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The map label for this gene is UraA [H]

Identifier: 20808770

GI number: 20808770

Start: 2296292

End: 2297569

Strand: Direct

Name: UraA [H]

Synonym: TTE2407

Alternate gene names: 20808770

Gene position: 2296292-2297569 (Clockwise)

Preceding gene: 20808769

Following gene: 20808786

Centisome position: 85.38

GC content: 41.86

Gene sequence:

>1278_bases
ATGCCTAATAAAGTGTACGAAATTGAAGAAACACCGCCTATAAAACAAATGGTCCCATTATCCTTGCAGCACGTCTTTGC
GATGTTCGGAGCAACCATTTTAGTACCTCTCTTGACAGGCCTTGACCCCTCAGTAACCTTATTCACCTCAGGCCTTGGAA
CACTGATATTTCACCTCATGACAAAAGGGAAAGTTCCCGCTTATCTTGGTTCATCTTTCGCCTTCATAGCTCCCATAATA
GCAGCAACAAAACAATTCGGCCTAAAAGGCGCCTTCTTCGGCATGTTCGCAGCCGGACTCGTATACGTGGTGGTTTTCAT
AATAATAAGCCTGACAGGGATTGACTGGCTAGAAAAACTGCTCCCTCCTGTAGTAGTAGGCCCTGTAGTGATGATAATAG
GTTTATCCCTTGCTCCTGTAGCAATAGCTCAAGCGCAAAAAGATTTAGCTACAGCTCTGTTTACAGCGGCATTAATAATC
ATCTTCAGCATGTTTGGAAAAGGCTTTATAAAAGTGATTCCAATCCTTTTAGGAACAATAGGTGGATATATATTTGCCAT
AACAAGAGGCCTTGTAGATTTTGGACCTGTTGCAAAAGCTTCATGGATTGCAATTCCCAAATTCTCCTTCTTAACAGGAC
ATACTCCTGAGGTCGCATGGGGTGCTGTAGCCTTAGTAGCGCCTCTAGCACTGGTCGCTATAATTGAAGACCTGGGACAT
GTTCTGGTAATAGGAAATATAGTTGAAAGGGACCTCATAAAAAATCCTGGATTTCACAGGGTAATGTTAGGAAATGGCCT
TGCAACTTCAATCGCAGCACTTTTTGGCGGACCACCCAGCACAACTTACGGCGAAAACATTGGAGTCCTCGCAATAACAA
GAGTCTACAGCTCAAAAGTTATTCAAGGTGCTGCAATCATTGCAATACTTTTAAGCTTTATACAAAAAATAGGCGCTTTG
ATAGAAGTAATACCCCAAGCAGTAATGGGTGGAGTTACTATAATCCTCTTTGGAATGATTGCAGCAGCAGGTATGAGGAC
ACTTGTAGAAAACAAAGTGGATTTTTCAGACAGCAGAAACTTAATAATAGCTTCTGTAATATTAACATTAGGAGTAGGCG
GTATAAAAATACCCTTGGGCAACTTTGTGTTCGAAGGCATAGGCCCTGCCACCTTAGCAGGAATACTTCTTAATCTGGTG
CTTCCCAAGATAAATCTGGGAGAAGAAAAAATGACTGAAAAAGTTAAAAGTTCAAAAGAAGCCGTCCAGAAAGCGTAA

Upstream 100 bases:

>100_bases
GAAAAAACCCTTTAATTTAGCCCAGCGAGGCTAAAAAGGAGGATATAAAAAGTTCCTCCTTGGGGGTTTTTCAGTAACCC
ATAATAAAGGAGGTTTTTTT

Downstream 100 bases:

>100_bases
AAATAAGGCCCTCTAAATCTCAAAAGAGGGCCTTATCACTTTTTTACCTCTATTCCTACTTCAAAAAGCCTATTCCAAGG
CATATATACATCAAACTCAT

Product: xanthine/uracil permease family protein

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MPNKVYEIEETPPIKQMVPLSLQHVFAMFGATILVPLLTGLDPSVTLFTSGLGTLIFHLMTKGKVPAYLGSSFAFIAPII
AATKQFGLKGAFFGMFAAGLVYVVVFIIISLTGIDWLEKLLPPVVVGPVVMIIGLSLAPVAIAQAQKDLATALFTAALII
IFSMFGKGFIKVIPILLGTIGGYIFAITRGLVDFGPVAKASWIAIPKFSFLTGHTPEVAWGAVALVAPLALVAIIEDLGH
VLVIGNIVERDLIKNPGFHRVMLGNGLATSIAALFGGPPSTTYGENIGVLAITRVYSSKVIQGAAIIAILLSFIQKIGAL
IEVIPQAVMGGVTIILFGMIAAAGMRTLVENKVDFSDSRNLIIASVILTLGVGGIKIPLGNFVFEGIGPATLAGILLNLV
LPKINLGEEKMTEKVKSSKEAVQKA

Sequences:

>Translated_425_residues
MPNKVYEIEETPPIKQMVPLSLQHVFAMFGATILVPLLTGLDPSVTLFTSGLGTLIFHLMTKGKVPAYLGSSFAFIAPII
AATKQFGLKGAFFGMFAAGLVYVVVFIIISLTGIDWLEKLLPPVVVGPVVMIIGLSLAPVAIAQAQKDLATALFTAALII
IFSMFGKGFIKVIPILLGTIGGYIFAITRGLVDFGPVAKASWIAIPKFSFLTGHTPEVAWGAVALVAPLALVAIIEDLGH
VLVIGNIVERDLIKNPGFHRVMLGNGLATSIAALFGGPPSTTYGENIGVLAITRVYSSKVIQGAAIIAILLSFIQKIGAL
IEVIPQAVMGGVTIILFGMIAAAGMRTLVENKVDFSDSRNLIIASVILTLGVGGIKIPLGNFVFEGIGPATLAGILLNLV
LPKINLGEEKMTEKVKSSKEAVQKA
>Mature_424_residues
PNKVYEIEETPPIKQMVPLSLQHVFAMFGATILVPLLTGLDPSVTLFTSGLGTLIFHLMTKGKVPAYLGSSFAFIAPIIA
ATKQFGLKGAFFGMFAAGLVYVVVFIIISLTGIDWLEKLLPPVVVGPVVMIIGLSLAPVAIAQAQKDLATALFTAALIII
FSMFGKGFIKVIPILLGTIGGYIFAITRGLVDFGPVAKASWIAIPKFSFLTGHTPEVAWGAVALVAPLALVAIIEDLGHV
LVIGNIVERDLIKNPGFHRVMLGNGLATSIAALFGGPPSTTYGENIGVLAITRVYSSKVIQGAAIIAILLSFIQKIGALI
EVIPQAVMGGVTIILFGMIAAAGMRTLVENKVDFSDSRNLIIASVILTLGVGGIKIPLGNFVFEGIGPATLAGILLNLVL
PKINLGEEKMTEKVKSSKEAVQKA

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=437, Percent_Identity=28.604118993135, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI44680148, Length=440, Percent_Identity=25.6818181818182, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI40316845, Length=440, Percent_Identity=25.6818181818182, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI44680143, Length=441, Percent_Identity=28.3446712018141, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1788843, Length=432, Percent_Identity=43.75, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI87081818, Length=412, Percent_Identity=42.4757281553398, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87082181, Length=462, Percent_Identity=27.7056277056277, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1790087, Length=453, Percent_Identity=27.8145695364238, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI87082178, Length=466, Percent_Identity=25.9656652360515, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17558856, Length=419, Percent_Identity=25.2983293556086, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71993493, Length=233, Percent_Identity=28.755364806867, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17542260, Length=232, Percent_Identity=29.3103448275862, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=144, Percent_Identity=29.8611111111111, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21356175, Length=438, Percent_Identity=24.8858447488584, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44664; Mature: 44533

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCC
>Mature Secondary Structure 
PNKVYEIEETPPIKQMVPLSLQHVFAMFGATILVPLLTGLDPSVTLFTSGLGTLIFHLM
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TKGKVPAYLGSSFAFIAPIIAATKQFGLKGAFFGMFAAGLVYVVVFIIISLTGIDWLEKL
HCCCCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPPVVVGPVVMIIGLSLAPVAIAQAQKDLATALFTAALIIIFSMFGKGFIKVIPILLGTI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GGYIFAITRGLVDFGPVAKASWIAIPKFSFLTGHTPEVAWGAVALVAPLALVAIIEDLGH
HHHHHHHHHHHHHCCCCCCCCEEECCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
VLVIGNIVERDLIKNPGFHRVMLGNGLATSIAALFGGPPSTTYGENIGVLAITRVYSSKV
EEEEHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
IQGAAIIAILLSFIQKIGALIEVIPQAVMGGVTIILFGMIAAAGMRTLVENKVDFSDSRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
LIIASVILTLGVGGIKIPLGNFVFEGIGPATLAGILLNLVLPKINLGEEKMTEKVKSSKE
HHHHHHHHHHCCCCEEECHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AVQKA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]