Click here to switch to the map view.

The map label for this gene is Sbm5 [H]

Identifier: 20808753

GI number: 20808753

Start: 2275912

End: 2277591

Strand: Reverse

Name: Sbm5 [H]

Synonym: TTE2389

Alternate gene names: 20808753

Gene position: 2277591-2275912 (Counterclockwise)

Preceding gene: 20808754

Following gene: 20808752

Centisome position: 84.69

GC content: 43.63

Gene sequence:

>1680_bases
ATGTACGATGAAAAGAAGCTAGAGGAAATAAAAATGAAAAAAGAGGATTGGGAGAAAAATCATAGGGGAAAAGCCATTGC
AAAATTCCCTGAGAGGAAAGAAGAGTTTAAGACATCTTCAGAGATAGAGATAAAGCCTATCTATACGCCGGAAGACGTTA
AGGATATAGATTACCTTGAAAAGCTGGGGTTCCCAGGGGAATATCCGTATACCAGAGGCGTACAGCCCACCATGTACAGA
GGAAAATTTTGGACAATGAGGCAATACGCTGGTTATGGCACTGCCGAAGAATCTAATAAGAGATTTAAATACCTCTTAGA
GCAAGGACAGACAGGGTTAAGCGTAGCCTTTGACCTTCCAACTCAGATAGGATATGATTCAGACCACCCTATGGCAGAGG
GAGAGGTGGGGAAAGTAGGAGTAGCGATAGATTCACTTTACGACATGGAAATACTGTTTGACGGGATCCCACTTGACAAA
GTCAGCACTTCCATGACCATAAATGCTCCAGCCGCTATACTTCTTGCCATGTACATTGCGGTTGCTGAAAAGCAAGGGGT
GTCTCCTGATAAACTGAATGGCACTATACAGAACGACATATTAAAGGAGTATGTGGCAAGGGGTACTTACATCTTTCCTA
CAGGTCCTTCTATGAGGCTCATCACCAATATATTTGAGTACTGCTCCAAATATGTGCCTAAATGGAATACAATAAGCATA
AGCGGTTACCACATGAGAGAAGCAGGAGCGACAGCTGTACAGGAAGTTGCATTCACCCTCGCAAATGCAATAGCATACGT
AGATGCAGCAATAAAAGCAGGGTTAGATGTGGACGAGTTTGCACCGAGGATTTCCTTCTTTTTCAGCGCTCACAACGATT
TGTTTGAAGAGGTGGCTAAATTTAGAGCCGCTAGGAGAATGTGGGCAAAAATAATGAAGGAGAGATTTGGCGCTAAAGAC
CCCCGTTCTATGATGATGAGATTCCACACTCAGACGGCTGGGTCTACTTTGACTGCCCAGCAACCTGACAACAACATAAT
AAGAGTGACCATTCAGGCTTTGGCTGCAGTATTAGGCGGAACTCAGTCACTTCACACAAACAGCAGAGATGAAGCGCTAG
CTCTTCCTACGGAGGATTCTGTCAGGATTGCATTAAGGACGCAGCAGATAATAGCTTATGAAAGTGGCGTCTGTGACACG
CCAGACCCGTTGGCGGGATCTTACTATGTCGAATACCTGACGGATGAGATAGAAAAGAGAGCTTTTGAGTATATAAAAAA
GATAGATGAACTGGGAGGAGCAGTAAAAGCGATAGACCTCGGGTATATGCAGAGGGAGATTCAGGAAAGCGCCTACAGGT
ATCAGATGGAAATAGAGTCAGGGAAGAGAATAATAGTAGGGCTTAATAAATTCCAGATGGAAGAGGAACCTCCCAAGAAT
CTCTTGAAAGTGGACCCTCAAGTGGAAATAGTGCAGAGGGAAAAGATAAAGAAAGTAAAGGAAATGAGAGATAATGCACG
GGTGGAAAAAGCTTTAAAGGCTTTGAAAAAGGCGGCAGAAGGCGATGACAATTTGATGCCATGGATACTGGATGCAGTGA
GAGAATACGCTACGCTAGGGGAAATAACAGATGTTTTAAGGTCTGTTTTTGGTGAGTATCAACAGCAGATAATATTCTGA

Upstream 100 bases:

>100_bases
GACTTTTGCCGCTTTTCTTTTTATTTTTTTTGAAAAGGTAAACAATTGTTAAAAATTATGCTATAATGTAAGAGGGAAAC
TTAAAGGAGGGAATTGATGT

Downstream 100 bases:

>100_bases
AATAGGAGGTTATAAGCATGGAAAGGCCTATAAGGGTACTGGTGGCGAAACCCGGCTTGGACGGGCATGACAGGGGCGCA
AAGGTGATAGCAAGAGCCTT

Product: methylmalonyl-CoA mutase N-terminal domain-containing protein

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MYDEKKLEEIKMKKEDWEKNHRGKAIAKFPERKEEFKTSSEIEIKPIYTPEDVKDIDYLEKLGFPGEYPYTRGVQPTMYR
GKFWTMRQYAGYGTAEESNKRFKYLLEQGQTGLSVAFDLPTQIGYDSDHPMAEGEVGKVGVAIDSLYDMEILFDGIPLDK
VSTSMTINAPAAILLAMYIAVAEKQGVSPDKLNGTIQNDILKEYVARGTYIFPTGPSMRLITNIFEYCSKYVPKWNTISI
SGYHMREAGATAVQEVAFTLANAIAYVDAAIKAGLDVDEFAPRISFFFSAHNDLFEEVAKFRAARRMWAKIMKERFGAKD
PRSMMMRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGGTQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVCDT
PDPLAGSYYVEYLTDEIEKRAFEYIKKIDELGGAVKAIDLGYMQREIQESAYRYQMEIESGKRIIVGLNKFQMEEEPPKN
LLKVDPQVEIVQREKIKKVKEMRDNARVEKALKALKKAAEGDDNLMPWILDAVREYATLGEITDVLRSVFGEYQQQIIF

Sequences:

>Translated_559_residues
MYDEKKLEEIKMKKEDWEKNHRGKAIAKFPERKEEFKTSSEIEIKPIYTPEDVKDIDYLEKLGFPGEYPYTRGVQPTMYR
GKFWTMRQYAGYGTAEESNKRFKYLLEQGQTGLSVAFDLPTQIGYDSDHPMAEGEVGKVGVAIDSLYDMEILFDGIPLDK
VSTSMTINAPAAILLAMYIAVAEKQGVSPDKLNGTIQNDILKEYVARGTYIFPTGPSMRLITNIFEYCSKYVPKWNTISI
SGYHMREAGATAVQEVAFTLANAIAYVDAAIKAGLDVDEFAPRISFFFSAHNDLFEEVAKFRAARRMWAKIMKERFGAKD
PRSMMMRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGGTQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVCDT
PDPLAGSYYVEYLTDEIEKRAFEYIKKIDELGGAVKAIDLGYMQREIQESAYRYQMEIESGKRIIVGLNKFQMEEEPPKN
LLKVDPQVEIVQREKIKKVKEMRDNARVEKALKALKKAAEGDDNLMPWILDAVREYATLGEITDVLRSVFGEYQQQIIF
>Mature_559_residues
MYDEKKLEEIKMKKEDWEKNHRGKAIAKFPERKEEFKTSSEIEIKPIYTPEDVKDIDYLEKLGFPGEYPYTRGVQPTMYR
GKFWTMRQYAGYGTAEESNKRFKYLLEQGQTGLSVAFDLPTQIGYDSDHPMAEGEVGKVGVAIDSLYDMEILFDGIPLDK
VSTSMTINAPAAILLAMYIAVAEKQGVSPDKLNGTIQNDILKEYVARGTYIFPTGPSMRLITNIFEYCSKYVPKWNTISI
SGYHMREAGATAVQEVAFTLANAIAYVDAAIKAGLDVDEFAPRISFFFSAHNDLFEEVAKFRAARRMWAKIMKERFGAKD
PRSMMMRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGGTQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVCDT
PDPLAGSYYVEYLTDEIEKRAFEYIKKIDELGGAVKAIDLGYMQREIQESAYRYQMEIESGKRIIVGLNKFQMEEEPPKN
LLKVDPQVEIVQREKIKKVKEMRDNARVEKALKALKKAAEGDDNLMPWILDAVREYATLGEITDVLRSVFGEYQQQIIF

Specific function: Unknown

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=521, Percent_Identity=51.4395393474088, Blast_Score=530, Evalue=1e-150,
Organism=Escherichia coli, GI1789284, Length=519, Percent_Identity=54.7206165703276, Blast_Score=544, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI25144500, Length=519, Percent_Identity=51.8304431599229, Blast_Score=542, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 63448; Mature: 63448

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDEKKLEEIKMKKEDWEKNHRGKAIAKFPERKEEFKTSSEIEIKPIYTPEDVKDIDYLE
CCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
KLGFPGEYPYTRGVQPTMYRGKFWTMRQYAGYGTAEESNKRFKYLLEQGQTGLSVAFDLP
HCCCCCCCCCCCCCCCCEECCCEEEHHHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEECC
TQIGYDSDHPMAEGEVGKVGVAIDSLYDMEILFDGIPLDKVSTSMTINAPAAILLAMYIA
HHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCHHHCCCCEEECCHHHHHHHHHHH
VAEKQGVSPDKLNGTIQNDILKEYVARGTYIFPTGPSMRLITNIFEYCSKYVPKWNTISI
HHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEEE
SGYHMREAGATAVQEVAFTLANAIAYVDAAIKAGLDVDEFAPRISFFFSAHNDLFEEVAK
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FRAARRMWAKIMKERFGAKDPRSMMMRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEHHHHHHHHHHCC
TQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVCDTPDPLAGSYYVEYLTDEIEKR
CHHCCCCCCCCEEECCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AFEYIKKIDELGGAVKAIDLGYMQREIQESAYRYQMEIESGKRIIVGLNKFQMEEEPPKN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECHHHCCCCCCCHH
LLKVDPQVEIVQREKIKKVKEMRDNARVEKALKALKKAAEGDDNLMPWILDAVREYATLG
HEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EITDVLRSVFGEYQQQIIF
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYDEKKLEEIKMKKEDWEKNHRGKAIAKFPERKEEFKTSSEIEIKPIYTPEDVKDIDYLE
CCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHH
KLGFPGEYPYTRGVQPTMYRGKFWTMRQYAGYGTAEESNKRFKYLLEQGQTGLSVAFDLP
HCCCCCCCCCCCCCCCCEECCCEEEHHHHCCCCCCCCCCHHHHHHHHCCCCCCEEEEECC
TQIGYDSDHPMAEGEVGKVGVAIDSLYDMEILFDGIPLDKVSTSMTINAPAAILLAMYIA
HHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCHHHCCCCEEECCHHHHHHHHHHH
VAEKQGVSPDKLNGTIQNDILKEYVARGTYIFPTGPSMRLITNIFEYCSKYVPKWNTISI
HHHHCCCCHHHCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEEE
SGYHMREAGATAVQEVAFTLANAIAYVDAAIKAGLDVDEFAPRISFFFSAHNDLFEEVAK
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FRAARRMWAKIMKERFGAKDPRSMMMRFHTQTAGSTLTAQQPDNNIIRVTIQALAAVLGG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEHHHHHHHHHHCC
TQSLHTNSRDEALALPTEDSVRIALRTQQIIAYESGVCDTPDPLAGSYYVEYLTDEIEKR
CHHCCCCCCCCEEECCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AFEYIKKIDELGGAVKAIDLGYMQREIQESAYRYQMEIESGKRIIVGLNKFQMEEEPPKN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECHHHCCCCCCCHH
LLKVDPQVEIVQREKIKKVKEMRDNARVEKALKALKKAAEGDDNLMPWILDAVREYATLG
HEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EITDVLRSVFGEYQQQIIF
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]