Click here to switch to the map view.

The map label for this gene is UvrA [H]

Identifier: 20808374

GI number: 20808374

Start: 1916459

End: 1919242

Strand: Reverse

Name: UvrA [H]

Synonym: TTE1970

Alternate gene names: 20808374

Gene position: 1919242-1916459 (Counterclockwise)

Preceding gene: 20808375

Following gene: 20808373

Centisome position: 71.36

GC content: 43.53

Gene sequence:

>2784_bases
ATGGCAAAAGATAAGATCGTGATAAAAGGAGCAAGGGTCCACAATTTGAAAAACATAGATGTAGAAATTCCAAGGGACAA
ACTCACAGTTATAACTGGATTATCAGGATCTGGCAAATCTTCTTTGGCTTTTGACACGATTTACGCAGAGGGACAGAGGA
GATATGTGGAGTCCCTTTCTGCCTATGCAAGGCAATTTCTGGGGCAAATGGATAAGCCTGATGTGGATTATATAGAAGGG
TTGTCTCCTGCGATTTCTATAGACCAAAAAACTACTACTAAAAATCCTCGATCTACAGTGGGCACCATAACAGAAATTTA
CGATTATCTCCGCCTTTTATATGCCAGAGTTGGAACTCCCCACTGCCCTATATGCGGCCGCGAGATAACAATGCAGACAA
TTGACCAGATGGTAGACAAAATAAAAGAGCTGCCGGAGGGAACGAGGATTCAAATCCTAGCTCCCGTGGTGAGAGGGAGA
AAAGGGGAGTATTCAAAGCTTTTGGCAGACATAAAAAAGAGCGGTTATGTGAGAGTGAAGATTGATGGCATAATGTACGA
TGTAAATGAGGAGATAAAACTTGACAAAAATAAAAAGCATACAATAGAAGTCGTGGTAGACAGGATAATAATGAAGCCTG
GAATTGACATGAGGCTTACAGATTCAATAGAGACCGCTTTGAAACTGGCAGATGGCCTTGTGACAATTGATGTCATAGAC
GGAGAGAGCTTTACTCTGTCTGAAAAATACGCTTGTCCCGCGTGCAATGTCAGCATTGAAGAGCTGTCTCCCAGGATGTT
TTCATTTAACAGCCCTTATGGAGCTTGCCCTGTTTGCATGGGATTGGGAGAGTTCATGAAGGTGGACCCAGAGCTTTTAA
TACAGGACCCGAAGAAATCTCTTGCGACAGGAGTTTTTCCGGGAATTGTAGCGTCCCAGGGAAGTTATGCCTATTATAAT
ATGTTGAGAGTGATAGAGTACTTTGGATATACCGAGTACACTCCCTATGAGGAGTTCAGTGAAGATTTAAAGAGCGTACT
CCTATACGGAAAAGATACGAAAGGAAAATCTTACGGCTTTGAAGGGATAATTAACAATTTAGAGAGAAGGTATGAAAGCA
GCACATCTGATTTCATAAAGGAAGAAATAGAAAAATACATGAGGCCTGTCACGTGTCCTGCTTGCAATGGTGCCAGGCTA
AAGCCAGAAGCTCTTGCTGTTACAGTTGGAGGCCTTTCTATAAAAGAGATGACAGACCTCACTATAGGGGAACTCTTGAA
ATTCATAGACAACCTTAAATTTTCAGAAAAGCAGGAGATGATAGCTCGCCCTATTTTGAAGGAAATAAAGGCAAGGCTAA
ACTTTCTTGTGGACGTAGGGCTTGACTACCTCACACTTTCGAGGCCGGCATCTACACTCTCTGGTGGTGAAGCCCAGAGG
ATAAGGCTTGCAAGCCAGATAGGTTCAGGGCTTGTGGGGGTTACCTATATACTGGATGAGCCAAGCATTGGACTTCACCA
GAGAGACAATCAAAGGCTTATAAATTCTCTCAAAAGGTTAAGGGACCAGGGCAATACGGTTATAGTGGTGGAGCACGACG
AGGAGACCATATACGCTGCAGACTATATAATAGACATAGGTCCGGGAGCTGGAGAGCACGGCGGAGAAGTGGTGGTGGCG
GGAACTATAGAAGATGTACTAAAGTGCGAGAGGTCTCTTACCGGCCAGTATTTGAGTGGTAAAATAAAGATAGAAGTGCC
TGAGAAGAGGAGAAAGCCCAATGGAAAGGCTATTATAGTGAGAGGAGCTAAGGAAAACAATTTGAAAAACATAGATGTGG
AATTTCCTTTGGGAGTTTTTATATGTGTGACAGGGGTATCAGGCTCAGGGAAGAGCACTCTTGTCAACGAAATACTTTAT
AAAGCCTTGGCACAGAAAATTTACAAATCAAAGGACAAACCCGGAAAGCACGACAGAATAGAAGGCATAGAGCACATAGA
CAAAGTGATAAATATCGACCAGTCTCCCATAGGGAGGACACCTCGCTCAAACCCGGCGACTTACACTGGAGTGTTTGACT
ATATAAGGGAAGTATTTGCCAATACTCCCGAAGCCAGGATGAGAGGCTACAAGCCGGGAAGATTTAGCTTTAACGTAAAA
GGTGGGAGATGTGAGGCCTGTGGCGGAGACGGCATAATAAAAATTGAGATGAATTTTCTGCCAGACGTCTATGTGCCTTG
TGAGGTGTGCAAGGGCAAAAGGTATAACAGGGAAACTTTAGAAGTAAAATACAAAGGAAAGAGCATAGCTGACGTGCTGG
ACATGACTGTTGAGGAGGCTTTGGAGCTCTTTGAAAATATCCCTCGAATAAAGAATAAACTCATGACGCTCTACGAGGTA
GGACTGGGGTATATAAAGCTTGGCCAACCTTCCACTCAGCTGTCCGGCGGAGAGGCTCAGAGAGTAAAACTCGCTACAGA
ACTTTCAAAGAGGCCTACAGGAAGGACTTTGTATATTTTAGATGAGCCTACGACAGGGCTTCACTTTGCTGATATACACA
GACTGCTCAATGTCCTAAACAAATTGACAGATGCAGGGAATACTGTGATAGTTATAGAGCACAATCTAGATGTGATAAAA
AGCGCAGATTACATCATAGACTTAGGGCCAGAAGGTGGAGACAGAGGGGGAATGGTCATAGCTACGGGAACTCCTGAAGA
GGTTGCAGCCAATGAGAATTCTTATACAGGATGGTTTTTAAGGAAAGTCCTTTCTCGAAATTGA

Upstream 100 bases:

>100_bases
GGCGGCAATAGAGCTTCAGTTTGAAAAAGCCGCAAAATTGAGAGACATGATACTTGAACTTAGGAAACAACTGGAGGAAG
TCAGCTTGAGGTGAAAATAT

Downstream 100 bases:

>100_bases
GGTGAATTTATGTATTACATTTTATCCCAAATTTTAAAATATGTGCTCATTTTTTTGATTTACCTTTTTTTGTACAGGGT
TTTTAAGATAATATACATGG

Product: excinuclease ATPase subunit

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 927; Mature: 926

Protein sequence:

>927_residues
MAKDKIVIKGARVHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDYIEG
LSPAISIDQKTTTKNPRSTVGTITEIYDYLRLLYARVGTPHCPICGREITMQTIDQMVDKIKELPEGTRIQILAPVVRGR
KGEYSKLLADIKKSGYVRVKIDGIMYDVNEEIKLDKNKKHTIEVVVDRIIMKPGIDMRLTDSIETALKLADGLVTIDVID
GESFTLSEKYACPACNVSIEELSPRMFSFNSPYGACPVCMGLGEFMKVDPELLIQDPKKSLATGVFPGIVASQGSYAYYN
MLRVIEYFGYTEYTPYEEFSEDLKSVLLYGKDTKGKSYGFEGIINNLERRYESSTSDFIKEEIEKYMRPVTCPACNGARL
KPEALAVTVGGLSIKEMTDLTIGELLKFIDNLKFSEKQEMIARPILKEIKARLNFLVDVGLDYLTLSRPASTLSGGEAQR
IRLASQIGSGLVGVTYILDEPSIGLHQRDNQRLINSLKRLRDQGNTVIVVEHDEETIYAADYIIDIGPGAGEHGGEVVVA
GTIEDVLKCERSLTGQYLSGKIKIEVPEKRRKPNGKAIIVRGAKENNLKNIDVEFPLGVFICVTGVSGSGKSTLVNEILY
KALAQKIYKSKDKPGKHDRIEGIEHIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEARMRGYKPGRFSFNVK
GGRCEACGGDGIIKIEMNFLPDVYVPCEVCKGKRYNRETLEVKYKGKSIADVLDMTVEEALELFENIPRIKNKLMTLYEV
GLGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGRTLYILDEPTTGLHFADIHRLLNVLNKLTDAGNTVIVIEHNLDVIK
SADYIIDLGPEGGDRGGMVIATGTPEEVAANENSYTGWFLRKVLSRN

Sequences:

>Translated_927_residues
MAKDKIVIKGARVHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDYIEG
LSPAISIDQKTTTKNPRSTVGTITEIYDYLRLLYARVGTPHCPICGREITMQTIDQMVDKIKELPEGTRIQILAPVVRGR
KGEYSKLLADIKKSGYVRVKIDGIMYDVNEEIKLDKNKKHTIEVVVDRIIMKPGIDMRLTDSIETALKLADGLVTIDVID
GESFTLSEKYACPACNVSIEELSPRMFSFNSPYGACPVCMGLGEFMKVDPELLIQDPKKSLATGVFPGIVASQGSYAYYN
MLRVIEYFGYTEYTPYEEFSEDLKSVLLYGKDTKGKSYGFEGIINNLERRYESSTSDFIKEEIEKYMRPVTCPACNGARL
KPEALAVTVGGLSIKEMTDLTIGELLKFIDNLKFSEKQEMIARPILKEIKARLNFLVDVGLDYLTLSRPASTLSGGEAQR
IRLASQIGSGLVGVTYILDEPSIGLHQRDNQRLINSLKRLRDQGNTVIVVEHDEETIYAADYIIDIGPGAGEHGGEVVVA
GTIEDVLKCERSLTGQYLSGKIKIEVPEKRRKPNGKAIIVRGAKENNLKNIDVEFPLGVFICVTGVSGSGKSTLVNEILY
KALAQKIYKSKDKPGKHDRIEGIEHIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEARMRGYKPGRFSFNVK
GGRCEACGGDGIIKIEMNFLPDVYVPCEVCKGKRYNRETLEVKYKGKSIADVLDMTVEEALELFENIPRIKNKLMTLYEV
GLGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGRTLYILDEPTTGLHFADIHRLLNVLNKLTDAGNTVIVIEHNLDVIK
SADYIIDLGPEGGDRGGMVIATGTPEEVAANENSYTGWFLRKVLSRN
>Mature_926_residues
AKDKIVIKGARVHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDYIEGL
SPAISIDQKTTTKNPRSTVGTITEIYDYLRLLYARVGTPHCPICGREITMQTIDQMVDKIKELPEGTRIQILAPVVRGRK
GEYSKLLADIKKSGYVRVKIDGIMYDVNEEIKLDKNKKHTIEVVVDRIIMKPGIDMRLTDSIETALKLADGLVTIDVIDG
ESFTLSEKYACPACNVSIEELSPRMFSFNSPYGACPVCMGLGEFMKVDPELLIQDPKKSLATGVFPGIVASQGSYAYYNM
LRVIEYFGYTEYTPYEEFSEDLKSVLLYGKDTKGKSYGFEGIINNLERRYESSTSDFIKEEIEKYMRPVTCPACNGARLK
PEALAVTVGGLSIKEMTDLTIGELLKFIDNLKFSEKQEMIARPILKEIKARLNFLVDVGLDYLTLSRPASTLSGGEAQRI
RLASQIGSGLVGVTYILDEPSIGLHQRDNQRLINSLKRLRDQGNTVIVVEHDEETIYAADYIIDIGPGAGEHGGEVVVAG
TIEDVLKCERSLTGQYLSGKIKIEVPEKRRKPNGKAIIVRGAKENNLKNIDVEFPLGVFICVTGVSGSGKSTLVNEILYK
ALAQKIYKSKDKPGKHDRIEGIEHIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEARMRGYKPGRFSFNVKG
GRCEACGGDGIIKIEMNFLPDVYVPCEVCKGKRYNRETLEVKYKGKSIADVLDMTVEEALELFENIPRIKNKLMTLYEVG
LGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGRTLYILDEPTTGLHFADIHRLLNVLNKLTDAGNTVIVIEHNLDVIKS
ADYIIDLGPEGGDRGGMVIATGTPEEVAANENSYTGWFLRKVLSRN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=941, Percent_Identity=58.1296493092455, Blast_Score=1101, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 102935; Mature: 102804

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDKIVIKGARVHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLS
CCCCCEEEECCEECCCCCCEEECCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
AYARQFLGQMDKPDVDYIEGLSPAISIDQKTTTKNPRSTVGTITEIYDYLRLLYARVGTP
HHHHHHHCCCCCCCHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
HCPICGREITMQTIDQMVDKIKELPEGTRIQILAPVVRGRKGEYSKLLADIKKSGYVRVK
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHCCEEEEE
IDGIMYDVNEEIKLDKNKKHTIEVVVDRIIMKPGIDMRLTDSIETALKLADGLVTIDVID
ECCEEEECCCCEEECCCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCEEEEEEEC
GESFTLSEKYACPACNVSIEELSPRMFSFNSPYGACPVCMGLGEFMKVDPELLIQDPKKS
CCCEEECCCCCCCCCCCCHHHCCCCCEECCCCCCCCHHHHCCHHHHHCCHHHEECCCHHH
LATGVFPGIVASQGSYAYYNMLRVIEYFGYTEYTPYEEFSEDLKSVLLYGKDTKGKSYGF
HHHCCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCH
EGIINNLERRYESSTSDFIKEEIEKYMRPVTCPACNGARLKPEALAVTVGGLSIKEMTDL
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCC
TIGELLKFIDNLKFSEKQEMIARPILKEIKARLNFLVDVGLDYLTLSRPASTLSGGEAQR
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHH
IRLASQIGSGLVGVTYILDEPSIGLHQRDNQRLINSLKRLRDQGNTVIVVEHDEETIYAA
HHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEE
DYIIDIGPGAGEHGGEVVVAGTIEDVLKCERSLTGQYLSGKIKIEVPEKRRKPNGKAIIV
EEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHCCCEECCEEEEECCHHHCCCCCCEEEE
RGAKENNLKNIDVEFPLGVFICVTGVSGSGKSTLVNEILYKALAQKIYKSKDKPGKHDRI
ECCCCCCCCEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
EGIEHIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEARMRGYKPGRFSFNVK
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEC
GGRCEACGGDGIIKIEMNFLPDVYVPCEVCKGKRYNRETLEVKYKGKSIADVLDMTVEEA
CCEEEECCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
LELFENIPRIKNKLMTLYEVGLGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGRTLYIL
HHHHHHCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
DEPTTGLHFADIHRLLNVLNKLTDAGNTVIVIEHNLDVIKSADYIIDLGPEGGDRGGMVI
ECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHEECCCEEEEECCCCCCCCCEEE
ATGTPEEVAANENSYTGWFLRKVLSRN
ECCCCHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AKDKIVIKGARVHNLKNIDVEIPRDKLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLS
CCCCEEEECCEECCCCCCEEECCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
AYARQFLGQMDKPDVDYIEGLSPAISIDQKTTTKNPRSTVGTITEIYDYLRLLYARVGTP
HHHHHHHCCCCCCCHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
HCPICGREITMQTIDQMVDKIKELPEGTRIQILAPVVRGRKGEYSKLLADIKKSGYVRVK
CCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHCCEEEEE
IDGIMYDVNEEIKLDKNKKHTIEVVVDRIIMKPGIDMRLTDSIETALKLADGLVTIDVID
ECCEEEECCCCEEECCCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHCCEEEEEEEC
GESFTLSEKYACPACNVSIEELSPRMFSFNSPYGACPVCMGLGEFMKVDPELLIQDPKKS
CCCEEECCCCCCCCCCCCHHHCCCCCEECCCCCCCCHHHHCCHHHHHCCHHHEECCCHHH
LATGVFPGIVASQGSYAYYNMLRVIEYFGYTEYTPYEEFSEDLKSVLLYGKDTKGKSYGF
HHHCCCCCHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCH
EGIINNLERRYESSTSDFIKEEIEKYMRPVTCPACNGARLKPEALAVTVGGLSIKEMTDL
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCC
TIGELLKFIDNLKFSEKQEMIARPILKEIKARLNFLVDVGLDYLTLSRPASTLSGGEAQR
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHH
IRLASQIGSGLVGVTYILDEPSIGLHQRDNQRLINSLKRLRDQGNTVIVVEHDEETIYAA
HHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEE
DYIIDIGPGAGEHGGEVVVAGTIEDVLKCERSLTGQYLSGKIKIEVPEKRRKPNGKAIIV
EEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHCCCEECCEEEEECCHHHCCCCCCEEEE
RGAKENNLKNIDVEFPLGVFICVTGVSGSGKSTLVNEILYKALAQKIYKSKDKPGKHDRI
ECCCCCCCCEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
EGIEHIDKVINIDQSPIGRTPRSNPATYTGVFDYIREVFANTPEARMRGYKPGRFSFNVK
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEC
GGRCEACGGDGIIKIEMNFLPDVYVPCEVCKGKRYNRETLEVKYKGKSIADVLDMTVEEA
CCEEEECCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHH
LELFENIPRIKNKLMTLYEVGLGYIKLGQPSTQLSGGEAQRVKLATELSKRPTGRTLYIL
HHHHHHCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEE
DEPTTGLHFADIHRLLNVLNKLTDAGNTVIVIEHNLDVIKSADYIIDLGPEGGDRGGMVI
ECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHEECCCEEEEECCCCCCCCCEEE
ATGTPEEVAANENSYTGWFLRKVLSRN
ECCCCHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]