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The map label for this gene is MenA [H]

Identifier: 20808836

GI number: 20808836

Start: 2367905

End: 2368834

Strand: Reverse

Name: MenA [H]

Synonym: TTE2481

Alternate gene names: 20808836

Gene position: 2368834-2367905 (Counterclockwise)

Preceding gene: 20808837

Following gene: 20808835

Centisome position: 88.08

GC content: 34.3

Gene sequence:

>930_bases
ATGGATAAAAAGGAATTTTTAAGGGTATGGAAGGGTTTTTGGCAGTTGGCAGACCCTAAGATATGGATAGCATCTACTGT
GCCTATGTTTGTAGCGACTGCCTATGCTTATGGTAAAACGGGAGAGTTTGACTTATTCTGGTTTGTTGTCTCAGTTATAG
GCATTTACCTTATTGAGATAGGTAAAAATGCAGTCAATGAATTTGTTGATTATAAATCTGGTGTAGATACTTTTGTAACT
CCAGATAAAAGAACTCCTTTTAGTGGAGGGAAGAAAACTATAGTCGAAGGTAAACTTACAGTCGAAGAAACAATAATTAT
TGCTTTAGTAACAATACTTGTTTCTTGTGCTATAGGGCTAGCTATTGTCATATTTAGAGAACCTCGTGTATTTATTGTAG
GGCTTGCTGGAGTTTTAATAGCAGTTTTTTATAGTTTGCCTCCTTTTAAATTAAGCTACAGAGGCTTTGGAGAAATAGCT
GTAGGAATAACTTTTGGGCCTTTGATAGTTATAGGGATGTATTTAGTGATGACTCATCATGTAAGTATAGATGTTTTATT
AGTTTCTTTGCCTATAGGGTTTTTAATAACCAATGTTCTTTGGATAAACCAGTATCCAGATTATGAAGCAGACCTCAAAG
GACATAAATACAATTTGTTAGTTAGAATTGGCAAACAAAAAGGAGTGATAGTGTACGCAGCTCTTTATGTAGCAGCCTAT
CTGTCTCTTGCTTTAATAGCTTTAGTTACTAAAAATCCAATATGGCTTATGACCTTTATAACAATTCCATTAGCTGTGAG
GTCTGTAAATGTTGCCCGCAAATATTATGACGAAATACCAAAACTGGTAAAAGCAAATGCCGATACGATAAAAATATATC
AAATTGTAGGACTCATAATGATTTTATCTTCACTGGCATCAAGATTTTAG

Upstream 100 bases:

>100_bases
AAAAGTGTATATAACTTCTGGGTTAAAAGGAAATTTTAGGATTACCGATCCAGAATATACTTTAATGACTAAGTAATTCC
ATTTTTCTGGAGGAAGTTTT

Downstream 100 bases:

>100_bases
GTTTTATTAAGATATTTTTAGAGGGGAGGTGAAGTGAAAAACATTGACATTATTTTAACAAAACAGTATAATATTTTTAC
ACAAAATTTGTATTAAAAGG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MDKKEFLRVWKGFWQLADPKIWIASTVPMFVATAYAYGKTGEFDLFWFVVSVIGIYLIEIGKNAVNEFVDYKSGVDTFVT
PDKRTPFSGGKKTIVEGKLTVEETIIIALVTILVSCAIGLAIVIFREPRVFIVGLAGVLIAVFYSLPPFKLSYRGFGEIA
VGITFGPLIVIGMYLVMTHHVSIDVLLVSLPIGFLITNVLWINQYPDYEADLKGHKYNLLVRIGKQKGVIVYAALYVAAY
LSLALIALVTKNPIWLMTFITIPLAVRSVNVARKYYDEIPKLVKANADTIKIYQIVGLIMILSSLASRF

Sequences:

>Translated_309_residues
MDKKEFLRVWKGFWQLADPKIWIASTVPMFVATAYAYGKTGEFDLFWFVVSVIGIYLIEIGKNAVNEFVDYKSGVDTFVT
PDKRTPFSGGKKTIVEGKLTVEETIIIALVTILVSCAIGLAIVIFREPRVFIVGLAGVLIAVFYSLPPFKLSYRGFGEIA
VGITFGPLIVIGMYLVMTHHVSIDVLLVSLPIGFLITNVLWINQYPDYEADLKGHKYNLLVRIGKQKGVIVYAALYVAAY
LSLALIALVTKNPIWLMTFITIPLAVRSVNVARKYYDEIPKLVKANADTIKIYQIVGLIMILSSLASRF
>Mature_309_residues
MDKKEFLRVWKGFWQLADPKIWIASTVPMFVATAYAYGKTGEFDLFWFVVSVIGIYLIEIGKNAVNEFVDYKSGVDTFVT
PDKRTPFSGGKKTIVEGKLTVEETIIIALVTILVSCAIGLAIVIFREPRVFIVGLAGVLIAVFYSLPPFKLSYRGFGEIA
VGITFGPLIVIGMYLVMTHHVSIDVLLVSLPIGFLITNVLWINQYPDYEADLKGHKYNLLVRIGKQKGVIVYAALYVAAY
LSLALIALVTKNPIWLMTFITIPLAVRSVNVARKYYDEIPKLVKANADTIKIYQIVGLIMILSSLASRF

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Escherichia coli, GI1790365, Length=281, Percent_Identity=26.6903914590747, Blast_Score=88, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17737429, Length=260, Percent_Identity=22.3076923076923, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34445; Mature: 34445

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKEFLRVWKGFWQLADPKIWIASTVPMFVATAYAYGKTGEFDLFWFVVSVIGIYLIEI
CCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GKNAVNEFVDYKSGVDTFVTPDKRTPFSGGKKTIVEGKLTVEETIIIALVTILVSCAIGL
CHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AIVIFREPRVFIVGLAGVLIAVFYSLPPFKLSYRGFGEIAVGITFGPLIVIGMYLVMTHH
EEEEEECCCEEEEEHHHHHHHHHHCCCCCEEECCCCCCEEEEEHHHHHHHHHHHHHHHHC
VSIDVLLVSLPIGFLITNVLWINQYPDYEADLKGHKYNLLVRIGKQKGVIVYAALYVAAY
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHH
LSLALIALVTKNPIWLMTFITIPLAVRSVNVARKYYDEIPKLVKANADTIKIYQIVGLIM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ILSSLASRF
HHHHHHHCC
>Mature Secondary Structure
MDKKEFLRVWKGFWQLADPKIWIASTVPMFVATAYAYGKTGEFDLFWFVVSVIGIYLIEI
CCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GKNAVNEFVDYKSGVDTFVTPDKRTPFSGGKKTIVEGKLTVEETIIIALVTILVSCAIGL
CHHHHHHHHHHCCCCCCEECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AIVIFREPRVFIVGLAGVLIAVFYSLPPFKLSYRGFGEIAVGITFGPLIVIGMYLVMTHH
EEEEEECCCEEEEEHHHHHHHHHHCCCCCEEECCCCCCEEEEEHHHHHHHHHHHHHHHHC
VSIDVLLVSLPIGFLITNVLWINQYPDYEADLKGHKYNLLVRIGKQKGVIVYAALYVAAY
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHH
LSLALIALVTKNPIWLMTFITIPLAVRSVNVARKYYDEIPKLVKANADTIKIYQIVGLIM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ILSSLASRF
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]