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The map label for this gene is LysA2 [H]

Identifier: 20808385

GI number: 20808385

Start: 1930740

End: 1932077

Strand: Direct

Name: LysA2 [H]

Synonym: TTE1981

Alternate gene names: 20808385

Gene position: 1930740-1932077 (Clockwise)

Preceding gene: 20808369

Following gene: 20808393

Centisome position: 71.79

GC content: 39.16

Gene sequence:

>1338_bases
ATGCTACACGGAACAATGAGAATAAATTCAAAAGGACATCTTGAAATAGGCGGATGTGACACAGTTGCCTTAGCTAAAAA
GTTTGGAACTCCTCTTTATGTAATAGATGAGGAACTTCTAAGACAAAATTGCAGAGCCTTTTACAATGGCTTTAAAAGAG
ATTATCCGGGAAACGAAGTAATCTATGCCAGCAAGGCTTTTATGACAATGGCCATATGCAAGATAATTGAAGAAGAAAAC
TTAGGCCTTGACGTAGTATCAGGTGGAGAACTTTATACAGCGCTAAAGGCAGGATTTCCTCCAGAAAAAATCTATTTTCA
CGGCAACAATAAGTCCCGAGAAGAACTCATAATGGCTTTAGAAAATGACATAGGAAAGATAATCGTAGATAACTGGCATG
AACTCAACATGCTAAATGAACTGGCAAGGAAAATGAACAAGGTACCCAATATTTATATAAGAGTATCACCAGGGATAGAG
GCTCACACTCATCAGTACGTAAAAACCGGACAGATAGATTCAAAATTTGGATTCCCTTTGTTCAACGGAGATGCAATGAG
AGCCATTGAATACGCTCTTACCCTTAAAAATGTGAATCTGGTAGGTCTTCATTCCCACATTGGCTCTCAAATTTTCGATT
CCTATTCTTACAAAGCTGAGATAGAAATAATGATGAATTTTATAAAACTCATTAAAGAGTTCCTCGGATGGGAAGTAGAA
GAATTAGACCTAGGAGGAGGATTTGGAATAGCGTATACGGAGGAAGACGACCCCCAGCCTATTGAAAAAATAGCTCATGA
GATGATGCAATCCGTCAAAGAATACTCTGTTTCCTTAAATGTAAAAATGCCCAAAATAATAGTAGAGCCAGGCAGGTCCA
TAATAGGCAATGCAGGAACAACTCTTTACACTGTTGGAGCTATAAAAGAAATACCCGGAATCAGAAAATATGTAGCAGTG
GACGGAGGCATGTCTGATAATATCCGCACAGCCTTATATGGAGCAAAATACGAGGCTATTGTGGCAAACAAAGCCAGACT
CCCAAGGGTAGAAAAGGTATCTATAGCAGGAAAACTATGTGAATCGGGAGACATGCTCATATGGGACATACTACTTCCTG
AAATCGAAGAAGGGGATATTCTAGCAGTCCTGTCAACTGGAGCTTACAACTACTCTATGGCCAGCAATTACAACAGGCTC
CCAAGACCCGCAGCAGTATTAGTTTCTAACGGGCAAGCTGATGTAATAGTTGAAAGAGAGACTTATGAGGACCTTGTAAG
AAAGGACGTCATTCCTGAAAGGTTATTAAGCGTAAAAAGAAAAATAGTAAATTATTAA

Upstream 100 bases:

>100_bases
GTCTATGATGAAAATAGACAGCTAAGGTAATACTTGGCTGTATTTTATTTTGTCTTGCAATTTTATAATTTAAATTATTA
AAGTAAATGAGGTTGAGAGT

Downstream 100 bases:

>100_bases
AAAAGAGAGGGGATGCCCTCTCTTTTTTATTTTACCCTTCAGCTGTACCCTCGCCTTCCTCTTCTTCCTCTTCACCAGCC
TCTTTAGGAACAAGTATAGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLHGTMRINSKGHLEIGGCDTVALAKKFGTPLYVIDEELLRQNCRAFYNGFKRDYPGNEVIYASKAFMTMAICKIIEEEN
LGLDVVSGGELYTALKAGFPPEKIYFHGNNKSREELIMALENDIGKIIVDNWHELNMLNELARKMNKVPNIYIRVSPGIE
AHTHQYVKTGQIDSKFGFPLFNGDAMRAIEYALTLKNVNLVGLHSHIGSQIFDSYSYKAEIEIMMNFIKLIKEFLGWEVE
ELDLGGGFGIAYTEEDDPQPIEKIAHEMMQSVKEYSVSLNVKMPKIIVEPGRSIIGNAGTTLYTVGAIKEIPGIRKYVAV
DGGMSDNIRTALYGAKYEAIVANKARLPRVEKVSIAGKLCESGDMLIWDILLPEIEEGDILAVLSTGAYNYSMASNYNRL
PRPAAVLVSNGQADVIVERETYEDLVRKDVIPERLLSVKRKIVNY

Sequences:

>Translated_445_residues
MLHGTMRINSKGHLEIGGCDTVALAKKFGTPLYVIDEELLRQNCRAFYNGFKRDYPGNEVIYASKAFMTMAICKIIEEEN
LGLDVVSGGELYTALKAGFPPEKIYFHGNNKSREELIMALENDIGKIIVDNWHELNMLNELARKMNKVPNIYIRVSPGIE
AHTHQYVKTGQIDSKFGFPLFNGDAMRAIEYALTLKNVNLVGLHSHIGSQIFDSYSYKAEIEIMMNFIKLIKEFLGWEVE
ELDLGGGFGIAYTEEDDPQPIEKIAHEMMQSVKEYSVSLNVKMPKIIVEPGRSIIGNAGTTLYTVGAIKEIPGIRKYVAV
DGGMSDNIRTALYGAKYEAIVANKARLPRVEKVSIAGKLCESGDMLIWDILLPEIEEGDILAVLSTGAYNYSMASNYNRL
PRPAAVLVSNGQADVIVERETYEDLVRKDVIPERLLSVKRKIVNY
>Mature_445_residues
MLHGTMRINSKGHLEIGGCDTVALAKKFGTPLYVIDEELLRQNCRAFYNGFKRDYPGNEVIYASKAFMTMAICKIIEEEN
LGLDVVSGGELYTALKAGFPPEKIYFHGNNKSREELIMALENDIGKIIVDNWHELNMLNELARKMNKVPNIYIRVSPGIE
AHTHQYVKTGQIDSKFGFPLFNGDAMRAIEYALTLKNVNLVGLHSHIGSQIFDSYSYKAEIEIMMNFIKLIKEFLGWEVE
ELDLGGGFGIAYTEEDDPQPIEKIAHEMMQSVKEYSVSLNVKMPKIIVEPGRSIIGNAGTTLYTVGAIKEIPGIRKYVAV
DGGMSDNIRTALYGAKYEAIVANKARLPRVEKVSIAGKLCESGDMLIWDILLPEIEEGDILAVLSTGAYNYSMASNYNRL
PRPAAVLVSNGQADVIVERETYEDLVRKDVIPERLLSVKRKIVNY

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=370, Percent_Identity=25.1351351351351, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789203, Length=417, Percent_Identity=29.7362110311751, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562780, Length=378, Percent_Identity=24.6031746031746, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322664, Length=394, Percent_Identity=22.0812182741117, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586472, Length=360, Percent_Identity=26.3888888888889, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24586474, Length=359, Percent_Identity=28.4122562674095, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49789; Mature: 49789

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHGTMRINSKGHLEIGGCDTVALAKKFGTPLYVIDEELLRQNCRAFYNGFKRDYPGNEV
CCCEEEEECCCCCEEECCCCHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCCCCEE
IYASKAFMTMAICKIIEEENLGLDVVSGGELYTALKAGFPPEKIYFHGNNKSREELIMAL
EEEHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCCCEEEEECCCCCHHHHHHHH
ENDIGKIIVDNWHELNMLNELARKMNKVPNIYIRVSPGIEAHTHQYVKTGQIDSKFGFPL
HHCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCEE
FNGDAMRAIEYALTLKNVNLVGLHSHIGSQIFDSYSYKAEIEIMMNFIKLIKEFLGWEVE
ECCCHHHHHHHHEEECCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEE
ELDLGGGFGIAYTEEDDPQPIEKIAHEMMQSVKEYSVSLNVKMPKIIVEPGRSIIGNAGT
EEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCEEEECCCCHHHCCCCC
TLYTVGAIKEIPGIRKYVAVDGGMSDNIRTALYGAKYEAIVANKARLPRVEKVSIAGKLC
EEEEECHHHHCCCCEEEEEECCCCCCCCHHHEECCCEEEEEECCCCCCCCEEEHHHHHHC
ESGDMLIWDILLPEIEEGDILAVLSTGAYNYSMASNYNRLPRPAAVLVSNGQADVIVERE
CCCCEEEEEEECCCCCCCCEEEEEECCCEEEEHHCCCCCCCCCEEEEEECCCEEEEEEHH
TYEDLVRKDVIPERLLSVKRKIVNY
HHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLHGTMRINSKGHLEIGGCDTVALAKKFGTPLYVIDEELLRQNCRAFYNGFKRDYPGNEV
CCCEEEEECCCCCEEECCCCHHHHHHHHCCCEEEECHHHHHHHHHHHHCCCCCCCCCCEE
IYASKAFMTMAICKIIEEENLGLDVVSGGELYTALKAGFPPEKIYFHGNNKSREELIMAL
EEEHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCCCEEEEECCCCCHHHHHHHH
ENDIGKIIVDNWHELNMLNELARKMNKVPNIYIRVSPGIEAHTHQYVKTGQIDSKFGFPL
HHCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCEE
FNGDAMRAIEYALTLKNVNLVGLHSHIGSQIFDSYSYKAEIEIMMNFIKLIKEFLGWEVE
ECCCHHHHHHHHEEECCCEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEE
ELDLGGGFGIAYTEEDDPQPIEKIAHEMMQSVKEYSVSLNVKMPKIIVEPGRSIIGNAGT
EEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCEEEECCCCHHHCCCCC
TLYTVGAIKEIPGIRKYVAVDGGMSDNIRTALYGAKYEAIVANKARLPRVEKVSIAGKLC
EEEEECHHHHCCCCEEEEEECCCCCCCCHHHEECCCEEEEEECCCCCCCCEEEHHHHHHC
ESGDMLIWDILLPEIEEGDILAVLSTGAYNYSMASNYNRLPRPAAVLVSNGQADVIVERE
CCCCEEEEEEECCCCCCCCEEEEEECCCEEEEHHCCCCCCCCCEEEEEECCCEEEEEEHH
TYEDLVRKDVIPERLLSVKRKIVNY
HHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]