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The map label for this gene is AarF2 [C]

Identifier: 20808256

GI number: 20808256

Start: 1789357

End: 1791033

Strand: Reverse

Name: AarF2 [C]

Synonym: TTE1840

Alternate gene names: 20808256

Gene position: 1791033-1789357 (Counterclockwise)

Preceding gene: 20808257

Following gene: 20808255

Centisome position: 66.59

GC content: 33.27

Gene sequence:

>1677_bases
ATGCAACATTTAAGAAGATATAGAGAAATAATTTTCGTATTCATCAAATACGGGTTTGGTGCTATAATTGACAATATTGG
AATTTTAAAACATATAAATGTAAGAAGAAAAATCTTGAAGCAAACAAATGATGAAAATATTGCGAAACTTTCCCGTGGAG
AAAGATTAAGACTTGCTCTTGAAGAATTAGGACCTACTTTTATAAAAATGGGGCAGATTTTAAGCACAAGGTCTGACATT
TTGCCAAAAGATATAATAAAAGAATTGGAAAAATTACAGGACAAAGCTCCTGCTTTTTCTTTTGATGAGGTGAAATCAGT
TATACAAAATGAATTTGGCGAAAGTTTGGAGGAAGCCTATGCTGAATTTGAACCTACTCCTCTAGCGGCGGCTTCTATAG
CACAAGTTCACAAGGCTTTGTTGTGGTCAGGCAAAACTGTTGTTGTCAAGGTTCAAAGGCCAGGGATAGAAAAAATCATA
GCCCAAGATATGAGGATATTAGAAGATATTGCCAAATTTGTTGATAATCATACAAAATATGGAAAAATATACAATTTTAC
AAAAATGGTAGAAGACTTCAAAAAGAGATTGGAAGAGGAATTAGATTTTAGAATAGAGGGGGAAAACGCAGAAAAGTTCA
AAAAGAATTTTTTAAAAGACAAAAAAGTCAAAATTCCTTCTATAATCTGGACCCATACGACAAGACGTGTATTGACGATG
GAATACATTGGTGGCATTCCGTTAAATGATTTTAATGCAATTGATGAGGCTGGATTAGACCGCGGTGCAATTGCAAGAAA
CCTTGCAAAATCTGTATTGAATCAGATTTTAAGGGATGGTTTTTTTCATGGAGACCCTCATCCGGGAAATATTATGGTGC
TAGAGGATGGGACAATAGCATTTTTAGATTTTGGAATGGTAGGTAGCTTAAGTCCAGAAAGGAAAAGACAGTTTTCTAAA
ATGTTGTTGGGGATTGTTTACAAAAATAGCAGGATGATTATTGAAAGCATTATAGATTTAAATGCTGTGACTCTAAATGT
CAATATGAAAAAGCTAGAAAAAGACATAAATAATTTGCGAGATAGATATGTTGAAATACCGTTAGAAAAGCTCAAAGTTG
GGGAAGTCCTCAATGGGATATTTGACCTTGTATTTTCGTATAATATTGTAATTCCCAATGAATTTAATATGCTGGCTAAA
AGCCTTATAACGTTAGAGGGAATAGTAGAAAAGTTAGATCCCAAAATTAGCGTTTTAGAAGTGGCAAAACCAATTGCAAA
GCAGTTGATACCTAAAATGTTTTCTACTCAACATATGAAAGAAGAGATAATAAATGCCACAATGGATTATAGCAGATTGA
TAAAGGAGTTGCCATCGTTTTTATTGAATTTTTTAAGGAAAACAGAAGAAGAAAATTATGCTATAGAATTGAAAATAAGA
GACCTTGAAAATTTAGAGAAACGGGTTGATAAGGTATTTAATCGGCTTTCCACCAGTATTATACTTTTGGCTTTAAGTAT
TGTCATTGCAGGGATTTTAATAGGGTCAGGAATGAGTGCTAATGCTGGTGCAGAAATGTATAAGCTTAATGGGATAATTT
TAAAGATTGGTTTAGCGATAGCTTTTGTCATAGTTTTAGGTTTAGCAATTTCTATTTTCCGATCTGGGCGGCTTTAA

Upstream 100 bases:

>100_bases
ATAAAAAGTATTGTTCGTGAGGAAGTCAGAAAAGTGCTGGAGGAAATGCAAAACACAGAAAAATAAGTAACTATAAAATT
TTGATGACAGGTGTGAAATA

Downstream 100 bases:

>100_bases
TAAATAAACTTCAAAAGGGGAAATCCAAGATGGAAGGTAAAAACCAATCGCAAAGAATATTAAATGCTGCATATAAGTGT
ATTTCAACTAAAGGATATGC

Product: protein kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MQHLRRYREIIFVFIKYGFGAIIDNIGILKHINVRRKILKQTNDENIAKLSRGERLRLALEELGPTFIKMGQILSTRSDI
LPKDIIKELEKLQDKAPAFSFDEVKSVIQNEFGESLEEAYAEFEPTPLAAASIAQVHKALLWSGKTVVVKVQRPGIEKII
AQDMRILEDIAKFVDNHTKYGKIYNFTKMVEDFKKRLEEELDFRIEGENAEKFKKNFLKDKKVKIPSIIWTHTTRRVLTM
EYIGGIPLNDFNAIDEAGLDRGAIARNLAKSVLNQILRDGFFHGDPHPGNIMVLEDGTIAFLDFGMVGSLSPERKRQFSK
MLLGIVYKNSRMIIESIIDLNAVTLNVNMKKLEKDINNLRDRYVEIPLEKLKVGEVLNGIFDLVFSYNIVIPNEFNMLAK
SLITLEGIVEKLDPKISVLEVAKPIAKQLIPKMFSTQHMKEEIINATMDYSRLIKELPSFLLNFLRKTEEENYAIELKIR
DLENLEKRVDKVFNRLSTSIILLALSIVIAGILIGSGMSANAGAEMYKLNGIILKIGLAIAFVIVLGLAISIFRSGRL

Sequences:

>Translated_558_residues
MQHLRRYREIIFVFIKYGFGAIIDNIGILKHINVRRKILKQTNDENIAKLSRGERLRLALEELGPTFIKMGQILSTRSDI
LPKDIIKELEKLQDKAPAFSFDEVKSVIQNEFGESLEEAYAEFEPTPLAAASIAQVHKALLWSGKTVVVKVQRPGIEKII
AQDMRILEDIAKFVDNHTKYGKIYNFTKMVEDFKKRLEEELDFRIEGENAEKFKKNFLKDKKVKIPSIIWTHTTRRVLTM
EYIGGIPLNDFNAIDEAGLDRGAIARNLAKSVLNQILRDGFFHGDPHPGNIMVLEDGTIAFLDFGMVGSLSPERKRQFSK
MLLGIVYKNSRMIIESIIDLNAVTLNVNMKKLEKDINNLRDRYVEIPLEKLKVGEVLNGIFDLVFSYNIVIPNEFNMLAK
SLITLEGIVEKLDPKISVLEVAKPIAKQLIPKMFSTQHMKEEIINATMDYSRLIKELPSFLLNFLRKTEEENYAIELKIR
DLENLEKRVDKVFNRLSTSIILLALSIVIAGILIGSGMSANAGAEMYKLNGIILKIGLAIAFVIVLGLAISIFRSGRL
>Mature_558_residues
MQHLRRYREIIFVFIKYGFGAIIDNIGILKHINVRRKILKQTNDENIAKLSRGERLRLALEELGPTFIKMGQILSTRSDI
LPKDIIKELEKLQDKAPAFSFDEVKSVIQNEFGESLEEAYAEFEPTPLAAASIAQVHKALLWSGKTVVVKVQRPGIEKII
AQDMRILEDIAKFVDNHTKYGKIYNFTKMVEDFKKRLEEELDFRIEGENAEKFKKNFLKDKKVKIPSIIWTHTTRRVLTM
EYIGGIPLNDFNAIDEAGLDRGAIARNLAKSVLNQILRDGFFHGDPHPGNIMVLEDGTIAFLDFGMVGSLSPERKRQFSK
MLLGIVYKNSRMIIESIIDLNAVTLNVNMKKLEKDINNLRDRYVEIPLEKLKVGEVLNGIFDLVFSYNIVIPNEFNMLAK
SLITLEGIVEKLDPKISVLEVAKPIAKQLIPKMFSTQHMKEEIINATMDYSRLIKELPSFLLNFLRKTEEENYAIELKIR
DLENLEKRVDKVFNRLSTSIILLALSIVIAGILIGSGMSANAGAEMYKLNGIILKIGLAIAFVIVLGLAISIFRSGRL

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=275, Percent_Identity=34.5454545454545, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI41393593, Length=271, Percent_Identity=33.5793357933579, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI217035081, Length=249, Percent_Identity=32.5301204819277, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI32261307, Length=314, Percent_Identity=27.0700636942675, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI27363457, Length=244, Percent_Identity=29.0983606557377, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI217416386, Length=239, Percent_Identity=28.8702928870293, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI34147522, Length=278, Percent_Identity=25.1798561151079, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI2367309, Length=533, Percent_Identity=30.0187617260788, Blast_Score=238, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17559152, Length=268, Percent_Identity=32.8358208955224, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32565180, Length=248, Percent_Identity=27.8225806451613, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17555620, Length=473, Percent_Identity=22.8329809725159, Blast_Score=92, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323282, Length=328, Percent_Identity=29.2682926829268, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6325148, Length=455, Percent_Identity=24.1758241758242, Blast_Score=116, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6321319, Length=324, Percent_Identity=25.3086419753086, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24662575, Length=255, Percent_Identity=37.6470588235294, Blast_Score=159, Evalue=6e-39,
Organism=Drosophila melanogaster, GI22024280, Length=264, Percent_Identity=35.2272727272727, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI18859849, Length=289, Percent_Identity=28.0276816608997, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63434; Mature: 63434

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHLRRYREIIFVFIKYGFGAIIDNIGILKHINVRRKILKQTNDENIAKLSRGERLRLAL
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHH
EELGPTFIKMGQILSTRSDILPKDIIKELEKLQDKAPAFSFDEVKSVIQNEFGESLEEAY
HHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AEFEPTPLAAASIAQVHKALLWSGKTVVVKVQRPGIEKIIAQDMRILEDIAKFVDNHTKY
HHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GKIYNFTKMVEDFKKRLEEELDFRIEGENAEKFKKNFLKDKKVKIPSIIWTHTTRRVLTM
CHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHH
EYIGGIPLNDFNAIDEAGLDRGAIARNLAKSVLNQILRDGFFHGDPHPGNIMVLEDGTIA
HHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEE
FLDFGMVGSLSPERKRQFSKMLLGIVYKNSRMIIESIIDLNAVTLNVNMKKLEKDINNLR
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHH
DRYVEIPLEKLKVGEVLNGIFDLVFSYNIVIPNEFNMLAKSLITLEGIVEKLDPKISVLE
HHHHHCCHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
VAKPIAKQLIPKMFSTQHMKEEIINATMDYSRLIKELPSFLLNFLRKTEEENYAIELKIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
DLENLEKRVDKVFNRLSTSIILLALSIVIAGILIGSGMSANAGAEMYKLNGIILKIGLAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHHHHHHH
AFVIVLGLAISIFRSGRL
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQHLRRYREIIFVFIKYGFGAIIDNIGILKHINVRRKILKQTNDENIAKLSRGERLRLAL
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHH
EELGPTFIKMGQILSTRSDILPKDIIKELEKLQDKAPAFSFDEVKSVIQNEFGESLEEAY
HHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AEFEPTPLAAASIAQVHKALLWSGKTVVVKVQRPGIEKIIAQDMRILEDIAKFVDNHTKY
HHCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCC
GKIYNFTKMVEDFKKRLEEELDFRIEGENAEKFKKNFLKDKKVKIPSIIWTHTTRRVLTM
CHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHH
EYIGGIPLNDFNAIDEAGLDRGAIARNLAKSVLNQILRDGFFHGDPHPGNIMVLEDGTIA
HHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEE
FLDFGMVGSLSPERKRQFSKMLLGIVYKNSRMIIESIIDLNAVTLNVNMKKLEKDINNLR
EEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHH
DRYVEIPLEKLKVGEVLNGIFDLVFSYNIVIPNEFNMLAKSLITLEGIVEKLDPKISVLE
HHHHHCCHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
VAKPIAKQLIPKMFSTQHMKEEIINATMDYSRLIKELPSFLLNFLRKTEEENYAIELKIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
DLENLEKRVDKVFNRLSTSIILLALSIVIAGILIGSGMSANAGAEMYKLNGIILKIGLAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHHHHHHH
AFVIVLGLAISIFRSGRL
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]