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The map label for this gene is IspA2 [H]

Identifier: 20808838

GI number: 20808838

Start: 2369922

End: 2370890

Strand: Reverse

Name: IspA2 [H]

Synonym: TTE2483

Alternate gene names: 20808838

Gene position: 2370890-2369922 (Counterclockwise)

Preceding gene: 20808839

Following gene: 20808837

Centisome position: 88.16

GC content: 30.86

Gene sequence:

>969_bases
ATGGATAAGTTTTGGAATGACAATTTAGAGGTAAAAGAAGAACTTGTAGAAGTTGTAAAAATCATGAAAAAGCGTGTAAA
AAGTTCAAACAAATTAATTAGCGATATACTACTAGATATGGTAAATAATAGTGGCAAAATGTTAAGGCCTGCTTTTGTAA
TTATATCGGCTAAATTTGGAAATTATGATAGAAAAAAGATATTACCTTTAGCAGCTGCTATTGAGATGCTTCACATGGCG
ACTTTAGTGCATGACGATATAATTGACAATGCTTTAATAAGGCGCAGTAAACCTACTATTCAGGCAGAATATGGTAAAGA
TTATGCAGTGTTTATTGGAGATTTTCTTTTCTCTCAAAGTTTTTTGCTTTTATCAGACAATATCAATGTTGCGAATTTAA
AAAAAGTCTCTAAAGTGGTTTCAAGAATATGCAAAGGAGAGATTGATCAATTTGAAAGCCGATATGACATAAATATTACA
ATAAACGATTATTTAAAAAGAATAGCTGCAAAAACTGCTGCTCTCTTCGCTTTAAGTTTTTATGTGGGAGCTTATGAAAG
CAACTGTGGAGAAGAGTTGGCCAAAATATTGGGTAGTATAGGCTATAATATTGGGATAGCTTTTCAAATTATAGATGATA
TTTTAGACTATACTGGGGAAGAAAGTGTTGTAGGGAAGCCTTTGTGTAATGATATAAGACAGGGTGTCTTTACACTTCCT
TTAATCTATTCTTTAGAAAGGAATAGAGATGAAAAAATTATATCGTTGATAAAAAAGAGAAATTATTGTGAGGATGACAT
AAAACGCATTGTTGCATTTGTTCAACAAAATGGTGGGATAACCCAATCAAAAATGTTAGCAGAGAAGTATACTAAAAAAG
CTTTTGACAAAATAGCTATGTTAAAAGATTCTCCACCAAAACAAATTTTAATTGATGTGACGACTAAGCTTTTATATAGA
AATTACTAA

Upstream 100 bases:

>100_bases
ATCTTTGTGGGTTTATCTTCTAAATTTCTTTTAAAACACTGGAACAAATTAAAAATATTAAAATACTAAATTTTTCTTGA
TAAAGGTTAAAGGTGGTTAA

Downstream 100 bases:

>100_bases
AATTGGTTAAAGGCCTTATTTTTGGAGGAGTTATTATATGAAAAAATTTATAGTACTTTTTAGTATTTTTCTACTAATAT
TTATATTTTCTGGGTGTTCA

Product: geranylgeranyl pyrophosphate synthase

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MDKFWNDNLEVKEELVEVVKIMKKRVKSSNKLISDILLDMVNNSGKMLRPAFVIISAKFGNYDRKKILPLAAAIEMLHMA
TLVHDDIIDNALIRRSKPTIQAEYGKDYAVFIGDFLFSQSFLLLSDNINVANLKKVSKVVSRICKGEIDQFESRYDINIT
INDYLKRIAAKTAALFALSFYVGAYESNCGEELAKILGSIGYNIGIAFQIIDDILDYTGEESVVGKPLCNDIRQGVFTLP
LIYSLERNRDEKIISLIKKRNYCEDDIKRIVAFVQQNGGITQSKMLAEKYTKKAFDKIAMLKDSPPKQILIDVTTKLLYR
NY

Sequences:

>Translated_322_residues
MDKFWNDNLEVKEELVEVVKIMKKRVKSSNKLISDILLDMVNNSGKMLRPAFVIISAKFGNYDRKKILPLAAAIEMLHMA
TLVHDDIIDNALIRRSKPTIQAEYGKDYAVFIGDFLFSQSFLLLSDNINVANLKKVSKVVSRICKGEIDQFESRYDINIT
INDYLKRIAAKTAALFALSFYVGAYESNCGEELAKILGSIGYNIGIAFQIIDDILDYTGEESVVGKPLCNDIRQGVFTLP
LIYSLERNRDEKIISLIKKRNYCEDDIKRIVAFVQQNGGITQSKMLAEKYTKKAFDKIAMLKDSPPKQILIDVTTKLLYR
NY
>Mature_322_residues
MDKFWNDNLEVKEELVEVVKIMKKRVKSSNKLISDILLDMVNNSGKMLRPAFVIISAKFGNYDRKKILPLAAAIEMLHMA
TLVHDDIIDNALIRRSKPTIQAEYGKDYAVFIGDFLFSQSFLLLSDNINVANLKKVSKVVSRICKGEIDQFESRYDINIT
INDYLKRIAAKTAALFALSFYVGAYESNCGEELAKILGSIGYNIGIAFQIIDDILDYTGEESVVGKPLCNDIRQGVFTLP
LIYSLERNRDEKIISLIKKRNYCEDDIKRIVAFVQQNGGITQSKMLAEKYTKKAFDKIAMLKDSPPKQILIDVTTKLLYR
NY

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=287, Percent_Identity=30.3135888501742, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI4758430, Length=305, Percent_Identity=21.9672131147541, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI83700220, Length=305, Percent_Identity=21.9672131147541, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789578, Length=301, Percent_Identity=29.2358803986711, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786623, Length=220, Percent_Identity=29.0909090909091, Blast_Score=78, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17505681, Length=235, Percent_Identity=30.2127659574468, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319475, Length=297, Percent_Identity=27.9461279461279, Blast_Score=109, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24651612, Length=276, Percent_Identity=28.9855072463768, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI281365769, Length=295, Percent_Identity=21.6949152542373, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24660002, Length=295, Percent_Identity=21.6949152542373, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36623; Mature: 36623

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKFWNDNLEVKEELVEVVKIMKKRVKSSNKLISDILLDMVNNSGKMLRPAFVIISAKFG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEEEEECCC
NYDRKKILPLAAAIEMLHMATLVHDDIIDNALIRRSKPTIQAEYGKDYAVFIGDFLFSQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCC
FLLLSDNINVANLKKVSKVVSRICKGEIDQFESRYDINITINDYLKRIAAKTAALFALSF
EEEEECCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
YVGAYESNCGEELAKILGSIGYNIGIAFQIIDDILDYTGEESVVGKPLCNDIRQGVFTLP
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LIYSLERNRDEKIISLIKKRNYCEDDIKRIVAFVQQNGGITQSKMLAEKYTKKAFDKIAM
HHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LKDSPPKQILIDVTTKLLYRNY
HCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKFWNDNLEVKEELVEVVKIMKKRVKSSNKLISDILLDMVNNSGKMLRPAFVIISAKFG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEEEEECCC
NYDRKKILPLAAAIEMLHMATLVHDDIIDNALIRRSKPTIQAEYGKDYAVFIGDFLFSQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCC
FLLLSDNINVANLKKVSKVVSRICKGEIDQFESRYDINITINDYLKRIAAKTAALFALSF
EEEEECCCCHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHH
YVGAYESNCGEELAKILGSIGYNIGIAFQIIDDILDYTGEESVVGKPLCNDIRQGVFTLP
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
LIYSLERNRDEKIISLIKKRNYCEDDIKRIVAFVQQNGGITQSKMLAEKYTKKAFDKIAM
HHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LKDSPPKQILIDVTTKLLYRNY
HCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]