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The map label for this gene is FtsI4 [H]

Identifier: 20808321

GI number: 20808321

Start: 1853520

End: 1855181

Strand: Direct

Name: FtsI4 [H]

Synonym: TTE1916

Alternate gene names: 20808321

Gene position: 1853520-1855181 (Clockwise)

Preceding gene: 20808305

Following gene: 20808324

Centisome position: 68.92

GC content: 42.06

Gene sequence:

>1662_bases
GTGACAAAGAGCCTTAAACTTCGCACTTTTTTTCTTTTTGTATTTTTTCTAATCCTTTTTTCCATACTTATAGGAAGGCT
TGTGTGGATACAGGTTGTAAACGCTGAAAAGCTCTCCCTTGCCGTAGAAAGGCAGACAACAGCAGACATAATAATAAGGC
CCCAGAGAGGAAATATCTACGATGTAAACGGCAATATACTCGCCTGCAATGTGCCTGCTGCGGATGTTTACGCCTCTCCA
AAATACATAAAAGACCCCGAGAAGGCTTCAGAAGAACTGTCAAAATATTTATCTATCAGCAAAGAAGCCCTCTTCAAGGT
TTTATCTAAAAAAGATTTGGAATGGACAGTGCTTGAAAGATTTGTTCCAATGGAAAAAGCTCTATCCATAAAAAAGCTCA
ACATCCCTGGAATATATGTAGAGGATACTTCTATGAGAAACTATCCAAATGGATCAATGCTTTCGCAGGTCCTGGGGTTT
ACTGGAGTAGATGGATACGGTCTATATGGCCTTGAATACTCCCTTGACAGGTATTTAAGCGGAGTTCCGGGAAGAGAGAT
ATCTTTAGTAGACAGGGAAGGACACAAAGTAGGAATACCCAGCAAATACTACAAGCCAAAAGAAGGCGAAGACGTAGTTT
TGACTGTTGATTCCGTCATTCAGGCTTATACAGAGAGAGCTATTAAAAAAGCTTATGAGAAGTACAAACCAGAAGATGGA
ATAACTGCAATTGTCATGAATCCAAAGACAGGAGAAATCCTGGCAATGGCAAATCTTCCGGACTTTGACCCAAATGACCC
GCAAAAAGTCCCTTCACAGGAATACTGGGCAAATCCAGCTGTATCCAGTATTTACGAACCTGGTTCTGTGTTTAAAGTAA
TAACAGCAGCAGCGGCGCTGGACTCCGCCGTGGTAACCCCTGAAGAGCAATTCTTTGACCCAGGGTATTATGAAGTGTCC
GGCAAAAAAATTAGAAGCTGGACAGTCCTTGGAAACATCACTTTTTCTCAGGCCATAGAAAAGTCCAGCGATACAGTTTT
TATACAAGTCGCCGAAAGGTTAGGGTTAGACACTTTTTATAAATACATACAGGCCTTTGGCTTTGGCGCCCCTACAGGCA
TTGAACTTCCTGGCGAGGCAAGCGGAATGATTTTGCCTAAGGATAAGGTGTATCCTGTTGACTTTGCCACCATGTCCTTT
GGACAGGGAATTGCAGTAACCCCCATTCAGATGATTACAGCCTTCTCAGCAGTTATAAACGGCGGAGACCTCATGTACCC
ACATATTGTAAAATACATTAAAAGTGAAGGCAAAATTGTAAAAGAATTTAAACCCCAAGTAGTGAGGCAGGTAATATCCA
AAGAGACTTCTGACACCCTAAGGTACATATTAGAAAAAACAGTGACAGAAGGAACAGGACAATTGGCTCAGGTTCCCGGT
TACAGGGTTGGCGGCAAAACTGGCACTACAGAAAATTACCAGAAAGGGAAATACACTGCTTCTTTTGCAGGCTTTGCTCC
TGTGGAAAATCCAAAAATAGCGGTTCTTGTCATTGTAAAAAATCCGACGCAAGGTGGACATATGGGAGGAGAAGTAGCTG
CTCCAATAGCCCAGGAAATACTGAAAGATACACTCACTTATTATGAAGCAGTGAGAAAATAG

Upstream 100 bases:

>100_bases
TGTACCATACTTTTACCAGTTAGTCAAATACAGACTATCCCAACCCGTCCTTTGTGTGATATAATTATCTTGAAAACAAA
TATAAAAGGAGTAGAAAGTC

Downstream 100 bases:

>100_bases
CTCACTCGCCTACTTCTTTTTTTATCCCCTCAATGACCTCATAAGCGCTCTTTCCTTCCTTAATCCCTTCCTTTACTCTT
TCAATAACGAGGTTATTGAC

Product: cell division protein FtsI/penicillin-binding protein 2

Products: NA

Alternate protein names: Sporulation-specific penicillin-binding protein [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MTKSLKLRTFFLFVFFLILFSILIGRLVWIQVVNAEKLSLAVERQTTADIIIRPQRGNIYDVNGNILACNVPAADVYASP
KYIKDPEKASEELSKYLSISKEALFKVLSKKDLEWTVLERFVPMEKALSIKKLNIPGIYVEDTSMRNYPNGSMLSQVLGF
TGVDGYGLYGLEYSLDRYLSGVPGREISLVDREGHKVGIPSKYYKPKEGEDVVLTVDSVIQAYTERAIKKAYEKYKPEDG
ITAIVMNPKTGEILAMANLPDFDPNDPQKVPSQEYWANPAVSSIYEPGSVFKVITAAAALDSAVVTPEEQFFDPGYYEVS
GKKIRSWTVLGNITFSQAIEKSSDTVFIQVAERLGLDTFYKYIQAFGFGAPTGIELPGEASGMILPKDKVYPVDFATMSF
GQGIAVTPIQMITAFSAVINGGDLMYPHIVKYIKSEGKIVKEFKPQVVRQVISKETSDTLRYILEKTVTEGTGQLAQVPG
YRVGGKTGTTENYQKGKYTASFAGFAPVENPKIAVLVIVKNPTQGGHMGGEVAAPIAQEILKDTLTYYEAVRK

Sequences:

>Translated_553_residues
MTKSLKLRTFFLFVFFLILFSILIGRLVWIQVVNAEKLSLAVERQTTADIIIRPQRGNIYDVNGNILACNVPAADVYASP
KYIKDPEKASEELSKYLSISKEALFKVLSKKDLEWTVLERFVPMEKALSIKKLNIPGIYVEDTSMRNYPNGSMLSQVLGF
TGVDGYGLYGLEYSLDRYLSGVPGREISLVDREGHKVGIPSKYYKPKEGEDVVLTVDSVIQAYTERAIKKAYEKYKPEDG
ITAIVMNPKTGEILAMANLPDFDPNDPQKVPSQEYWANPAVSSIYEPGSVFKVITAAAALDSAVVTPEEQFFDPGYYEVS
GKKIRSWTVLGNITFSQAIEKSSDTVFIQVAERLGLDTFYKYIQAFGFGAPTGIELPGEASGMILPKDKVYPVDFATMSF
GQGIAVTPIQMITAFSAVINGGDLMYPHIVKYIKSEGKIVKEFKPQVVRQVISKETSDTLRYILEKTVTEGTGQLAQVPG
YRVGGKTGTTENYQKGKYTASFAGFAPVENPKIAVLVIVKNPTQGGHMGGEVAAPIAQEILKDTLTYYEAVRK
>Mature_552_residues
TKSLKLRTFFLFVFFLILFSILIGRLVWIQVVNAEKLSLAVERQTTADIIIRPQRGNIYDVNGNILACNVPAADVYASPK
YIKDPEKASEELSKYLSISKEALFKVLSKKDLEWTVLERFVPMEKALSIKKLNIPGIYVEDTSMRNYPNGSMLSQVLGFT
GVDGYGLYGLEYSLDRYLSGVPGREISLVDREGHKVGIPSKYYKPKEGEDVVLTVDSVIQAYTERAIKKAYEKYKPEDGI
TAIVMNPKTGEILAMANLPDFDPNDPQKVPSQEYWANPAVSSIYEPGSVFKVITAAAALDSAVVTPEEQFFDPGYYEVSG
KKIRSWTVLGNITFSQAIEKSSDTVFIQVAERLGLDTFYKYIQAFGFGAPTGIELPGEASGMILPKDKVYPVDFATMSFG
QGIAVTPIQMITAFSAVINGGDLMYPHIVKYIKSEGKIVKEFKPQVVRQVISKETSDTLRYILEKTVTEGTGQLAQVPGY
RVGGKTGTTENYQKGKYTASFAGFAPVENPKIAVLVIVKNPTQGGHMGGEVAAPIAQEILKDTLTYYEAVRK

Specific function: Penicillin-binding protein with an unknown catalytic activity. May have a specialized role in the morphogenesis of spore cortex, which is a modified form of peptidoglycan. Pore cortex formation is determined primarily by the mother cell [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PASTA domain [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=560, Percent_Identity=29.6428571428571, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786854, Length=613, Percent_Identity=25.4486133768352, Blast_Score=171, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005543
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR011927 [H]

Pfam domain/function: PF03793 PASTA; PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 61121; Mature: 60990

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSLKLRTFFLFVFFLILFSILIGRLVWIQVVNAEKLSLAVERQTTADIIIRPQRGNIY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHEEEEEECCCCEEEEEECCCCCEE
DVNGNILACNVPAADVYASPKYIKDPEKASEELSKYLSISKEALFKVLSKKDLEWTVLER
ECCCCEEEEECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FVPMEKALSIKKLNIPGIYVEDTSMRNYPNGSMLSQVLGFTGVDGYGLYGLEYSLDRYLS
HCCHHHHCCEEEECCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHC
GVPGREISLVDREGHKVGIPSKYYKPKEGEDVVLTVDSVIQAYTERAIKKAYEKYKPEDG
CCCCCEEEEEECCCCEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
ITAIVMNPKTGEILAMANLPDFDPNDPQKVPSQEYWANPAVSSIYEPGSVFKVITAAAAL
CEEEEECCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHCCCCHHHHHHHHHHHH
DSAVVTPEEQFFDPGYYEVSGKKIRSWTVLGNITFSQAIEKSSDTVFIQVAERLGLDTFY
CCCCCCCHHHHCCCCEEEECCCEEEEEEEEECCHHHHHHHCCCCEEEEEEHHHHCHHHHH
KYIQAFGFGAPTGIELPGEASGMILPKDKVYPVDFATMSFGQGIAVTPIQMITAFSAVIN
HHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCEEHHHCCCCCCEECHHHHHHHHHHHHC
GGDLMYPHIVKYIKSEGKIVKEFKPQVVRQVISKETSDTLRYILEKTVTEGTGQLAQVPG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCC
YRVGGKTGTTENYQKGKYTASFAGFAPVENPKIAVLVIVKNPTQGGHMGGEVAAPIAQEI
EEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHH
LKDTLTYYEAVRK
HHHHHHHHHHHCC
>Mature Secondary Structure 
TKSLKLRTFFLFVFFLILFSILIGRLVWIQVVNAEKLSLAVERQTTADIIIRPQRGNIY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHEEEEEECCCCEEEEEECCCCCEE
DVNGNILACNVPAADVYASPKYIKDPEKASEELSKYLSISKEALFKVLSKKDLEWTVLER
ECCCCEEEEECCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FVPMEKALSIKKLNIPGIYVEDTSMRNYPNGSMLSQVLGFTGVDGYGLYGLEYSLDRYLS
HCCHHHHCCEEEECCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHHHHHC
GVPGREISLVDREGHKVGIPSKYYKPKEGEDVVLTVDSVIQAYTERAIKKAYEKYKPEDG
CCCCCEEEEEECCCCEECCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
ITAIVMNPKTGEILAMANLPDFDPNDPQKVPSQEYWANPAVSSIYEPGSVFKVITAAAAL
CEEEEECCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHCCCCHHHHHHHHHHHH
DSAVVTPEEQFFDPGYYEVSGKKIRSWTVLGNITFSQAIEKSSDTVFIQVAERLGLDTFY
CCCCCCCHHHHCCCCEEEECCCEEEEEEEEECCHHHHHHHCCCCEEEEEEHHHHCHHHHH
KYIQAFGFGAPTGIELPGEASGMILPKDKVYPVDFATMSFGQGIAVTPIQMITAFSAVIN
HHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCEEHHHCCCCCCEECHHHHHHHHHHHHC
GGDLMYPHIVKYIKSEGKIVKEFKPQVVRQVISKETSDTLRYILEKTVTEGTGQLAQVPG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCC
YRVGGKTGTTENYQKGKYTASFAGFAPVENPKIAVLVIVKNPTQGGHMGGEVAAPIAQEI
EEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHH
LKDTLTYYEAVRK
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8289242; 9384377; 8244929; 8436954 [H]