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The map label for this gene is thrS

Identifier: 20808138

GI number: 20808138

Start: 1664044

End: 1665978

Strand: Reverse

Name: thrS

Synonym: TTE1713

Alternate gene names: 20808138

Gene position: 1665978-1664044 (Counterclockwise)

Preceding gene: 20808139

Following gene: 20808137

Centisome position: 61.95

GC content: 41.65

Gene sequence:

>1935_bases
TTGTACAGTTTGGGTAACCAGGTTAAGGCGATGGTAATTACTTTAAGGGACGGCACGAAAAGAGAATTTGAAAAGGGAAT
CACTGTGTATGAAATTGCAAAAAGTATAAGCGATAAACTGGCGAGAGAGGCTGTGGGAGGAAAATTTAATGGCAAGATAG
TAGAGCTTAATACGAAGATTGAAGAAGATGGGGAGTTAGAGATTTTGACTTTTGAAGATGAAGAGGGGAAAAAGATTTAC
TGGCACACTTCTTCCCATATTCTGGCACAAGCTGTCAAAAGGCTTTTTAAAGATGTCAAACTGGCAATCGGCCCTGCCAT
AGACAATGGCTTTTACTACGATTTTGATACAGAAAGGCCTTTCACAACAGAAGATTTTGAGGCTATAGAGGAGGAAATGA
ATAAAATAATAAAAGAGGACTACAAGTTAGAGAGATTTGTCCTTTCAAAAGAAGAAGCTATAAAGTTTATGAAAGAAAAA
GATGAGCCCTATAAGGTAGAGTTGATTGAAGAGATACCAGAAGGAGAAGAAATTTCCTTTTACAAGCAGGGAGAGTTTGT
GGACCTATGTGCAGGACCTCATCTCCCCTCTACAGGCATGGTAAAGGCCATAAAATTGCTTTCAGTAGCTGGTGCTTATT
GGAAGGGCGATGAGAAGAACAAGATGCTGCAAAGAATATATGGCATAAGCTTCCCCAAGAAGAGCATGCTGGACGAGTAC
CTACATATGATGGAAGAGGCTAAAAAGAGGGACCACAGAAAATTGGGGAAGGAGCTTGACTTATTTAGCATACATCCTGA
AGGGCCTGGTTTTCCATTTTTCCATCCGAAGGGCATGATTATAAGGAATATATTGGAGGATTTTTGGAGAAAAGAGCACA
TAAAGAGGGGATACCAGGAGATAAGAACTCCTATAATTTTAAACGAGGAGCTCTGGAAGAGGTCTGGACACTGGGACCAC
TACAAAGAGAACATGTACTTTACGGAAATTGACGGACAGACTTATGCGATAAAACCGATGAACTGTCCTGGAGCGATGTT
AGTTTATAAGTCAACACTTAGAAGCTATAGAGATTTGCCGTTAAGGCTTTGCGAGCTGGGATTAGTCCACAGGCATGAGC
TTTCTGGAGTGCTGCACGGGCTCATGAGGGTGAGAAGTTTCACGCAGGACGATGCTCACCTTTTCATGACTCCAGAACAG
GTGGAAGATGAGATTTTAGGGGTAATAAACCTGGTTGACTATTTCTACAAGATATTCGGATTTGAGTATCATGTGGAACT
TTCTACAAGACCTGAGAATTCTATGGGAACAGATGAAGAGTGGGAGCTGGCGACAAATGCCTTGATTTCTGCTTTAAAGA
GAGCTAATCTGCCTTACAAGGTGAATGAGGGAGAAGGGGCTTTTTACGGGCCTAAGATAGATTTCCACTTAAAGGACAGC
ATAGGTCGCACATGGCAGTGCGGGACAATTCAACTGGATTTCCAGATGCCAGAGAGGTTTGAACTGGAGTATATAGGACC
AGACGGAGAAAAACACAGACCTATAATGTTGCACAGGGTGATTTACGGCAGCATAGAAAGGTTTATTGGAATTTTAACAG
AGCATTTTGCAGGAGCTTTTCCCACATGGCTTGCGCCTGTGCAGGTGAGAGTTTTGCCTATTTCTGAAAAGCACCATGAA
TATGCGAGAAAAGTCTATGAGCGCTTGCAGGAGCACGATATAAGGGTTGAGCTAGATGACAGAAATGAAAAAATAGGATA
CAAGATAAGGGAAGCACAGCTTCAAAAAATTCCTTACATGCTGATTGTGGGAGATAGGGAAGTAGAAGAGGGAAATGTTT
CGTTAAGGTCCAGAAAAGATGGGGATTTGGGGCCAATTTCTCTAGACAATTTCATAGAAAAAATTCTAAAAGAGATAGCT
ACAAAAGCGCTCTAA

Upstream 100 bases:

>100_bases
CTTGGGGCAGGGGCTATGGCTTTCCCAAATACCGCCTGCTGGGGCTGGGAAAGTCTGAAGGGCGGACTACAAATACCCCA
GCTATCTAAACTGTACATTT

Downstream 100 bases:

>100_bases
AATCAAAATGTCCCTTTTCAAAAGGGGCATTTTGATTTCTTGAAAGAATTTTAAAAACATGGTAAGCTAAAATTAAAATA
TTTTATTTTGAAGGGAAGGG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MYSLGNQVKAMVITLRDGTKREFEKGITVYEIAKSISDKLAREAVGGKFNGKIVELNTKIEEDGELEILTFEDEEGKKIY
WHTSSHILAQAVKRLFKDVKLAIGPAIDNGFYYDFDTERPFTTEDFEAIEEEMNKIIKEDYKLERFVLSKEEAIKFMKEK
DEPYKVELIEEIPEGEEISFYKQGEFVDLCAGPHLPSTGMVKAIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDEY
LHMMEEAKKRDHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKRGYQEIRTPIILNEELWKRSGHWDH
YKENMYFTEIDGQTYAIKPMNCPGAMLVYKSTLRSYRDLPLRLCELGLVHRHELSGVLHGLMRVRSFTQDDAHLFMTPEQ
VEDEILGVINLVDYFYKIFGFEYHVELSTRPENSMGTDEEWELATNALISALKRANLPYKVNEGEGAFYGPKIDFHLKDS
IGRTWQCGTIQLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAFPTWLAPVQVRVLPISEKHHE
YARKVYERLQEHDIRVELDDRNEKIGYKIREAQLQKIPYMLIVGDREVEEGNVSLRSRKDGDLGPISLDNFIEKILKEIA
TKAL

Sequences:

>Translated_644_residues
MYSLGNQVKAMVITLRDGTKREFEKGITVYEIAKSISDKLAREAVGGKFNGKIVELNTKIEEDGELEILTFEDEEGKKIY
WHTSSHILAQAVKRLFKDVKLAIGPAIDNGFYYDFDTERPFTTEDFEAIEEEMNKIIKEDYKLERFVLSKEEAIKFMKEK
DEPYKVELIEEIPEGEEISFYKQGEFVDLCAGPHLPSTGMVKAIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDEY
LHMMEEAKKRDHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKRGYQEIRTPIILNEELWKRSGHWDH
YKENMYFTEIDGQTYAIKPMNCPGAMLVYKSTLRSYRDLPLRLCELGLVHRHELSGVLHGLMRVRSFTQDDAHLFMTPEQ
VEDEILGVINLVDYFYKIFGFEYHVELSTRPENSMGTDEEWELATNALISALKRANLPYKVNEGEGAFYGPKIDFHLKDS
IGRTWQCGTIQLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAFPTWLAPVQVRVLPISEKHHE
YARKVYERLQEHDIRVELDDRNEKIGYKIREAQLQKIPYMLIVGDREVEEGNVSLRSRKDGDLGPISLDNFIEKILKEIA
TKAL
>Mature_644_residues
MYSLGNQVKAMVITLRDGTKREFEKGITVYEIAKSISDKLAREAVGGKFNGKIVELNTKIEEDGELEILTFEDEEGKKIY
WHTSSHILAQAVKRLFKDVKLAIGPAIDNGFYYDFDTERPFTTEDFEAIEEEMNKIIKEDYKLERFVLSKEEAIKFMKEK
DEPYKVELIEEIPEGEEISFYKQGEFVDLCAGPHLPSTGMVKAIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDEY
LHMMEEAKKRDHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKRGYQEIRTPIILNEELWKRSGHWDH
YKENMYFTEIDGQTYAIKPMNCPGAMLVYKSTLRSYRDLPLRLCELGLVHRHELSGVLHGLMRVRSFTQDDAHLFMTPEQ
VEDEILGVINLVDYFYKIFGFEYHVELSTRPENSMGTDEEWELATNALISALKRANLPYKVNEGEGAFYGPKIDFHLKDS
IGRTWQCGTIQLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAFPTWLAPVQVRVLPISEKHHE
YARKVYERLQEHDIRVELDDRNEKIGYKIREAQLQKIPYMLIVGDREVEEGNVSLRSRKDGDLGPISLDNFIEKILKEIA
TKAL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=640, Percent_Identity=44.0625, Blast_Score=551, Evalue=1e-156,
Organism=Homo sapiens, GI38570111, Length=644, Percent_Identity=42.5465838509317, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI20070344, Length=635, Percent_Identity=38.8976377952756, Blast_Score=480, Evalue=1e-135,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=48.0314960629921, Blast_Score=645, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=183, Percent_Identity=28.4153005464481, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71984184, Length=627, Percent_Identity=40.9888357256778, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71984192, Length=627, Percent_Identity=40.9888357256778, Blast_Score=527, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6322112, Length=651, Percent_Identity=42.5499231950845, Blast_Score=546, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322654, Length=397, Percent_Identity=39.2947103274559, Blast_Score=301, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24583839, Length=628, Percent_Identity=43.6305732484076, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583842, Length=628, Percent_Identity=43.6305732484076, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI28574141, Length=628, Percent_Identity=43.6305732484076, Blast_Score=562, Evalue=1e-160,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_THETN (Q8R9A4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_623309.1
- ProteinModelPortal:   Q8R9A4
- SMR:   Q8R9A4
- GeneID:   996687
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE1713
- NMPDR:   fig|273068.3.peg.1692
- HOGENOM:   HBG352811
- OMA:   FHPKGMV
- ProtClustDB:   PRK00413
- BioCyc:   TTEN273068:TTE1713-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 75015; Mature: 75015

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLGNQVKAMVITLRDGTKREFEKGITVYEIAKSISDKLAREAVGGKFNGKIVELNTKI
CCCCCCCEEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
EEDGELEILTFEDEEGKKIYWHTSSHILAQAVKRLFKDVKLAIGPAIDNGFYYDFDTERP
CCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEECCCEEEECCCCCC
FTTEDFEAIEEEMNKIIKEDYKLERFVLSKEEAIKFMKEKDEPYKVELIEEIPEGEEISF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEHHHHHCCCCCCEEE
YKQGEFVDLCAGPHLPSTGMVKAIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDEY
EECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHH
LHMMEEAKKRDHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKRGYQE
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IRTPIILNEELWKRSGHWDHYKENMYFTEIDGQTYAIKPMNCPGAMLVYKSTLRSYRDLP
HCCCEEECHHHHHCCCCCCHHHCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCH
LRLCELGLVHRHELSGVLHGLMRVRSFTQDDAHLFMTPEQVEDEILGVINLVDYFYKIFG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHC
FEYHVELSTRPENSMGTDEEWELATNALISALKRANLPYKVNEGEGAFYGPKIDFHLKDS
EEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEECCC
IGRTWQCGTIQLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAF
CCCEEECCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PTWLAPVQVRVLPISEKHHEYARKVYERLQEHDIRVELDDRNEKIGYKIREAQLQKIPYM
CHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCEE
LIVGDREVEEGNVSLRSRKDGDLGPISLDNFIEKILKEIATKAL
EEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYSLGNQVKAMVITLRDGTKREFEKGITVYEIAKSISDKLAREAVGGKFNGKIVELNTKI
CCCCCCCEEEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
EEDGELEILTFEDEEGKKIYWHTSSHILAQAVKRLFKDVKLAIGPAIDNGFYYDFDTERP
CCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEECCCEEEECCCCCC
FTTEDFEAIEEEMNKIIKEDYKLERFVLSKEEAIKFMKEKDEPYKVELIEEIPEGEEISF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEHHHHHCCCCCCEEE
YKQGEFVDLCAGPHLPSTGMVKAIKLLSVAGAYWKGDEKNKMLQRIYGISFPKKSMLDEY
EECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHH
LHMMEEAKKRDHRKLGKELDLFSIHPEGPGFPFFHPKGMIIRNILEDFWRKEHIKRGYQE
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IRTPIILNEELWKRSGHWDHYKENMYFTEIDGQTYAIKPMNCPGAMLVYKSTLRSYRDLP
HCCCEEECHHHHHCCCCCCHHHCCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCH
LRLCELGLVHRHELSGVLHGLMRVRSFTQDDAHLFMTPEQVEDEILGVINLVDYFYKIFG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHC
FEYHVELSTRPENSMGTDEEWELATNALISALKRANLPYKVNEGEGAFYGPKIDFHLKDS
EEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEECCEEEEEECCC
IGRTWQCGTIQLDFQMPERFELEYIGPDGEKHRPIMLHRVIYGSIERFIGILTEHFAGAF
CCCEEECCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
PTWLAPVQVRVLPISEKHHEYARKVYERLQEHDIRVELDDRNEKIGYKIREAQLQKIPYM
CHHCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCEE
LIVGDREVEEGNVSLRSRKDGDLGPISLDNFIEKILKEIATKAL
EEECCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336