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The map label for this gene is HcaD [C]

Identifier: 20808293

GI number: 20808293

Start: 1827159

End: 1828499

Strand: Reverse

Name: HcaD [C]

Synonym: TTE1884

Alternate gene names: 20808293

Gene position: 1828499-1827159 (Counterclockwise)

Preceding gene: 20808295

Following gene: 20808292

Centisome position: 67.99

GC content: 36.47

Gene sequence:

>1341_bases
ATGGAGACGGATGTTTTAGTAATTGGAGGAAGTGCGGGTGGAATTTTAGCGGCTTTATCTGTTAAAAAGACGTACAAAGA
CAAAAAAGTAACAGTTATAAGAATGGCAGAAAGAGTGATGGTTCCTTGTGGAATCCCTTATATTTTTGGTACTTTAAAAG
ATACTTCAAAAAATGTGATCCCTGATTCTATGCTTACAAATGCAGGAGTAGAGTTGGTAATAGACGAAGTTGTCTCTATT
GATAGGCAAAATAAAAAAGTTTCTACAAGAAAAAATGGAGATATTTCTTATAAAAAATTAATTTTAGCGACAGGTTCCCT
ACCGATAGTTCCGACATTTATACCTGGCTATGACTTGGACAATGTATTCACAATAAAGAAGGATGAGGAGTATTTGAAAT
TTGTTCAACAAAAGATTAACGAAGCAGAGGATGTTGTAGTAGTAGGTGGGGGCTTCATTGGAGTTGAAATGGCAGAGCAG
GTACAATTATTAGGTAAGAATGTTACAATAATAGAAGTGGCAGATAAACTCTTGTGGCAGGCTTTTGACCCAGAATTTAG
TGATATGGCGGAAGCTAAATTAAAAGAGCATGGTATAAAAGTGCTTACAGGTACAAAAGTTACAAAGTTTATTGGAGAAA
AAGAAGTCAAAGAGGTAGAAATCCATACTGGAGAGAGGATAAAGGCAGACGTTGTTATAGTAGCTATGGGAGTAAAGCCT
AATACAAAGTTAGCTGAAGAAGCGGGTATTAAACTAAATGAAAAAGGCGCAATAACTGTTGATGAATATATGAGGACAAA
TGACCCAGATATTTTCGCAGTAGGTGACTGCGCGGAAAAGAAATGTTTCTTCACAAGGAAAAACGTACCAATACTTTTGG
CTTCTATTGCAGCTAATGAAGCTAAAATTGCTGGTGTAAATGCATTTGAGTTAAGATTAGTAAGAGAAAATAAAGGCACT
ATAAGTGCTTTCTCAACAAAGATATACAATACTGCTTTTGCTGCAGCAGGCCTCACAGAAACACAAGCTAGAGCTGAGGG
ATTTGATATAGTCATTGGTGAATTTAACACTATAGACAAACACCCTGGAACACTGCCAAATACCATGAATGTTAAGATAA
AATTGATTTTTTCAAGGTATTCAGGAGTTATACTGGGAGCTCAACTAGCAGGTGGAGATAATGTGGGTGAAATGATAAAC
ATTTTAAGCCTAGCAATACAAAAAGGGACAACAGCTTCAGAATTGACTACTTTCCAAGTGGCGACCCATCCACTTCTTAC
TTCATCGCCAGTTTCTTACCCAATAAGTTCTGCTGCTTTAGATGCTTTGTCAAAAATATGA

Upstream 100 bases:

>100_bases
TTTATTGACATAATTTCATTAGAAACCTATAATTGAAATAGGGGCCCCTCAGGGTAGGGGGGGGGTAAAAGAAAAATATA
ATCAGGAGGTAATTTATAGT

Downstream 100 bases:

>100_bases
TTAAGTGTTATAATTAAATTAAAATGAAAAAAGGCAGGATTTTAACAAACCTGCCTTTTTTCATGAGTTAAAAGGGGAGG
GAGAATTTTTATGGATAATA

Product: uncharacterized NAD(FAD)-dependent dehydrogenase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
METDVLVIGGSAGGILAALSVKKTYKDKKVTVIRMAERVMVPCGIPYIFGTLKDTSKNVIPDSMLTNAGVELVIDEVVSI
DRQNKKVSTRKNGDISYKKLILATGSLPIVPTFIPGYDLDNVFTIKKDEEYLKFVQQKINEAEDVVVVGGGFIGVEMAEQ
VQLLGKNVTIIEVADKLLWQAFDPEFSDMAEAKLKEHGIKVLTGTKVTKFIGEKEVKEVEIHTGERIKADVVIVAMGVKP
NTKLAEEAGIKLNEKGAITVDEYMRTNDPDIFAVGDCAEKKCFFTRKNVPILLASIAANEAKIAGVNAFELRLVRENKGT
ISAFSTKIYNTAFAAAGLTETQARAEGFDIVIGEFNTIDKHPGTLPNTMNVKIKLIFSRYSGVILGAQLAGGDNVGEMIN
ILSLAIQKGTTASELTTFQVATHPLLTSSPVSYPISSAALDALSKI

Sequences:

>Translated_446_residues
METDVLVIGGSAGGILAALSVKKTYKDKKVTVIRMAERVMVPCGIPYIFGTLKDTSKNVIPDSMLTNAGVELVIDEVVSI
DRQNKKVSTRKNGDISYKKLILATGSLPIVPTFIPGYDLDNVFTIKKDEEYLKFVQQKINEAEDVVVVGGGFIGVEMAEQ
VQLLGKNVTIIEVADKLLWQAFDPEFSDMAEAKLKEHGIKVLTGTKVTKFIGEKEVKEVEIHTGERIKADVVIVAMGVKP
NTKLAEEAGIKLNEKGAITVDEYMRTNDPDIFAVGDCAEKKCFFTRKNVPILLASIAANEAKIAGVNAFELRLVRENKGT
ISAFSTKIYNTAFAAAGLTETQARAEGFDIVIGEFNTIDKHPGTLPNTMNVKIKLIFSRYSGVILGAQLAGGDNVGEMIN
ILSLAIQKGTTASELTTFQVATHPLLTSSPVSYPISSAALDALSKI
>Mature_446_residues
METDVLVIGGSAGGILAALSVKKTYKDKKVTVIRMAERVMVPCGIPYIFGTLKDTSKNVIPDSMLTNAGVELVIDEVVSI
DRQNKKVSTRKNGDISYKKLILATGSLPIVPTFIPGYDLDNVFTIKKDEEYLKFVQQKINEAEDVVVVGGGFIGVEMAEQ
VQLLGKNVTIIEVADKLLWQAFDPEFSDMAEAKLKEHGIKVLTGTKVTKFIGEKEVKEVEIHTGERIKADVVIVAMGVKP
NTKLAEEAGIKLNEKGAITVDEYMRTNDPDIFAVGDCAEKKCFFTRKNVPILLASIAANEAKIAGVNAFELRLVRENKGT
ISAFSTKIYNTAFAAAGLTETQARAEGFDIVIGEFNTIDKHPGTLPNTMNVKIKLIFSRYSGVILGAQLAGGDNVGEMIN
ILSLAIQKGTTASELTTFQVATHPLLTSSPVSYPISSAALDALSKI

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI65787454, Length=357, Percent_Identity=27.4509803921569, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI226437568, Length=357, Percent_Identity=27.4509803921569, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI21389617, Length=357, Percent_Identity=27.4509803921569, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI91199540, Length=363, Percent_Identity=26.9972451790634, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI50301238, Length=392, Percent_Identity=27.0408163265306, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789065, Length=203, Percent_Identity=33.9901477832512, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786307, Length=366, Percent_Identity=27.3224043715847, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789765, Length=209, Percent_Identity=29.6650717703349, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788892, Length=229, Percent_Identity=27.0742358078603, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787352, Length=320, Percent_Identity=26.5625, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081717, Length=282, Percent_Identity=27.3049645390071, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082354, Length=393, Percent_Identity=23.9185750636132, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789915, Length=193, Percent_Identity=31.0880829015544, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=207, Percent_Identity=32.3671497584541, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI32565766, Length=295, Percent_Identity=25.4237288135593, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71983419, Length=258, Percent_Identity=29.0697674418605, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71983429, Length=258, Percent_Identity=29.0697674418605, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=370, Percent_Identity=24.8648648648649, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321091, Length=285, Percent_Identity=24.5614035087719, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324402, Length=246, Percent_Identity=26.4227642276423, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21358499, Length=345, Percent_Identity=27.536231884058, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI281359715, Length=231, Percent_Identity=25.1082251082251, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281359713, Length=231, Percent_Identity=25.1082251082251, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639250, Length=231, Percent_Identity=25.1082251082251, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18543267, Length=231, Percent_Identity=25.1082251082251, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639252, Length=231, Percent_Identity=25.1082251082251, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639257, Length=231, Percent_Identity=25.1082251082251, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585130, Length=353, Percent_Identity=22.3796033994334, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 48219; Mature: 48219

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METDVLVIGGSAGGILAALSVKKTYKDKKVTVIRMAERVMVPCGIPYIFGTLKDTSKNVI
CCCCEEEEECCCCCEEEEEEHHHHCCCCCEEEEEEHHHHCCCCCCHHHEEECCCCCCCCC
PDSMLTNAGVELVIDEVVSIDRQNKKVSTRKNGDISYKKLILATGSLPIVPTFIPGYDLD
CCHHHHHCCHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEEECCCCCEEEEECCCCCCC
NVFTIKKDEEYLKFVQQKINEAEDVVVVGGGFIGVEMAEQVQLLGKNVTIIEVADKLLWQ
CEEEEECCHHHHHHHHHHCCCCCCEEEECCCEEEHHHHHHHHHHCCCEEEEHHHHHHHHH
AFDPEFSDMAEAKLKEHGIKVLTGTKVTKFIGEKEVKEVEIHTGERIKADVVIVAMGVKP
HCCCCHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCEEEEECCCCEEEEEEEEEEECCCC
NTKLAEEAGIKLNEKGAITVDEYMRTNDPDIFAVGDCAEKKCFFTRKNVPILLASIAANE
CCCHHHHCCCEECCCCCEEHHHHHCCCCCCEEEECCCCCCCEEEEECCCCEEEEEECCCC
AKIAGVNAFELRLVRENKGTISAFSTKIYNTAFAAAGLTETQARAEGFDIVIGEFNTIDK
EEEECCCEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
HPGTLPNTMNVKIKLIFSRYSGVILGAQLAGGDNVGEMINILSLAIQKGTTASELTTFQV
CCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHEEEEEE
ATHPLLTSSPVSYPISSAALDALSKI
EECCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
METDVLVIGGSAGGILAALSVKKTYKDKKVTVIRMAERVMVPCGIPYIFGTLKDTSKNVI
CCCCEEEEECCCCCEEEEEEHHHHCCCCCEEEEEEHHHHCCCCCCHHHEEECCCCCCCCC
PDSMLTNAGVELVIDEVVSIDRQNKKVSTRKNGDISYKKLILATGSLPIVPTFIPGYDLD
CCHHHHHCCHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEEECCCCCEEEEECCCCCCC
NVFTIKKDEEYLKFVQQKINEAEDVVVVGGGFIGVEMAEQVQLLGKNVTIIEVADKLLWQ
CEEEEECCHHHHHHHHHHCCCCCCEEEECCCEEEHHHHHHHHHHCCCEEEEHHHHHHHHH
AFDPEFSDMAEAKLKEHGIKVLTGTKVTKFIGEKEVKEVEIHTGERIKADVVIVAMGVKP
HCCCCHHHHHHHHHHHCCEEEEECCHHHHHHCCCCCEEEEECCCCEEEEEEEEEEECCCC
NTKLAEEAGIKLNEKGAITVDEYMRTNDPDIFAVGDCAEKKCFFTRKNVPILLASIAANE
CCCHHHHCCCEECCCCCEEHHHHHCCCCCCEEEECCCCCCCEEEEECCCCEEEEEECCCC
AKIAGVNAFELRLVRENKGTISAFSTKIYNTAFAAAGLTETQARAEGFDIVIGEFNTIDK
EEEECCCEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
HPGTLPNTMNVKIKLIFSRYSGVILGAQLAGGDNVGEMINILSLAIQKGTTASELTTFQV
CCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHEEEEEE
ATHPLLTSSPVSYPISSAALDALSKI
EECCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]