGGACTTT
TTAATAGATAAGGTAGGTAT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MYKVVLLRHGESIWNMENRFTGWTDVDLSPKGIEEAKQAGKILKEKGFTFDAAFTSVLKRAIRTLWIVLDELDLMWIPVY
KSWRLNERHYGALQGLNKAETAKKYGEEQVKLWRRSAEVRPPALTKDDPRYPGNDPRYADLSEDEIPLTENLIDTINRVI
PYWESTIAPTIKSGKRVIIAAHGNSLRGLVKYLDNLSNEEIMELNIPTGIPLVYELDENLKPIRHYYLADEEELKKKQQE
VAEQGKARA

Sequences:

>Translated_249_residues
MYKVVLLRHGESIWNMENRFTGWTDVDLSPKGIEEAKQAGKILKEKGFTFDAAFTSVLKRAIRTLWIVLDELDLMWIPVY
KSWRLNERHYGALQGLNKAETAKKYGEEQVKLWRRSAEVRPPALTKDDPRYPGNDPRYADLSEDEIPLTENLIDTINRVI
PYWESTIAPTIKSGKRVIIAAHGNSLRGLVKYLDNLSNEEIMELNIPTGIPLVYELDENLKPIRHYYLADEEELKKKQQE
VAEQGKARA
>Mature_249_residues
MYKVVLLRHGESIWNMENRFTGWTDVDLSPKGIEEAKQAGKILKEKGFTFDAAFTSVLKRAIRTLWIVLDELDLMWIPVY
KSWRLNERHYGALQGLNKAETAKKYGEEQVKLWRRSAEVRPPALTKDDPRYPGNDPRYADLSEDEIPLTENLIDTINRVI
PYWESTIAPTIKSGKRVIIAAHGNSLRGLVKYLDNLSNEEIMELNIPTGIPLVYELDENLKPIRHYYLADEEELKKKQQE
VAEQGKARA

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI4505753, Length=250, Percent_Identity=63.2, Blast_Score=320, Evalue=6e-88,
Organism=Homo sapiens, GI50593010, Length=250, Percent_Identity=57.2, Blast_Score=304, Evalue=5e-83,
Organism=Homo sapiens, GI71274132, Length=250, Percent_Identity=60.4, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI4502445, Length=252, Percent_Identity=48.8095238095238, Blast_Score=261, Evalue=4e-70,
Organism=Homo sapiens, GI40353764, Length=252, Percent_Identity=48.8095238095238, Blast_Score=261, Evalue=4e-70,
Organism=Homo sapiens, GI310129614, Length=162, Percent_Identity=62.962962962963, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI1786970, Length=246, Percent_Identity=72.7642276422764, Blast_Score=368, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322697, Length=246, Percent_Identity=54.0650406504065, Blast_Score=256, Evalue=3e-69,
Organism=Saccharomyces cerevisiae, GI6324516, Length=293, Percent_Identity=31.740614334471, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320183, Length=296, Percent_Identity=30.7432432432432, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24646216, Length=251, Percent_Identity=55.7768924302789, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI85725270, Length=251, Percent_Identity=56.5737051792829, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI85725272, Length=251, Percent_Identity=56.5737051792829, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24650981, Length=251, Percent_Identity=56.5737051792829, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI28571817, Length=249, Percent_Identity=37.7510040160643, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI28571815, Length=249, Percent_Identity=37.7510040160643, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24648979, Length=249, Percent_Identity=37.7510040160643, Blast_Score=177, Evalue=8e-45,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_THETN (Q8R7C8)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_624013.1
- ProteinModelPortal:   Q8R7C8
- SMR:   Q8R7C8
- GeneID:   998001
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE2487
- NMPDR:   fig|273068.3.peg.1885
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK14115
- BioCyc:   TTEN273068:TTE2487-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28752; Mature: 28752

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKVVLLRHGESIWNMENRFTGWTDVDLSPKGIEEAKQAGKILKEKGFTFDAAFTSVLKR
CEEEEEEECCCHHHCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AIRTLWIVLDELDLMWIPVYKSWRLNERHYGALQGLNKAETAKKYGEEQVKLWRRSAEVR
HHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
PPALTKDDPRYPGNDPRYADLSEDEIPLTENLIDTINRVIPYWESTIAPTIKSGKRVIIA
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEEEE
AHGNSLRGLVKYLDNLSNEEIMELNIPTGIPLVYELDENLKPIRHYYLADEEELKKKQQE
ECCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCHHHHHHHCCCHHHHHHHHHH
VAEQGKARA
HHHCCCCCC
>Mature Secondary Structure
MYKVVLLRHGESIWNMENRFTGWTDVDLSPKGIEEAKQAGKILKEKGFTFDAAFTSVLKR
CEEEEEEECCCHHHCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AIRTLWIVLDELDLMWIPVYKSWRLNERHYGALQGLNKAETAKKYGEEQVKLWRRSAEVR
HHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
PPALTKDDPRYPGNDPRYADLSEDEIPLTENLIDTINRVIPYWESTIAPTIKSGKRVIIA
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHCCCCEEEEE
AHGNSLRGLVKYLDNLSNEEIMELNIPTGIPLVYELDENLKPIRHYYLADEEELKKKQQE
ECCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCHHHHHHHCCCHHHHHHHHHH
VAEQGKARA
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336