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The map label for this gene is MutS3 [H]

Identifier: 20808311

GI number: 20808311

Start: 1843288

End: 1844712

Strand: Reverse

Name: MutS3 [H]

Synonym: TTE1906

Alternate gene names: 20808311

Gene position: 1844712-1843288 (Counterclockwise)

Preceding gene: 20808312

Following gene: 20808310

Centisome position: 68.59

GC content: 31.93

Gene sequence:

>1425_bases
GTGAATGAGACAAAGAATGAAGATTTAATCGATTATTTTTATATGCCTCTTAATGATGTGGAAGAAATCAAATACAGGCA
CGAAGTGTTTATTGAATTAGAAAATAATCAGTTGCTATTTGATGCTATTAAAACATTTGTTGATAAAATGAGCAATGTCA
AGAGAGAATTATCATTTTCAGAAAAACTCGAATACCAGTATAACAAAAAAGGTTGGTGGCTGGAAGCTGTAGACAAATAT
GTGAAAGCAGTTAGTGAATTAGCTCTGTATTTTTTAAATGAAAAATTGTTTTCTAAAGGACTGCAAAACTTTTCAAAATA
TCTGATAAAATATGCTAACAGTGATTACTTTACTAAACTCAGGGAAATGGTTGAAAGGGTGAAGAAGTCTTTAGAGGAGG
TAACTTATTGCCTTAACATCGATGGGTTAAGAGTGATGGTATATAAATGTGAAGAGGAAGAAGAATATGAAAATGATATT
ATAAAAACTTTTGAGAAATTTAAAACCTCAGATAATAAAGATTACAAATTAATAGTACCAACGATGATAGGAATGGATCA
TGTAGAAAATGAAATTATAAACGCTGTCGTAAAATTTTATCCTCAACCTTTTGAATTGTTAGATTCTTTCTATGAAGAAT
ATTATCACTTTATGGATCCGGTAGTGGAGAGGTTTTCTGAAGAAATAAGGTTTTACATTATTTATCTTGATTTTACAAAA
AAGTTTAAACAATTAGGATTAAGTTTTTGTTATCCTGAAATTACGACAAATAAAGAAGAAGTTTATTTGTACGAAGGATT
TGACCTTGCTCTTGCGTATGACAAAGTTACAAAGGGAGAAACTGTTGTTGTAAATGATTTTTGGTTGGAAAATGGTGAAA
GATTAGTGGTAGTTACAGGTCCGAATCAGGGAGGTAAGACTACTTTTGCTAGGATGTTTGGACAGGTGCATTACCTTGCA
AAGCTTGGAGTTCCAATACCGGGTAAAAAAGCCAAGATCTTTTTGTGCGATAAGATATTTACCCATTTTGAAAGAGAAGA
AAAAGTTCAAAATTTAAGAGGGAAATTAGAAGCTGACCTTTTAGAGATAAAACAGATTATTAATATGGCAACACCAATGA
GCCTCATAATATTAAACGAAACTTTTTCTTCTGCAACTGTGGCAGATGCGATTTTTTTGGCTAAAAATGTTATTGCAAAA
ATTCTCGAAATAGACTGTTACGCTCTATACGTAACATTTCTTGATGAACTTACATCTATAGGAGAAAAAGTAGTAAGTAT
GGTAGCAACGGTTTCTGAACAGGACCCGTCGATAAAAACGTATAAGATTTTGAGAAAACCTGCTGATGGGAAAGCATATG
CCATTTTATTGGCAGAGAAATACGGACTTAGTTACGAACAATTAAAAAGGAGGTTGAAAGGTTGA

Upstream 100 bases:

>100_bases
TATACTGTTTAAAGATTATGAAAGGAAAGATAAACTGAATTATGAAAGAAATCAAAATGTTTTTGAAGACCTTCATTTAG
ATCAAATTATTAATAACCTC

Downstream 100 bases:

>100_bases
GAGTTTTTCTATTATATGAAGATCAGGATTATAATTTTAAGTCTCATGGAAAATACGATGAAGAGCATAATGAAAATTTA
ATAAAGGACCTTGGTCTTGA

Product: MutS-like ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNETKNEDLIDYFYMPLNDVEEIKYRHEVFIELENNQLLFDAIKTFVDKMSNVKRELSFSEKLEYQYNKKGWWLEAVDKY
VKAVSELALYFLNEKLFSKGLQNFSKYLIKYANSDYFTKLREMVERVKKSLEEVTYCLNIDGLRVMVYKCEEEEEYENDI
IKTFEKFKTSDNKDYKLIVPTMIGMDHVENEIINAVVKFYPQPFELLDSFYEEYYHFMDPVVERFSEEIRFYIIYLDFTK
KFKQLGLSFCYPEITTNKEEVYLYEGFDLALAYDKVTKGETVVVNDFWLENGERLVVVTGPNQGGKTTFARMFGQVHYLA
KLGVPIPGKKAKIFLCDKIFTHFEREEKVQNLRGKLEADLLEIKQIINMATPMSLIILNETFSSATVADAIFLAKNVIAK
ILEIDCYALYVTFLDELTSIGEKVVSMVATVSEQDPSIKTYKILRKPADGKAYAILLAEKYGLSYEQLKRRLKG

Sequences:

>Translated_474_residues
MNETKNEDLIDYFYMPLNDVEEIKYRHEVFIELENNQLLFDAIKTFVDKMSNVKRELSFSEKLEYQYNKKGWWLEAVDKY
VKAVSELALYFLNEKLFSKGLQNFSKYLIKYANSDYFTKLREMVERVKKSLEEVTYCLNIDGLRVMVYKCEEEEEYENDI
IKTFEKFKTSDNKDYKLIVPTMIGMDHVENEIINAVVKFYPQPFELLDSFYEEYYHFMDPVVERFSEEIRFYIIYLDFTK
KFKQLGLSFCYPEITTNKEEVYLYEGFDLALAYDKVTKGETVVVNDFWLENGERLVVVTGPNQGGKTTFARMFGQVHYLA
KLGVPIPGKKAKIFLCDKIFTHFEREEKVQNLRGKLEADLLEIKQIINMATPMSLIILNETFSSATVADAIFLAKNVIAK
ILEIDCYALYVTFLDELTSIGEKVVSMVATVSEQDPSIKTYKILRKPADGKAYAILLAEKYGLSYEQLKRRLKG
>Mature_474_residues
MNETKNEDLIDYFYMPLNDVEEIKYRHEVFIELENNQLLFDAIKTFVDKMSNVKRELSFSEKLEYQYNKKGWWLEAVDKY
VKAVSELALYFLNEKLFSKGLQNFSKYLIKYANSDYFTKLREMVERVKKSLEEVTYCLNIDGLRVMVYKCEEEEEYENDI
IKTFEKFKTSDNKDYKLIVPTMIGMDHVENEIINAVVKFYPQPFELLDSFYEEYYHFMDPVVERFSEEIRFYIIYLDFTK
KFKQLGLSFCYPEITTNKEEVYLYEGFDLALAYDKVTKGETVVVNDFWLENGERLVVVTGPNQGGKTTFARMFGQVHYLA
KLGVPIPGKKAKIFLCDKIFTHFEREEKVQNLRGKLEADLLEIKQIINMATPMSLIILNETFSSATVADAIFLAKNVIAK
ILEIDCYALYVTFLDELTSIGEKVVSMVATVSEQDPSIKTYKILRKPADGKAYAILLAEKYGLSYEQLKRRLKG

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI4504191, Length=184, Percent_Identity=26.6304347826087, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI284813531, Length=105, Percent_Identity=30.4761904761905, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4557761, Length=147, Percent_Identity=26.530612244898, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1789089, Length=195, Percent_Identity=26.1538461538462, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17534743, Length=184, Percent_Identity=24.4565217391304, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=144, Percent_Identity=31.25, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321912, Length=202, Percent_Identity=30.1980198019802, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320047, Length=104, Percent_Identity=31.7307692307692, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664545, Length=301, Percent_Identity=23.5880398671096, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24584320, Length=169, Percent_Identity=24.8520710059172, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 55547; Mature: 55547

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETKNEDLIDYFYMPLNDVEEIKYRHEVFIELENNQLLFDAIKTFVDKMSNVKRELSFS
CCCCCCCCHHHHEECCCCCHHHHHHHEEEEEEECCCEEHHHHHHHHHHHHHHHHHHCCHH
EKLEYQYNKKGWWLEAVDKYVKAVSELALYFLNEKLFSKGLQNFSKYLIKYANSDYFTKL
HHHCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
REMVERVKKSLEEVTYCLNIDGLRVMVYKCEEEEEYENDIIKTFEKFKTSDNKDYKLIVP
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEH
TMIGMDHVENEIINAVVKFYPQPFELLDSFYEEYYHFMDPVVERFSEEIRFYIIYLDFTK
HHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEHHH
KFKQLGLSFCYPEITTNKEEVYLYEGFDLALAYDKVTKGETVVVNDFWLENGERLVVVTG
HHHHCCHHHCCCCCCCCCCEEEEEECCEEEEEECCCCCCCEEEEEEEEECCCCEEEEEEC
PNQGGKTTFARMFGQVHYLAKLGVPIPGKKAKIFLCDKIFTHFEREEKVQNLRGKLEADL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
LEIKQIINMATPMSLIILNETFSSATVADAIFLAKNVIAKILEIDCYALYVTFLDELTSI
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEKVVSMVATVSEQDPSIKTYKILRKPADGKAYAILLAEKYGLSYEQLKRRLKG
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEEHHHCCCHHHHHHHHCC
>Mature Secondary Structure
MNETKNEDLIDYFYMPLNDVEEIKYRHEVFIELENNQLLFDAIKTFVDKMSNVKRELSFS
CCCCCCCCHHHHEECCCCCHHHHHHHEEEEEEECCCEEHHHHHHHHHHHHHHHHHHCCHH
EKLEYQYNKKGWWLEAVDKYVKAVSELALYFLNEKLFSKGLQNFSKYLIKYANSDYFTKL
HHHCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
REMVERVKKSLEEVTYCLNIDGLRVMVYKCEEEEEYENDIIKTFEKFKTSDNKDYKLIVP
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEEEEEH
TMIGMDHVENEIINAVVKFYPQPFELLDSFYEEYYHFMDPVVERFSEEIRFYIIYLDFTK
HHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEHHH
KFKQLGLSFCYPEITTNKEEVYLYEGFDLALAYDKVTKGETVVVNDFWLENGERLVVVTG
HHHHCCHHHCCCCCCCCCCEEEEEECCEEEEEECCCCCCCEEEEEEEEECCCCEEEEEEC
PNQGGKTTFARMFGQVHYLAKLGVPIPGKKAKIFLCDKIFTHFEREEKVQNLRGKLEADL
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
LEIKQIINMATPMSLIILNETFSSATVADAIFLAKNVIAKILEIDCYALYVTFLDELTSI
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEKVVSMVATVSEQDPSIKTYKILRKPADGKAYAILLAEKYGLSYEQLKRRLKG
HHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEEEHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA