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The map label for this gene is UvrB

Identifier: 20808375

GI number: 20808375

Start: 1919249

End: 1921237

Strand: Reverse

Name: UvrB

Synonym: TTE1971

Alternate gene names: 20808375

Gene position: 1921237-1919249 (Counterclockwise)

Preceding gene: 20808376

Following gene: 20808374

Centisome position: 71.44

GC content: 42.53

Gene sequence:

>1989_bases
ATGGGAGGTTTTAAGCTGGTTTCAAATTTCAAGCCTACAGGAGACCAGCCTCAGGCGATTGAAAAACTGGTGGAAGGGGT
AAGACGGGGATATAGGTACCAGACGTTGTTAGGAGTTACAGGTTCAGGCAAAACTTTTACTATGGCCAACATCATAGCCC
GCTTGAATAGGCCTACCCTGGTGATCGCTCACAACAAAACTCTTGCGGCACAGCTTTACAGCGAGTTTAAGGAATTCTTT
CCAGAAAATGCTGTAGAGTATTTTGTGAGCTATTACGACTATTACCAGCCAGAAGCTTATGTTCCTGAGACTGACACTTA
CATTGAAAAAGACGCTTCTATAAATGAAGAGATTGACAAGTTGAGGCACTCGGCGACAGCTGCGCTCTTTGAAAGAAGAG
ATGTGATAATTGTTGCCAGTGTCTCTTGTATATACGGCTTAGGCGATCCTATAGATTATGAGAATTTGATGCTTTCACTA
AGGCCTGGAATGGTAAAAGACAGAGATGAGATAATAAGAAAACTGGTGGAGATTCAGTACGAAAGGAATGATATAAACTT
CACAAGAGGGAAATTCAGAGTAAGAGGCGATGTGATAGAGGTATTTCCTGCTTCCTTCTCAAATAAAGCTATAAGGATAG
AGCTTTTTGGGGATGAAATAGACAGGATAGCAGAAATAGACGTCCTAACAGGAGAAGTTTTAGGGTACAGAAAGCATGTG
GCTATTTTTCCTGCTTCCCACTATGCCACATCAAGGGACAAGCTGGAAAGGGCTATAAAAAGCATAAGGGAAGAGCTTGA
AGAGAGGTATAAAGAGTTAAAAGAAATGGGGAAAATTGTAGAAGCGGAGAGGCTATGGCAGAGGACTAATTACGACCTTG
AGATGTTACAAGAGATGGGCTACTGTAAGGGGATAGAAAATTATTCGCGGCACATATCTGGGAGGCCTCCGGGAAGTCCT
CCTTATACACTGCTTGATTACTTTCCTGAGGATTTCCTCATATTCATAGATGAGTCTCATGTTACTATTCCTCAGCTGAG
GGGAATGTACAACGGAGACAGGTCCAGAAAAGAGGCATTGGTGGAATACGGCTTTAGACTTCCTTCTGCTTATGACAACA
GGCCCCTTACATTTGAAGAGTTTGAACAAAGGGTAAATCAGGTCATCTTTGTATCAGCAACCCCTGGACCTTATGAGATG
GAACATTCTGAACAGGTGGTAGAACAGCTCATAAGGCCGACAGGGCTTGTAGACCCAGAAGTGATTGTGAGGCCTGTGAA
AGGGCAGGTGGACGATTTAATAGCGGAGATAAGGAAGACTGTTGCAAAAGGGTACAGGGTTTTGGTTACAACTTTGACTA
AAAAGATGGCGGAGGATTTGTCAGACTACTTAAAAGAAATGGGAATAAGAGTGAGGTACTTGCATTCAGATATAGAGACA
ATTGAGAGGGTAGAAATTATAAGGGATTTGAGGCTGGGTAAATTTGACGTTTTAATAGGCATAAATCTCTTGAGGGAAGG
GCTTGATATTCCGGAGGTTGCACTGGTGGCTATTTTGGATGCGGATAAAGAAGGATTCTTGAGGTCAGAGACTTCTCTGA
TACAGACGATAGGCCGTGCAGCGAGAAACGCTGAAGGAAGAGTTATAATGTACGCTGATACAATAACAAATTCTATGAGA
AGAGCTATAGATGAAACAAATAGGAGAAGAAAAATTCAAATGGAGTACAATGAGAAGCACGGCATAGTGCCAAAGACAGT
GGTCAAAGGAGTAAGGGATGTCATACAGGCAACACAGGTGGCTGAAAAGGAGGAAAAGTACGAAAAGACAGCCAATTTTT
ACGATCCCGATGTGATAAAGTCTACCATAGAACAGCTTGAAAAAGAGATGAGGCAGGCGGCAATAGAGCTTCAGTTTGAA
AAAGCCGCAAAATTGAGAGACATGATACTTGAACTTAGGAAACAACTGGAGGAAGTCAGCTTGAGGTGA

Upstream 100 bases:

>100_bases
AACGGGATAGTGAGGACCTCACAGGACTTTTAAAATTTGTGCTGAGAGGTCCTTTGTGTTATAATATTACAATAGACCAA
ATTGCAAAGAGGGTATTGGT

Downstream 100 bases:

>100_bases
AAATATATGGCAAAAGATAAGATCGTGATAAAAGGAGCAAGGGTCCACAATTTGAAAAACATAGATGTAGAAATTCCAAG
GGACAAACTCACAGTTATAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 662; Mature: 661

Protein sequence:

>662_residues
MGGFKLVSNFKPTGDQPQAIEKLVEGVRRGYRYQTLLGVTGSGKTFTMANIIARLNRPTLVIAHNKTLAAQLYSEFKEFF
PENAVEYFVSYYDYYQPEAYVPETDTYIEKDASINEEIDKLRHSATAALFERRDVIIVASVSCIYGLGDPIDYENLMLSL
RPGMVKDRDEIIRKLVEIQYERNDINFTRGKFRVRGDVIEVFPASFSNKAIRIELFGDEIDRIAEIDVLTGEVLGYRKHV
AIFPASHYATSRDKLERAIKSIREELEERYKELKEMGKIVEAERLWQRTNYDLEMLQEMGYCKGIENYSRHISGRPPGSP
PYTLLDYFPEDFLIFIDESHVTIPQLRGMYNGDRSRKEALVEYGFRLPSAYDNRPLTFEEFEQRVNQVIFVSATPGPYEM
EHSEQVVEQLIRPTGLVDPEVIVRPVKGQVDDLIAEIRKTVAKGYRVLVTTLTKKMAEDLSDYLKEMGIRVRYLHSDIET
IERVEIIRDLRLGKFDVLIGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRAARNAEGRVIMYADTITNSMR
RAIDETNRRRKIQMEYNEKHGIVPKTVVKGVRDVIQATQVAEKEEKYEKTANFYDPDVIKSTIEQLEKEMRQAAIELQFE
KAAKLRDMILELRKQLEEVSLR

Sequences:

>Translated_662_residues
MGGFKLVSNFKPTGDQPQAIEKLVEGVRRGYRYQTLLGVTGSGKTFTMANIIARLNRPTLVIAHNKTLAAQLYSEFKEFF
PENAVEYFVSYYDYYQPEAYVPETDTYIEKDASINEEIDKLRHSATAALFERRDVIIVASVSCIYGLGDPIDYENLMLSL
RPGMVKDRDEIIRKLVEIQYERNDINFTRGKFRVRGDVIEVFPASFSNKAIRIELFGDEIDRIAEIDVLTGEVLGYRKHV
AIFPASHYATSRDKLERAIKSIREELEERYKELKEMGKIVEAERLWQRTNYDLEMLQEMGYCKGIENYSRHISGRPPGSP
PYTLLDYFPEDFLIFIDESHVTIPQLRGMYNGDRSRKEALVEYGFRLPSAYDNRPLTFEEFEQRVNQVIFVSATPGPYEM
EHSEQVVEQLIRPTGLVDPEVIVRPVKGQVDDLIAEIRKTVAKGYRVLVTTLTKKMAEDLSDYLKEMGIRVRYLHSDIET
IERVEIIRDLRLGKFDVLIGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRAARNAEGRVIMYADTITNSMR
RAIDETNRRRKIQMEYNEKHGIVPKTVVKGVRDVIQATQVAEKEEKYEKTANFYDPDVIKSTIEQLEKEMRQAAIELQFE
KAAKLRDMILELRKQLEEVSLR
>Mature_661_residues
GGFKLVSNFKPTGDQPQAIEKLVEGVRRGYRYQTLLGVTGSGKTFTMANIIARLNRPTLVIAHNKTLAAQLYSEFKEFFP
ENAVEYFVSYYDYYQPEAYVPETDTYIEKDASINEEIDKLRHSATAALFERRDVIIVASVSCIYGLGDPIDYENLMLSLR
PGMVKDRDEIIRKLVEIQYERNDINFTRGKFRVRGDVIEVFPASFSNKAIRIELFGDEIDRIAEIDVLTGEVLGYRKHVA
IFPASHYATSRDKLERAIKSIREELEERYKELKEMGKIVEAERLWQRTNYDLEMLQEMGYCKGIENYSRHISGRPPGSPP
YTLLDYFPEDFLIFIDESHVTIPQLRGMYNGDRSRKEALVEYGFRLPSAYDNRPLTFEEFEQRVNQVIFVSATPGPYEME
HSEQVVEQLIRPTGLVDPEVIVRPVKGQVDDLIAEIRKTVAKGYRVLVTTLTKKMAEDLSDYLKEMGIRVRYLHSDIETI
ERVEIIRDLRLGKFDVLIGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRAARNAEGRVIMYADTITNSMRR
AIDETNRRRKIQMEYNEKHGIVPKTVVKGVRDVIQATQVAEKEEKYEKTANFYDPDVIKSTIEQLEKEMRQAAIELQFEK
AAKLRDMILELRKQLEEVSLR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=663, Percent_Identity=61.0859728506787, Blast_Score=796, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_THETN (Q8R8M4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623546.1
- ProteinModelPortal:   Q8R8M4
- SMR:   Q8R8M4
- GeneID:   997167
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1971
- NMPDR:   fig|273068.3.peg.1941
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   TTEN273068:TTE1971-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76405; Mature: 76273

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGFKLVSNFKPTGDQPQAIEKLVEGVRRGYRYQTLLGVTGSGKTFTMANIIARLNRPTL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHCCCCEE
VIAHNKTLAAQLYSEFKEFFPENAVEYFVSYYDYYQPEAYVPETDTYIEKDASINEEIDK
EEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHH
LRHSATAALFERRDVIIVASVSCIYGLGDPIDYENLMLSLRPGMVKDRDEIIRKLVEIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHH
ERNDINFTRGKFRVRGDVIEVFPASFSNKAIRIELFGDEIDRIAEIDVLTGEVLGYRKHV
CCCCCCEECCEEEEECCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEE
AIFPASHYATSRDKLERAIKSIREELEERYKELKEMGKIVEAERLWQRTNYDLEMLQEMG
EEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
YCKGIENYSRHISGRPPGSPPYTLLDYFPEDFLIFIDESHVTIPQLRGMYNGDRSRKEAL
HHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHH
VEYGFRLPSAYDNRPLTFEEFEQRVNQVIFVSATPGPYEMEHSEQVVEQLIRPTGLVDPE
HHHHCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHH
VIVRPVKGQVDDLIAEIRKTVAKGYRVLVTTLTKKMAEDLSDYLKEMGIRVRYLHSDIET
HHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHH
IERVEIIRDLRLGKFDVLIGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRA
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHHH
ARNAEGRVIMYADTITNSMRRAIDETNRRRKIQMEYNEKHGIVPKTVVKGVRDVIQATQV
HCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AEKEEKYEKTANFYDPDVIKSTIEQLEKEMRQAAIELQFEKAAKLRDMILELRKQLEEVS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LR
CC
>Mature Secondary Structure 
GGFKLVSNFKPTGDQPQAIEKLVEGVRRGYRYQTLLGVTGSGKTFTMANIIARLNRPTL
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHCCCCEE
VIAHNKTLAAQLYSEFKEFFPENAVEYFVSYYDYYQPEAYVPETDTYIEKDASINEEIDK
EEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHH
LRHSATAALFERRDVIIVASVSCIYGLGDPIDYENLMLSLRPGMVKDRDEIIRKLVEIQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCHHHHHEEECCCCCCCHHHHHHHHHHHHH
ERNDINFTRGKFRVRGDVIEVFPASFSNKAIRIELFGDEIDRIAEIDVLTGEVLGYRKHV
CCCCCCEECCEEEEECCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEE
AIFPASHYATSRDKLERAIKSIREELEERYKELKEMGKIVEAERLWQRTNYDLEMLQEMG
EEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
YCKGIENYSRHISGRPPGSPPYTLLDYFPEDFLIFIDESHVTIPQLRGMYNGDRSRKEAL
HHCCHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHH
VEYGFRLPSAYDNRPLTFEEFEQRVNQVIFVSATPGPYEMEHSEQVVEQLIRPTGLVDPE
HHHHCCCCCCCCCCCCCHHHHHHHHCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHH
VIVRPVKGQVDDLIAEIRKTVAKGYRVLVTTLTKKMAEDLSDYLKEMGIRVRYLHSDIET
HHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHH
IERVEIIRDLRLGKFDVLIGINLLREGLDIPEVALVAILDADKEGFLRSETSLIQTIGRA
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHEECCCCCCCHHHHHHHHHHHHHH
ARNAEGRVIMYADTITNSMRRAIDETNRRRKIQMEYNEKHGIVPKTVVKGVRDVIQATQV
HCCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AEKEEKYEKTANFYDPDVIKSTIEQLEKEMRQAAIELQFEKAAKLRDMILELRKQLEEVS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336